• Title/Summary/Keyword: Clinical research trend

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Research Trends of Pattern Identification of Korean Medicine Using the Network Analysis (네트워크 분석을 통한 국내 변증 연구의 동향)

  • Jin, Hee-Jeong;Lee, JaeChul;Jang, Eunsu
    • The Journal of the Korea Contents Association
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    • v.14 no.12
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    • pp.1037-1046
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    • 2014
  • This study aims to analyze Korea's trend of 'pattern identification(PI)' research using network analysis. We selected 368 papers from OASIS (Oriental Medicine Advanced Searching Integrated System) by review of two Korean medicine experts. Network analysis between keyword of PI studies were performed. As a result, number of PI studies has increased over the last 10 years. 'Korean journal of oriental physiology and pathology' and 'Journal of Korean oriental internal medicine' have published most papers related to PI. As research category, there are 144 papers in the cross-sectional study, and 71 papers in case report study. In the case of randomized clinical trials, there are only 3 papers. In studies for PI, stroke, pattern analysis, and blood stasis were the keywords make up the main network.

A Trend Analysis of Radiological Research in Korea using Topic Modeling (토픽모델링을 이용한 국내 방사선 학술연구 트렌드 분석)

  • Hong, Dong-Hee
    • Journal of the Korean Society of Radiology
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    • v.16 no.3
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    • pp.343-349
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    • 2022
  • We intend to use topic modeling to identify radiation-themed papers published from 1989 to 2022 and analyze the relevance and weight between topics. This study analyzed topics derived from national subjects for 717 papers published until recently in 2022 to contribute to the revitalization of research in the field of radiation. Through text mining, overall research trends on the subject distribution of the study were analyzed, and five topics were derived through topic modeling. First, among the papers to be analyzed, a total of 1,675 words were frequency-analyzed through the preprocessing process of key words in a total of 717 papers centered on keywords. Second, as a result of analyzing topics based on the association of constituent words for five topics, it was found that studies focused on minimizing dose in the range that does not degrade image quality in the fields of radiation, image, CT clinical. In addition, it was found that various studies were mainly conducted in the MRI, and the study of ultrasound in various areas of disease analysis was actively attempted.

The Analysis on Trend of Articles about Retina and Optic Nerve Disease in Journal of Korean Medicine (국내 한의학 학술지에 게재된 망막과 시신경질환 관련 논문들의 경향성 분석)

  • Na-Yeon Choi;Hyung-Sik Seo;Tae-Gwon Kim;Kang Kwon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.36 no.2
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    • pp.26-44
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    • 2023
  • Objectives : This study was designed to examine and analyze the recent trend of Korean medicine research on retinal and optic nerve diseases, which is increasing. Methods : This study examines papers related to diseases occurring in the retina and optic nerve that were published in Korean journals of Korean medicine, and analyzes the results of research so far by classifying them by year, journal, disease type and type of paper. Results : 1. Since it was first published in 1995, a total of 17 articles have been published until 2018, with 2 articles(11.1%) each in 1997, 2014 and 2018, and 1 article(5.6%) each in other years. 2. The number of searched journals was 17 paper; 4 review articles, 1 original articles, 12 case reports. 3. Distribution of journals; the percentage of Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology ranked the highest(41.2%). 4. Classification of 12 case reports into three categories; 7 retinal diseases, 3 optic nerve diseases, 2 other diseases. Conclusions : Currently, researches on retinal and optic nerve involvement in the Korean medicine journals have been conducted mainly through case reports. In the future, more clinical research and case reports are necessary to give practical application to patients.

Application of Iron Oxide as a pH-dependent Indicator for Improving the Nutritional Quality

  • Meng, Xiangpeng;Ryu, Jina;Kim, Bumsik;Ko, Sanghoon
    • Clinical Nutrition Research
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    • v.5 no.3
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    • pp.172-179
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    • 2016
  • Acid food indicators can be used as pH indicators for evaluating the quality and freshness of fermented products during the full course of distribution. Iron oxide particles are hardly suspended in water, but partially or completely agglomerated. The agglomeration degree of the iron oxide particles depends on the pH. The pH-dependent particle agglomeration or dispersion can be useful for monitoring the acidity of food. The zeta potential of iron oxide showed a decreasing trend as the pH increased from 2 to 8, while the point of zero charge (PZC) was observed around at pH 6.0-7.0. These results suggested that the size of the iron oxide particles was affected by the change in pH levels. As a result, the particle sizes of iron oxide were smaller at lower pH than at neutral pH. In addition, agglomeration of the iron oxide particles increased as the pH increased from 2 to 7. In the time-dependent aggregation test, the average particle size was 730.4 nm and 1,340.3 nm at pH 2 and 7, respectively. These properties of iron oxide particles can be used to develop an ideal acid indicator for food pH and to monitor food quality, besides a colorant or nutrient for nutrition enhancement and sensory promotion in food industry.

Clinical Research Trends on Precocious Puberty and Sleep (성조숙증과 수면에 관한 임상연구동향)

  • Seo, Hee Ae;Lee, Sun Haeng;Chang, Gyu Tae
    • The Journal of Pediatrics of Korean Medicine
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    • v.35 no.4
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    • pp.75-81
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    • 2021
  • Objectives The purpose of this study is understanding the trend of clinical researches on the correlation between precocious puberty and sleep. Methods 18 papers were searched by using keywords 'Precious publicity' and 'Sleep' in Pubmed, China National Knowledge Infrastructure, and those were analyzed for this study. Results Children aged 6 to 18 were participated in longitudinal studies and questionnaire surveys. Hormone levels and EEG were also measured in those children. This study had placed emphasis on the sleeping time and sleep quality, and sex hormones secretion during sleep and changes in the hormone secretion related to the sleep cycles. Historically, oriental medicine studies have demonstrated that there were correlations between precocious puberty and sleep. There are studies from China showed the importance of lifestyle management in preventing and treating precocious puberty, especially with light exposure during sleep. Conclusions Sleep is closely correlated with precocious puberty and it is an important factor to be considered in the prevention and treatment of precocious puberty.

Recent Trends in Clinical Research of Acupuncture Treatment for Intellectual Disability - Focused on Chinese Randomized Controlled Trials - (지적장애의 침 치료에 대한 최신 임상연구 동향 - 중국 무작위 배정 임상연구를 중심으로 -)

  • Kim, Jae Hyun;Park, Yong Seok;Lee, Jihong;Chang, Gyu Tae
    • The Journal of Pediatrics of Korean Medicine
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    • v.35 no.4
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    • pp.34-47
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    • 2021
  • Objectives The purpose of this study is to analyze the trend of recent randomized controlled trials (RCTs) which used acupuncture for the treatment of intellectual disability in China, and to evaluate the efficacy of the treatment. Methods The RCTs published from January 2017 to July 2021 were searched using China National Knowledge Infrastructure (CNKI). Then, those were analyzed by acupuncture treatment methods used and their results. Results A total of 18 randomized controlled trials were selected and analyzed. Most studies showed significantly higher Intelligence Quotient, Development Quotient, and a total effective rate in an acupuncture treatment group than those of the control group. The most used acupoints were EX-HN1 followed by Niesanzhen, Naosanzhen, Zhisanzhen, Shouzhizhen, GV20. Conclusions Based on the results of the analyzed randomized controlled trials, an acupuncture treatment has shown to be effective in the treatment of intellectual disability. However, additional well designed clinical trials are needed to solidify these findings.

A Comparative Study of Clinical Papers about Pharmacopuncture in Korea and China - Focusing on Papers about Musculoskeletal and Nervous Diseases - (중국과 국내에서의 약침 관련 임상논문 비교 연구 - 근골격계 및 신경계 질환을 위주로 -)

  • Lee, Han-Gil;Hong, Seo-Young
    • Journal of Korean Medicine Rehabilitation
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    • v.19 no.3
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    • pp.47-67
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    • 2009
  • Objectives : To research the trend of the study related to pharmacopuncture about musculoskeletal and nervous diseases in China and to make a comparison with clinical application on pharmacopuncture about musculoskeletal and nervous diseases in China and Korea. Methods : I reviewed and analyzed four Chinese Journals relating pharmacopucture from 2004 to 2008 and two Korean Journals relating pharmacopuncture from 1999 to 2008. Results : The following results were obtained in this study. 1. The pharmacopuncture was often used for diseases of spines and joints. 2. In the medicine of pharmacopuncture, Salviae Miltiorrhizae Radix, Angelicae Gigantis Radix were mainly used in China, and Bee-venom in Korea. 3. As a method of needling, local acupoint and Ashi-point were mainly ueed in both China and Korea. 4. In combined treatments, acupuncture, electronic acupuncture, Chuna, heating acupuncture were mainly used in China, and acupuncture, herb medicine, physiotherapy in Korea. 5. In the case of control group study, compared with other treatments pharmacopuncture was not verified the superiority of effectiveness in China, but in Korea, the effectiveness of a pharmacopuncture could be compared with that of others and the effectivenss of different pharmacopuncture could be compared. Conclusions : As seen above, in Korea, clinician should carry out clinical application about musculoskeletal and nervous diseases with various herbal injections besides Bee-venom. And I think that it will be starting point to use Salviae Miltiorrhizae Radix and Angelicae Gigantis Radix that were often used in China.

Biomonitoring of Metal Exposure During Additive Manufacturing (3D Printing)

  • Ljunggren, Stefan A.;Karlsson, Helen;Stahlbom, Bengt;Krapi, Blerim;Fornander, Louise;Karlsson, Lovisa E.;Bergstrom, Bernt;Nordenberg, Eva;Ervik, Torunn K.;Graff, Pal
    • Safety and Health at Work
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    • v.10 no.4
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    • pp.518-526
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    • 2019
  • Background: Additive manufacturing (AM) is a rapidly expanding new technology involving challenges to occupational health. Here, metal exposure in an AM facility with large-scale metallic component production was investigated during two consecutive years with preventive actions in between. Methods: Gravimetric analyzes measured airborne particle concentrations, and filters were analyzed for metal content. In addition, concentrations of airborne particles <300 nm were investigated. Particles from recycled powder were characterized. Biomonitoring of urine and dermal contamination among AM operators, office personnel, and welders was performed. Results: Total and inhalable dust levels were almost all below occupational exposure limits, but inductively coupled plasma mass spectrometry showed that AM operators had a significant increase in cobalt exposure compared with welders. Airborne particle concentrations (<300 nm) showed transient peaks in the AM facility but were lower than those of the welding facility. Particle characterization of recycled powder showed fragmentation and condensates enriched in volatile metals. Biomonitoring showed a nonsignificant increase in the level of metals in urine in AM operators. Dermal cobalt and a trend for increasing urine metals during Workweek Year 1, but not in Year 2, indicated reduced exposure after preventive actions. Conclusion: Gravimetric analyses showed low total and inhalable dust exposure in AM operators. However, transient emission of smaller particles constitutes exposure risks. Preventive actions implemented by the company reduced the workers' metal exposure despite unchanged emissions of particles, indicating a need for careful design and regulation of the AM environments. It also emphasizes the need for relevant exposure markers and biomonitoring of health risks.

A relationship between Stroke and Sasang Constitution in Korean

  • Ko, Ho-Yeon;Jun, Chan-Yong;Park, Jong-Hyeong;Yoon, Yoo-Sik;Lee, Sun-Dong;Han, Chang-Ho;Jung, Woo-Sang;Moon, Sang-Kwan;Cho, Ki-Ho;Ko, Seong-Gyu
    • Advances in Traditional Medicine
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    • v.5 no.4
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    • pp.336-346
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    • 2005
  • Experts of Sasang Constitution Medicine of Traditional Korean Medicine have classified stroke patients with four types of Sasang constitutions in their clinical practice and some types of Sasang constitutions have been regarded as risk factors of stroke, but this is uncertain because there were no evidences by large scale of prospective studies. The purpose of this was to study the association between strokes and Sasang constitutions. Case-control study has been conducted to the patients admitted to the research hospitals. The patients were confirmed stroke by brain MRI or CT scans and recruited from May 2003 to August 2005. The subjects who met the requirement of inclusion and exclusion criteria were 108 patients as the cases and 107 as healthy controls. Data collection has been performed by the trained specialists majoring neurologists through interviews, physical examinations, and laboratory testes. No statistical significance was obtained between the strokes and Sasang constitutions, yet Taeumin, and Soyangin types showed a trend of increase in the incidence of strokes as compared with Soeumin. To acquire more concrete data on this theme, we need further and large scale of prospective researches.

Effect of Varying the Energy Density of Protein-adequate Diets on Nutrient Metabolism, Clinical Chemistry, Immune Response and Growth of Muzaffarnagari Lambs

  • Singh, V.K.;Pattanaik, Ashok Kumar;Goswami, T.K.;Sharma, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.8
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    • pp.1089-1101
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    • 2013
  • Effects of varied dietary energy densities on immune response and performance of Muzzafarnagari lambs were ascertained in a 180-d study. Animals (n = 24), in three groups, were fed diets providing 100% (100E), 80% (80E) or 70% (70E) of their metabolizable energy requirement. Mean nutrient digestibilities varied significantly among treatments. Nitrogen intake was lower (p<0.01) in the 70E. Nitrogen retention, was reduced (p<0.001) in 80E and 70E vs 100E. The average daily gain (p<0.001) was $47.01{\pm}4.23$, $13.54{\pm}1.72$ and $-16.67{\pm}8.24$ g for 100E, 80E and 70E, respectively. Hemoglobin concentration, haematocrit, total and differential leukocyte counts were lower (p<0.001) for 80E and 70E than for 100E with a similar trend (p<0.05) for serum glucose and total protein. Serum cortisol was reduced (p<0.001) with decreased energy availability. Antibody titre to Brucella abortus S19 showed an initial reduction in 80E and 70E vs 100E. Delayed-type hypersensitivity response was lower (p<0.001) in 80E and 70E vs 100E, accompanying a lower (p<0.001) nitric oxide production by the peripheral lymphocytes. It is concluded that the reduced dietary energy density significantly affects the growth performance and immune response of lambs.