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Effects of Radiation Mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi Complex Extract on the Mediators Related to Degenerative Arthritis (방사선 형질전환 차조기와 백출 복합추출물이 퇴행성관절염 관련 매개체에 미치는 영향)

  • Sim, Boo-Yong;Joo, In-Hwan;Kim, Sung-Kyu;Ji, Joong-Gu
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.2
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    • pp.368-377
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    • 2021
  • The present study aimed to evaluate the effects of radiation mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi complex extract(Perilla frutescens var. crispa complex extract) on the mediators related to degenerative arthritis in a monosodium iodoacetate-induced rat model of degenerative arthritis. Perilla frutescens var. crispa complex extract was administered orally at doses of 25, 50 or 100 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µl of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral Perilla frutescens var. crispa complex extract for another 4 weeks. It was evaluated that the treatment effects based on serum bio-markers, and morphological and histopathological analysis of the knee joints. Compared with those in negative control rats, the Perilla frutescens var. crispa complex extract treatments significantly reduced the serum levels of inflammation, bone metabolism markers (i.e., TNF-α, MMP-3, COX-2, PGE2, COMP, and Aggrecan). Otherwise, it was significantly increased the production of CTX-2 in cartilage absorption mediators. In addition, the Perilla frutescens var. crispa complex extract treatments effectively preserved the knee cartilage and synovial membrane. As a result, it indicates that the Perilla frutescens var. crispa complex extract improved degenerative arthritis symptoms. Thus, the Perilla frutescens var. crispa complex can be used in food material for the management of degenerative arthritis.

A Study on Family Support Service for Adoptive Families in terms of Necessity and Role of the Family Center (가족센터(구 건강가정지원센터)의 입양가족 대상 서비스 제공의 필요성과 역할 정립에 관한 연구)

  • Lee, Sunhyung;Bae, Jiyeon
    • Journal of Family Resource Management and Policy Review
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    • v.26 no.2
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    • pp.1-17
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    • 2022
  • This study provides a critical analysis of the Family Center's programs for adoptive families by interviewing employees at these centers and at Adoption Agencies who have experiences with adoption programs. For this study, nine such workers from three separate Family Centers and three such workers from two separate Adoption Agencies have (voluntarily) engaged in in-depth interviews. Major findings from the interviews are that the Family Centers were initially motivated to carry out adoption family programs for three principal reasons: they located many families (in need of adoption family program); potential adoptees were interested in the program; adoption families participated in the pre-existing programs such as Self-help Group and Co-parenting Space. Workers in the study also reported that they approach to an adoption family and their contemplation on ways to provide better services to the adoption families. They don't have any official and formal manual or guidelines from the Government Ministries and offices such as Korean Institute for Healthy Family; as a result, the workers at Family Centers have endeavored to gain connection with Adoption Agencies in hopes of cooperation with them and to improve the services at Family Centers. For benefits of Family Centers as a delivery system, they mentioned nationwide infrastructure, family professional, and arrangement of integrated program for family. For improvements, they listed awareness education based on a thorough consideration of adoptee's varied characteristics, close cooperation with adoption institutions, provision of basic operational manual from Korean Institute for Healthy Family, and governmental efforts to enlarge the consideration pool for families.

A Study on Optimal Reinforcing Type of Precast Retaining Wall Reinforced by Micropiles (마이크로파일로 보강된 프리캐스트 콘크리트 옹벽의 최적보강형태에 관한 연구)

  • Kim, Hong-Taek;Park, Jun-Yong;Yoo, Chan-Ho
    • Journal of the Korean Geotechnical Society
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    • v.22 no.11
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    • pp.89-99
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    • 2006
  • The PCRW (Precast Concrete Retaining Wall) has many advantages compared with cast in place concrete retaining wall : shorter construction period, excellency of quality and minimum interference with the adjacent structure and traffics. However, shallow foundation type of PCRW, which has comparatively better ground condition, has some disadvantages such as difficulty in transportation and higher cost due to the size of PCRW being expanded by resisting only with self-weight if there is no other supplementary reinforcement. The presented study, in order to complement such disadvantages of PCRW, have applied the micropile method. The micropile method has advantages like low-cost and high-efficiency and does not require huge space, because it can be executed with small size equipment. However, the mechanical behavior characteristics of the PCRW reinforced by micropile, which is installed to improve the reinforcement effect, is not yet clearly identified and there is no suggested standard as to the length, diameter, install angle and install position of micropiles. Hence, this method is yet being designed depend on engineer's experience. In this study, various laboratory model tests as to sliding and overturning were performed in order to identify and present the optimum type of reinforcement and reinforcement effect of the PCRW reinforced by micropiles. In addition, it also executed numerical analysis for the purpose of verifying the optimum type of reinforcement for micropiles based on the results of laboratory model tests. The optimum reinforcement type of micropiles was estimated by model test and numerical analysis. The length of micropiles is 0.4 times wall height and the diameter is 0.04 times wall length.

Production of Transgenic Bovine Embryos Following Nuclear Transfer of Bovine Fetal Fibroblasts Transfected by Foreign Genes (외래유전자를 도입한 소 태아세포의 핵치환에 의한 형질전환 소 수정란 생산)

  • Kil, K.S.;Uhm, S.J.;Kim, E.H.;Chung, H.J.;Kim, T.;Park, H.;Lee, H.T.;Chung, K.S.
    • Korean Journal of Animal Reproduction
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    • v.24 no.4
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    • pp.429-437
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    • 2000
  • This study investigated the successful introduction of genes of erythropoietin (EPO) and enhanced green fluorescent protein (EGFP) in bovine embryos following nuclear transfer of bovine fetal fibroblasts (bFF), which were transfected by retrovirus vector system. Non-starved bFF were, transferred into perivitelline space of enucleated oocytes. The bFF-oocyte units were accomplished by cell to cell fusion and activated with calcium inophore and 6-dimethylaminopurine. Reconstructed embryos were co-cultured with bovine oviduct epithelial cells in CRlaa medium for 8 days. Out of 187 (EPO) and 210 (EGFP) bovine eggs reconstructed by nuclear transfer, 149 (EPO : 80.0%) and 158 (EGFP : 75.2%) embryos were cleaved, and among them 36 (EPO : 24.2%) and 35 (EGFP : 22.2%) embryos developed to the blastocyst stage. Of these blastocysts, 100% integration of EPO gene in 36 embryos was determined by PCR, and 100% expression of EGFP gene in 35 embryos was observed under the fluorescent microscope. This result indicates that bovine oocytes reconstructed by nuclear transfer of transfected bFF can successfully develop to the blastocyst stage. Furthermore, this novel procedure may be presumably an attractive method efficiently to produce the transgenic cattles.

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Experimental Study of Metal Surface Wave Communication for Engine room of Vessels (선박 기관실에서의 금속체 표면파 통신 활용 연구)

  • Jin-Woo Kong;Hak-Sun Kim
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2022.06a
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    • pp.108-109
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    • 2022
  • In this study analyzed experimental data on noise interference caused by engine operating apply surface wave communication in the engine room. For the experiment, 7 areas of the engine room on 256 ton tug boat and measured noise during engine on off using signal analyzer for effect surface wave communication. In order to construct and actual communication network based on the analysis of the noise and confirm the characteristics of surface wave communication in the area made metal bulkheads the actual communication network installed communication equipment between three metal bulkheads and conducted a comparative experiment with wireless communication. The difference was confirmed. As a result, in the case of surface wave communication, there was no significant difference in the transmission and reception rates before and after engine operation in an environment with three bulkheads, but in the case of Wi-Fi using wireless, the performance deteriorated significantly during operation. was confirmed. As a result of analyzing the experimental data, it was confirmed that noise caused by engine operation affects wireless communication but does not affect surface wave communication. Therefore, even in the area with a lot of electromagnetic wave noise in the ship, when the surface wave communication system is configured using the ship's metal structure, it is possible to replace the wireless communication and furthermore, it is possible to apply the surface wave communication in the enclosed space and the engine room in the ship.

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Standard Procedures and Field Application Case of Constant Pressure Injection Test for Evaluating Hydrogeological Characteristics in Deep Fractured Rock Aquifer (고심도 균열암반대수층 수리지질특성 평가를 위한 정압주입시험 조사절차 및 현장적용사례 연구)

  • Hangbok Lee;Chan Park;Eui-Seob Park;Yong-Bok Jung;Dae-Sung Cheon;SeongHo Bae;Hyung-Mok Kim;Ki Seog Kim
    • Tunnel and Underground Space
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    • v.33 no.5
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    • pp.348-372
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    • 2023
  • In relation to the high-level radioactive waste disposal project in deep fractured rock aquifer environments, it is essential to evaluate hydrogeological characteristics for evaluating the suitability of the site and operational stability. Such subsurface hydrogeological data is obtained through in-situ tests using boreholes excavated at the target site. The accuracy and reliability of the investigation results are directly related to the selection of appropriate test methods, the performance of the investigation system, standardization of the investigation procedure. In this report, we introduce the detailed procedures for the representative test method, the constant pressure injection test (CPIT), which is used to determine the key hydrogeological parameters of the subsurface fractured rock aquifer, namely hydraulic conductivity and storativity. This report further refines the standard test method suggested by the KSRM in 2022 and includes practical field application case conducted in volcanic rock aquifers where this investigation procedure has been applied.

Technology Development Strategy for Spatial Information Linkage of Public Data Portal Attribute Data (공공데이터포털 속성데이터의 공간정보 연계를 위한 기술개발 전략)

  • Min, Kyung-Ju;Lee, Sung-Hun;Yu, Seon-Cheol;Ahn, Jong-Wook
    • Journal of Cadastre & Land InformatiX
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    • v.53 no.2
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    • pp.107-122
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    • 2023
  • The demand for spatial information in the era of the 4th Industrial Revolution is expanding Additionally, interest in attribute data related to geography or location is increasing. In the field of spatial information, spatial information policies and services tailored to the public can be provided through linkage and integration with new attribute data, and these data are resources for this purpose. In order to meet this expanding and diverse demand for spatial information utilization, it is necessary to develop technologies for linking and utilizing various attribute information such as public data. In this study, we aim to present a technology development strategy for linking and integrating attribute data and spatial information through a review of theories related to data linkage and integration, the current status of data on public data portals, and existing prior research. As a result, it was suggested that the data identifier of the attribute data to be linked should be used to develop linkage technology between spatial information and attribute data, and an attribute data linkage process that can be used when designing a prototype for technology development was presented.

RAM Modeling and Analysis of Earth Observation Constellation Satellites (지구관측 군집위성의 RAM 모델링 및 분석)

  • Hongrae Kim;Seong-keun Jeong;Hyun-Ung Oh
    • Journal of Aerospace System Engineering
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    • v.18 no.1
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    • pp.11-20
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    • 2024
  • In the recent era of NewSpace, unlike high-reliability satellites of the past, low-reliability satellites are being developed and mass-produced at a lower cost to launch constellations satellites. To achieve cost-effective cluster satellite development, satellite users and developers need to assess the feasibility of maintaining mission performance over the expected lifespan when cluster satellites are launched. Plans for replacements due to random failures should also be established to maintain performance. This study proposed a method for assessing system reliability and availability to maintain mission performance and establish replacement strategies for Earth observation constellation satellites. In this study, a constellation reliability and availability model considering mission performance required for a satellite constellation, situations of satellite backup, and additional ground backups was established. The reliability model was structured based on the concept of a k-out-of-n system and the availability model used a Markov chain model. Based on the proposed reliability model, the minimum number of satellites required to meet mission requirements was defined and satellites needed in orbit during the required mission period to satisfy mission reliability were calculated. This research also analyzed the number of spare satellites in orbit and on the ground required to meet the desired availability during required service period through availability analysis.

An Experimental Study to Predict the Concentration of Moving Tire and Road Wear Particles from Road to Ocean Environment (도로에서 해양 환경까지 이동하는 타이어 마모입자의 농도를 예측하기 위한 실험적 연구)

  • Tae-Woo Kang;Won-Hyun Ji
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.12 no.2
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    • pp.196-205
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    • 2024
  • In this study, sample collection and quantification analysis of Tire and Road Wear Particles (TRWP) from the road surface were conducted to predict the amount of TRWP generated on the road surface moving by environmental compartment depending on rainfall intensity. Samples were collected from TRWP remaining on the road surface two days after the 3 days average rainfall (0-60 mm/day) occurred and the road surface was completely dry. Only TRWP were separated from the collected samples through size and density separation, and the difference in the content of TRWP remaining on the road surface after rainfall was based on the value of 60.2 g o f TRWP o n a day witho ut rain (0 mm/day). By calculating, it was co nfirmed that 0-49.4 g o f TRWP can mo ve to the environmental compartment depending on the intensity of rainfall. In addition, it was confirmed that when the rainfall intensity was 60 mm/day, the amount of TRWP moving to each environmental section was 3.75 times higher compared to 5 mm/day, and using the results of previous research, the total amount of TRWP that can be transported to the environmental compartment by rainfall from the domestic road environment annually is 9,592 tons, and 288 tons of this can be affected by marine microplastics. However, this study has limitations in terms of limited space and predicted results, but it would like to mention the need to improve the domestic road environment and sewage treatment system to reduce TRWP. In the future, we plan to conduct sample collection and concentration analysis studies of TRWP in real environmental compartments to verify the results of this study.

Evaluation of Applicability for 3D Scanning of Abandoned or Flooded Mine Sites Using Unmanned Mobility (무인 이동체를 이용한 폐광산 갱도 및 수몰 갱도의 3차원 형상화 위한 적용성 평가)

  • Soolo Kim;Gwan-in Bak;Sang-Wook Kim;Seung-han Baek
    • Tunnel and Underground Space
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    • v.34 no.1
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    • pp.1-14
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    • 2024
  • An image-reconstruction technology, involving the deployment of an unmanned mobility equipped with high-speed LiDAR (Light Detection And Ranging) has been proposed to reconstruct the shape of abandoned mine. Unmanned mobility operation is remarkably useful in abandoned mines fraught with operational difficulties including, but not limited to, obstacles, sludge, underwater and narrow tunnel with the diameter of 1.5 m or more. For cases of real abandoned mines, quadruped robots, quadcopter drones and underwater drones are respectively deployed on land, air, and water-filled sites. In addition to the advantage of scanning the abandoned mines with 2D solid-state lidar sensors, rotation of radiation at an inclination angle offers an increased efficiency for simultaneous reconstruction of mineshaft shapes and detecting obstacles. Sensor and robot posture were used for computing rotation matrices that helped compute geographical coordinates of the solid-state lidar data. Next, the quadruped robot scanned the actual site to reconstruct tunnel shape. Lastly, the optimal elements necessary to increase utility in actual fields were found and proposed.