• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권2호
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• pp.51-62
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• 2021

Objectives: Tic disorder is a neurodevelopmental disorder characterized by multiple involuntary movements of muscles or vocalization. Although tic symptoms subside as the patient ages, some patients suffer from significant functional impairments related to severe tic symptoms. This manuscript aimed to review the latest scientific evidences for the effect of cognitive-behavioral interventions on tic disorder. Methods: The relevant studies were identified by searching medical research databases. We focused our search on studies published between 2000 and 2020 in order to reflect the latest scientific evidence. A total of 821 articles were identified in the initial database search and 27 articles were finally included for the review after the exclusion of duplicated and irrelevant articles. Results: Behavioral therapies including habit reversal training, Comprehensive Behavioral Intervention for Tics, and exposure and response prevention were the most widely studied interventions for tic disorder and are recommended as first-line treatments for tic disorders with high confidence. Cognitive psychophysiologic approaches were also reported to be effective. Conclusion: Further studies are needed to support the future treatment of tics with low-cost and more widely available treatments, in order to ensure better treatment outcomes.

• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.415-425
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• 2022

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

• 인지과학
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• 제27권1호
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• pp.61-99
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• 2016

본 논문은 이성적 정보와 감성적 정보에 대해 어떠한 정보 유형이 광고소구의 관점에서 더 효과적인가를 반응시간과 재인 측면에서 검증함과 동시에, 정보의 유형별로 뇌 기능 상의 관계를 fMRI를 이용하여 분석하여 정보유형별 인지처리 상의 차이를 설명하고자 하였다. 이를 위해 두 가지 실험을 수행하였는데, 첫 번째 실험은 두 종류의 자극 유형에 해당하는 광고카피 - 이성에 소구하는 자극과 감성에 소구하는 자극 - 에 대해 어떠한 유형에 해당하는지를 피실험자가 결정하게 하는 과제를 수행하게 하였으며, 자극의 제시로부터 소구 형태를 판단하기까지 소요되는 반응시간의 측정을 통해 각 자극 유형별 효과를 측정하고, 이 때 활성화되는 뇌 영역을 분석하여 인지처리 상의 기능을 비교하였다. 두번째 실험은 자극 유형별로 재인효과를 측정하고, 이 때 활성화되는 뇌 기능 영역 간의 차이를 분석하여 재인 시의 인지처리 상의 기능을 비교하였다. 이러한 실험연구를 통한 결과를 요약하면 다음과 같다. 첫째, 반응시간의 측면에서 감성적 자극에 대한 반응시간이 이성적 자극에 대한 반응시간보다 빠르게 이루어 졌고, 재인 측면에서는 이성적 자극에 대한 기억의 효과가 감성적 자극에 대한 기억보다 높게 나타났다. 둘째, fMRI를 이용한 뇌 기능상의 특징을 보면 이성적 자극의 경우 상대적으로 활성화의 수준이 높은 뇌 영역들은 행동 조정 혹은 작업 기억과 연계된 곳이었다. 반면, 감성적 자극의 경우 상대적으로 활성화의 수준이 높은 뇌 영역은 언어처리와 연계된 곳이었다. 본 연구를 통하여 이성적 자극과 감성적 자극의 소구 효과가 다름을 확인할 수 있었고, 각 소구 형태별로 뇌 기능상의 인지적 차이를 확인할 수 있었다.

• 한국생활과학회지
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• 제6권1호
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• pp.1-14
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• 1997

The purpose of this study was to comprehend the age-related differences in the relationship and developmental tendency between Orphanage and Normal Children's affective and cognitive perspective-taking ability. The subjects were 5-year-old (N=64) and 7-year-old (N=64) children. In each group, there were equal number of boys and girls, 128 Children were composed of(male: 32, female: 32) and orphanage Children(male: 32, female: 32). Feshbach & Roe's child perspective-taking ability test was modified for this study and the test included four facial expression cards and six different stories including three types of affection. In the procedure of study, after a set of story cards containing one of three affective types, the subject was asked to retell the story shown in each cards to study cognitive perspective-taking ability, and for the affective perspective-taking ability. Then the subject was asked to tell the feeling of the hero in the story and to select one of the four facial expression which is consistent with the feeling. The cognitive perspective-taking ability and affective perspective-taking ability response were coded three kinds of scoring respectively. Scored data were analyzed with MANOVA. t-test, Pearson Correlations and Fisher-z test. The results were shown as follow : First, both Orpanage and Normal Children's the cognitive and affective perspective-taking ability increased with age. Secondly, both Orpanage and Normal Children's perspective-taking ability was lower than Normal Children's perspective-taking ability. Thirdly, both Orpanage and Normal Children's correlation between cognitive and affective perspective-taking ability increased with age.

• 한국의류산업학회지
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• 제13권5호
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• pp.769-777
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• 2011

Anti-aging is one of the key words to have characterized Korean society, and Korean adults in their 40s and 50s are very interested in this word. In this study, their cognitive ages and body images which are expected to have been influenced by anti-ageing were determined and correlation between them was examined. A survey was conducted and 368 of 500 questionnaires were used in data analysis. Data were analyzed by descriptives, factor analysis, reliability analysis, correlation analysis, and multiple response analysis through SPSS 12.0. The results are as follows. First, the cognitive ages of Korean adults in their 40s and 50s showed to be 37.5 years old which are 9.1 years old younger than their average actual ages. Second, their attitudinal body images appeared to be composed of appearance orientation and appearance evaluation, and appearance orientation represented to be a little higher than appearance evaluation. In addition, it showed that the correlation between cognitive ages and the attitudinal body images was low and negative. Third, people in their 40s and 50s revealed to think good health and impression as ideal body images. It was found that they regarded a face as the most important body part for ideal body images and were sensitive of their weight. Forth, correlation between cognitive ages and variables of ideal body images was identified to be significant in 4 variables which are slender, shapely and slim figure and good body proportions. In conclusion, it was shown that Korean adults in their 40s and 50s recognized themselves to be 9.1 years old younger and, the younger they perceive themselves, the younger body images they want. Also, it could be confirmed that anti-ageing is a megatrend in Korean society.

• 동의생리병리학회지
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• 제22권3호
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• pp.556-561
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• 2008

ChongMyeong-Tang (CMT) have been used clinically to treat patient with amnesia and dementia. In addition, CMT have been also used for examinee to improve learning ability in Korea. This study was designed to investigate the effects of Gagam-ChongMeong-Tang (GCMT) on cognitive dysfunction recovery after ischemic brain injury in rats. Rats were divided into three groups; (1) normal, (2) commercial diet after ischemic brain injury (control), (3) CMT diet after ischemic brain injury (experiment). In our study, we carried out Morris water maze test for cognitive motor behavior test and immunohistochemistry study through the change BDNF in the hippocampus($7^{th},\;14^{th}\;day$). In Morris water maze test, cognitive motor function recovery was significantly increased in the experiment group as compared with control group on $7^{th}\;and\;14^{th}\;day$ day (p<0.01). In immunohistochemistric response of BDNF in the hippocampus, more immune reaction was investigated in the experiment group as compared with control group on $7^{th}\;and\;14^{th}\;day$. Especially more immune reaction was experimented $14^{th}$ day. These results imply that GCMT can play a role in facilitating recovery of cognitive function after ischemic brain injury in rats.

• 한국초등과학교육학회지:초등과학교육
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• 제18권2호
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• pp.21-33
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• 1999

The purpose of this study was to develop an Instrument for the Measurement of Cognitive Conflict Levels of students who confronted with an anomalous situation in science teaming. Anomalous situation is generated when students' prediction is disconsistent with the observed fact. In this study, the researchers identified 4 components of cognitive conflict and developed three items for each component. The items were developed and revised by four pilot tests. In the first pilot test, 55 elementary school students participated in the test In the second pilot test, 88 students of the 5th and 6th grader participated in the test. The instrument of measuring cognitive conflict levels was given to the subjects right after demonstrating anomalous situation. For the demonstration, two different problem situations were developed: one was a pulley problem and the other was electric bulbs in parallel. Answered reasons for each items were analyzed to assess students' understanding on each items. In third pilot test, 125 elementary school students participated in the test. A factor analysis of the responses was carried out and reliability of the test was assessed by calculating internal consistency values. The items were finalized by three pilot tests. After 1 month after the third pilot test, researchers conducted the finalized test items to 323 students of the 5th and 6th grader. The final instrument showed moderate reliability (Cronbach-α 0.82∼0.87) and good content validity(0.93). A factor analysis of the response was carried out. 4 main factors completely coincided with 4 components that we supposed to be the conducts of cognitive conflict. The instrument can provide a means for both teachers and researchers to assess the cognitive conflict of a large number of students within a single class period. The results can be used by teachers to better understand the process of conceptual change of their students and to match instruction and materials accordingly.

• 대한한방내과학회지
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• 제40권5호
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• pp.920-928
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• 2019

Objectives: After epidural hemorrhage, sequelae may cause cognitive impairments, such as attention, memory, and performance disturbances. This case study reports on the use of traditional Korean medicine in a patient with cognitive impairments after a traumatic epidural hemorrhage. Methods: During the 46-day hospitalization period, traditional Korean medicine treatments, including Sunkihwalhyul-tang-gamibang, Ukgan-san-gajinpibanha Granule, Kyungohk-go, acupuncture, and cupping, were administered. The degree of cognitive impairment was measured based on the Mini Mental State Examination-Korea (MMSE-K), Modified Barthel Index (MBI), and correct answer ratio. Results: After traditional Korean medicine treatment, the MMSE-K score increased from 13 to 19 and the MBI score increased from 63 to 71. The patient's conversations in daily life also proceeded more smoothly than before hospitalization, and the correct answer ratio rose. Conclusion: This case reports the improvement of cognitive impairment after traumatic epidural hemorrhage in response to traditional Korean medicine treatment; further study is needed.

• 한국융합학회논문지
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• 제12권7호
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• pp.19-29
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• 2021

우수한 선수들은 게임을 읽는 머리, 스포츠형 두뇌를 가진다. 그러나 스포츠 두뇌를 종합적으로 측정하는 인지 검사도구는 개발된 바 없다. 따라서 본 연구의 목적은 스포츠 인지기능을 측정하기 위한 컴퓨터 기반 프로그램을 개발하는 것이다. 스포츠 인지기능 문헌고찰을 바탕으로 정보처리속도, 실행기능(인지유연성, 억제능력), 공간능력을 스포츠 인지기능으로 선정하였다. 정보처리속도 측정을 위해 단순 및 선택반응시간 검사, 실행기능 측정을 위해 기호잇기검사, 자극수반과제, 공간능력 측정을 위해 심적회전과제가 선택되었고, 이들을 컴퓨터 기반 측정 프로그램으로 개발하였다. 검사를 실행하면, 각 검사에 대한 설명과 함께 연습시행이 주어진 뒤, 본 과제가 시작되며, 과제 종료와 동시에 주요 변인들이 통계처리되어 txt 파일형태로 자동저장된다. 스포츠 인지검사도구는 추후 타당도와 신뢰도 평가를 거쳐, 스포츠 영재발굴과 선수선발에 유용하게 활용될 수 있을 것이다.

• 한국축산식품학회지
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• 제43권4호
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• pp.612-624
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• 2023

The gut-brain axis encompasses a bidirectional communication pathway between the gastrointestinal microbiota and the central nervous system. There is some evidence to suggest that probiotics may have a positive effect on cognitive function, but more research is needed before any definitive conclusions can be drawn. Inflammation-induced by lipopolysaccharide (LPS) may affect cognitive function. To confirm the effect of probiotics on oxidative stress induced by LPS, the relative expression of antioxidant factors was confirmed, and it was revealed that the administration of probiotics had a positive effect on the expression of antioxidant-related factors. After oral administration of probiotics to mice, an intentional inflammatory response was induced through LPS i.p., and the effect on cognition was confirmed by the Morris water maze test, nitric oxide (NO) assay, and interleukin (IL)-1β enzyme-linked immunosorbent assay performed. Experimental results, levels of NO and IL-1β in the blood of LPS i.p. mice were significantly decreased, and cognitive evaluation using the Morris water maze test showed significant values in the latency and target quadrant percentages in the group that received probiotics. This proves that intake of these probiotics improves cognitive impairment and memory loss through anti-inflammatory and antioxidant mechanisms.