• Journal of Ginseng Research
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• 제46권6호
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• pp.722-730
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• 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs the respiratory system and multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes and inflammasome-mediated inflammatory signaling pathways, which are key determinants of hyperinflammation and cytokine storm in COVID-19 patients. Additionally, SARS-CoV-2 inhibits inflammasome activation to evade the host's antiviral immunity. Therefore, regulating inflammasome initiation has received increasing attention as a preventive measure in COVID-19 patients. Ginseng and its major active constituents, ginsenosides and saponins, improve the immune system and exert anti-inflammatory effects by targeting inflammasome stimulation. Therefore, this review discussed the potential preventive and therapeutic roles of ginseng in COVID-19 based on its regulatory role in inflammasome initiation and the host's antiviral immunity.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2021년도 제64차 하계학술대회논문집 29권2호
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• pp.283-284
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• 2021

최근 SARS-CoV-2 백신들의 예방접종이 진행됨에 따라 코로나 19 팬데믹의 종결이 예상되고 있다. 하지만 계속해서 출현 중인 변종 바이러스들은 팬데믹 종결의 위험요소로 남아있다. 본 논문에서는 사전학습된 단백질 BERT와 단백질-단백질 상호작용 모델을 활용한 SARS-CoV-2 스파이크 단백질의 변이 예측 분석 알고리즘을 제안한다. 제안하는 기술은 변이 단백질 서열의 예측과 변이 단백질과 human ACE2 수용체의 친화도에 따른 자연선택으로 이루어진다. 이를 통해 시간이 지나며 나타날 수 있는 변종 바이러스들을 시뮬레이션 할 수 있어 변종 바이러스들의 해결에 기여할 것으로 기대된다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제6권2호
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• pp.68-73
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• 2006

We propose a damascene gate FinFET with Si nanocrystals implemented on bulk silicon wafer for low voltage flash memory device. The use of optimized SRON (Silicon-Rich Oxynitride) process allows a high degree of control of the Si excess in the oxide. The FinFET with Si nanocrystals shows high program/erase (P/E) speed, large $V_{TH}$ shifts over 2.5V at 12V/$10{\mu}s$ for program and -12V/1ms for erase, good retention time, and acceptable endurance characteristics. Si nanocrystal memory with damascene gate FinFET is a solution of gate stack and voltage scaling for future generations of flash memory device. Index Terms-FinFET, Si-nanocrystal, SRON(Si-Rich Oxynitride), flash memory device.

• Bulletin of the Korean Chemical Society
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• 제32권3호
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• pp.988-992
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• 2011

$CO_2$ adsorption on mineral sorbents has a potential to sequester $CO_2$. This study used a density functional theory (DFT) study of $CO_2$ adsorption on barium oxide (BaO) in the presence of $H_2O$ to determine the role of $H_2O$ on the $CO_2$ adsorption properties on the ($2{\times}2$; $11.05\;{\AA}{\times}11.05\;{\AA}$) BaO (100) surface because BaO shows a high reactivity for $CO_2$ adsorption and the gas mixture of power plants generally contains $CO_2$ and $H_2O$. We investigated the adsorption properties (e.g., adsorption energies and geometries) of a single $CO_2$ molecule, a single $H_2O$ molecule on the surface to achieve molecular structures and molecular reaction mechanisms. In order to evaluate the coordinative effect of $H_2O$ molecules, this study also carried out the adsorption of a pair of $H_2O$ molecules, which was strongly bounded to neighboring (-1.91 eV) oxygen sites and distant sites (-1.86 eV), and two molecules ($CO_2$ and $H_2O$), which were also firmly bounded to neighboring sites (-2.32 eV) and distant sites (-2.23 eV). The quantum mechanical calculations show that $H_2O$ molecule does not influence on the chemisorption of $CO_2$ on the BaO surface, producing a stable carbonate due to the strong interaction between the $CO_2$ molecule and the BaO surface, resulting from the high charge transfer (-0.76 e).

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 하계학술대회 논문집 B
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• pp.799-801
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• 2002

To develop GIS (Gas Insulated Switchgear), prediction of the flow field including pressure in GIS is very important. The transport phenomena in GIS including arc is also being studied in these days. In this study, to predict the arc behaviour for GIS with voltage rating up to 800kV developed by HHI (Hyundai Heavy Industries Co. Ltd.), the analysis of flow and electric field in GIS were investigated. To simulate the compressible flow in GIS, the CFX, commercial CFD code, was used. The movement of the piston and the electrode of the GIS was simulated with moving grid method, which was superior to the method of varying the property of cells in the aspect of accuracy and convergence of solution. The calculated maximum pressure within the puffer cylinder was matched with experimental data within 5% error. Also, the oscillation of pressure in GIS after the movement of electrode was well predicted.

• 한국분말재료학회지
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• 제4권2호
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• pp.113-121
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• 1997

The densification of the compacts of Co+32%Cr+20%W+l.5%C, Co+32%Cr+20%W+3.0%C and Co+32%Cr+20%W+4.5%C sintered under $H_2$ gas or vacuum was investigated. The effect of V and B addition on the densification was also investigated. The densification of these compacts were always incomplete regardless of sintering atmosphere, temperature and time. The amounts of oxygen and carbon in compacts sintered in $H_2$ for 3.6ks at 1523K were 0.105~0.160 mass% and 0.33~0.89 mass%, respectively. And those in vacuum were 0.028~0.032% and 0.957~4.08%, respectively. Relative density(Ds) of Co+29%Cr+17%W+3.0%C compact containing 6%V and Co+32%Cr+20%W+2.97%C compact containing 0.03%B were 99 and 100%, respectively, indicating complete densification by solid phase sintering. Victors hardness of sintered compacts containing 6%V or 0.03%B were 632 and 568, showing 50~60% increase in comparison to those without V or B. These results can be explained in terms of oxidation/reduction of oxides and equilibrium pressure of CO in isolated pore, instead of presence of liquid formation and grain boundary separation from pores due to large grain growth.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 추계학술대회 논문집 Vol.17
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• pp.435-438
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• 2004

The effects sintering additives such as $xwt%(0.242Bi_2O_3-0.782V_2O_5)$ on the microwave dielectric and sintering properties of $MgCo_2(VO_4)_2$ ceramics were investigated. Highly dense samples were obtained for $MgCo_2(VO_4)_2$ at the sintering temperature of $950^{\circ}C$ with $0.242Bi_2O_3-0.758V_2O_5$ additions of $0.5{\sim}5wt%$. The microwave dielectric properties of $MgCo_2(VO_4)_2$ with $0.5wt%(0.242Bi_2O_3-0.758V_2O_5)$ sintered at $950^{\circ}C$ were as follows : $Q{\times}f_0\;=\;45,375GHz,\;\epsilon_r\;=\;9.7\;and\;\tau_f\;=\;-23.2ppm/^{\circ}C$.

• Food Science and Biotechnology
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• 제14권1호
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• pp.6-10
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• 2005

Optimal extraction conditions such as pressures, temperatures, and modifiers on glycyrrhizin extraction from licorice were investigated using supercritical $CO_2\;(SC-CO_2)$ at 3 mL/min flow rate. Morphology of licorice tissue, after glycyrrhizin extraction, was examined by SEM, and absolute density ($g/cm^3$) measurement and glycyrrhizin content were determined by HPLC. Pure $SC-CO_2$ had no effect on glycyrrhizin extraction, but recovery of glycyrrhizin ($32.66{\pm}0.77%$) was enhanced when water was used as modifier. The highest recovery was $97.22{\pm}2.17%$ when 70% (v/v) aqueous methanol was added to 15% (v/v) $SC-CO_2$ at 50 MPa and $60^{\circ}C$. Under optimal extraction conditions, 30 MPa pressure and $60^{\circ}C$ heating temperature, glycyrrhizin recovery reached maximum ($102.67{\pm}1.13%$) within 60 min. Licorice tissue was severely damaged by excessive swelling, and absolute density of licorice residues was highest when aqueous methanol was used as a modifier.

• KEPCO Journal on Electric Power and Energy
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• 제1권1호
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• pp.151-156
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• 2015

In order to improve the properties of high-temperature superconducting wire for superconducting cable system, we optimized the electro-polishing (EP), ion-beam assisted deposition (IBAD), superconducting (SC) layer, and baking (heat) treatment. The buffer layer was deposited on electro-polished substrate with RMS roughness ($R_{RMS}$) less than 5 nm. The IBAD process was carried out at $V_{beam}$: 1100 V and $V_{accel}$: 850 V that resulted in highly crystalline film of $LaMnO_3$. Chemical composition of SC layer is key to higher critical current, and we found that composition can be determined by surface color of SC layer. We adopt a proprietary contorl system based on RGB analysis of the surface and achieved critical current of 150 A/4 mm-width. The proposed baking treatment resulted in decreasing of about 10% of fraction defects.

• Bulletin of the Korean Chemical Society
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• 제11권1호
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• pp.11-15
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• 1990

The temperature dependence of electrical conductivities and thermoelectric power of $I_2$-doped poly(1,4-penylene vinylene-co-2,5-dimethoxy-1,4-phenylene vinylene)s [poly(PV-co-DMPV)] and poly(1,4-phenylene vinylene-co-2,5-thienylene vinylene)s [poly(PV-co-TV)] were studied. The former copolymers were also doped with $FeCl_3$. All the samples used were in thin film forms. The temperature dependence of electrical conductivity implies that the variable range hopping conduction mechanism applises to these systems. The activation energy for the electrical conduction in dimethoxy-phenylene vinylene (DMPV) copolymers ranged from about 7 to 30 meV depending on the polymer composition and the nature of the dopant. It was significantly higher for $I_2$-doped thienylene vinylene (TV) copolymers, namely 90-200 meV. The values of the room temperature thermoelectric power were $30-70{\mu}V/K$ for DMPV copolymer and $100-800{\mu}V/K$ for TV copolymers. Anisotropy in the electrical conductivities was also studied for oriented films obtained by uniaxial stretching of the precursor polymer films.