• BMB Reports
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• 제40권1호
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• pp.95-99
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• 2007

Bovine coding region single nucleotide polymorphisms located proximal to quantitative trait loci were identified to facilitate bovine QTL fine mapping research. A total of 692,763 bovine SNPs was extracted from 39,432 UniGene clusters, and 53,446 candidate SNPs were found to be a depth >3. In order to validate the in silico SNPs experimentally, 186 animals representing 14 breeds and 100 mixed breeds were analyzed. Genotyping of 40 randomly selected candidate SNPs revealed that 43% of these SNPs ranged in frequency from 0.009 to 0.498. To identify non-synonymous SNPs and to correct for possible frameshift errors in the ESTs at the predicted SNP positions, we designed a program that determines coding regions by protein-sequence referencing, and identified 17,735 nsSNPs. The SNPs and bovine quantitative traits loci informations were integrated into a bovine SNP data: BcSNPdb (http://snugenome.snu.ac.kr/BtcSNP/). Currently there are 43 different kinds of quantitative traits available. Thus, these SNPs would serve as valuable resources for exploiting genomic variation that influence economically and agriculturally important traits in cows.

• 대한수의학회지
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• 제29권3호
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• pp.407-416
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• 1989

The prospect of live vaccines consisting of genetically modified vaccinia virus expressing foreign genes is exciting, but important issues concerning safety and efficacy need to resolved. Vaccinia virus (VV) is an efficient expression vector with broad host range infectivity and large DNA capacity. This vector has been particularly useful for identifying target antigens for humoral and cell-mediated immunity. The WHO smallpox eradication program, involving the extensive use of VV vaccines, resulted in the late 1970s in the elimination of one of the world's most feared diseases. This achievement is a triumph for preventive medicine and for international collaboration in public health. In 1980, WHO recommended that the routine use of smallpox vaccine should be stopped. Against this background, the prospect of li ve vaccines consisting of genetically modified VV expressing foreign antigens arising from the work of Moss, and Paoletti and their colleagues in 1982 has been greeted with enthusiasm. These investigators have shown that genes coding for immunogenic proteins can be inserted into VV DNA without impairing the ability of the virus to grow in cell culture. Moreover experimental animals infected with VV recombinants containing genes coding for a variety of immunizing proteins have been shown to be protected against challenge infection with the corresponding infectious agent. In this communication, I describe current progress in the construction of a novel plasmid vector that facilitate the insertion and expression of foreign genes in VV as well as the selection of recombinants.

• 정보교육학회논문지
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• 제21권5호
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• pp.583-593
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• 2017

초보자들을 위한 프로그래밍 교육의 어려움을 극복하기 위해 UMC(Use-Modify-Create) 학습, 디자인 기반학습, 발견학습, 놀이학습 등 다양한 학습전략을 적용한 연구들이 이루어지고 있다. 이에 본 연구에서는 학습자의 컴퓨팅 사고 향상을 위해 HVC(History-VR Coding-Collaboration) 학습전략 모델을 개발하였다. HVC 모델은 블록형태의 결합 모듈로 구성되어 있으며 이를 12차시로 구성된 스토리텔링 기반의 가상현실 블록 프로그래밍 교육과정을 개발하여 적용하였다. 연구 결과 HVC 모델 및 SW교육 프로그램이 학습자의 컴퓨팅 사고 향상에 유의미한 차이를 보였다.

• Human Ecology Research
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• 제53권2호
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• pp.179-193
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• 2015

This study examined the retirement adaptation process for middle-aged and elderly couples. Twelve couples who had experienced retirement were recruited by theoretical sampling. Data were collected through in-depth interviews and analyzed through the grounded theory approach of Strauss and Corbin (1998). This study showed the results of 124 concepts, 41 sub-categories and 17 categories indicated through an open coding process. As a paradigm in axial coding, the causal conditions in the adjustment procedures of elderly couples whose spouses are retired were 'retirement preparation,' 'retirement acceptance,' and 'marital satisfaction.' A central phenomenon was 'crisis and conflicts of twilight couples.' The contextual conditions that correspond to this phenomenon were 'psychological separation from adult children,' 'division of household labor,' and 'economic status.' The action/interaction strategies to control the phenomenon were 'recognition of marital relationships,' 'conflicts coping,' 'resolution methods,' and 'self-reflection.' The intervening conditions that facilitate action/interaction strategies were 'attitudes of husbands,' 'mutual awareness of couple,' 'health status,' and 'support systems.' The consequences were 'readaptation of marital relationships,' and 'unresolved conflicts,' and 'trying alone.' This research classified middle-aged and elderly couples' adaptation into three types such as mutual effort, separation & resignation, and conflicts vestige. The findings provide basic information to develop a retirement adaptation program for the middle-aged and elderly.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 ICEIC The International Conference on Electronics Informations and Communications
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• pp.302-309
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• 2004

The transmission capacity of wireless communication systems may become dramatically high by employ multiple transmit and receive antennas with space-time coding techniques appropriate to multiple transmit antennas. For large number of transmit antennas and at high bandwidth efficiencies, the receiver may become too complex whenever correlation across transmit antennas is introduced. Reducing decoding complexity at receiver by combining array processing and space-time codes (STC) helps a communication system using STC to overcome the big obstacle that prevents it from achieving a desired high transmission rate. Multi-carrier CDMA (MC-CDMA) allows providing good performance in a channel with high inter-symbol interference. Antenna array, STC and MC-CDMA system have a similar characteristic that transmit-receive data streams are divided into sub-streams. Thus, there may be a noticeable reduction of receiver complexity when we combine them together. In this paper, the combination of array processing and STC in MC-CDMA system over slow selective-fading channel is investigated and compared with corresponding existing MC-CDMA system using STC. A refinement of this basic structure leads to a system design principle in which we have to make a trade off between transmission rate, decoding complexity, and length of spreading code to reach a given desired design goal.

• 한국전자통신학회논문지
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• 제14권4호
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• pp.769-774
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• 2019

오늘날과 같은 소프트웨어 중심사회에서 정보 기술의 발달은 매우 중요한 위치를 차지하고 있으며 최근 로봇을 활용한 소프트웨어 교육이 대세가 되어가고 있다. 본 연구는 명령블록 코딩 프로그램과 연계하여 과학 + SW 융합 교육에 대한 커리큘럼 및 콘텐츠를 제공하여 효율적인 SW 융합 교육 가능을 제안하였으며 기존 정형화 되지 않은 화학실험장치의 한계점을 보완하였으며 단순 구동 형태의 로봇에서 벗어나 타 수업과 연계가 가능한 소프트웨어 교육 융합형 '화학실험교구'를 개발하였다.

• Journal of Chest Surgery
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• 제23권2호
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• pp.342-351
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• 1990

In recent years there are so many medical informations that surgeons should know to handle or analyze their large amount of surgical cases. Proper use of computer system offers new opportunities for the storage and manipulation of their hospital informations. But little is reported about which system, is appropriate, how much can we do with such a system, or what kind of work can be done with that, especially in the area of Thoracic and Cardiovascular Surgery section. Authors designed a computer-based patient file management system using 16 Bit AT IBM personal computer and dBASE IV program, and developed a coding system for the diagnosis and operation name, which offers the basis for the classification of the surgical patient data. And the result of some experiences which was got from the total surgical cases of Thoracic and Cardiovascular Section, Seoul District Armed Forces General Hospital during past 5years, was described.

• 실천공학교육논문지
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• 제16권2호
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• pp.151-157
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• 2024

기존 저학년 대상의 게임 기반 교육 프로그램은 대부분 간단한 블록코딩 연구로써 프로그래밍 심화 중점의 수업 운영 사례가 부족하다. 본 연구는 지역 초등학교 3학급 대상으로 방학 2주동안 마인크래프트 기반 파이썬 코딩 기초 수업을 실제 운영했다. 학습 프로그램은 수업 흥미 및 동기를 개선하기 위해 랜파티를 통한 건축 퀘스트, 게임 내 자체 스크립트 등 공식 웹사이트의 표준 학습 프로그램을 재구성했다. 이외 설문조사를 통해 수업 주제에 대한 만족도와 선호도를 분석했고, 앞으로 교육 프로그램 개발 방향성에 대한 유의미한 결과를 얻을 수 있었다. 본 연구는 앞으로 전 연령층의 게임 기반 교육 프로그램 설계/개발을 위한 기초 연구로써 의의를 갖는다.

• 한국보건간호학회지
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• 제32권1호
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• pp.81-95
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• 2018

Purpose: This study was conducted to identify the effects of a group cognitive improvement program on cognitive function, depression and self-esteem in elderly individuals with mild cognitive impairment. Methods: This was an experimental study that employed a pre-post design of a non-equivalence control group. The subjects were 52 elderly people with mild cognitive impairment, 25 of whom were assigned to the experimental group and 27 to the control group. The program was conducted for a total of 12 sessions for 60 minutes each. Data were analyzed using the ${\chi}2-test$, Fisher's exact test, and Independent t-test with the SPSS 20.0 program. Results: After the intervention, the group who participated showed improvement in all areas of cognitive function based on MMSE-KC (F=26.37, p.<0.001), the Rey Complex Figure Test: copy (F=20.66, p.<0.001), Immediate memory of Seoul Verbal Learning Test-Elderly's version (F=29.68, p.<0.001), delayed memory (F=45.79 p.<0.001), memory recall (F=28.97, p.<0.001), Forward of Digit Span Test (F=9.25, p=.004), backward (F=8.33, p.=0.006), language comprehension (F=13.42, p.<0.001), and digit symbol coding (F=17.74, p.<0.001) relative to the control group. Moreover depression (F=24.09, p.<0.001) was decreased in program participants, whereas self-esteem (F=40.24, p.<0.001) was increased. Conclusion: The program could be a useful intervention because the results show that the group cognitive improvement program has a significant effect on cognitive function, depression and self-esteem in elderly with mild cognitive impairment.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.313-324
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• 2013

본 연구는 2006년부터 2012년까지 이루어진 자활 참여자의 자활 경험과 전망에 대한 종단적 질적연구이다. 연구자는 총 12인에 대한 심층면접 자료에 대해 근거이론 분석을 시도하였다. 개방코딩 결과 삶의 경험, 자활의 경험 및 성공과 실패, 변화 및 자활 전망에 대해 총 181개의 개념이 도출되었다. 축코딩을 통한 패러다임분석에서 자활 성공의 인과적 조건으로 일과 교육의 기회 및 자활을 위한 노력이 제시되었다. 중심현상은 자활 제도에 적응하며 현상유지와 안주를 하는 것으로 나타났고, 이에 대한 맥락적 조건들은 피하고 싶은 빈곤 경험 및 안정적 자녀양육으로 나타났다. 공동체 실패를 경험한 경우, 내부의 갈등과 수익창출 실패가 맥락적 조건으로 작용하였다. 중심현상에 대한 상호작용 전략은 부족한 자활공동체 지원과 통합급여 방식이라는 중재적 조건을 통해 촉진되었다. 이러한 중재적 조건 하에서는 공동체로 독립하는 것은 위험으로 인식되어, 제도의 목표를 향한 인과적 조건과 제도에 안주하려는 중심현상간의 괴리가 발견되었다. 이러한 분석은 정책 입안자와 참여자가 생각하는 자활의 의미가 다를 수 있으며, 현행 자활모델이 보다 참여자가 처한 상황을 반영하여 현장중심의 자활유인을 제시해야 한다는 정책적 함의를 제공한다.