• Title/Summary/Keyword: Clinical anatomy

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The clinical anatomy of the accessory submandibular gland: a comprehensive review

  • Andrea Yazbeck;Joe Iwanaga;Jerzy A. Walocha;Lukasz Olewnik;R. Shane Tubbs
    • Anatomy and Cell Biology
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    • v.56 no.1
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    • pp.9-15
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    • 2023
  • An accessory submandibular gland is a rare variation. As such, there is limited literature regarding the embryology, anatomy, variations, clinical imaging, and pathology of the accessory submandibular gland. In this article, we review the existing literature on the accessory submandibular gland from clinical and anatomical perspectives. The goal of this review is to provide comprehensive knowledge of this variation which can be useful for oral and maxillofacial/head and neck surgeons, radiologists, and anatomists. Within this review, the embryologic origin as well as the anatomy of the accessory submandibular gland is detailed. Several imaging modalities which can be used to visualize the accessory submandibular gland are outlined as well as its variations. Lastly, this review investigates several reported clinical considerations regarding the accessory submandibular gland including sialoliths, Wharton's duct obstruction, and pleomorphic adenoma.

Pectorobrachioepicondylaris musculoaponeurotic band: case description with evidence of median nerve compression

  • Ana Carrera;Arada Chaiyamoon;Francisco Reina;Joe Iwanaga;Aida Cateura;Miguel Angel Reina;Jose Ramon Sanudo;R. Shane Tubbs
    • Anatomy and Cell Biology
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    • v.56 no.2
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    • pp.280-284
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    • 2023
  • Upper limb muscle variations can be encountered on imaging or at surgery. We report an unusual muscle and band found during routine dissection of the arm in a cadaver. This case is described and salient literature reviewed. A band was found that traveled from the insertion of the pectoralis major tendon distally and obliquely toward the medial intermuscular septum and medical epicondyle. Fibers of the brachialis were found to interdigitate into the band. A tunnel was formed that carried the median nerve and brachial vessels. Evidence of median nerve compression was observed. We considered this an example of a pectorobrachioepicondylaris muscle. However, some can lead to clinical presentations. Although the significance of the case reported herein is not certain, signs of median nerve compression were identified. We believe that the term pectorobrachioepicondylaris bests describes the muscle reported herein and that our case represents a previously unreported variant of this muscle.

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs

  • Ogedengbe, Oluwatosin O;Jegede, Ayoola I;Onanuga, Ismail O;Offor, Ugochukwu;Naidu, Edwin CS;Peter, Aniekan I;Azu, Onyemaechi O
    • Toxicological Research
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    • v.32 no.4
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    • pp.317-325
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    • 2016
  • Increased access to highly active antiretroviral therapy (HAART) has made the management of drug toxicities an increasingly crucial component of HIV. This study investigated the effects of adjuvant use of coconut oil and HAART on testicular morphology and seminal parameters in Sprague-Dawley rats. Twelve adult male Sprague-Dawley rats, weighing 153~169 g were distributed into four groups (A-D) and treated as follows: A served as control (distilled water); B (HAART cocktail-Zidovudine, Lamivudine and Nevirapine); C (HAART + Virgin coconut oil 10 mL/kg) and D (Virgin coconut oil 10 mL/kg). After 56 days of treatment, animals were killed and laparotomy to exercise the epididymis for seminal fluid analyses done whilst testicular tissues were processed for histo-morphometric studies. Result showed a significant decline in sperm motility (P < 0.05) and count (P < 0.0001) in HAART-treated animals while there was insignificant changes in other parameters in groups C and D except count that was reduced (P < 0.0001) when compared with controls. Histomorphological studies showed HAART caused disorders in seminiferous tubular architecture with significant (P < 0.01) decline in epithelial height closely mirrored by extensive reticulin framework and positive PAS cells. Adjuvant Virgin coconut oil + HAART resulted in significant decrease in seminiferous tubular diameter (P < 0.05), but other morphometric and histological parameters were similar to control or Virgin coconut oil alone (which showed normal histoarchitecture levels). While derangements in testicular and seminal fluid parameters occurred following HAART, adjuvant treatment with Virgin coconut oil restored the distortions emanating thereof.

Encountering Peritoneo-Cutaneous Perforators in Microsurgical DIEP Flap Breast Reconstruction

  • Duncan Loi;Justin L. Easton;Warren M. Rozen
    • Archives of Plastic Surgery
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    • v.50 no.2
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    • pp.153-155
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    • 2023
  • The vascular anatomy of the deep inferior epigastric artery perforator (DIEP) flap has been well studied in the planning for autologous breast reconstruction. Preoperative imaging with computed tomography angiography (CTA) provides accurate assessment of this vascular anatomy, which varies widely across patients. Several papers to date have described their encounter with an anomalous "epiperitoneal" or "peritoneo-cutaneous" perforator during flap harvest, a perforator that pierces the posterior rectus sheath from a peritoneal origin, to traverse rectus abdominis and supply the DIEP flap integument. In the course of over 3,000 CTA assessments of the vascular anatomy of the abdominal wall, we have encountered dominant peritoneo-cutaneous perforators in 1% of cases, and smaller perforators seen in many more cases, approaching 5% of cases. With increasing sensitivity of imaging, we also describe a unique case of multiple large bilateral peritoneo-cutaneous perforators, and present these findings in the context of DIEP flap harvest. It is critical to recognize these peritoneo-cutaneous perforators preoperatively to avoid mistaking them for a DIEP during the raising of a DIEP flap. The routine use of preoperative CTA enables the safe identification of individual vascular anatomy, including significant peritoneo-cutaneous perforators.

Histology and immunohistochemistry of the human carotid sinus nerve

  • Davin Bryant;Erin McCormack;Juan J. Cardona;Arada Chaiyamoon;Devendra Shekhawat;Francisco Reina;Ana Carrera;Joe Iwanaga;Aaron S. Dumont;R. Shane Tubbs
    • Anatomy and Cell Biology
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    • v.56 no.4
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    • pp.463-468
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    • 2023
  • The carotid sinus nerve (CSN) is well known as mediating baroreflexes. However, studies of its detailed histological analysis are scant in the literature. Therefore, the current anatomical study sought to better elucidate the microanatomy of the CSN. Ten fresh frozen adult cadavers underwent dissection of the CSN. Then, it was harvested and submitted for histological and immunohistochemical staining. Specimens were all shown to be nerve fibers on histology and immunohistochemistry. We identified tyrosine hydroxylase positive fibers in all CSN specimens. These fibers were always found to be within the CSN and not on its surface i.e., epineurium. Based on our findings, the majority of fibers contained in the CSN are tyrosine positive in nature. Further studies are necessary to understand the true function of this autonomic nerve fibers.

A Study on the Fields of Anatomy and Physiology Important in Clinical Practice of Physical Therapy (물리치료 임상 실무에서 필요로 하는 해부$\cdot$생리 내용에 대한 연구)

  • Kim, Hyun-Joo
    • The Journal of Korean Physical Therapy
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    • v.14 no.2
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    • pp.86-97
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    • 2002
  • To evaluate the fields of human anatomy and physiology important in clinical practice of physical therapy, a questionnaire survey was performed for 70 physical therapists who were practicing in general hospitals, clinics, public health centers, and rehabilitation centers in several provinces including Seoul and Chungcheongdo. Fields of anatomy and physiology were divided into 13 chapters and subdivided into 52 items. And the preferred ranks were statistically analysed according to the career of physical therapists, nature of the institute and the post of duty. As results joint system, muscular system, skeletal system and nervous system were ranked in the fields of great importance. The relative importance of practical knowledge in anatomy and physiology should be considered in educating students as well as reeducation of practitioners.

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Atlanto-occipital assimilation: embryological basis and its clinical significance

  • Hari Hara Hanusun N;Akanksha Singh;Pooja Poddar;Jessy J P;Neerja Rani;Hitesh Gurjar;Seema Singh
    • Anatomy and Cell Biology
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    • v.57 no.1
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    • pp.147-151
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    • 2024
  • Atlanto-occipital assimilation is an osseous embryological anomaly of the craniovertebral junction in which the atlas (C1) is fused to the occiput of skull. Embryologically, this assimilation may happen due to failure of the segmentation and separation of the caudal occipital and the cranial cervical sclerotome. The segmentation clock is maintained by NOTCH and WNT signalling pathways along with Hox genes and retinoic acid. This condition is likely to be a consequence of mutation in above mentioned genes. The knowledge of this assimilation may be crucial for the clinicians as it may lead to various neurovascular symptoms. The present case report involves the analysis of atlanto-occipital assimilation with its clinical significance and embryological basis.

A comprehensive review of the mental spine

  • Ross Champagne;Rithvik Vutukuri;Chung Yoh Kim;R. Shane Tubbs;Joe Iwanaga
    • Anatomy and Cell Biology
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    • v.57 no.1
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    • pp.1-6
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    • 2024
  • Clinical case reports and research regarding the mental spines and their associated structures create a detailed picture of the floor of the mouth for assessment during clinical treatment. This compilation of information covers the mental spines, the attached geniohyoid and genioglossus muscles, the lingual foramina, and the veins and arteries of the jaw and floor of the mouth. It is important to consider the variations in the mental spines for oral and maxillofacial treatment involving the mandible. Differences in anatomy of the mental spine, including their number, location, and size, can impact diagnosis and treatment approaches.

The pterygomandibular raphe: a comprehensive review

  • Rithvik Vutukuri;Norio Kitagawa;Keiko Fukino;R. Shane Tubbs;Joe Iwanaga
    • Anatomy and Cell Biology
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    • v.57 no.1
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    • pp.7-12
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    • 2024
  • The pterygomandibular raphe (PMR) is a tendinous structure connecting the bucinator and the superior pharyngeal constrictor muscles. With its implications in the spread of oral cancer, the proper treatment of obstructive sleep apnea, and dental procedures, it is important to obtain a thorough understanding of the PMR. We reviewed the existing literature to compile the published information regarding its anatomy, embryology, imaging, variations, functions, pathologies, and clinical relevance of the pterygomandibular raphe.