• Biomolecules & Therapeutics
• /
• v.29 no.2
• /
• pp.175-183
• /
• 2021

The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal epithelial barrier function, but the molecular mechanism is not yet clarified. MAPK activation and barrier permeability were studied using monolayers of Caco-2 cells treated with tissue necrosis factor α (TNF-α) transfected with FUGW-HO-1 or pLKO.1-sh-HO-1 plasmid. Intestinal mucosal barrier permeability and MAPK activation were also investigated using carbon tetrachloride (CCl4) administration with CoPP (a HO-1 inducer), ZnPP (a HO-1 inhibitor), CO releasing molecule 2 (CORM-2), or inactived-CORM-2-treated wild-type mice and mice with HO-1 deficiency in intestinal epithelial cells. TNF-α increased epithelial TJ disruption and cleaved caspase-3 expression, induced ERK, p38, and JNK phosphorylation. In addition, HO-1 blocked TNF-α-induced increase in epithelial TJs disruption, cleaved caspase-3 expression, as well as ERK, p38, and JNK phosphorylation in an HO-1-dependent manner. CoPP and CORM-2 directly ameliorated intestinal mucosal injury, attenuated TJ disruption and cleaved caspase-3 expression, and inhibited epithelial ERK, p38, and JNK phosphorylation after chronic CCl4 injection. Conversely, ZnPP completely reversed these effects. Furthermore, mice with intestinal epithelial HO-1 deficient exhibited a robust increase in mucosal TJs disruption, cleaved caspase-3 expression, and MAPKs activation as compared to the control group mice. These data demonstrated that HO-1-dependent MAPK signaling inhibition preserves the intestinal mucosal barrier integrity by abrogating TJ dysregulation and epithelial cell damage. The differential targeting of gut HO-1-MAPK axis leads to improved intestinal disease therapy.

• Polymer(Korea)
• /
• v.24 no.4
• /
• pp.529-537
• /
• 2000

The effects of the gel content on the cell structures of PP sheets by using an electron-curing system were investigated. Three extruded PP sheets crosslinked by three different doses were used for the batch foaming process with the supercritical state $CO_2$. Experiments were also performed in order to study the effects of the gel content, saturation pressure and temperature on cell structures. Then foaming conditions, such as temperature and duration of time, were changed. The amount of gas absorbed into PP samples was not affected by gel contents and the operating condition of saturation pressure, which was higher than 2000 psi. The foam cells of PP with a low gel content grew irregularly at a higher foaming temperature and for a longer duration of foaming time. However, PP samples with high gel content showed even cell structures and narrow tell size distributions under the severe conditions of high foaming temperatures and long duration of foaming time.

• Fisheries and Aquatic Sciences
• /
• v.18 no.4
• /
• pp.367-372
• /
• 2015

We investigated the effects of dietary supplementation of two types (powder or liquid) of propolis on innate immunity and disease resistance of olive flounder Paralichthys olivaceus against Edwerdsiella tarda. A total of 600 fish averaging 30 g were randomly distributed into 24 tanks in groups of 25. Three tanks were assigned to each of eight experimental diets: 0 (Control), 0.25, 0.5, 0.75 and 1 % propolis in powder form and 0.25, 0.5 and 1 % propolis in liquid form (PP0.25, PP0.5, PP0.75, PP1, LP0.25, LP0.5 and LP1, respectively). Fish were fed each experimental diet twice daily for four weeks to apparent satiation. At the end of the feeding trial, lysozyme and myeloperoxidase activities and total immunoglobulin level were significantly higher in fish fed the PP1 and LP0.5 diets compared to those fed the control diet. The PP1 diet was also associated with a significant increase in anti-protease activity compared to the control diet. After challenge with E. tarda, fish fed the LP0.5 diet showed numerically higher survival compared to the other groups. This study indicates that non-specific immune responses of olive flounder can be enhanced by dietary supplementation with powder and liquid forms of propolis, and that the optimal level would be 1% in powder form or 0.5% in liquid form. It seemed that growth performance and feed utilization are not affected by the propolis supplementation in diets for olive flounder.

• Journal of the Korea Concrete Institute
• /
• v.18 no.1 s.91
• /
• pp.83-90
• /
• 2006

This paper investigates experimentally the fire resistance performance and spatting resistance of high performance reinforced concrete column member subjected to fire containing polypropylene fiber(PP fiber) and cellulose fiber(CL fiber). An increase in PP fiber and CL fiber contents, respectively resulted in a reduction of fluidity due to fiber ball effect. Air content is constant with m increase in fiber content. Compressive strength reached beyond 50 MPa. Based on fire resistance test, severe failure occurred with control concrete specimen, which caused exposure of reinforcing bar. No spall occurred with specimen containing PP fiber. This is due to the discharge of internal vapour pressure. Use of CL fiber superior to control concrete in the side of spatting resistance, localized failure at comer of specimen was observed. Corner of specimen had deeper neutralization than surface of specimen. Specimen containing PP fiber had the least damaged area due to spatting. Neutralization depth ranged between 6 and 8 mm Residual compressive strength of specimen containing PP fiber maintained 40%, which is larger than control concrete with 20% of residual strength. Specimen containing CL fiber had 25% or residual strength.

• Journal of Korean Society of Environmental Engineers
• /
• v.31 no.9
• /
• pp.775-782
• /
• 2009

PP-g-AA-Am nonwoven fabric, which possess anionic exchangeable function, was prepared by chemical modification of carboxyl (-COOH) group of PP-g-AA nonwoven fabric to amine ($-NH_2$) group using diethylene triamine (DETA). Its adsorption characteristics for anionic nutrients including isotherm, kinetics and co-anions were studied by batch adsorption experiments. Adsorption equilibriums of $PO_4$-P on PP-g-AA-Am fabric were well described by the Langmuir isotherm model, and their adsorption energies were ranged 10.3 kJ/mol indicating an ion-exchange process as primary adsorption mechanism. The adsorption selectivity of PP-g-AA-Am nonwoven fabric for anions under competition with each other was in following order: $SO_4\;^{2-}$>$PO_4\;^{3-}$>$NO_3\;^-$>$NO_2\;^-$. Also, all results obtained from this study indicate that the $PO_4$-P removal capacity of PP-g-AA-Am nonwoven fabric was extremely superior to that of PA308 anion-exchange resin.

• Journal of Adhesion and Interface
• /
• v.9 no.2
• /
• pp.16-23
• /
• 2008

In this study, novel waste wool/polypropylene NFRPs (natural fiber reinforced polymer composites), which are constituted with waste wool discarded as industrial scrap during manufacturing processes of woven fabrics and general purpose thermoplastic polypropylene (PP), were fabricated by means of compressionmolding and their mechanical and thermal properties were characterized. The mechanical properties of PP resin were significantly improved by an introduction of waste wool to PP. In particular, as the loading of waste wool was 50 vol% in the NFRP, the flexural strength of the NFRP was increased about 20%, the flexural modulus about 143%, the tensile strength about 76%, and the tensile modulus about 90% in comparison with each of PP control. In addition, the maximum value of the heat deflection temperature (HDT) obtained with the NFRP was $138^{\circ}C$ at a 50 vol% loading of waste wool. This is $21^{\circ}C$ higher than the HDT of PP control. The result here suggests that waste wool be a potential candidate for a reinforcing material of thermoplastic matrix resins.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.6
• /
• pp.4039-4045
• /
• 2014

The crystallization behavior of irradiated polypropylene (PP) and the blend is an important parameter for polymer processing. Blends of PP/low density polyethylene (LDPE) with different LDPE contents were prepared by melt mixing in a twin screw extruder. The effect of the LDPE content on the irradiation effectiveness of the PP/LDPE blend with trimethylolpropane-trimetacrylate (TMPTMA) as a crosslinking co-agent was investigated in conjunction with the LDPE loading in the blend. The non-isothermal crystallization and crystal structure were measured by DSC, X-ray diffraction (XRD), and polarized optical microscopy (POM). A decrease in the melting temperature of PP was observed due to irradiation, which may be due to the PP chain scissioning effect of irradiation. The Ozawa component n represents a rod shaped, disc shaped and sphere-shaped geometry of the crystal if the value corresponds to 2, 3 and 4, respectively. Based on Ozawa analysis, the values of n were 3.8 and 2.3 for the pure PP and PP blends with 30 wt% LDPE, respectively. The fact that the crystal geometry of PP changed from spherical to disc and rod shaped was confirmed by Ozawa analysis and POM. The ${\beta}$ form XRD peak of the PP/LDPE blend at $16.1^{\circ}$ disappeared after irradiation due to the crosslinking reaction.

• Korean journal of food and cookery science
• /
• v.12 no.4
• /
• pp.499-505
• /
• 1996

The facillities for Kimchi preservation were investigated in order to develop the taste, flavor and commercial quality of Kimchi during fermentation. Four kinds of facillities used for this experiment were PP(Polypropylene). PSC(Polypropylene+ceramic)and PPP was selected newly and laminated of three layers with PETG (Polyester G), PS (Polystyrene) and PETG. The change of total number of lactic acid Bacteria, pH, acidity, color, gas contents and free internal volume of package were measured for the Kimchi packaged by 4 facillities during 6 days fermentation at 15$^{\circ}C$. The total No. of lactic acid Bacteria within the Kimchi in the PPP facillity was more and remained longer time (120 hrs.) than other Kimchi in the PP, PS and PPC facillities. Also the pH of all Kimchi were decreased to pH 4 within 72 hrs. and the pH of Kimchi in the PPP facillity was kept as pH 4 for 120 hrs., so that was shown to be decreased more dully than others. In case of fimchi in the PPP facillity, the color was retained better, CO$_2$ contents was lower similar to PPC facillity, and swelling degree of free internal volume was higher than others. By the sensory evaluation, the Kimchi in the PPP facillity represented as better than others for color, flavor, texture and total preferences until 48 hrs. fermentation. And the PPP facillity is transparent, so these will be selected and confirmed more easily, also PPP facillity is so hard to endure the swelling pressure of internal gas. Therefore it is thought that the PPP facillity used as Kimchi package will be desirable for better taste, flavor, and commercial quality.

• Korean Journal of Food Science and Technology
• /
• v.37 no.6
• /
• pp.933-938
• /
• 2005

To investigate pertinent packaging treatment of fresh-cut potatoes (Solanum tuberosum L.), potato cubes were subjected to passive, gas exchange, and vacuum packaging conditions. Low density polyethylene film (LDPE), polypropylene film (PP), anti-fogging film (AP), and perforated film (PF) were used as passive packaging treatments. Mixed gases of 5% $CO_2/5%\;O_2$ (MA1) and 10% $CO_2/5%\;O_2$ (MA2) were applied as gas exchange packaging. Packs filled with cubes were kept at $5^{\circ}C$, and changes in weight loss, surface color, vitamin C content and sensory quality of cubes were analyzed during storage. Respiration rate of cubes was 2.11 times higher than that of intact raw potatoes at $5^{\circ}C$. Gas concentrations in passive packaging was maintained at 1-2% $O_2$ and 4-14% $CO_2$ after 7 days. Gas levels changed depending on films used. Cubes packed in PP and MA2 showed lowest weight loss and browning during storage. Firmness of cubes was not affected by packaging treatment. Vitamin C content was highest in cubes packed with AF. Cubes packed in MA2 showed highest quality upto 10days storage, followed by those packed in PP and AF.

• Polymer(Korea)
• /
• v.39 no.1
• /
• pp.64-70
• /
• 2015

Thermally expandable microcapsules (TEMs) can be expanded upon heating since the activation energy of liquid hydrocarbon at the core of the TEMs increased at high temperature. Due to this property, TEMs are widely used in the industry as blowing agents or light-weight fillers. In this article, chemical blowing agent and TEM were used for making polypropylene (PP) foams, and their mechanical properties were compared. Physical properties (tensile strength, impact strength etc.) of PP foams decreased with increasing the amount of blowing agents while weight of specimen decreased. However, PP foam produced with TEMs showed higher impact strength than the one with a chemical blowing agent. In order to figure out the difference of impact strength, the morphology of PP foamed was investigated. Expanding properties of TEM can be controlled by changing core back distance.