• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.124-132
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• 2005

Cardiac PET emerged as a powerful tool that allowed in vivo quantification of physiologic processes including myocardial perfusion and metabolism, as well as neuronal and receptor function for more than 25 years. Wow PET imaging has been playing an important role in the clinical evaluation of patients with known or suspected ischemic heart disease. This important clinical role is expected to grow with the availability of PET/CT scanner that allow a true integration of structure and function. The objective of this review is to provide an update on the current and future role of PET in clinical cardiology with a special eye on the great opportunities now offered by PET/CT.

• The Korean Journal of Nuclear Medicine
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• v.35 no.4
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• pp.224-230
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• 2001

EBM is "the conscientious, explicit and judicious use of current best evidence in mating decisions about the care of the individual patient. It means integrating individual clinical expertise with the best available external clinical evidence from systematic research." EBM is the integration of clinical expertise, patient values, and the best evidence into the decision making process for patient care. The practice of EBM is usually triggered by patient encounters which generate questions about the effects of therapy, the utility of diagnostic tests, the prognosis of diseases, or the etiology of disorders. The best evidence is usually found in clinically relevant research that has been conducted using sound methodology. Evidence-based medicine requires new skills of the clinician, including efficient literature-searching, and the application of formal rules of evidence in evaluating the clinical literature. Evidence-based medicine converts the abstract exercise of reading and appraising the literature into the pragmatic process of using the literature to benefit individual patients while simultaneously expanding the clinician's knowledge base. This review will briefly discuss about concepts of evidence medicine and method of critical appraisal of literatures.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.19 no.4
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• pp.221-228
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• 2016

The gastrointestinal exposome represents the integration of all xenobiotic components and host-derived endogenous components affecting the host health, disease progression and ultimately clinical outcomes during the lifespan. The human gut microbiome as a dynamic exposome of commensalism continuously interacts with other exogenous exposome as well as host sentineling components including the immune and neuroendocrine circuit. The composition and diversity of the microbiome are established on the basis of the luminal environment (physical, chemical and biological exposome) and host surveillance at each part of the gastrointestinal lining. Whereas the chemical exposome derived from nutrients and other xenobiotics can influence the dynamics of microbiome community (the stability, diversity, or resilience), the microbiomes reciprocally alter the bioavailability and activities of the chemical exposome in the mucosa. In particular, xenobiotic metabolites by the gut microbial enzymes can be either beneficial or detrimental to the host health although xenobiotics can alter the composition and diversity of the gut microbiome. The integration of the mucosal crosstalk in the exposome determines the fate of microbiome community and host response to the etiologic factors of disease. Therefore, the network between microbiome and other mucosal exposome would provide new insights into the clinical intervention against the mucosal or systemic disorders via regulation of the gut-associated immunological, metabolic, or neuroendocrine system.

• Toxicological Research
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• v.13 no.3
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• pp.237-245
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• 1997

As the development of a pharmaceutical product is a dynamic process which involves continuousfeed-back between non-clinical and clinical studies, the integration of pharmacokinetics into toxicity testing became increasingly important in recent years. Toxicokinetic measurements in the toxicity studies is considered to be an important scientific approach in the interpretation of the toxicology findings and the promotion of rational study design development. Primarily this research project was conducted to determine the systemic exposure achieved in acute toxicity test and its relationship to dose level and the time course of the toxicity study. Acute hepatotoxicity study and its relevant toxicokinetic study in mice were performed using acetarninophen (AA) as a model compound. The correlation between acute hepatotoxicity indices and toxicokinetic parameters following intraperitoneally administration of various dosages of AA in mice was evaluated and discussed minutely in the text. Based on these studies, single-dose toxicity testing of AA including kinetic studies was evaluated in ICR mice for 7 days and interpreted in the text. Our results from the integration of toxicokinetic monitoring into single-dose toxicity study enable to elucidate the relation of the exposure achieved in toxicity study to toxicological findings and assist in the selection of appropriate dose levels for use in repeated-dose toxicity or later studies.

• Journal of the Korean Society of Visualization
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• v.21 no.2
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• pp.14-23
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• 2023

The pressure difference across stenotic blood vessels is a commonly used clinical metric for diagnosing many cardiovascular diseases. At present, most clinical pressure measurements rely solely on invasive catheterization. In this study, we propose a novel method for non-invasive pressure estimation using the incompressible Navier-Stokes equations and a 3D multi-path integration approach. We verify spatio-temporal convergence on an in-silico dataset of a cylindrical straight pipe phantom with steady and pulsatile flow fields. We then evaluate the proposed method on an in vitro dataset of reconstructed control, pre-operative, and post-operative carotid artery cases acquired from 4D flow MRI. The performance of our method is compared to existing approaches based on the pressure Poisson equation and work-energy relative pressure. The results demonstrate the proposed method's high accuracy, robustness to spatio-temporal subsampling, and reduced sensitivity to noise, highlighting its great potential for non-invasive pressure estimation.

• Mass Spectrometry Letters
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• v.15 no.2
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• pp.69 -78
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• 2024

The advancement of high-throughput omics technologies and systems biology is essential for understanding complex biological mechanisms and diseases. The integration of proteomics and metabolomics provides comprehensive insights into cellular functions and disease pathology, driven by developments in mass spectrometry (MS) technologies, including electrospray ionization (ESI). These advancements are crucial for interpreting biological systems effectively. However, integrating these technologies poses challenges. Compared to genomic, proteomics and metabolomics have limitations in throughput, and data integration. This review examines developments in MS equipped electrospray ionization (ESI), and their importance in the effective interpretation of biological mechanisms. The review also discusses developments in sample preparation, such as Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX), analytical techniques, and data analysis, highlighting the application of these technologies in the study of cancer or Huntington's disease, underscoring the potential for personalized medicine and diagnostic accuracy. Efforts by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and integrative data analysis methods such as O2PLS and OnPLS extract statistical similarities between metabolomic and proteomic data. System modeling techniques that mathematically explain and predict system responses are also covered. This practical application also shows significant improvements in cancer research, diagnostic accuracy and therapeutic targeting for diseases like pancreatic ductal adenocarcinoma, non-small cell lung cancer, and Huntington's disease. These approaches enable researchers to develop standardized protocols, and interoperable software and databases, expanding multi-omics research application in clinical practice.

• The Journal of Korean Medicine
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• v.44 no.4
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• pp.14-25
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• 2023

Objectives: South Korea, the United States, and the United Nations have imposed extensive economic sanctions against North Korea, which increased the use of traditional Korean medicine in North Korea to maintain its national health care system. This study attempts to study the latest trends of traditional Korean medicine research through bibliographic analysis of one of the North Korean medical journals. It will then provide insights into how traditional Korean medicine is used in North Korea. Methods: This study is based on 611 clinical research articles out of 931 articles extracted from 13 volumes of Koryo Medicine (2016 ~ 2019). The articles were classified according to the researched treatment, diseases and use alongside conventional drugs. Results: Based on the analysis of Koryo Medicine, the proportion of clinical research articles investigating the treatment effects was very high (65.6%). Also, clinical research using herbal medicine as treatment was the most common, accounting for 17.69% of the total. Some of the clinical research in Koryo Medicine were conducted in tandem with conventional drug treatment, especially on acupuncture. Conclusion: This study conducted a bibliographic analysis of Koryo Medicine to understand the current status of traditional Korean medicine within North Korea. The analysis identified main diseases, treatment methods, and integration with conventional drugs in the clinical research of traditional Korean medicine. As a country actively seeking to use traditional Korean medicine, North Korea will become an interesting field of global traditional medicine and complementary medicine research.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.1
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• pp.45-55
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• 2018

Objective : The purpose of this systematic review was to inform intervention of sensory integration in adult patients and to provide evidence regarding occupational therapy. Methods : Studies for this review were collected by searching the Pubmed, Scopus, SAGE Journal, Medline, RISS database for articles from 1980 to 2017, using the following keywords: "(sensory integration OR sensory processing OR sensory integrative OR sensory based OR sensory defensiveness) AND adult" A total of 8 studies were included in the analysis. The selected papers were analyzed by using PICO (Patient, Intervention, Comparison, Outcome) framework. Results : The participants' diagnoses were learning disabilities, intellectual disability, dementia and sensory processing disorder. Assessment tools and intervention methods varied according to the researcher's intent. In most studies, sensory integration intervention was shown to be effective. Conclusion : This study was able to confirm that sensory integration intervention was available and effective for adult patients. This was intended to provide clinical evidence for occupational therapists, and further studies should be conducted to establish the application of sensory integration interventions to adults based on this study.

• The Journal of Korean Academy of Sensory Integration
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• v.7 no.1
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• pp.27-36
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• 2009

Introduction : Occupational therapists commonly use clinical observation to assess neuromuscular function witch is a fundamental component of sensory integration function. Clinical Observation of Motor and Postural Skills (COMPS) is a standardized assessment with seven items and used to screen if a child's problem is due to neuromuscular and sensory integration system. However, developmental standard of the test need to be validated with Korean children. Objective : This study is purposed to propose developmental standard of the COMPS for Korean children. Method : Seven to nine years old students (76 male and 70 female) participated in this study. In order to find out any difference by gender and age, the data was analyzed using t-test and ANOVA. Results : There is no significant difference by gender for all other items except Prone Extension Position (PEP). There is significant difference between children who are 7 years old and those who are 9 years old for Slow Motion(SM), Finger-Nose Touching (FNT), Asymmetrical Tonic Neck Reflex (ATNR), Supine Flexion(SF). There is also significant difference between those who are 8 years old and 9 years old for SM, FNT, ATNR. However, there is no significant difference between those who are 7 years and 8 years old. Conclusions : This study examines any difference in neuromuscular characteristics by age among school-aged children, based on the COMPS. The result of this study will provide a good evidence to establish developmental standard of COMPS for Korean children. It issuggested to continue further standardization work of the COMPS in order to establish a developmental standard for Korean children.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.6
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• pp.1167-1174
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• 2009

In the monitoring of a patient in a sickroom, not only the physiologic and environmental data of the patient, which is automatically measured, but also the clinical data(clinical chart)of the patient, which is drew up by a doctor or nurse, are recognized as important data. However, since in the current environment of a sickroom, clinical data is collected being divided from the data that is automatically measured, the two data are used without an effective integration. This is because the integration of the two data is difficult due to their different collection times, which leads the reconstruction of clinical data to be remarkably uncertain. In order to solve these problems, a method to synchronize the continuous environmental data of a sickroom and clinical data is appearing as an important measure. In addition, the increase of use of small machines and the development of solutions based on wireless communications provide a communication platform to the developers of health care. Thus, this paper realizes a remote system for taking care of patients based on a web that uses mobile phones. That is, clinical data made by a nurse or doctor and the environmental data of a sick room comes to be collected by a collection module through a wireless sensor network. An observer can see clinical data and the environmental data of a sickroom through his/her mobile phone, integrating and storing his/her data into the database. Families of a patient can see clinical data made by hospital and the environment of the sick room of the patent through their computers or mobile phones outside the hospital. Through the system,hospital can provide better medical services to patients and their families.