• Journal of the Korean Society of School Health
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• v.29 no.3
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• pp.245-255
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• 2016

Purpose: This study was aimed to examine the effects of smartphone overuse and individual factors including age, relationship with friends, satisfaction with school life, and time of smartphone usage on perceived cognitive functions, fatigue, and daytime sleepiness among college students. Methods: Three-hundred college students were recruited after confirming the absence of major depressive symptoms. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation, and multiple regression. Results: Smartphone overuse commonly explained the variance in perceived cognitive functions, fatigue, and daytime sleepiness, after controlling for individual factors. In addition, satisfaction with school life was significantly related with better effectiveness of cognitive functions while being male, having good relationships with friends and satisfaction with school life were relatively associated with a lower level of fatigue. Conclusion: The findings of this study revealed that the overuse of smartphone can serve as a psycho-cognitive burden leading to ineffective functioning in daily living. Students who are female and have issues regarding school life and friendship may be a high risk group for experiencing psycho-cognitive dysfunction associated with smartphone overuse. Further investigation is needed to develop effective interventions to improve psycho-cognitive health associated with the excessive use of smartphone in young adults.

• The Journal of Korean Physical Therapy
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• v.31 no.2
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• pp.67-75
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• 2019

Purpose: Patients with brain damage suffer from limitations in performing the activities of daily living (ADL) because of their motor function and visual perception impairment. The aim of this study was to help improve the motor function and visual perception ability of patients with brain damage by providing them with virtual reality-based contents. The usability results of the patients and specialists group were also evaluated. Methods: The ADL contents consisted of living room, kitchen, veranda, and convenience store, similar to a real home environment, and these were organized by a rehabilitation specialist (e.g., neurologist, physiotherapist, and occupational therapist). The contents consisted of tasks, such as turning on the living room lights, organizing the drawers, organizing the kitchen, watering the plants on the veranda, and buying products at convenience stores. To evaluate the usability of the virtual reality-based visual cognitive rehabilitation service, general elderly subjects (n=11), stroke patients (n=7), stroke patients with visual impairment (n=4), and rehabilitation specialists (n=11) were selected. The questionnaires were distributed to the subjects who were using the service, and the subjective satisfaction of individual users was obtained as data. The data were analyzed using SPSS 21.0 software. The general characteristics of the users and the evaluation scores of the experts were analyzed using descriptive statistics. Results: The usability test result of this study showed that the mean value of the questionnaire related to content understanding and difficulty was high, between 4-5 points. Conclusion: The virtual reality rehabilitation service of this study is an efficient service that can improve the function, interest, and motivation of stroke patients.

• Fisheries and Aquatic Sciences
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• v.26 no.1
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• pp.24-34
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• 2023

Reactive oxygen species (ROS) at high concentrations induce oxidative stress, an imbalanced redox state that is a prevalent cause of neurodegenerative disorders. This study aimed to investigate the protective effect of Capsosiphon fulvescens (CF) extract on oxidative stress-induced impairment of cognitive function in models of neurodegenerative diseases. CF was extracted with subcritical water and several solvents and H₂O₂ (0.25 mM) or aluminum chloride (AlCl₃; 25 µM) as an inducer of ROS was treated in PC12 neuronal cells and zebrafish larvae. All statistical analyses were performed using one-way analysis of variance and Dunnett's test using GraphPad Prism. H₂O₂ and AlCl₃ were found to significantly induce ROS production in PC12 neuronal cells and zebrafish larvae. In addition, they strongly affected intracellular Ca²⁺ levels, antioxidant enzyme activity, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) signaling, acetylcholinesterase (AChE) activity, and hallmarks of Alzheimer's disease. However, treatment of H₂O₂-induced PC12 cells or AlCl₃-induced zebrafish larvae with CF subcritical water extract at 90℃ and CF water extract effectively regulated excessive ROS production, intracellular Ca²⁺ levels, and mRNA expression of superoxide dismutase, glutathione peroxide, glycogen synthase kinase-3 beta, β-amyloid, tau, AChE, BDNF, and TrkB. Our study suggested that CF extracts can be a potential source of nutraceuticals that can improve the impairment of cognitive function and synaptic plasticity by regulating ROS generation in neurodegenerative diseases.

• Korean Journal of Pharmacognosy
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• v.51 no.4
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• pp.310-316
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• 2020

Kyung-Ok-Go (KOK) is a traditional prescription used for debilitating natural aging and post-illness debilitation. KOK has been used in a variety of ways because it strengthens immunity, prevents illness, and helps recovery in case of illness. In particular, recent research has revealed that KOK helps improve memory and cognition. Therefore, in this study, we investigated whether KOK was effective in improving memory decline and depression-state observed during menopause. In the present study, we employed ovariectomized mouse as an animal model for measuring menopausal syndrome. The administration of KOK for 8 weeks, the object recognition memory and working memory were improved in novel object recognition test and Y-maze test. And in the forced swimming test, the immobility time were decreased. Additionally, the expression level of mature brain derived neurotropic factor (mBDNF) was increased by KOK administration in ovariectomized mouse hippocampus. These results suggested that KOK could improve cognitive decline and depression during menopausal period, and it might be come from enhancing expression level of mBDNF in hippocampus.

• Journal of the Korea Convergence Society
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• v.6 no.6
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• pp.153-162
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• 2015

A descriptive research is studied to identify the physical factors affecting to cognitive function among elderly residents over 65 years old in a community. The data were collected from 352 participants as part of a health-related survey by home visits in Seoul in 2010-2012. Their cognitive function was measured using the Korean form of Hasegawa Dementia Scale(HDS-K) and the collected data were analyzed by using t-test, ANOVA, and multiple regression analysis. From the analysis, the prevalence rate of cognitive impairment was 13.6%. Elderly residents in a community showed different cognition levels by the status of age, change of weight, change of BMI, walking and flexibility exercise. Especially, the lowest cognition level was found in the normal BMI group with decreased BMI change by over 3. The factors influencing on cognition level of the elderly with normal BMI were age, change of weight, change of BMI, and walking exercise. The variance indicated 12.2% as their cognition level. Therefore, for preventing the cognitive impairment of the elderly that were rapidly decreased of BMI, we need the program to manage their nutrition and walking exercise.

• Journal of Yeungnam Medical Science
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• v.27 no.1
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• pp.27-36
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• 2010

Purpose : The purpose of this study was to find out cognitive function of the patients with subjective memory complaint. Material and Methods : From March 1st 2005 to May 31st 2009, 155 normal individuals without any medical illness who visited Yeungnam University Hospital to undergo medical checkup with neurocognitive test was enrolled, and checked by using Cognitive Assessment & Reference Diagnostic System. Results : 107 of the patients had normal cognitive function, 21 patients (about 15%) were diagnosed with dementia, and 10 patients (about 7%) were diagnosed with considerable psychiatric illness, such as depression, anxiety disorder, adjustment disorder. In amnesia, agnosia, aphasia, attention, calculation, dysexecution, Dementia group and Psychiatric illness group has worse score than Normal individuals group. But, in apraxia, Dementia group has worse score than Psychiatric illness group and Normal individual group. Conclusion : Because the patients with subjective memory complaint can be diagnosed as any psychiatric illness as well as dementia, sensitive screening test and early psychiatric approach is needed.

• Korean Journal of Biological Psychiatry
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• v.10 no.2
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• pp.147-158
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• 2003

Objective:The differences of various neurocognitive functions, including attention, memory, motor function, and higher cognitive function were compared between PTSD patients and normal control subjects. Also, correlation with PTSD symptom severity and neurocognitive functions were evaluated between PTSD patients and normal control subjects. Method:We assessed the neurocognitive functions by computerized neurocognitive test(CNT) batteries. The visual continuous performance test(CPT) and digit span test, finger tapping test and Wisconsin card sorting test(WCST) were executed. The Impact of Event Scale-Revised(IES-R) was used in the evaluation of the severity of PTSD. Result:The PTSD patients showed significantly impaired neurocognitive performance in all of the items, compared with normal control subjects. The relation between impairment in neurocognitive functions and symptom severity showed significant correlations. Conclusion:These results imply that PTSD patients have impaired neurocognitive functions concerning with specific brain areas, especially the frontal area. For the thorough evaluation of further neurocognitive functions, more detailed evaluation items of neurocognitive functions and brain imaging studies are necessary in the future study.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.1 no.1
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• pp.161-171
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• 1990

The study was to examine the effectiveness of the educational program for the parents of autistic children in promoting the development and amelioration of psychopathology. Behavioral pathology and developmental function of autistic children of two parent groups, parents who participated in educational program and parents who did not participate in that program, were compared before and after partent education program. For these purpose, the data were collected from 30 subjects(15 for participant group and 15 for non-participant group) who were diagnosed as Autism according to DSM-III at Child-Psychiatry of Seoul National University Hospital during May 16, 1987 through April 30, 1988. Pre and post tests by Schopler's Psycho-Educational Profile scale were performed for all of the subjects and the data were analyzed by Wilcoxon Rank Sum test, Wilcoxon Sign Rank test and $X^2-test.$ The results obtained were as follows ; 1) The autistic children of participant group were significantly higher than those of non-participant group after education on Imitation, Gross motor and Eye-hand Integration scale of developmental function area (p<0.05) 2) After education, the autistic children of participant group were significantly improved in Affect and Language scale of behavioral pathology area (p<0.05). 3) After education, the autistic children of participant group were significantly improved in developmental function, such as perception, Fine motor, Gross motor, Eye-hand Integration, Cognitive Performance, Cognitive Language (p<0.05). 4) The autistic children of non-participant group were significantly improved in Relating behavior and developmental functions such as Perception, Fine motor and Eye-hand Integration at post test in comparison to pre test (p<0.05). From these results, it might be concluded that the autistic children of participant group were improved much more, and obtained higher score in developmental function area than those of non-participant group. It is suggested that this kind of education program helped and supported the parents to do some more appropriate approach for the development of their children.

• Korean Journal of Psychosomatic Medicine
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• v.11 no.2
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• pp.97-117
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• 2003

Objective: This study is to examine the validity and reliability of Computerized Neurocognitive Function Test among normal children in elementary school. Methods: K-ABC, K-PIC, and Computerized Neurocognitive Function Test were performed to the 120 body of normal children(10 of each male and female) from June, 2002 to January, 2003. Those children had over the average of intelligence and passed the rule out criteria. To verify test-retest reliability for those 30 children who were randomly selected, Computerized Neurocognitive Function Test was carried out again 4 weeks later. Results: As a results of correlation analysis for validity test, four of continues performance tests matched with those on adults. In the memory tests, results presented the same as previous research with a difference between forward test and backward test in short-term memory. In higher cognitive function tests, tests were consist of those with different purpose respectively. After performing factor analysis on 43 variables out of 12 tests, 10 factors were raised and the total percent of variance was 75.5%. The reasons were such as: 'sustained attention, information processing speed, vigilance, verbal learning, allocation of attention and concept formation, flexibility, concept formation, visual learning, short-term memory, and selective attention' in order. In correlation with K-ABC to prepare explanatory criteria, selectively significant correlation(p<.0.5-001) was found in subscale of K-ABC. In the test-retest reliability test, the results reflecting practice effect were found and prominent especially in higher cognitive function tests. However, split-half reliability(r=0.548-0.7726, p<.05) and internal consistency(0.628-0.878, p<.05) of each examined group were significantly high. Conclusion: The performance of Computerized Neurocognitive Function Test in normal children represented differ developmental character than that in adult. And basal information for preparing the explanatory criteria could be acquired by searching for the relation with standardized intelligence test which contains neuropsycological background.

• 한국체육학회지인문사회과학편
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• v.54 no.1
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• pp.553-566
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• 2015

This study was performed to identify the effects of different intensities of regular aerobic exercise on erythropoietin (EPO) and BDNF levels, and cognitive function and working memory in middle-aged women. Women aged 40 to 60 years residing in G-gu, Y-si, Gyeonggi-do were divided into 3 groups: control group, moderate-intensity aerobic exercise group and high-intensity aerobic exercise. All groups were asked to exercise at the given intensities, twice a week for a total of 12 weeks. Blood samples were collected from participants on week 0 (before exercising), week 6 and week 12, and then cognitive function and working memory tests were followed to measure erythropoietin (EPO) and BDNF levels, cognitive function and working memory. Repeated measures ANOVA, univariate analysis and follow-up test were performed on all data to compare the group, period and interaction through a SPSS. As a result, a significant difference over time was observed in EPO, BDNF, cognitive function and working memory; therefore, a follow-up one-way ANOVA analysis was performed on each group. As a result of analysis, a significant increase in erythrocyte, hematocrit, BDNF level and working memory was observed in moderate-intensity aerobic exercise group while erythrocyte and working memory were significantly increased inhigh-intensity aerobic exercise group. When comparing the results between the groups, the level of hematocrit was shown to be significantly higher in both moderate-and high-intensity aerobic group than the control group and also the higher level of hemoglobin was observed in both moderate-and high-intensity aerobic group comparing to control group. Considering the results of this study, therefore, a 12-week long aerobic exercise at moderate to high intensity positively affected EPO and BDNF levels, cognitive function and working memory in middle-aged women.