• Title/Summary/Keyword: Clinical protocols

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Development of dot blot hybridization method using non-radio labeled probes for the diagnosis of malignant catarrhal fever (Dot blot hybridization에 의한 malignant catarrhal fever virus의 진단법 개발)

  • Kim, Ok-Jin
    • Korean Journal of Veterinary Pathology
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    • v.7 no.1
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    • pp.1-4
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    • 2003
  • Malignant catarrhal fever (MCF) is a systemic disease of ruminants caused by a gamma herpesvirus, ovine herpesvirus 2 (OvHV-2). Dot blot hybridization (DBH) protocols for detecting and differentiating this MCF virus were developed. OvHV-2 specific primer pairs, 556/555, were used for the amplification of target DNA. Then, the amplified DNA was labeled with incorporation of digoxigenin (DIG). The Dig-labeled probe was able to detect and differentiate specifically OvHV-2 DNA. This DBH technique can be applied to confirm the presence of MCF virus on clinical samples and to differentiate specifically between OvHV-2 infection and other viral infections.

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Commissioning and Validation of a Dedicated Scanning Nozzle at Samsung Proton Therapy Center

  • Chung, Kwangzoo;Han, Younyih;Ahn, Sung Hwan;Kim, Jin Sung;Nonaka, Hideki
    • Progress in Medical Physics
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    • v.27 no.4
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    • pp.267-271
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    • 2016
  • In this study, we present the commissioning and validation results of a dedicated scanning nozzle. The dedicated scanning nozzle is installed in one of the two gantry treatment rooms at Samsung Proton Therapy Center. Following a successful completion of the acceptance test, the commissioning process including the beam data measurement for treatment planning system has been conducted. Extended measurements have been conducted as a validation of the clinical performance of the nozzle and various quality assurance protocols have been prepared.

The Effects of Interferential Current Stimulation on Peripheral Blood Flow (간섭파 자극후의 말초혈류량 변화)

  • Ko, Kyung-Hyun;Kim, Ju-Cheol;Yi, Chung-Hwi
    • Journal of Korean Physical Therapy Science
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    • v.1 no.1
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    • pp.121-127
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    • 1994
  • The purpose of this study was to determine whether vasodilation occurs when interferential current is applied to the cervical sympathetic chain and peripheral sympathetic nerves. A digital thermometer was used to record skin temperature change. The protocols used for interferential stimulation were 90-100 Hz, applied for 20 minutes via two pairs of electrodes 1) to the throat and 2) to the forearm. Forty subjects were stimulated at each of the two sites. There was no significant correlation between inital skin temperature, sex or age and temperature change. Even though there was a statistically significant temperature increase with cervical sympathetic chain stimulation, this had no clinical vasodilatory effect. More research on interferential current stimulation is needed so that the potential benefits to normal subjects and patients is better understood.

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Current Trends and Future Development in Pharmacologic Stress Testing (약물부하 검사법의 현재와 미래)

  • Bae, Jin-Ho;Lee, Jae-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.2
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    • pp.107-113
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    • 2005
  • Pharmacologic stress testing for myocardial perfusion imaging is a widely used noninvasive method for the evaluation of known or suspected coronary artery disease. The use of exercise for cardiac stress has been practiced for over 60 years and clinicians are familial with its using. However, there are inevitabe situations in which exorcise stress is inappropriate. A large number of patients with cardiac problems are unable to exercise to their full potential due to comorbidity such as osteoarthritis, vascular disease and pulmonary disease and a standard exercise stress test for myocardial perfusion imaging is suboptimal means for assessment of coronary artery disease. This problem has led to the development of the pharmacologic stress test and to a great increase in its popularity. All of the currently used pharmacologic agents have well-documented diagnostic value. This review deals the physiological actions, clinical protocols, safety, nuclear imaging applications of currently available stress agents and future development of new vasodilating agents.

Protocol for management of odontogenic keratocysts considering recurrence according to treatment methods

  • Titinchi, Fadi
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.46 no.5
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    • pp.358-360
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    • 2020
  • The management of odontogenic keratocysts (OKC) remains a hotly debated topic in oral and maxillofacial surgery. Despite numerous studies and systematic reviews on treatment options, there is a lack of consensus and no accepted protocol on the management of OKC. Hence, the aim of this study was to briefly summarize all large systematic reviews in the literature on the management of OKC and formulate an evidence-based management protocol. Data from five large systematic reviews were combined to calculate the mean recurrence rate for each technique. Decompression followed by enucleation along with adjuvant methods such as application of Carnoy's solution and peripheral ostectomy can result in very low recurrence and is an acceptable first line treatment. The surgical approach should be determined by lesion size, patient age, proximity to vital structures, accessibility, soft tissue/cortical perforation, and if the lesion is recurrent.

External vs internal connection implant system (External vs internal implant : 각각의 장점과 고려사항)

  • Seong, Dong-Jae;Hong, Seoung-Jin;Ha, Seung-Ryong
    • The Journal of the Korean dental association
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    • v.54 no.3
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    • pp.184-190
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    • 2016
  • The osseointegration of titanium implants has been examined over the past 50 years. Many implant systems have been introduced and have become popular to the implant dentistry. The designs of the connection between implant fixture and abutment are divided into external vs internal connection. From beginning, the $Br{\aa}nemark$ system was characterized by an external hexagon. Internal connection has been developed to reduce stress transferred to the bone. These differences may have impact on the clinical procedures and protocols, laboratory and components costs, and incidence of complications. Therefore, the clinician has to know the different biomechanical features and understand their implications to produce successful implant-supported prosthesis with an external or an internal connection system.

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Effects of Cotrolled Ovarian Hyperstimulation (COH) Protocols on Pregnancy and Delivery Rate in In-Vitro Fertilization and Embryo Transfer (체외수정시술시 과배란유도 방법이 임신율에 미치는 영향)

  • Hong, J.E.;Lee, J.S.
    • Clinical and Experimental Reproductive Medicine
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    • v.24 no.3
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    • pp.361-368
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    • 1997
  • A total of 55 patients with various etiologies of infertility particitated in a study comparing two regimens of controlled ovarian hyperstimulation (COH) with GnRH agonists and gonadotropins. Nineteen patients were given an ultra-short stimulation protocol when the agonist was administered for 3 day from Day 2 of the cycle. The remaining 36 patients were given a long stimulation protocol when the agonist was administered from the mid-luteal phase of the cycle preceding the stimulation cycle. The mean number of gonadotropins used per patient was not different between two groups. No significant differences were found in the mean number of oocytes recovered, fertilization rate and embryo cleavage rate between two groups. Pregnancy and delivery rates were higher in ultra-short protocol than in long protocol, but these were not significant. These results suggest that an ultra-short protocol is as effective as a long protocol in in-vitro fertilization and embryo transfer.

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A review of complications of maxillary sinus augmentation and available treatment methods

  • Kim, Joongmin;Jang, Hyonseok
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.45 no.4
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    • pp.220-224
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    • 2019
  • Maxillary sinus grafting is a dependable procedure that has been in use for a long time. However, clinical complications often arise. To prevent complications of maxillary sinus grafting, it is necessary to know the contra-indications, both for general implantation and for maxillary bone grafting. In addition, presence of various complications requires careful consideration of treatment method; therefore, dentists should be familiar with the treatment protocols. Complications can be divided into postoperative, immediate postoperative, and delayed postoperative complications. Particularly for the outpatient, it is necessary to quickly distinguish between treatable cases and cases for which transfer is required. The purpose of this review is to discuss the contra-indications, complications, and treatment options for complications of maxillary sinus graft.

Current concept of the surgery-first orthognathic approach

  • Choi, Jong-Woo;Lee, Jang-Yeol
    • Archives of Plastic Surgery
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    • v.48 no.2
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    • pp.199-207
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    • 2021
  • Traditional orthognathic surgery has long been performed after presurgical orthodontic treatment. Despite some concerns, the surgery-first orthognathic approach (SFOA) or surgery-first approach (SFA) without presurgical orthodontic treatment has gradually gained popularity. In recent years, several articles dealing with the concepts of the SFA have been published worldwide. However, the SFA has not yet been standardized, and many surgeons use slightly different protocols and concepts. This review article discusses the beginning and evolution of the SFA and its current concepts, including some opinions based on the authors' clinical experiences over the last 15 years. According to recent investigations, the SFA could be applied effectively in several situations including class III malocclusion, class II malocclusion, and facial asymmetry. However, debate on the SFA continues and many issues remain to be resolved. This review article addresses the current issues regarding the SFOA, including its advantages and disadvantages, as well as its indications and contraindications. The authors summarize various aspects of the SFA and expect that this review article will help surgeons and orthodontists better understand the current status of the SFA.

Neuromodulation for Insomnia Management (불면증 치료법으로서의 뉴로모듈레이션)

  • Yoon, Ho-Kyoung
    • Sleep Medicine and Psychophysiology
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    • v.28 no.1
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    • pp.2-5
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    • 2021
  • Hyperarousal or increased brain excitability is thought to play a key role in the pathophysiology of insomnia. Neuromodulation techniques are emergent complementary therapies for insomnia and can improve sleep by modulating cortical excitability. A growing body of literature support the idea that neuromodulation can be effective in improving sleep or treating insomnia. Recent evidence has revealed that neuromodulation methods can improve objective and subjective sleep measures in individuals with insomnia, although effects vary according to protocol. Different mechanisms of action might explain the relative efficacy of neuromodulation techniques on sleep outcomes. Further research testing different stimulation parameters, replicating existing protocols, and adding standardized sleep-related outcomes could provide further evidence on the clinical utility of neuromodulation techniques.