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Radiation Therapy for Primary Eyelid Cancers in Tunisia

  • Belaid, A;Nasr, C;Benna, M;Cherif, A;Jmour, O;Bouguila, H;Benna, F
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.7
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    • pp.3643-3646
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    • 2016
  • Management of eyelid cancers is based on surgery and/or radiotherapy (RT). The treatment objective is to control tumors with acceptable functional and esthetic outcomes. The aim of this study was to evaluate the results of radiation therapy in management of epithelial eyelid cancers, reviewing retrospectively the clinical records of patients treated in our institution from January 1989 to December 2013. We focused on clinical and histological features, treatment characteristics, tolerance and disease control. One hundred and eight patients (62 men and 46 women) were enrolled, with a mean age of 61 years [ranges 15-87]. The most frequent tumor location was the inner canthus (42.6%). Median tumor size was 21 mm [ranges 4-70]. Histological type was basal cell carcinoma in 88 cases (81.5%), squamous cell carcinoma in 16 (14.8%) and sebaceous carcinoma in 4 (3.7%). Radiation therapy was exclusive in 67 cases (62%) and post-operative for positive or close margins in the remaining cases. Kilovoltage external beam radiotherapy (KVRT) was used in 63 patients (58.3%) and low-dose-rate interstitial brachytherapy in 37 (34.3%). Eight (7.4%) were treated with cobalt or with a combination of KVRT-cobalt, KVRT-electron beams, KVRT-brachytherapy or cobalt-electron beams. The total delivered radiation doses were 70 Gy (2 Gy/fraction) in 62 patients (57.4%), 66 Gy (2 Gy/fraction) in 37 (34.3%) and 61.2 Gy (3.4Gy/fraction) in 9 (8.3%). After a median follow-up of 64 months, we noted 10 cases of local recurrences(9.2%): 7 after exclusive and 3 after post-operative RT. No local recurrence occurred in patients treated with brachytherapy. Actuarial 5-year local recurrence-free rate, disease-free survival and overall survival were respectively 90%, 90% and 97%. T-stage was found to be a significant factor for recurrence (p=0.047). All acute radiation-related reactions were scored grade I or II. Delayed effects were eye watering in 24 cases (22.2%), eye dryness in 19 (17.6%), unilateral cataract in 7 (6.4%) and ectropion in 4 (3.7%). Radiation therapy and especially brachytherapy is an efficient treatment of eyelid cancers, allowing eye conservation and functional preservation with good local control rates and acceptable toxicity.

An Energy Efficient Variable Area Routing protocol in Wireless Sensor networks (무선 센서 네트워크에서 에너지 효율적인 가변 영역 라우팅 프로토콜)

  • Choi, Dong-Min;Moh, Sang-Man;Chung, Il-Yong
    • Journal of Korea Multimedia Society
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    • v.11 no.8
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    • pp.1082-1092
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    • 2008
  • In wireless sensor networks, clustering protocol such as LEACH is an efficient method to increase whole networks lifetime. However, this protocol result in high energy consumption at the cluster head node. Hence, this protocol must changes the cluster formation and cluster head node in each round to prolong the network lifetime. But this method also causes a high amount of energy consumption during the set-up process of cluster formation. In order to improve energy efficiency, in this paper, we propose a new cluster formation algorithm. In this algorithm, we define a intra cluster as the sensor nodes within close proximity of each other. In a intra cluster, a node senses and transmits data at a time on the round-robin basis. In a view of whole network, intra cluster is treated as one node. During the setup phase of a round, intra clusters are formed first and then they are re-clustered(network cluster) by choosing cluster-heads(intra clusters). In the intra cluster with a cluster-head, every member node plays the role of cluster-head on the round-robin basis. Hence, we can lengthen periodic round by a factor of intra cluster size. Also, in the steady-state phase, a node in each intra cluster senses and transmits data to its cluster-head of network cluster on the round-robin basis. As a result of analysis and comparison, our scheme reduces energy consumption of nodes, and improve the efficiency of communications in sensor networks compared with current clustering methods.

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Outcomes of Local Excision for Early Rectal Cancer: a 6-year Experience from the Largest University Hospital in Thailand

  • Lohsiriwat, Varut;Anubhonganant, Worabhong;Prapasrivorakul, Siriluck;Iramaneerat, Cherdsak;Riansuwan, Woramin;Boonnuch, Wiroon;Lohsiriwat, Darin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.9
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    • pp.5141-5144
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    • 2013
  • Background: This study aimed to determine clinical outcomes of local excision for early rectal cancer from a University Hospital in Thailand. Materials and Methods: We performed a retrospective review of 22 consecutive patients undergoing local excision for early rectal cancer (clinical and radiological T1/T2) from 2005-2010 at the Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok. Data were collected from patients' medical records, including demographic and clinical characteristics, pathological report and surgical outcomes. Results: This study included 10 males and 12 females, with average age of 68 years. Nineteen patients (86%) underwent transanal excision and the others had trans-sacral excision. Median operative time was 45 minutes. Postoperative complications occurred in 2 patients (9%); 1 fecal fistula and 1 wound infection following trans-sacral excision. There was no 30-day postoperative mortality. Median hospital stay was 5 days. Pathological reports revealed T1 lesion in 12 cases (55%), T2 lesion in 8 cases (36%) and T3 lesion in 2 cases (9%). Eight patients received additional treatment; one re-do transanal excision, two proctectomies, and five adjuvant chemoradiation. During the median follow-up period of 25 months, local recurrence was detected in 4 patients (18%); two cases of T2 lesions with close or positive margins, and two cases of T3 lesions. Three patients with local recurrence underwent salvage abdominoperineal resection. No local recurrence was found in T1/T2 lesions with free surgical margins. Conclusions: Local excision is a feasible and acceptable alternative to radical resection only in early rectal cancer with free resection margins and favorable histopathology.

THE SHEAR BOND STRENGTH BETWEEN DICOR AND SEVERAL VENEERING PORCELAINS (Dicor와 수종 전장도재간의 전단결합강도)

  • Ryoo, Kyung-Hee;Lee, Sun-Hyung
    • The Journal of Korean Academy of Prosthodontics
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    • v.31 no.2
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    • pp.165-179
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    • 1993
  • Dicor has not been prescribed routinely, in spite of many advantages, because of esthetic limitations by excessive translucency and external shading. In an attempt to solve these problems, the technique of veneering Dicor by aluminous poreclain has been used and recently Dicor Plus system was developed. The purpose of this study was to evaluate the compatibility between Dicor and several veneering porcelains by measuring the shear bond strength and observing the failure mode and interface appearance with SEM. Total 55 Dicor disks(10.0mm diam. X 3.0mm thickness) were fabricated by lost wax technique and divided into five groups of 11. Veneering porcelains such as Dicor Plus, Vitadur Alpha, Vitadur N, Vivodent, and Ceramco II were built up over the center of the treated Dicor surface using paper tube(5.0mm diam. X 4.0mm height) and fired according to the manufacturesr’instructions. A representative sample from each group was completely embedded in epoxy resin and crosssectioned, and remaining 50 samples were embedded in epoxy resin with the bonded area perpendicular to table base. The shear bond strengths were measured by applying the shear load parallel to Dicor surface close to the bonded area. Failure modes and interface appearances were observed using SEM at 15 and 1000 magnification respectively. The obtained results were as follows : 1. The mean shear bond strengths showed Dicor-Dicor Plus(10.53 MPa); Dicor-Vitadur Alpha(8.84 MPa); Dicor-Vitadur N(7.37 MPa); Dicor-Vivodent(4.28 MPa); Dicor-Ceramco II(0.89 MPa). 2. The shear bond strength of Dicor-CeramcoII was significantly decreased compared with Dicor-Dicor Plus(p<0.01), but had no significant difference compared with Dicor-Vivodent(p>0.01). 3. The shear bond strengths of Dicor-Vitadur Alpha and Dicor-Vitadur N were not significantly different compared with Dicor-Dicor Plus(p>0.01). 4. SEM examination of bond failure modes revealed that Dicor-Dicor plus, Dicor-Vitadur Alpha, Dicor-Vitadur N exhibited cohesive failure within Dicor and Dicor-Vivodent exhibited adhesive failure. And Dicor-Ceramco III exhibited adhesive failure and cohesive failure within CeramcoIII together. 5. SEM examination of interfaces revealed that Dicor-Dicor Plus exhibited the most tight contact and Dicor-Vitadur Alpha, Dicor-Vitadur N exhibited acceptible contacts. But Vivodent exhibited discontinuous gap and Ceramco II exhibited large continuous gap.

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Floating Sector Caisson for Maintenance of the Large Underwater Structures (대형 수중구조물 보수를 위한 부유식 섹터케이슨)

  • Lee, Joong-Woo;Lee, Seung-Chul;Lee, Jung-Su;Kwak, Seung-Kyu;Kim, Ki-Dam
    • Journal of Navigation and Port Research
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    • v.31 no.5 s.121
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    • pp.421-426
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    • 2007
  • Recently, the defect maintenance period of the new construction structure was extended from 5 years to 10 years. And according to change of realization on the quality of construction and maintenance, a development of semi-permanent method of construction is required for maintenance of blind parts of underwater structure, such as bridge, dam, harbor, etc. In this study, we proposed a floating type sector dry caisson, which is effective to the maintenance of submerged large structures. These large structures were being maintained incompletely, partly due to unskilled divers and difficult working condition. Considering the easiness of access to the maintenance area and the cost for set up the working structure, especially for the case of structure slabs close to the sea surface and harrow pile span structures, we developed and introduced a sector dry caisson instead of the full caisson structure. By doing this, it is easy to move out the caisson rapidly in emergence case. Therefore, we expect that the floating sector caisson will contribute to reduce working time and improve the quality of underwater work in future days.

Subclinical Hypothyroidism in Patients with Bipolar Disorders Managed by Lithium or Valproic Acid (리튬 또는 발프로산으로 치료받은 양극성장애 환자의 무증상 갑상선저하증)

  • Choi, Hyeon Man;Chang, Jae Seung;Kim, Jayoun;Kim, Jeong Hyun;Choi, Jung Eun;Ha, Tae Hyon;Ha, Kyooseob
    • Korean Journal of Biological Psychiatry
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    • v.20 no.4
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    • pp.151-158
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    • 2013
  • Objectives To investigate the pattern of subclinical hypothyroidism (SCH) in patients with bipolar disorders managed by lithium or valproic acid. Methods The study participants were 106 patients with DSM-IV bipolar disorders receiving planned maintenance treatment at the Mood Disorders Clinic of Seoul National University Bundang Hospital (aged between 17 and 64, mean duration of follow-up = 875.65 days). Using the bipolar disorder registry, thyroid function data were analyzed to assess the frequency of and the risk factors for SCH in patients managed by lithium (n = 64) or valproic acid (n = 42) for more than 5 months. Results Overall frequencies of SCH were 20.3% (13/64) in the lithium group, 14.3% (6/42) in the valproic acid group, and between the two groups there is no difference (p = 0.43). No differences were observed in the potential risk factors for SCH between the two groups including age, sex, subtype of bipolar disorder, baseline TSH, and concomitant antipsychotic use. In cases with SCH, thyroid-stimulating hormone (TSH) showed a tendency to increase at 3 month after the initiation of lithium or valproic acid. A gradual increase in the number of patients showing SCH was found within the first 3 years of medication. Conclusions With regular monitoring and careful assessment, there was no difference in the risk of SCH between lithium and valproic acid maintenance. The risk of mood stabilizer-associated SCH may gradually increase within 3 years following the commencement of medication, thereby mandating close monitoring for the first 3 years of treatment. Further studies with large sample size would be needed to confirm these findings.

Analysis of Vertical Profiles and Optical Characteristics of the Asian Dust Using Ground-based Measurements (지상관측장비를 이용하여 관측한 봄철 황사의 연직분포와 광학적 특성 분석)

  • Lee, Byung-Il;Yoon, Soon-Chang;Kim, Yoonjae
    • Atmosphere
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    • v.18 no.4
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    • pp.287-297
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    • 2008
  • The vertical profiles and optical properties of Asian dust are investigated using ground-based measurements from 1998 to 2002. Vertical profiles of aerosol extinction coefficient are evaluated using MPL (Micro Pulse Lidar) data. Optical parameters such as aerosol optical thickness ($\tau$), ${\AA}ngstr\ddot{o}m$ exponent ($\alpha$), single scattering albedo ($\omega$), refractive index, and volume size distribution are analyzed with sun/sky radiometer data for the same period. We can separate aerosol vertical profiles into three categories. First category named as 'Asian dust case', which aerosol extinction coefficient is larger than $0.15km^{-1}$ and dust layer exists from surface up to 3-4km. Second category named as 'Elevated aerosol case', which aerosol layer exists between 2 and 6km with 1-2.5km thickness, and extinction coefficient is smaller than $0.15km^{-1}$. Third category named as 'Clear sky case', which aerosol extinction coefficient appears smaller than $0.15km^{-1}$. and shows that diurnal variation of background aerosol in urban area. While optical parameters for first category indicate that $\tau$ and $\alpha$ are $0.63{\pm}0.14$, $0.48{\pm}0.19$, respectively. Also, aerosol volume concentration is increased for range of 1 and $4{\mu}m$, in coarse mode. Optical parameters for second category can be separated into two different types. Optical properties of first type are very close to Asian dust cases. Also, dust reports of source region and backward trajectory analyses assure that these type is much related with Asian dust event. However, optical properties of the other type are similar to those of urban aerosol. For clear sky case, $\tau$ is relatively smaller and $\alpha$ is larger compare with other cases. Each case shows distinct characteristics in aerosol optical parameters.

A Study of the Improvement and Practical Use on the Website Measurement Scale (웹사이트 측정도구의 개발과 활용에 대한 연구)

  • Kim, Dae-Hwan;Bae, Young
    • Survey Research
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    • v.10 no.1
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    • pp.91-112
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    • 2009
  • The aim of this study is to suggest a new website measurement scale revised in accordance with the present tendency, and to test the practical use of it. The empirically current studies suggest the information, connectivity, practical function, lay - out, design, interlace, system, service as a website measurement scale. However. this study suggest a new website measurement scale including communication between internet users, platform for editing information. The test of a practical use about measurement scale progressed by a survey on computer access. A sample of 300 internet users answered the question based on a new website measurement scale. The result of this study shows that primary factors of the website measurement scale are information, user interface, website service, and communication. The influence of these factors on user's website preference changed as compared with the past. The result also shows that there is close correlation between information factor and communication factor. And the communication factor suggested on this study has effected in user's website satisfaction. Results imply that the idea of web2.0 is practically an important strategy for improving website satisfaction. And, because influence of primary factors on the website satisfaction has changed continually, strategic planning will have to be kept up.

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A SPECTROSCOPIC STUDY OF THE CLOSE BINARY AG VIRGINIS (근접쌍성 AG Virginis의 분광학적 연구)

  • Kim, Ho-Il;Lee, Chung-Uk;Lee, Jae-Woo;Sohn, Mi-Rim
    • Journal of Astronomy and Space Sciences
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    • v.22 no.4
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    • pp.353-362
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    • 2005
  • We performed a new high-resolution spectroscopy of AG Vir for 4 nights from 25 March 2004 using the BOES (Bohyunsan Optical Echelle Spectrograph) attached to the 1.8-m reflector at Bohyunsan Optical Astronomy Observatory, and obtained a total of 59 spectra where all orbital phases are covered. To get the radial velocities of the binary system, both method of the CCF (Cross-Co..elation Function)and the BF (Broadening Function) were applied to the analysis of all the observed spectra. From these, the CCF could calculate the radial velocities of the primary star alone, while the BF could determine those of the primary and the secondary components. New absolute dimensions were deduced with the combination of our spectroscopic orbital elements ($K_1=90.5km/s$$K_2=258.8$) and the photometric solutions of Bell, Rainger, & Hilditch (1990): $A_1,=1.99M_\bigodot,\;M_2=0.62M_\bigodot,\;R_1=2.21R_\bigodot,\;R_2=1.36R_\bigodot,\;L_1=13.17L_\bigodot,\;and\;L_2=3.47L_\bigodot$. Our absolute parameters are larger and brighter than those derived from Bell, Rainger, & Hilditch (1990). We re-analyzed all the previous radial-velocity curves of AG Vir and, as a result, can see that its system velocity scatters largely up to ${\pm}8km/s$. However, we, at present, cannot determine this as the light-time effect due to the third body, which was suggested as a cause of the orbital period changes by Qian (2001).

The study about the cause of the Korean professional pitchers' injury and its classification (한국 프로야구투수들의 부상 발생원인 및 분류에 관한 연구)

  • Nam Joung-Chul;Kim Sang-Su;Lee Dong-Ho
    • The Journal of Korean Physical Therapy
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    • v.14 no.4
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    • pp.172-182
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    • 2002
  • Objectives: We did research in the cause of the Pitchers' injury and their recovery process to make a detailed injury list for the purpose of finding the cause of the Korean professional pitchers' injury and its classification. We drew the conclusion through the results as following. Methods: We posed a question to the 80 pitchers playing in the first team of the eight Korean professional baseball team and analyzed the 62 pieces of question paper except the paper having a mistake. We used SAS/PC statistical package in analyzing the data. Results: In the frequency of the pitchers' shoulder injury in the last three years, the injured of all the players were 61.3$\%$ and the injury free players were 28.7$\%$. The cause of the injury was 45.2$\%$ wrong pitching motion, which was the highest value. For the shape of a pain when injured, the reverberation ache feeling when he is hit in the weight commanded an absolute majority as 19.4$\%$. Those who had muscular pain were 17.7$\%$, which was felt mostly at the pitching motion. The most trouble name of the injured shoulder was bicepstendinitis as 16.1$\%$ while the injury of shoulder joint was the lowest as 1.6$\%$. As the most widely used treatment, 25.8 percent of all the players had taken an electronical thraphy after injury. 14.5 percent of the players who had an injury to the shoulder told that they have an operation and 85 percent of them didn't. As a sort of the operation, a repairing of labrum was 44.4 percent, which is the highest value and the 77.8 percent pitchers are performing a normal pitching through rehabilitation after the operation and 22.2 percent of them are undergoing rehabilitation training. Conclusion: The research have shown that the main cause of the injury, concerning the Korean professional pitchers throwing lots of ball in both matches and practices, is overuse syndrome, bad mechanism, muscle weakness and instability of balance. I think that the role of trainer, physical therapy, and team physician taking charge of the players' injury must learn physical test method by heart exactly to check up the state of the injury definitely at the initial phase. Moreover, when the cause of the injury part after a close examination is discovered, the scientific and good surgery is essential to the rehabilitation success and making a classification of shoulder instability is useful to make a operation plan as well as the players' rehabilitation, treatment.

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