• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2001.04a
• /
• pp.22-27
• /
• 2001

Cochlea is well known to have the ability to analyze a wide frequency and this ability seems to be caused to the Basilar Membrane(BM) configuration. However, the relationship between the Cochlea frequency-position map is not clear. In this paper, the three-dimensional BM Model was made using the Finite Element method. Then, an attempt was made to examine the influence of the BM configuration on the Cochlea frequency-position map. Theoretical consideration reveals that the wide frequency-position of Cochlea is achieved by not only the BM configuration change along the length of the Cochlea but also the change of the Young's module of the BM along the length of the Cochlea.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.11 no.1
• /
• pp.114-119
• /
• 2002

Cochlea is well known to have the ability to analyze a wide frequency and this ability seems to be caused to the Basilar Membrane(BM) configuration. However, the relationship between the Cochlea frequency-position map is not clear. In this paper, the three-dimensional BM Model was made using the Finite Element Method. Then an attempt was made to examine the influence of the BM configuration on the Cochlea frequency-position map. Theoretical consideration reveals that the wide frequency-position of Cochlea is achieved by not only the BM configuration change along the length of the Coohlea but also the change of the Young's module of the BM along the length of the Cochlea.

• Journal of Biomedical Engineering Research
• /
• v.16 no.1
• /
• pp.77-84
• /
• 1995

Nl and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. Nl -N2 audiograms were made by means of regulating stimulant intensities in order to produce constant Nl -N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip 15 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both nonlinear and active functions of the Cochlea can be monitored by Nl -N2 audiograms. Key words : Guinea Pig, Cochlea, Wl and N2 Gross Neural Action Potential, Nl -N2 audiogram.

• Journal of Biomedical Engineering Research
• /
• v.16 no.4
• /
• pp.471-480
• /
• 1995

The modification of Nl -N2 Audiograms before and after loudtone exposure onto the tympanic membrane of guinea pigs was examined. The exposure was a loud continuous tone of 106 dB SPL intensity at 10 KHz for 10 minutes. The comparison between Wl-H2 Audiograms pre and post loudtone exposure indicates that the exposed cochlea permanently lost its normal hearing function. The largest threshold shifts wore found between 12-13.2KHz. The functional change of the cochlea after the loudtone exposure depends on the state of the cochlea before the trauma. More sensitive cochlea is more critically damaged in its function after the trauma than less sensitive cochlea.

• The Journal of the Acoustical Society of Korea
• /
• v.24 no.1E
• /
• pp.1-6
• /
• 2005

The inner hair cell stereocilia of the guinea pig cochlea was examined under a scanning electron microscope (SEM) after loud tone exposure onto the ear drum of the animal. Before and after guinea pigs were exposed to intensive and continuous tone such as 106 dB SPL in intensity, the functioning of the cochlea was monitored by N1-N2 audiograms. The structural damage of the stereocilia of inner hair cells (IHCs) and outer hair cells (OHCs) was examined using the SEM in x 1500 magnification. The comparison between the functional change of the cochlea and the structural damage of the IHC stereocilia is done by means of photographic observation. It can be shown that the functional change might be related to the structural damage of the IHC stereocilia after intensive acoustic trauma.

• Journal of Biomedical Engineering Research
• /
• v.25 no.3
• /
• pp.207-215
• /
• 2004

A finite element analysis is used in this study to model 6 kinds of electrode by a genetic program in order to evaluate the mechanical effect on the 3D human cochlea model and the behavior of electrode. Human cochlea is modeled by the spiral-approximation method and the shape of scala tympani is extracted from the mid section of the human cochlea. Contact pressure at the tip and the insertion force are found to be highest when the wires stack horizontally. Axial rotation of electrode is minimal comparing with the stimulating current spread. The results indicate that the electrode stiffness is important to minimize the trauma.

• BMB Reports
• /
• v.50 no.10
• /
• pp.487-495
• /
• 2017

Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

• Journal of Biomedical Engineering Research
• /
• v.11 no.1
• /
• pp.83-88
• /
• 1990

A New speech processing algorithm using neural networks is proposed. We transform input data into frequency domain and process them by neural networks of 22 output neurons which have Bark scale on the ground that the Bark scale is similiar with that of the characteristics of human cochlea. An utilized neural network is multilayer perceptron, and the characteristics of cochlea have it trained by error back propagation learning algorithm. The trained neural networks suffices functions of human cochlea including the effects of automatic gain control, compression and equalization. Simulation results show that the proposed speech processing algorithm has good performance in automatic gain control, compression and equalization.

• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.5 no.1
• /
• pp.41-46
• /
• 2011

A sensorineural hearing loss(SNHL) occurs when the cochlea in the inner has functional problem. The region in the cochlea with no(or very few) functioning inner hair cells or neurons called 'dead regions'. Amplification using hearing aid over a frequency range corresponding to a dead region may not a beneficial. In this paper, we compared speech recognition with different location of dead region and gain and searched effective gain for hearing aid with dead region. In order to experiment, eight people who has normal hearing ware tested, and we used white noise and babble noise(SNR=0 dB). we divided by three conditions, low, mid and high frequency dead region. In addition, the gains in dead region ware 14.5 dB, 11.5dB and 6 dB gain. There ware different results by location of dead region. The result of WRS and preference in mid-frequency dead region and high-frequency dead region ware higher than them in low-frequency dead region. When we compared as gains, the score of WRS with lower gain was higher than 14.5 dB gain, and the preference was lower as higher gain.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.10
• /
• pp.5631-5635
• /
• 2013

Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.