• Journal of Acupuncture Research
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• 제22권6호
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• pp.27-36
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• 2005

Introduction : The aim of the study is to investigate the suppressive action of electroacupuncture on cold alloynia development in the rat model of neuopathic pain. Methods : To produce neuropathic pain, the right superior caudal trunk was resected $1{\sim}2\;mm$ between S1 and S2 spinal nerves. The rats were divided into control and four electroacupuncture groups: Two electroacupuncture groups were given 2 Hz or 100 Hz electroacupuncture for 20 minutes everyday after the sacral nerve injury. Other two electroacupuncture groups were given 2 Hz or 100 Hz electroacupuncture for 20 minutes just one session at one hour after the sacral nerve injury. The right point of Joksamni (ST36) was applied for electroacupuncture. The control group was induced neuropathic pain without electroacupuncture. The cold allodynia was assessed by immersing the tail in $4^{\circ}C$ water. The latency to an abrupt tail movement after rat tail immersion was measured with a cut-off time of 15 sec at 4th, 7th and 14th day after the sacral nerve injury. Results : The results were as follows; 1. At 4th experimental day, there were no significant differences between 2 Hz or 100 Hz electroacupuncture groups and the control group. 2. At 7th experimental day, everyday 2 Hz or 100 Hz electroacupuncture groups showed significant differences compared with the control group. But There were no significant differences between 2 Hz and 100 Hz electroacupuncture groups. 3. At 14th experimental day, everyday 2 Hz electroacupuncture group showed significant differences compared with the control group. But everyday 100 Hz electroacupuncture group showed no significant difference compared with the control group and everyday 2 Hz electroacupuncture group. 4. There were no significant differences between the control and 2 Hz or 100 Hz electroacupuncture groups which were done just one session at one hour after the surgery. 5. Everyday 2 Hz electroacupuncture group showed significant differences in the one session of the 100 Hz electroacupuncture group. Conclusion : Everyday 2 Hz electroacupuncture exerts a suppressive action on cold allodynia development in the rat model of neuropathic pain.

• 동의생리병리학회지
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• 제22권1호
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• pp.234-245
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• 2008

Yeonkyopaedok-san(YPS) extract is widely used to treat the common cold. The purpose of this study was to evaluate the efficacy of YPS on the common cold. Two hundred Patients with common colds of recent onset were randomized to the double blind, placebo-controlled study. They received 800 mg YPS extract or placebo in capsules, orally dissolved 3 times a day for 7 days. The total symptom score was assessed by the physician, using a 5-point scale on start and finish. Resolution of cold symptoms based on subjective daily symptoms. Total symptom score was significantly decreased in YPS groups in comparison to that in placebo group (p=0.027). Headache (p=0.012), loss of appetite (p=0.037), eyeball discomfort (p=0.002) were more affected. Time to resolution of cold symptoms did not show significant effect (p=0.592). Adverse effects were less in the YPS group than placebo group (2% vs 3%). In this community-based, randomized controlled trial, YPS were effective in treating cold symptoms in college students.

• 대한한의학방제학회지
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• 제21권2호
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• pp.144-157
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• 2013

Objectives : The aim of this study was to evaluate the efficacy of Hwangnyeonhaedok-tang (HH) and Geongangbuja-tang (GB) on the plasma hormone level in mice exposed to cold stress. HH and GB are the representative prescriptions of cold and hot property, respectively. Methods : We established cold condition by confining ICR mice to a $4^{\circ}C$ cage for 24 hours, ICR mice were given a HH (100, 300, 1000 mg/kg) or GB (100, 300, 1000 mg/kg) extract orally twice a day for three consecutive days. From the second day, they were given cold stress ($4^{\circ}C$) for twenty four hours. To measure the plasma corticosterone, insulin, thyroxine, epinephrine and norepinephrine levels of mice, their blood samples were collected from cardiac puncture, immediately centrifuged at $4^{\circ}C$. The protein level of HSP70 and JNK was examined using western blot analysis in cortex and hypothalamus. Results : Oral administration of GB more significantly reduced plasma corticosterone level raised by cold stress than HH. Gardeniae Fructus (CJ), the constituent of HH, significantly increased the thyroxine level. Western blot analysis showed that cold stress-induced Heat shock protein 70 (HSP70) expression was increased by HH and GB, HH decreased JNK expression and GB increased JNK expression dose-depently in hypothalamus. Scutellariae Radix (HG), Zingiberis Rhizoma (GG) and Aconiti Tuber (BJ) decreased HSP70 in hypothalamus and GG, BJ decreased HSP70 in cortex as well. Conclusions : These results suggest Geongangbuja-tang (GB) is more effective for ameliorating the stress response caused by cold stress.

• 한국건설순환자원학회논문집
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• 제6권4호
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• pp.259-266
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• 2018

본 연구에서는 3가지 수준의 재령(28일, 91일, 365일)을 고려하고 OPC 콘크리트와 GGBFS 콘크리트를 대상으로 콜드조인트 콘크리트의 탄산화 거동 및 강도특성을 평가하였다. GGBFS 콘크리트의 압축강도는 91일에서 OPC 콘크리트의 86% 수준이었으나, 지속적인 수화반응으로 인해 재령 365일 재령에서는 107%로 높게 평가되었다. 탄산화 속도계수는 91일을 기점으로 OPC 및 GGBFS 콘크리트 모두 크게 감소하였으며 콜드조인트 효과는 OPC 콘크리트에서 크게 평가되지만 GGBFS 콘크리트에서는 비슷한 수준으로 평가되었다. 콜드조인트에서 OPC 콘크리트의 경우 28일에서는 1.06배, 365일에서는 1.33배 수준으로 탄산화 속도계수가 증가하였다. 그러나 GGBFS 콘크리트의 경우 28일에서는 1.08배, 재령 365일에서는 1.04배로 큰 차이가 발생하지 않았다.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2009년도 하계학술발표대회 논문집
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• pp.990-995
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• 2009

Experimental basic study was performed to understand the characteristics of sub-cooled refrigerant using a cold heat storage system. This system was made up general vapor-compression refrigeration cycle added sub-cooler and ice storage tank. The purpose of this study are to application use of cold-heat storage systems multiplicity of fields and to understand of sub-cooling system. At the condition using ice storage system, the ice making process was operated during night time by electric power. And then, the refrigerant was sub-cooled using stored cold-heat after being discharged from the air cooling condenser during the day time. Comparing the result at general operation with the operation using sub-cooling system. This study showed the effects of the sub-cooled degree. The cooling performance was increased owing to the sub-cooling of refrigerant during day time, and the compressor consume power was a little decreased. Thus the COP was also increased owing to the sub-cooling of refrigerant.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 가을학술발표대회논문집
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• pp.131-132
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• 2023

In this paper, standard specification of heat curing section of cold weather concrete between Korea and China were compared. First, Korea concrete specification (KCS 14 20 40) stipulates that the application period is less than 4℃ per day or less than 0℃ per day right after pouring, but in China, the outdoor daily average temperature is less than 5℃ for five consecutive days. This is believed to be due to the difference in temperatures between Korea and China in winter. Next, in the case of Korea, KCS do not show that the concrete temperature in curing should be 5℃ or higher to prevent early frost damage and obtain the minimum required compressive strength. On the other hand, in the case of China, the specificaion does not show that the curing method is selected based on the concrete surface coefficient after considering the outdoor temperature. In addition, in Korea and China regulation, the temperature of the space during thermal curing was shown to be similar.

• 한국구조물진단유지관리공학회 논문집
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• 제21권5호
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• pp.21-29
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• 2017

시공지연 등으로 발생한 콜드조인트는 전단력에 취약하며 염화물 침투 및 확산을 촉진시킨다. 본 연구는 압축 및 인장하중과 콜드조인트 조건을 고려한 1년 양생된 콘크리트의 염화물 확산계수를 분석하였으며 선행연구인 91일 재령의 결과와 비교하였다. 91일 재령결과와 비교할 때, 하중을 재하하지 않은 일반적인 경우에는 건전부에서는 10.7%, 콜드조인트에서는 10.5%로 낮게 평가 되었다. 건전부와 콜드조인트의 감소율의 차이는 비슷하지만 염화물 확산계수는 콜드조인트에서 크게 발생하였다. 압축력 30%의 경우 건전부는 하중재하시 발생된 공극압밀로 인하여 확산계수가 감소하였다. 콜드조인트 콘크리트의 경우 365일 재령은 91일 재령보다 압축력 30%일 경우 10.9%, 압축력 60%일 경우 5.8% 확산계수가 낮게 평가되었는데, 이는 장기간 수중양생에 따른 지속적인 수화반응에 의해 확산계수가 낮게 평가되었기 때문이다. 인장력의 경우 압축부와는 다르게 동일 수준의 인장하중과 재령, 콜드조인트 유 무에 따른 확산계수의 차이가 비교적 크지 않았다. 이는 콘크리트가 1년 재령임에도 불구하고 인장력에 취약한 재료적 특성인 미세균열이 지배적인 영향으로 작용하였기 때문이다.

• The Korean Journal of Pain
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• 제13권2호
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• pp.156-163
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• 2000

Background: Peripheral nerve injury sometimes leads to chronic neuropathic pain such as causalgia. A subset of patients with causalgia have a sympathetically maintained pain which is often evoked by cooling stimuli. However, our knowledge on adrenergic receptor types responsible for cold-evoked pain that is sympathetically dependent is lacking. The present study was conducted to investigate subtypes of adrenoceptors involved in mediating cold-evoked pain that developed following peripheral nerve injury. Methods: Neuropathic surgery was performed by a unilateral ligation of L5 and L6 spinal nerves of rats. Behavioral sign of cold-evoked pain was examined for 5 min by measuring cumulative duration of time that the rat lifted its foot off a metal plate held at cold temperature ($5^{\circ}C$). Whether cold-evoked pain behavior was affected by antagonists of various subtypes of adrenoceptors, which were administered intraperitoneally before and after the ligation, was investigated. Results: After ligation, duration of foot lifting on the ligated side at cold temperature increased as compared to the pre-operative period. This increase maintained for the entire 40-day test period. Pretreatment with alpha-antagonist phentolamine produced a suppression of cold-evoked pain behavior that was not affected by beta-antagonist propranolol pretreatment. Prazosin, alpha-1 antagonist, suppressed cold- evoked pain behavior when treated either before or after nerve ligation. On the other hand, alpha-2 antagonist yohimbine was without effect on cold-evoked pain behavior whether it was treated before or after the ligation. Conclusions: The results suggest that peripheral nerve injury develops cold-evoked pain that is sympathetically dependent, and that alpha-1 adrenoreceptor plays a critical role for the generation of this type of pain in its initiation as well as maintenance.

• 한국식품조리과학회지
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• 제11권2호
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• pp.140-144
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• 1995

This study was surveyed to know Korean festival foods. 1. 62.97% of the students had high level of interest in festival foods, but that was not significantly different by sex and major. 2. The percentage of which they knew about festival foods 92.7% in Seolnal (New Year's day), 89.6% in Chongwol Daeboreum (the 15th of January), 82.0% in Sambok (the period of summer hot day), 74.7% in Chuseok (Korea thanks giving day), 43.3% in Hansik (the day which eat cold foods), and less than 30ft in the other festival day. 3. The festival day which are celebrated was Seolnal, Chuseok, and Chongwol Daeboreum in the order, and Dongii was a lower percentage than the other previous studies. 4. The festival day which they had to succeed was Seolnal, Chuseok, Chongwol Daeboreum, and Dongii in the order of the higher ratio.

• The Korean Journal of Physiology and Pharmacology
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• 제25권5호
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• pp.489-494
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• 2021

Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. However, peripheral neuropathic complications, especially cold allodynia, undermine the life-prolonging outcome of this anti-cancer agent. Rosavin, a phenylpropanoid derived originally from Rhodiola rosea, exhibits a wide range of therapeutic properties. The present study explored whether and how rosavin alleviates oxaliplatin-induced cold hypersensitivity in mice. In the acetone drop test, cold allodynia behavior was observed from days 3 to 5 after a single injection of oxaliplatin (6 mg/kg, i.p.). Cold allodynia was significantly attenuated following rosavin treatment (10 mg/kg, i.p.). Specific endogenous 5-HT depletion by three consecutive pretreatments with parachlorophenylalanine (150 mg/kg/day, i.p.) abolished the analgesic action of rosavin; this effect was not observed following pretreatment with naloxone (opioid receptor antagonist, 10 mg/kg, i.p.). Furthermore, 5-HT_1A receptor antagonist WAY-100635 (0.16 mg/kg, i.p.), but not 5-HT₃ receptor antagonist MDL-72222 (1 mg/kg, i.p.), blocked rosavin-induced analgesia. These results suggest that rosavin may provide a novel approach to alleviate oxaliplatin-induced cold allodynia by recruiting the activity of 5-HT_1A receptors.