• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2093-2098
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• 2015

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

• Nuclear Engineering and Technology
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• 제51권8호
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• pp.1970-1977
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• 2019

Understanding the irradiation hardening effect of structural steels under various irradiation conditions plays an important role in developing advanced nuclear systems. Such being the case, a crystal plasticity model for body-centered cubic (BCC) crystal based on the density of dislocations and irradiation defects is summarized and numerically implemented in this paper. Based on this model, nano-indentation hardness of Chinese A508-3 steels with ion irradiation is calculated. Very good agreement is observed between simulation and experimental data of several different irradiation doses subjected to various operating temperatures, from which, it can be concluded that indentation hardness increases with increasing irradiation dose at both room temperature and high temperature. Consequently, the validity of this model has been proved properly, and furthermore, the model established in this paper could guide the study of irradiation hardening effect and temperature effect to some extent.

• International Journal of Naval Architecture and Ocean Engineering
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• 제10권6호
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• pp.692-710
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• 2018

The Three-dimensional (3-D) dynamical behaviors of a fluid-conveying pipe subjected to vortex-induced vibration are investigated with different internal flow velocity ${\nu}$. The values of the internal flow velocity are considered in both subcritical and supercritical regimes. During the study, the 3-D nonlinear equations are discretized by the Galerkin method and solved by a fourth-order Runge-Kutta method. The results indicate that for a constant internal flow velocity ${\nu}$ in the subcritical regime, the peak Cross-flow (CF) amplitude increases firstly and then decrease accompanied by amplitude jumps with the increase of the external reduced velocity. While two response bands are observed in the In-line (IL) direction. For the dynamics in the lock-in condition, 3-D periodic, quasi-periodic and chaotic vibrations are observed. A variety of CF and IL responses can be detected for different modes with the increase of ${\nu}$. For the cases studied in the supercritical regime, the dynamics shows a great diversity with that in the subcritical regime. Various dynamical responses, which include 3-D periodic, quasi-periodic as well as chaotic motions, are found while both CF and IL responses are coupled while ${\nu}$ is beyond the critical value. Besides, the responses corresponding to different couples of ${\mu}_1$ and ${\mu}_2$ are obviously distinct from each other.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1416-1428
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• 2021

Pebble flow characteristics can be significantly affected by the configuration of pebble bed, especially for HTGR pebble beds. How to achieve a desired uniform flow pattern without stagnation is the top priority for reactor design. Pebbles flows inside some specially designed pebble bed with arc-shaped contraction configurations at the bottom, including both concave-inward and convex-outward shapes are explored based on discrete element method. Flow characteristics including pebble retention, residence-time frequency density, flow uniformity as well as axial velocity are investigated. The results show that the traditionally designed pebble bed with cone-shape bottom is not the most preferred structure with respect to flow pattern for reactor design. By improving the contraction configuration, the flow performance can be significantly enhanced. The flow in the convex-shape configuration featured by uniformity, consistency and less stagnation, is much more desirable for pebble bed design. In contrast, when the shape is from convex-forward to concave-inward, the flow shows more nonuniformity and stagnation in the corner although the average cross-section axial velocity is the largest due to the dominant middle pebbles.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1350-1364
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• 2023

2D/1D coupling method is an important neutron transport calculation method due to its high accuracy and relatively low computation cost. However, 2D/1D coupling method may diverge especially in small axial mesh size. To analyze the convergence behavior of 2D/1D coupling method, a Fourier analysis for k-eigenvalue neutron transport problems is implemented. The analysis results present the divergence problem of 2D/1D coupling method in small axial mesh size. Several common attempts are made to solve the divergence problem, which are to increase the number of inner iterations of the 2D or 1D calculation, and two times 1D calculations per outer iteration. However, these attempts only could improve the convergence rate but cannot deal with the divergence problem of 2D/1D coupling method thoroughly. Moreover, the choice of axial solvers, such as DGFEM SN and traditional SN, and its effect on the convergence behavior are also discussed. The results show that the choice of axial solver is a key point for the convergence of 2D/1D method. The DGFEM SN based 2D/1D method could converge within a wide range of optical thickness region, which is superior to that of traditional SN method.

• Asian Journal of Innovation and Policy
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• 제5권3호
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• pp.251-274
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• 2016

Practical methodology for categorizing collaborative disciplines or research in a quantitative manner is presented by developing a Correlation Matrix of Major Disciplines (CMMD) using bibliometric data collected between 2009 and 2014. First, 21 major disciplines in science and engineering are defined based on journal publication frequency. Second, major disciplines using a comparing discipline correlation matrix is created and correlation score using CMMD is calculated based on an analyzer function that is given to the matrix elements. Third, a correlation between the major disciplines and 14 research fields using CMMD is calculated for validation. Collaborative researches are classified into three groups by partially accepting the definition of pluri-discipline from peer review manual, European Science Foundation, inner-discipline, inter-discipline and cross-discipline. Applying simple categorization criteria identifies three groups of collaborative research and also those results can be visualized. Overall, the proposed methodology supports the categorization for each research field.

• 기술혁신학회지
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• 제12권3호
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• pp.499-524
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• 2009

최근 국가연구개발사업의 추진에 있어서 국제공동연구의 비중이 점차 높아지고 있으나 국제공동연구로부터 발생되는 지식재산권 등의 성과물 관리제도는 미흡한 실정이다. 국제공동연구의 대부분을 수행하고 있는 대학이나 출연(연) 등 공공연구기관의 자체적인 성과관리체계가 미흡하고, 정부차원의 관련 법령도 제대로 정비되지 않고 있다. 본 논문에서는 국제공동연구 수행과 관련한 성과물 관리제도의 실태와 문제점을 분석하고 그 개선방안을 제시하였다.

• Nuclear Engineering and Technology
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• 제52권3호
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• pp.581-588
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• 2020

The membrane fouling is an important problem for FO applied to the radioactive wastewater treatment. The FO fouling characteristics for simulated radioactive wastewater treatment was investigated. On-line cleaning by deionized (DI) water and external cleaning by ultrasound and HCl were applied for the fouled membrane. The effectiveness and foulant removing amount by each-step cleaning were evaluated. The membrane fouling was divided into three stages. Co(II), Sr(II), Cs(I), Na(I) were all found deposited on both active and support layers of the membrane surface, resulting in membrane surface became rougher and more hydrophobic, which increased membrane resistance. On-line cleaning by DI water recovered the water flux to 69%. HCl removed more foulants than ultrasound.

• 한국산학기술학회논문지
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• 제19권3호
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• pp.75-82
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• 2018

최근 신흥개발국들은 한국형 경제개발 정책에 관심을 갖고 한국의 지역혁신 모델을 접목하고자 노력하고 있다. 한국도 신흥국의 수요에 맞추어 지역혁신 모델을 수출하고 해당국과 경제협력을 강화하는데 관심이 있다. 본 연구는 신흥국에 대한 한국형 지역혁신모델 전수사업을 분석하고 정책을 제시하고자 한다. 이를 위해 태국, 키르키즈공화국, 베트남, 멕시코 등 신흥 4개국의 혁신기관 실무자들이 공동학습 - 네트워크- 상호작용 활동에 참여하는 행태를 표적집단면접법에 의해 분석하였다. 한국의 혁신기관에서 제공하는 전수사업에서 현지국가 혁신주체의 초기 활동을 분석한 결과, 전수사업의 연수 시간과 이후 현지인들에 의한 자체 공동학습 참여율의 관계는 가장 밀접한 상관관계 (0.975)가 있음을 발견하였다. 그러나 이들의 자체 공동학습과 현지의 네트워크 참여율의 상관계수는 다소 낮아 (0.667), 현지에서 공동학습을 네트워크로 연결하는 정책이 필요하다. 네트워크 참여율과 혁신주체의 상호작용 참여율은 높은 상관관계 (0.950)로 나타나, 네트워크 구축이 지역혁신 모델의 관건이라는 것을 보여준다. 본 연구는 교육과 컨설팅 형태의 연수보다는 현지의 혁신 네트워크 활동을 촉진하는 사업을 추천한다. 본 연구는 충남테크노파크의 사례와 같이 혁신주체들이 스스로 학습 네트워크를 구축하여 지역에 맞는 혁신모델을 창출하고 지역혁신플랫폼을 직접 운영하는 단계까지 추진하는 전수사업 정책을 제안한다.

• World Technopolis Review
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• 제7권1호
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• pp.2-14
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• 2018

Nowadays, we are standing in front of the $4^{th}$ Industrial Revolution that is featured by a great range of new and advanced technologies that influences all the domains of economies and industries. The great question that this revolution raises is how it can lead to a future that reflects the peoples' common objectives and values on how these advanced technologies can affect the life and transform the economic, social, cultural, and human environment. It is commonly agreed that to be adapted to these changes and needs and shape a society with competitive economies with highly-skilled individuals, we need to encourage innovation, entrepreneurship, new knowledge generation and exchange and true and effective collaboration and communication. In this complex scene, education seems to have a central and critical role on finding new ways of developing expertise and innovation within the existing knowledge procedures, with more and better cooperation between the key players. This paper argues the concepts, opportunities and challenges that are related to the learning ecosystem towards the needs raised by the $4^{th}$ Industrial Revolution. The education is discussed as catalyst but also as carrier of innovation and innovation practices and the basis of a relevant framework is presented that takes into account all the aspects, domains and key players of educational world and interacting domains. Having introduced the ideas of innovation, collaboration and technology advancement in this environment, this paper also presents a real case of practice, focusing on how more than 5.000 schools around Europe succeeded the last four (4) years to implement innovation activities in a collaborative way and under a unique but also flexible pedagogical innovation framework.