• BMB Reports
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• v.53 no.8
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• pp.413-418
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• 2020

ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions and regulate fundamental biological processes, while the KH domain binds to RNA or ssDNA and is associated with transcriptional and translational regulation. In recent years, studies containing relevant information on ANKHD1 in cancer biology and its clinical relevance, as well as the increasing complexity of signaling networks in which this protein acts, have been reported. Among the signaling pathways of interest in oncology regulated by ANKHD1 are Hippo signaling, JAK/STAT, and STMN1. The scope of the present review is to survey the current knowledge and highlight future perspectives for ANKHD1 in the malignant phenotype of cancer cells, exploring biological, functional, and clinical reports of this protein in cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4495-4499
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• 2013

Morinda citrifolia, also known as Great Morinda, Indian Mulberry, or Noni, is a plant belonging to the family Rubiaceae. A number of major chemical compounds have been identified in the leaves, roots, and fruits of the Noni plant. The fruit juice is in high demand in alternative medicine for different kinds for illnesses such as arthritis, diabetes, high blood pressure, muscle ached and pains, menstrual difficulties, headache, heart diseases, AIDS, gastric ulcer, sprains, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, and drug addiction. Several studies have also demonstrated anti-inflammatory, antioxidant and apoptosis-inducing effects of Noni in various cancers. Based on a toxicological assessment, Noni juice was considered as safe. Though a large number of in vitro, and, to a certain extent, in vivo studies demonstrated a range of potentially beneficial effects, clinical data are essentially lacking. To what extent the findings from experimental pharmacological studies are of potential clinical relevance is not clear at present and this question needs to be explored in detail before an recommendations can be made.

• The Journal of Korean Physical Therapy
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• v.12 no.3
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• pp.433-444
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• 2000

The purpose is paper was to discuss current concepts related to anatomic stabilizing structures of the shoulder joint complex and their clinical relevance to shoulder instability. The clinical syndrome of shoulder instability represents a wide spectrum of symtoms and signs which may produce various levels of dysfunctions, from subtle subluxations to gross joint instability. The glenohumeral joint attains functional stability through a delicate and intricate interaction between the passive and active stabilizing structures. The passive constraints include the bony geometry, glenoid labrum, and the glenohumeral joint capsuloligaments structure. Conversely, the active constraints, also referred to as active mechanism, include the shoulder complex musculature, the projprioceptive system, and the musculoligamentous relationship. The interaction of the active and passive mechanism which provide passive and active glenohumeral joint stability will be throughtly discussed in this paper

• Sleep Medicine and Psychophysiology
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• v.30 no.1
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• pp.9-12
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• 2023

Periodic limb movements during sleep (PLMS) are prevalent in various sleep disorders, such as restless legs syndrome (RLS), periodic limb movements disorder, obstructive sleep apnea (OSA), REM sleep behavior disorder (RBD), and narcolepsy. PLMS has been hypothesized to be related to the decline of dopaminergic transmission. In RLS, PLMS is suggested to be related to iron deficiency and symptom severity. PLMD is a rare sleep disorder, and the role of PLMS in PLMD has not been clearly investigated yet. PLMS in OSA, which remain after proper PAP therapy, may need further management. The clinical relevance of PLMS in RBD and narcolepsy have not been investigated thoroughly and need further studies. Whether PLMS are to be considered as a mere symptom of individual sleep disorders or not can be elucidated through studies investigating the efficacy of therapeutic approaches to reduce PLMS in various sleep disorders.

• Anatomy and Cell Biology
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• v.57 no.1
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• pp.7-12
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• 2024

The pterygomandibular raphe (PMR) is a tendinous structure connecting the bucinator and the superior pharyngeal constrictor muscles. With its implications in the spread of oral cancer, the proper treatment of obstructive sleep apnea, and dental procedures, it is important to obtain a thorough understanding of the PMR. We reviewed the existing literature to compile the published information regarding its anatomy, embryology, imaging, variations, functions, pathologies, and clinical relevance of the pterygomandibular raphe.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.1874-1883
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• 2015

The purpose of this study was to verify clinical reasoning of nursing students as well as clarify the relevance between clinical reasoning and academic achievement. 87 students broke into 30 groups of two or three. The students performed post operative care for adult patients in the simulation practicum course of their final semester. Data were collected by evaluating the video-recorded nursing practicum using the clinical reasoning rubric. Clinical reasoning of 61(70.1%) students was limited to the beginning level and that of 6(6.9%) students of the highest scoring was at the third level among the four levels of ability. There was no significant correlation between clinical reasoning and the final cumulative GPA, while there was low level of significant correlation between clinical reasoning and GPA of adult health nursing course or adult health nursing practicum course. Therefore, it is necessary to improve the nursing curriculum to enhance nursing students' clinical reasoning.

• Journal of Convergence for Information Technology
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• v.11 no.4
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• pp.137-145
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• 2021

This study was conducted to identify the correlation between the self-efficacy, communication competence, and clinical practice satisfaction of dental hygiene students and the factors affecting clinical practice satisfaction. The data survey was conducted on 201 students of Chungcheong Province who experienced clinical practice. Data were analyzed by anova and logistic regression analysis. As a result of the study, clinical practice satisfaction was positively correlated with self-efficacy (r=.337), communication competence (r=.293) and self-efficacy was positively correlated with communication competence (r=.633). Factors affected to clinical practice satisfaction were self-efficacy, academic score, and major satisfaction. Therefore, it will be necessary to develop clinical practice education programs that can enhance students' self-efficacy and improve their communication competence.

• Korean Journal of Clinical Pharmacy
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• v.19 no.2
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• pp.81-88
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• 2009

Objectives: With more and more health economic evaluations being performed in many countries, the question of whether the results from the foreign studies can be transferred to other country is becoming important. The objective of this study was to conduct a case study using three transferability diagnosis tools for economic evaluation on rheumatoid arthritis. Methods: Three diagnosis tools were used to assess transferability: Welte's tool, Boulenger's and Urdahl's. Five researchers who have experience on economic evaluation made consensus on the evaluation through the semi-delphi method. Results: With Welte's tool, absolute and relative prices in healthcare, practice variation, health-status preference, productivity and work-loss time were evaluated as biased. The transferability information score by Boulenger's was 85.9%, which means qood quality reporting. In case of Urdahl's, research questions were well defined and reporting was transparent and explicitly stated. However, both the relevance of data inputs to Korea and robustness of model were relatively low. In conclusion the UK study on rheumatoid arthritis could be partially transferable to Korea, and will need modeling-based adjustments.

• Journal of Digital Convergence
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• v.17 no.2
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• pp.255-264
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• 2019

This study was a cross-sectional study done to determine the relevance and impact factors of critical thinking and nursing practice environment on clinical decision making among nurses. A survey was conducted for April 2017 with self-report questionnaire. Participants were 261 registered nurses working in one tertiary hospital. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation coefficients, and hierarchical regression analysis with SPSS/WIN(21.0). Factors affecting clinical decision making included age, educational background, position, work shift, clinical career. Clinical decision making had a positive correlation with critical thinking and nursing practice environment. And position, critical thinking and nursing practice environment accounted for 35.8% of the variance in clinical decision making. Therefore, quality management for developing nursing professionalism and administrative support for effective staffing and resource adequacy in addition improving critical thinking increase nurses'clinical decision making.

• Biomedical Science Letters
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• v.25 no.1
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• pp.40-53
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• 2019

Of the Acinetobacter spp., A. baumannii (genospecies 2) is the most clinically significant in terms of hospital-acquired infections worldwide. It is difficult to perform Acinetobacter-related taxonomy using phenotypic characteristics and routine laboratory methods owing to clusters of closely related species. The ability to accurately identify Acinetobacter spp. is clinically important because antimicrobial susceptibility and clinical relevance differs significantly among the different genospecies. Based on the medical importance of pathogenic Acinetobacter spp., the distribution and characterization of Acinetobacter spp. isolates from 123 clinical samples was determined in the current study using four typically applied bacterial identification methods; partial rpoB gene sequencing, amplified rRNA gene restriction analysis (ARDRA) of the intergenic transcribed spacer (ITS) region of the 16~23S rRNA, the $VITEK^{(R)}$ 2 system (an automated microbial identification system) and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). A. baumannii isolates (74.8%, 92/123) were the most common species, A. nosocomialis (10.6%, 13/123) and A. pittii isolates (7.5%, 9/123) were second and third most common strains of the A. calcoaceticus-A. baumannii (ACB) complex, respectively. A. soli (5.0%, 6/123) was the most common species of the non-ACB complex. RpoB gene sequencing and ARDRA of the ITS region were demonstrated to lead to more accurate species identification than the other methods of analysis used in this study. These results suggest that the use of rpoB genotyping and ARDRA of the ITS region is useful for the species-level identification of Acinetobacter isolates.