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Differential Inhibitory Action of Taurine between Electrically Evoked Response and Low $Mg^{++}-Induced$ Spontaneous Activity in the CA1 Area of the Rat Hippocampal Slices

  • Baek, Soo-Youn;Yang, Sung-Gu;Lee, Chang-Joong
    • The Korean Journal of Physiology and Pharmacology
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    • v.1 no.5
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    • pp.467-475
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    • 1997
  • Although one of the major physiological functions of taurine(2-aminoethanesulfonic acid) is the inhibitory action on the central nervous system(CNS), the mechanism of taurine in controlling the neuronal excitation in the CNS has been in controversy. Electrically evoked pEPSP and spontaneous activity induced by the perfusion of low $Mg^{++}-ACSF$ were recorded in the CA1 pyramidal cell layer of the hippocampal slice. To test the inhibitory effect of taurine on spontaneous responses, taurine was treated for 2 min at various concentrations(1 mM-10 mM). Taurine reduced the spontaneous activity by 22.2% at 1 mM, and 100% at 2 mM in low $Mg^{++}-ACSF$. Evoked response was induced by electrical stimulation of Schaffer collateral-commissural fibers. Taurine reduced the evoked response by 11.68% at 3 mM, and 24.25% at 5 mM. Even 20 mM of taurine reduced the evoked response only by 24 % after 5 min treatment. That is, the inhibitory efficacy was much higher in spontaneous activity than in evoked response. The $GABA_A$ receptor antagonist, 100 uM bicuculline, blocked the inhibitory action of taurine, while $GABA_B$ receptor antagonist, 700 uM phaclofen, did not. Taurine blocked the spontaneous activity in the presence of CNQX, and did not block the electrically evoked responce in the presence of APV. The results suggest that taurine causes hyperpolarization in the cell by binding to $GABA_A$ receptor and preferentially attenuates NMDA receptor-mediated hyperexcitation, leaving synaptic transmission unmodified.

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Biomechanical Evaluation of Elbow Moment in Pitching Types according to the Throwing Speed: A Pilot Study

  • Lee, Chang-Hyung;Yang, Jin-Hwan;Lee, Seung-Hoo;Lee, Gyu-Chang;Park, Jong-Chul
    • Korean Journal of Applied Biomechanics
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    • v.30 no.1
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    • pp.1-6
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    • 2020
  • Objective: The incidence rate of elbow ulnar collateral ligament injuries is dependent on the throwing speed or pitching type, especially in adolescent baseball players. However, mixed results have been reported due to a lack of controlled biomechanical analysis. Thus, the purpose of this study was to investigate the biomechanical analysis of the elbow in relation to throwing speed and pitching type. Method: Four overhead type high-school baseball players were recruited for this study. The participants were asked to throw balls with different types of pitch and speed. While the throwing speeds were measured, each pitching moment of the elbow was recorded. Descriptive statistics, frequency analysis, mean comparison analysis, and Pearson's correlation analysis were performed in order to examine differences in peak varus and valgus moment during pitching motion in the elbow in all throwing speed and pitching types. Results: There was no significant difference in physical characteristics, throwing speed, and momentum variability among all players. The mean varus moments were 44.38±1.55 Nm, 48.83±1.66 Nm, and 48.94±0.95 Nm, and the moment gaps between varus and valgus were 7.36±3.25 Nm, 7.44±2.02 Nm, and 7.36±2.62 Nm in fastball, curveball, and slider ball, respectively. The varus moment was higher in the curved and slider balls than in the fastballs, and there was no significant differences between the varus moments regarding the pitching type. However, the increase in valgus moment and decrease in moment gap according to throwing speed was significantly increased in the slider ball (r=0.718 and -0.591, respectively). Conclusion: The possibility of elbow injury caused by the valgus moment or moment gapincreases more rapidly in slider balls as the speed increases. Based on our results, appropriate pitching guidelines should be suggested to prevent ulnarligament injuries, especially in adolescent baseball players.

Arthroscopic Findings of the Canine Stifle Joint (정상견 무릎의 관절경 검사소견)

  • 정순욱;정월순
    • Journal of Veterinary Clinics
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    • v.16 no.2
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    • pp.300-308
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    • 1999
  • Arthroscopy is a valuable diagnostic and operative tool in equine and human orthopedics. The arthroscope is a difficult instrument to use and requires patience, practice, and persistence in order to obtain good results. This technique was found to be less traumatic than arthrotomy, invasiveness, rapid recovery and the feasibility of surgically correcting many arthropathies. The use of the arthroscope in the dog provides a new dimension in the study and diagnosis of joint derangements. The purpose of this report is to introduce the use of the arthroscope in the dog-more specifically, in the stifle of the dog. A diameter 2.7 mm fore-oblique viewing arthroscope, cold light source, video and video printer are used. With the fore-oblique viewing type it is possible to view directly as well as slightly to the side and the range of viewing can be increased by rotating the arthroscope around the object The scope is connected with a cold light source by means of a fiber-optic light guide. The stifle joint was flexed to 20~30$^{\circ}$. The joint were lavaged with lactated Ringer's solution during arthroscopic examination. Arthroscopy of the stifle was performed prior to arthrotomy in 1 dead dog and 4 healthy dogs, and other 3 dogs was performed only arthroscopic examination. In this study only the conventional approaches were used and in most cases it was possible to view all the intra-articular structures via the lateral infrapatellar approach. In the stifle joint, endoscopic observation was performed to find lateral femoral condyle, patella, medial femoral condyle, trochlear groove, tibia, fat, cranial cruciate ligament, caudal cruciate ligament lateral meniscus, tendon of long digital extensor muscle, medial meniscus, and medial collateral ligament Post-arthroscopic examination, the lameness had disappeared within 12~24 hours. Pain and swelling in the stifle joint had disappeared within 24~36 hours. Post-arthroscopic secondary infection was never encountered in the dogs. In conclusion, arthroscopic insertion technique in canine stifle joint using a diameter 2.7 mm 30$^{\circ}$ arthroscope was established and arthroscopical views of all anatomical structures in the normal stilfe joint were obtained through lateral infrapatellar portal.

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Lymphangiographic Interventions to Manage Postoperative Chylothorax

  • Jeong, Hyuncheol;Ahn, Hyo Yeong;Kwon, Hoon;Kim, Yeong Dae;Cho, Jeong Su;Eom, Jungseop
    • Journal of Chest Surgery
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    • v.52 no.6
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    • pp.409-415
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    • 2019
  • Background: Postoperative chylothorax may be caused by iatrogenic injury of the collateral lymphatic ducts after thoracic surgery. Although traditional treatment could be considered in most cases, resolution may be slow. Radiological interventions have recently been developed to manage postoperative chylothorax. This study aimed to compare radiological interventions and conservative management in patients with postoperative chylothorax. Methods: We retrospectively reviewed periprocedural drainage time, length of hospital stay, and nil per os (NPO) duration in 7 patients who received radiological interventions (intervention group [IG]) and in 9 patients who received conservative management (non-intervention group [NG]). Results: The baseline characteristics of the patients in the IG and NG were comparable; however, the median drainage time and median length of hospital stay after detection of chylothorax were significantly shorter in the IG than in the NG (6 vs. 10 days, p=0.036 and 10 vs. 20 days, p=0.025, respectively). NPO duration after chylothorax detection and total drainage duration were somewhat shorter in the IG than in the NG (5 vs. 7 days and 8 vs. 14 days, respectively). Conclusion: This study showed that radiological interventions reduced the duration of drainage and the length of hospital stay, allowing an earlier return to normal life. To overcome several limitations of this study, a prospective, randomized controlled trial with a larger number of patients is recommended.

A Literary Review on Needle Retaining Time: Centered on the Chinese Medical Journal (유침(留鍼)시간에 대한 문헌적 고찰: 중국 문헌을 중심으로)

  • Wang, Kai-Hsia;Lee, Eun-Sol;Cho, Hyun-Seok;Kim, Kyung-Ho
    • Journal of Acupuncture Research
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    • v.28 no.5
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    • pp.65-76
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    • 2011
  • Objectives : Study about needle retaining time. Methods : We reviewed the ancient and the present text of China with using the China academic journal(CAJ) of China national knowledge infrastructure(CNKI) Results & Conclusions : 1. Needle retaining time is important in acupuncture, because the therapy effect is influenced by it. 2. The time of needle retaining is up to those conditions like different disease, viscera and bowels(臟腑), meridian and collateral(經絡), obtaining Qi(得氣), seasons, constitution of the patients and acupuncture tools. In ${\ll}$Hwangdineijing(黃帝內經) ${\gg}$, needle retaining time is called by 'Zhiruzhichu(直入直出)', 'Jichu(疾出)', 'Liu(留)', 'Buliu(不留)', 'Jiuliu(久留)' and 'Liu ${\bigcirc}$ hu(留${\bigcirc}$呼)', and the time was shorter than nowadays. 3. The respiration number was counted to check needle retaining time but we can't find out any evidence. Recently in China, 'obtaining Qi(得氣)' and 'Qi arrival(氣至)' is used to check it. 4. Looking into clinical researches, different diseases need different needle retaining time. For example, 20~30min is appropriate time for musculoskeletal system. 60min is for circulatory system, 10~20min is for peripheral facial nerve paralysis. Insomnia and some stubborn diseases need longer time. Cold and heat(寒熱), deficiency and excess(虛實) are always influences the needle retaining as well. 5. It is important to figure out the most effective needle retaining time for different disease with the base of connection between needle retaining time and effect.

Anatomical Review of Lateral Upper Arm Flap for the Oral and Maxillofacial Reconstruction (구강악안면재건을 위한 외측상완피판의 해부학적 고찰)

  • Seo, Mi Hyun;Kim, Soung Min;Kang, Ji Young;Myoung, Hoon;Lee, Jong Ho
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.34 no.4
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    • pp.286-292
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    • 2012
  • The lateral upper arm flap (LUAF) was initially described by in 1982 by Song et al. as a simple skin flap, addressing the availability of cutaneous nerves for anastomoses. Katsaros et al., reported the use of a lateral upper arm skin flap, but also considered using it as a composite graft. The LUAF for the oral and maxillofacial reconstruction has several advantages over other flaps, such as constant anatomy, good color match and texture, thin design and plasticity. There is no functional limitation in the donor arm, such as strength and extension, and donor defects can be closed primarily with a linear scar, even when a flap of up to 8 cm in width is taken. For a better understanding of LUAF as a routine reconstructive option in moderate defect of maxillofacial region, the constant anatomical findings must be learned and memorized by young doctors during the specialized training course for the Korean national board of oral and maxillofacial surgery. This article review the anatomical basis of LUAF with Korean language.

Clinical Usefulness of M-test on Patients with Chronic Neck Pain: A Single Arm Pre-post Comparison Study (M-test에 근거한 만성 경항통 환자의 진단 및 치료: 전후비교 임상연구)

  • Cho, Woo-Young;Chung, Seok-Hee
    • Journal of Korean Medicine Rehabilitation
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    • v.26 no.4
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    • pp.67-75
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    • 2016
  • Objectives The purpose of this study was to investigate the clinical usefulness of M-test (Meridian test) as an adjunctive evaluation and treatment in patients with chronic neck pain. Methods This study was a single arm pre-post comparison study. Thirty-six eligible subjects with chronic neck pain were recruited from August to September, 2015. M-test was used for evaluating the condition of meridian, which can induce the limitation of ROM and body discomfort. Subjects were offered intradermal acupuncture treatment on one-acupoint for 48 hours. Cervical numeric rating scale (NRS), cervical range of motion (ROM), neck disability index (NDI) and surface electromyography (SEMG) were measured before and after the treatment. Total NRS and the number of movement limitation of M-test were also measured before and after the treatment. Results Among the 36 participating subjects, 4 subjects were lost to follow-up or excluded in accordance with the criteria. Significant differences on Cervical NRS and NDI were found after the treatment (p<0.001). There was a significant difference in the range of left cervical rotation (p<0.05). Root mean square (RMS) of SEMG significantly decreased on the right sternocleidomastoid muscle (p<0.05), but significantly increased on the right trapezius muscle (p<0.05). Median frequency (MdF) of SEMG significantly increased on both sternocleidomastoid muscles. There appears to be significant differences after the treatment in total NRS and the number of movement limitation of M-test (p<0.05). Conclusions These results suggest that the evaluation and treatment of M-test based on the meridian and collateral theory were effective on cervical NRS and NDI, and also improved the movability of human body.

MAXILLARY MOLAR DISTALIZATION WITH A PENDULUM APPLIANCE (Pendulum 장치를 이용한 상악 대구치의 원심이동 증례)

  • Lee, H.J.;Kim, Y.J.;Kim, J.W.;Jang, K.T.;Lee, S.H.;Kim, C.C.;Hahn, S.H.
    • Journal of the korean academy of Pediatric Dentistry
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    • v.35 no.3
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    • pp.523-531
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    • 2008
  • Maxillary molar distalization is a treatment approach for patients with Class II malocclusions who do not require extractions and mesial movements of mandibular molars. The pendulum appliance is effective for distalization of the maxillary molars and independent of patient cooperation. This appliance can stabilize the maxillary premolars and use the palatal rugae area as an additional anchorage. However, caution is needed to control collateral effects, including increase of lower facial height, incisor protrusion and damage to the rugae area. This article reports the cases in which maxillary molar distalization achieved by pendulum appliance resolves the space problems and corrects the molar relationships.

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A Case of Rasmussen Aneurysm Treated by Pulmonary Arterial Embolization (폐동맥색전술로 치료된 Rasmussen 동맥류 1예)

  • Park, Sung-Oh;Ko, Hyuk;Kim, Su-Hee;Park, Wan;Lee, Deck-Hee;Ryul, Dae-Sik;Jung, Bock-Hyun
    • Tuberculosis and Respiratory Diseases
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    • v.51 no.1
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    • pp.53-58
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    • 2001
  • A 42 year-old male with a history of multidrug-resistant pulmonary tuberculosis suddenly developed massive hemoptysis. Embolization of a bronchial artery branch and the collateral systemic arteries did not resolve the recurrent bleeding. Spiral computerized tomography(spiral CT) of the chest showed contrast enhanced nodules within a large cavity at the left lower lobe in the arterial phase suggesting a Rasmussen aneurysm. A pulmonary angiogram showed abnormal vascular nodules at that site. Coils were deployed at both the proximal and distal vessels of this aneurysmal sac for embolization. Transcatheter arterial embolization is a safe and effective means of controlling bleeding from this pulmonary arterial pseudoaneurysm. Here we report a case of a Rasmussen aneurysm diagnosed by spiral CT, which was successfully treated by pulmonary arterial embolization with a coil.

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The Characteristic of a Functional Design for a Commercial Outdoor-Wear Jacket (국내 아웃도어 브랜드 등산복 재킷의 기능별 디자인 특성)

  • Lee, Young-Wha;Seo, Moon-Jung;Seo, In-Kyung;Kim, Young-In
    • Journal of the Korean Society of Costume
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    • v.63 no.7
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    • pp.1-16
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    • 2013
  • The objective of this study is to analyze the characteristic of a functional design for a commercial outdoor brand jacket based on 3 types of functions : windproof, waterproof, and cold proof. To analyze the design and fabric characteristics of outdoor jackets by function, 903 men's and women's outdoor jacket images were selected from the catalogues during S/S 2009 - F/W 2011 of the 6 brands: The North Face, Columbia Sports Wear, Kolon Sports, K2, Arcteryx and Mont-Bell. These brands were selected based on their high market share and brand awareness of the outdoor brands in Korea. In this study, design elements analysis was conducted as following 8 elements: hood/collar height/central front flap/waistline/pocket location/ventilation for the body part/sleeve patterns/cuff for the sleeve part. Fabrics were analyzed by the frequency of fabric types used in the 3 jacket types. According to the result derived from the analysis of the six brands of outdoor wear jacket design trends by year, detachable hood and a co-use of velcro and elastic bands have been mainly designed for all of windproof, waterproof, and cold proof jacket to all in order to respond quickly to changes in the external environment. For reinforced storage function on trekking, the number of pockets has been gradually growing, and a function was being developed to connect an electronic device to a pocket. The method, result, and collateral observations relevant to each of these phases are described. Outdoor jacket design characteristics were investigated for outdoor brands, which can provide data to suggest more accurate functional design, and satisfy functional design needs. In this regard, this research was significant in the sense that it suggested preliminary data to reconsider competitiveness of the brand products.