• Journal of The Korean Astronomical Society
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• v.37 no.5
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• pp.315-322
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• 2004

Several arguments have been presented in the literature to support the connection between radio halos and cluster mergers. The spectral index distributions of the halos in A665 and A2163 provide a new strong confirmation of this connection, i.e. of the fact that the cluster merger plays an important role in the energy supply to the radio halos. Features of the spectral index (flattening and patches) are indication of a complex shape of the radiating electron spectrum, and are therefore in support of electron reacceleration models. Regions of flatter spectrum are found to be related to the recent merger. In the undisturbed cluster regions, instead, the spectrum steepens with the distance from the cluster center. The plot of the integrated spectral index of a sample of halos versus the cluster temperature indicates that clusters at higher temperature tend to host halos with flatter spectra. This correlation provides further evidence of the connection between radio emission and cluster mergers.

• 한국전산유체공학회:학술대회논문집
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• 2000.10a
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• pp.92-100
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• 2000

At the end of 1999. the TeraCluster project has started in the KORDIC Supercomputer center to study PC clusters for parallel computing. The aim is to replace the Cray T3E with a new cluster system in 2002. The PC cluster without a fast network is well suited for applications which do not require large amount of global communications. Since CFD problems are not very communication intensive, whole test cluster may be efficiently used. As an example of practical CFD simulations. the flow past the ONERA M6 wing and the flow past infinite wing are simulated on a cluster of Linux workstations.

• Journal of Korean Academy of Nursing
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• v.39 no.5
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• pp.683-692
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• 2009

Purpose: The purpose of this study was to identify cancer-related symptom clusters and to validate the conceptual meanings of the revealed symptom clusters in patients with hepatocellular carcinoma. Methods: This study was a cross-sectional survey and methodological study. Patients with hepatocellular carcinoma (N=194) were recruited from a medical center in Seoul. The 20-item Symptom Checklist was used to assess patients' symptom severity. Selected symptoms were factored using principal-axis factoring with varimax rotation. To validate the revealed symptom clusters, the statistical differences were analyzed by status of patients' performance status, Child-Pugh classification, and mood state among symptom clusters. Results: Fatigue was the most prevalent symptom (97.4%), followed by lack of energy and stomach discomfort. Patients' symptom severity ratings fit a four-factor solution that explained 61.04% of the variance. These four factors were named pain-appetite cluster, fatigue cluster, itching-constipation cluster, and gastrointestinal cluster. The revealed symptom clusters were significantly different for patient performance status (ECOG-PSR), Child-Pugh class, anxiety, and depression. Conclusion: Knowing these symptom clusters may help nurses to understand reasonable mechanisms for the aggregation of symptoms. Efficient symptom management of disease-related and treatment-related symptoms is critical in promoting physical and emotional status in patients with hepatocellular carcinoma.

• Journal of Microbiology and Biotechnology
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• v.31 no.12
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• pp.1643-1655
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• 2021

Recent studies have reported dysbiosis of the microbiome in breast tissue collected from patients with breast cancer and the association between the microbiota and disease progression. However, the role of the microbiota in breast tissue remains unclear, possibly due to the complexity of breast cancer and various factors, including racial and geographical differences, influencing microbiota in breast tissue. Here, to determine the potential role of microbiota in breast tumor tissue, we analyzed 141 tissue samples based on three different tissue types (tumor, adjacent normal, and lymph node tissues) from the same patients with breast cancer in Korea. The microbiota was not simply distinguishable based on tissue types. However, the microbiota could be divided into two cluster types, even within the same tissue type, and the clinicopathologic factors were differently correlated in the two cluster types. Risk of regional recurrence was also significantly different between the microbiota cluster types (p = 0.014). In predicted function analysis, the pentose and glucuronate interconversions were significantly different between the cluster types (q < 0.001), and Enterococcus was the main genus contributing to these differences (q < 0.01). Results showed that the microbiota of breast tissue could interact with the host and influence the risk of regional recurrence. Although further studies would be recommended to validate our results, this study could expand our understanding on the breast tissue microbiota, and the results might be applied to develop novel prediction methods and treatments for patients with breast cancer.

• Annual Conference on Human and Language Technology
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• 2017.10a
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• pp.56-59
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• 2017

CNN(Convolutional Neural Network)을 이용하여 발화 주제 다중 분류 task를 multi-labeling 방법과, cluster 방법을 이용하여 수행하고, 각 방법론에 MSE(Mean Square Error), softmax cross-entropy, sigmoid cross-entropy를 적용하여 성능을 평가하였다. Network는 음절 단위로 tokenize하고, 품사정보를 각 token의 추가한 sequence와, Naver DB를 통하여 얻은 named entity 정보를 입력으로 사용한다. 실험결과 cluster 방법으로 문제를 변형하고, sigmoid를 output layer의 activation function으로 사용하고 cross entropy cost function을 이용하여 network를 학습시켰을 때 F1 0.9873으로 가장 좋은 성능을 보였다.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.27.1-27.1
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• 2010

Globular cluster (GC) systems in most galaxies, particularly in ellipticals, show bimodal color distributions. Because broadband colors trace metallicity at old ages, this phenomenon has been commonly interpreted as bimodal metallicity distributions, implying the presence of two sub-populations in the globular cluster system within a galaxy. However, a new explanation has recently been proposed, in which the non-linear nature of color-metallicity relations induced by horizontal-branch stars can produce bimodal color distributions even from unimodal metallicity distributions. In this study, we put these two explanations to the test on the origin of color bimodality, using multi-band (U,B,V and I) photometry of globular clusters in NGC 1399, the central giant elliptical galaxy in Fornax galaxy cluster. We find significant changes in the morphology of color distributions when using different colors. The observation is also well reproduced by the Monte Carlo realization of GC color when a unimodal metallicity distribution and the theoretical non-linear color-metallicity relations are assumed. We discuss the implications regarding theories on galaxy formation and evolution.

• Journal of Microbiology
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• v.34 no.2
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• pp.105-116
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• 1996

Of actinomycetes isolated from volcanic compost soils, 115 representative strains which showed distinctive morphologicla features were numerically classified, compared with reference strains of Streptomyces. One hundred and twenty unit characters were tested and the average probability of error was 4.27%. The cluster analysis resulted in two groups: group A included strains of actinomycetes except streptomycetes. Group A was divided into 2 major clusters (over 5 strains), 10-diaminopimelic acid. Group B was divided into 5 clusters, of which 4 clusters contained mesodiminopimelic acid and 1 cluster LL-diaminopimelic acid. The major clusters of group A showed higher abilities of substrate utilization and degradation, and higher resistance to inhibitors, whereas the minor and single member clusters of group A showed relatively higher antimicrobial activities. On the other hand, all clusters of group B showed relatively lower abilities of substrate utilization and degradation and lower resistance to inhibitors.

• Journal of The Korean Astronomical Society
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• v.28 no.1
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• pp.15-30
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• 1995

A velocity inhomogeneity, which is defined as a regional preponderence of either radial or tangential orbits, is searched with a new technique for the Coma cluster of galaxies. It is found within $\~2h^{-1}$ Mpc from the cluster center that the Coma shows conspicuous inhomogeneities in velocity and that the inhomogeneities are real at a $99\%$ level of confidence. Even in the central region (7' - 30' from the center), zones that are dominated by radial and tangential orbits are distinguishable. Defining the cluster's 'equator' as the direction defined by the Coma-A1367 supercluster, tangential orbits dominate the 'polar' zones in the central region. Galaxies that are located in 30'-100' also inhomogeneous in velocity in that the 'polar' zones are mostly radial while the rest is nearly homogeneous. These results indicate that the Coma galaxies are exceedingly more radial in orbit, implying that merging or infalls are either still going on or an earlier virialization is likely to have occurred preferentially near the 'equator'. Incorporating the velocity inhomogeneity into mass estimators, the most appropriate mass is turned out to be $0.4\times10^{15}h^{-1}M_\bigodot(R\;\leq\;0.6h^{-1} Mpc),\;and\;1.0\times10^{15}h^{-1} M_\bigodot(R\;\leq\;2.1h^{-1}Mpc)$. The corresponding mass to blue light ratio on the average is $\~$300h. These estimates are consistent with Merritt (1987) and Hughes (1989) and the MILE is seemed to favour the mass-follows-light models than the uniform spread of dark matter throughout the cluster.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.30.2-31
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• 2020

We present the properties of circumnuclear gas associated with the AGN located in the center of Abell 1644-South. A1644-S is the main cluster in a merging system, which is also known for gas sloshing in its core as seen in X-ray. The X-ray emission of A1644-S shows a rapidly declining profile, indicating the presence of cooling gas flow. This flow of cool gas may fuel the supermassive black hole embedded in the brightest cluster galaxy, leading to the activation of the central AGN. Indeed, we find a parsec-scale bipolar jet feature in the center of A1644-S in our recent KaVA observation, which implies that its central AGN is likely to have been (re)powered quite recently. In order to verify the hypothesis that cooling gas flow in the cluster core can (re)activate the central AGN, we probe the cold gas properties of the central 1 kpc region of A1644-S using the archival VLA and ALMA data. Based on the spatially resolved morphology and kinematics of HI and CO gas, we challenge to identify inflow/outflow gas streams and clumps. We study the role of circumnuclear cool gas in fueling the centrally located cluster AGN in the cool-core environment. We also discuss how the feedback due to the (re)powered AGN affects the surrounding medium.

• Macromolecular Research
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• v.13 no.3
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• pp.167-175
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• 2005

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The SOC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.