• 대한간호학회지
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• 제26권1호
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• pp.177-193
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• 1996

For the purpose of integrating nursing diagnosis into the nursing curriculum, a descriptive survey research was done using the inductive method with questionnaires and a literature review. Research subjects included nurse educators, textbooks of adult nursing published in Korea, and the course outline for adult nursing used in one college of nursing. The Results show that there was common agreement on 39 nursing diagnosis which should be in cluded in the adult nursing curriculum, textbooks of adult nursing, and patient care on the medical-surgical units. The two existing nursing diagnosis classification systems(NANDA and Gordon's Human Response Patterns) show different basic frameworks and difficulties were discovered in integration of nursing diagnosis into the curriculum. To develop a conceptual framework for a nursing diagnosis classification system, diagnosis were classified into three categories ; health promotion, high risk problem, and actual problem on the basis of the framework used in adult nursing textbooks and Gordon's 11 Functional Health Patterns. Subconcepts for actual problems were classified as ; activity and rest, nutrition and elimination, perception and coordination, stress and coping. Progress in this study supports further development of a conceptual framework of nursing based on a nursing diagnosis classification system, from which improvement in nursing education and clinical practice can be expected.

• Genomics & Informatics
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• 제5권2호
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• pp.83-87
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• 2007

The analysis of DNA microarray data is a rapidly evolving area of bioinformatics, and various types of microarray are emerging as some of the most exciting technologies for use in biological and clinical research. In recent years, microarray technology has been utilized in various applications such as the profiling of mRNAs, assessment of DNA copy number, genotyping, and detection of methylated sequences. However, the analysis of these heterogeneous microarray platform experiments does not need to be performed separately. Rather, these platforms can be co-analyzed in combination, for cross-validation. There are a number of separate laboratory information management systems (LIMS) that individually address some of the needs for each platform. However, to our knowledge there are no unified LIMS systems capable of organizing all of the information regarding multi-platform microarray experiments, while additionally integrating this information with tools to perform the analysis. In order to address these requirements, we developed a web-based LIMS system that provides an integrated framework for storing and analyzing microarray information generated by the various platforms. This system enables an easy integration of modules that transform, analyze and/or visualize multi-platform microarray data.

• 생물정신의학
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• 제11권2호
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• pp.77-87
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• 2004

Due to the high population prevalence of major depression and the strong emphasis on pharmacotherapy for this disorder, antidepressants are among the most frequently prescribed pharmacological agents. But the clinicians are still unable to predict accurately the response of their depressed patients to medication. This article reviews the biological predictors of treatment response including monoamine, neuroendocrine, pharmacogenetic, and psychophysiologic markers. The biological predictors of response, despite some interesting leads that may in the long term be of considerable importance, are not yet sufficiently established to be of routine clinical usefulness. Many of the predictive factors explored in this article are examples of mediators and moderators that affect outcomes. Each one alone may not provide definitive answers for predicting response to treatment, but each must be taken into account at the outset of treatment. It is clear that treatments must be individualized for each patient. It would be necessary to develop the algorithm in order to predict the responsiveness of antidepressant treatment with integration of the results from the previous studies.

• 중환자간호학회지
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• 제13권3호
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• pp.24-40
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• 2020

Purpose : This study aims to develop the Forensic Nursing Competency Scale suitable to South Korea. Methods : The initial items were generated through literature review and interviews. Items were evaluated by experts for content and face validity. By conducting a pilot test, 74 measurement items were developed. In total, 333 copies of the questionnaire were analyzed regarding the validity and reliability of the study. Data were analyzed using SPSS 23.0 program and AMOS 18.0 program. Results : The study selected 53 questions after testing the content, face, and construct validity of the scale. The final 53 questions were composed of 15 sub-components in eight domains. These eight domains encompassed nursing practice, communication, critical thinking, human caring and relationships, evidence management, active information collection, professional development, and knowledge integration. Conclusions : In order to verify the effectiveness of the scale, future studies need to compare the forensic nursing competency in two groups to assess differences in these competency. Moreover, it is necessary to develop a forensic nursing educational program and validate its effectiveness by using this scale.

• Journal of Microbiology and Biotechnology
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• 제11권5호
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• pp.804-811
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• 2001

In many Gram-negative bacteria, autoinducers, such as N-acyl-L-homoserine lactone(acyl-HSL) and its derivative molecules, mediate the cell-density-dependnet expression of certain operons. The current study identified the autoinducers produced by Burkholderia cepacia G4, a trichloroethylene-degrading lagoon isolate, using TLC bioassays with Agrobacterium tumefaciens NT1(pDCI141E33) and Chromobacterium violaceum CVO26, and a GC-MS analysis. The ${R_f}\;and\;{R_t}$ values and mass spectra were compared with those of synthetic compounds. Based on the analyses, it was confirmed that G4 produces N-hexanoyl (C6)-, N-octanoyl (C8)-, N-decanoyl (C10)-, N-dodecanoyl (C12)-HSL, and an unknown active species. The integration of the GC peak areas exhibited a ratio of C8-HSL:C10-HSL:C12-HSL at 3:17:1 with C6-HSL and C10-HSL production at trace and micromolar levels, respectively, in the culture supernatants. Nutants partially defective in producing acyl-HSLs were also partially defective in the biosynthesis of an antibiotic substance. These results indicate that the autoinducer-dependent gene regulation in G4 is dissimilar to the clinical B. cepacia strains isolated from patients with cystic fibrosis.

• 대한정형도수물리치료학회지
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• 제19권1호
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• pp.69-77
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• 2013

The pelvic girdle function as an integrated unit with all three bones moving at all three joints, are influenced by the lower extremities below and vertebral column and trunk above sacroiliac movements are caused by spinal motion, whereas iliosacral movements are caused by movements of the lower limbs. Concept of normal functional integration among the lumbar spine, pelvic and hip joint is basic to the understanding of dysfunction in this region and also functional movement of the lumbo-pelvic-hip region are part of the clinical examination, consequently the integrated biomechanics of these region need to be understood. The purpose of this review is to ascertain the integrated biomechanics among the lumbo-pelvic-hip complex by consideration of literature and to give sufficient information to be able to render accurate assessment and treatment for the syndromes described.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2005년도 춘계학술발표대회
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• pp.71-74
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• 2005

임상정보 문서는 환자 진료기록뿐만 아니라 처방전, 개인적 유전자정보를 가지고 있다. 이러한 임상 정보 문서는 병원 시스템들간에 교환 및 공유함으로써 양질의 의료서비스를 제공할 수 있다. 이와 관련하여 임상정보의 통합을 위한 기존의 연구들은 각각 HL7 메시지를 XML 문서로 변환하고 XML 기반의 CDA 를 관계형 데이터베이스에 저장하는 연구가 진행되었다. 그러나 관계형 데이터베이스는 문서의 데이터 별 테이블 단위로 생성, 저장된다. 그러나 HL7 과 CDA 는 문서 중심의 XML 문서이기 때문에 관계형 데이터베이스에 저장 시 문서 별 많은 변이가 존재하여 테이블 증가를 갖는다. 따라서 비정규적인 구조에 적합한 데이터베이스를 선택하기 위해 XML 전용 데이터베이스와 관계형 데이터베이스 비교하고 효율적 저장을 위해 압축기법을 제시한다. 압축기법을 적용한 임상 정보 데이터베이스는 대용량 임상정보 문서의 크기를 압축함으로써 문서의 크기를 줄임으로써 데이터베이스의 효율적 저장을 향상시킨다.

• Clinical and Experimental Pediatrics
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• 제55권12호
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• pp.449-454
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• 2012

The purpose of this review is to present the basic concepts of attachment theory and temperament traits and to discuss the integration of these concepts into parenting practices. Attachment is a basic human need for a close and intimate relationship between infants and their caregivers. Responsive and contingent parenting produces securely attached children who show more curiosity, self-reliance, and independence. Securely attached children also tend to become more resilient and competent adults. In contrast, those who do not experience a secure attachment with their caregivers may have difficulty getting along with others and be unable to develop a sense of confidence or trust in others. Children who are slow to adjust or are shy or irritable are likely to experience conflict with their parents and are likely to receive less parental acceptance or encouragement, which can make the children feel inadequate or unworthy. However, the influence of children's temperament or other attributes may be mitigated if parents adjust their caregiving behaviors to better fit the needs of the particular child. Reflecting on these arguments and our childhood relationships with our own parents can help us develop the skills needed to provide effective guidance and nurturance.

• Genomics & Informatics
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• 제3권3호
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• pp.68-73
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• 2005

Pharmacogenomics research requires an intelligent integration of large-scale genomic and clinical data with public and private knowledge resources. We developed a web-based knowledge base for KPRN (Korea Pharmacogenomics Research Network, http://kprn.snubi. org/). Four major types of information is integrated; genetic variation, drug information, disease information, and literature annotation. Eighteen Korean pharmacogenomics research groups in collaboration have submitted 859 genotype data sets for 91 disease-related genes. Integrative analysis and visualization of the large collection of data supported by integrated biomedical path­ways and ontology resources are provided with a user-friendly interface and visualization engine empowered by Generic Genome Browser.

• 대한물리의학회지
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• 제7권3호
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• pp.275-282
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• 2012

Purpose : Bridge exercise has been commonly used in clinical rehabilitation settings to improve trunk control, and hip adductor muscles were a related muscle that may affect trunk muscle activation. The aim of this study was to investigate whether the co-contraction of hip adductor muscles may affect trunk muscle activation during bridge exercises. Methods : Thirty-eight healthy young subjects (19 men and 19 women) performed bridge exercises (with and without hip adduction movement). Surface electromyography (EMG) data were collected from the dominant-side internal oblique (IO), rectus abdominis (RA), multifidus (MF) and erect spine (ES) during bridge exercises to compare trunk muscles activation patterns. Result : The EMG activities of IO and RA appeared to be significantly higher during bridge exercise with hip adductor co-contraction than during bridge exercise alone (p<.01), but there were no significant differences in those of MF and ES. Furthermore, there were significant differences in the IO:RA EMG ratio during bridge exercise with hip adductor co-contraction (p<.05). Conclusion : These findings suggest that integration of hip adduction during bridge exercise may be beneficial in increasing deep muscles' activity for trunk stabilization.