• 한국컴퓨터정보학회논문지
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• 제22권7호
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• pp.117-123
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• 2017

This is a descriptive study to investigate the relationship between MBTI personality type, clinical practice stress, and resilience in nursing college students. The participants of this study were 75 college students of Gangwon-do nursing college. The data were analyzed by t-test, ANOVA, $Scheff{\acute{e}}$ test and Pearson correlation coefficient using SPSS win18.0. Thirteen personality types were observed in this study participants. The NT types was the highest with a mean of 4.15 in clinical practice stress according to 4 functions of MBTI and the ST types was the highest with a mean of 3.32 in resilience according to 4 fuctions of MBTI. The NT type was the highest with a mean of 4.15 in clinical practice stress according to 4 temperaments of MBTI and the SJ type was the highest with a mean of 3.27 in resilience according to 4 temperaments of MBTI. Significant differences in clinical practice stress were observed according to 4 functions(F=27.117, p<.001) and 4 temperaments(F=27.310, p<.001) of MBTI. Significant differences in resilience were observed according to 4 temperament(F=2.825, p=.045) of MBTI. Further study is necessary to provide the basic data to construct the curriculum of nursing health education which is suitable for the characteristic of MBTI personality type.

• Clinical and Experimental Pediatrics
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• 제53권3호
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• pp.273-285
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• 2010

Completion of the human genome project has allowed a deeper understanding of molecular pathophysiology and has provided invaluable genomic information for the diagnosis of genetic disorders. Advent of new technologies has lead to an explosion in genetic testing. However, this overwhelming stream of genetic information often misleads physicians and patients into a misguided faith in the power of genetic testing. Moreover, genetic testing raises a number of ethical, legal, and social issues. Diagnostic genetic tests can be divided into three primary but overlapping categories: cytogenetic studies (including routine karyotyping, high-resolution karyotyping, and fluorescent in situ hybridization studies), biochemical tests, and DNA-based diagnostic tests. DNA-based testing has grown rapidly over the past decade and includes preandpostnatal testing for the diagnosis of genetic diseases, testing for carriers of genetic diseases, genetic testing for susceptibility to common non-genetic diseases, and screening for common genetic diseases in a particular population. Theoretically, once a gene's structure, function, and association with a disease are well established, the clinical application of genetic testing should be feasible. However, for routine applications in a clinical setting, such tests must satisfy a number of criteria. These criteria include an acceptable degree of clinical and analytical validity, support of a quality assurance program, possibility of modifying the course of the diagnosed disease with treatment, inclusion of pre-and postnatal genetic counseling, and determination of whether the proposed test satisfies cost-benefit criteria and should replace or complement traditional tests. In the near future, the application of genetic testing to common diseases is expected to expand and will likely be extended to include individual pharmacogenetic assessments.

• 한국컴퓨터정보학회논문지
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• 제28권5호
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• pp.113-120
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• 2023

본 연구는 간호대학생의 간호전문직관 형성에 미치는 영향요인을 알아보기 위해 시도하였다. 연구방법은 K대학교 간호학과 3학년(n=169)을 대상으로 구조화된 자기보고형 설문지로 조사하였으며, 수집된 자료는 SPSS/WIN 25.0 프로그램을 이용하여 분석하였다. 연구결과는 전공만족도, 간호사 이미지, 임상실습교육환경 및 실습소속감이 간호전문직관과 통계적으로 유의한 양의 상관관계를 보였으며, 전공만족도가 간호전문직관에 가장 큰 영향을 미치는 것으로 나타났다. 이에 긍정적인 간호전문직관을 형성하기 위해서는 전공만족도를 높이기 위한 다양하고 체계적인 교육프로그램 개발과 적용이 요구된다.

• 한국임상약학회지
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• 제34권2호
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• pp.79-99
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• 2024

Background: There was an important revision of the Korean Clinical Practice Guideline for Stroke (KCPGS) for antithrombotic therapy in patients with acute ischemic stroke in 2022. This review is to provide an updated information in this revision. Methods: The revision history by year after the first announcement was examined for each topic, focusing on antithrombotic therapy during acute phase which was revised in 2022. We compared before and after the revision, and investigated the clinical outcomes presented as evidence. It was also compared with the current U.S. guidelines. Results: The major changes about antiplatelet therapy are a clause stating that dual antiplatelet therapy with clopidogrel and aspirin initiated within 24 hours from the stroke onset and maintained for up to 21-30 days is recommended as an acute treatment, as well as the clause that antithrombotic therapy may be initiated within 24 hours after intravenous thrombolytics and that the use of glycoprotein IIb/IIIa receptor antagonists can be considered in highly selected patients as rescue therapy taking into account of benefit and risk. The change to the use of anticoagulants is that it may be reasonable to start oral anticoagulant between 4 and 14 days after stroke onset for patients with acute ischemic stroke and atrial fibrillation. Conclusions: It will be helpful in improving health outcomes for clinical pharmacists to be aware of the latest information for antithrombotic therapy and to actively use it in pharmaceutical care of stroke patients.

• 생물정신의학
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• 제19권4호
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• pp.172-178
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• 2012

Data from clinical studies are needed for psychiatrists to make quick and scientific decisions based on the best available evidence in clinical settings. Various methods of clinical studies are useful for clinicians to have reliable answers to unmet clinical needs. Although randomized controlled trials may provide high-quality information about major issues, well-designed, naturalistic and observational studies often give us unbiased explanation for real-world phenomena. Adequate selection of clinical variables and appropriate number of participants are key factors of well-designed clinical studies. Statistical methods can add an extra dimension to initial design of clinical studies. Given ethical issues in clinical studies on psychiatric disorders, special regards should be paid to participants' ability to provide informed consents. New strategies of clinical studies need to be developed to meet clinical needs and protect the rights and welfare of study participants.

• 대한물리치료과학회지
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• 제22권1호
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• pp.1-10
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• 2015

Background : The purpose of this study is to provide information for making positive interpersonal relations by understanding the degree of difficulties of personal relations that physical therapy students may have on clinical practice. Methods : The study has been made based on the survey results of 10 university that completed clinical practice physical therapy students. The survey was conducted through direct contact and mail between October 1 and December 10, 2013, and analysed 291 survey sheets. Results : The results reveal that clinical instructor's attitude toward students was satisfying(71.82%). The results reveal that students felt convenient when faced with other department staffs in the hospital(70.44%). The results reveal that students didn't feel uncomfortable when they addressed themselves to patients(83.85%). The results reveal that students didn't feel uncomfortable when they were working with other college students(74.57%). Conclusions : The results of the study indicate that educators who are developing clinical practice programs and clinical practitioners should consider stressors during clinical practice and the educational implications to physical therapy students.

• 유전체소식지
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• 제5권4호
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• pp.9-16
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• 2005

Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic expression data transforms the challenges m biomedical research into ones in bioinformatics. Clinical informatics has long developed technologies to imp개ve biomedical research by integrating experimental and clinical information systems. Biomedical informatics, powered by high throughput techniques, genomic-scale databases and advanced clinical information system, is likely to transform our biomedical understanding forever much the same way that biochemistry did to biology a generation ago. The emergence of healthcare and biomedical informatics revolutionizing both bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics and prognostics.

• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.605-612
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• 2011

In multi-center randomized clinical trial the treatment eect may be changed over centers. It is thus important to investigate the heterogeneity in treatment eect between centers. For this, uncorrelated random-eect models assuming independence between random-eect terms have been often used, which may be a strong assumption. In this paper we propose a correlated frailty modelling approach of investigating such heterogeneity using the hierarchical-likelihood method when the outcome is time-to-event. In particular, we show how to construct a proper prediction interval for frailty, which explores graphically the potential heterogeneity for a treatment-by-center interaction term. The proposed method is illustrated via numerical studies based on data from the design of a multi-center clinical trial.

• 대한한의학회지
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• 제30권6호
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• pp.80-85
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• 2009

Objective: This study aimed to build an overview of randomized clinical controlled trials (RCTs) for chronic fatigue-related symptoms to extract the useful data for management of patients and development of therapeutics using Korean traditional medicine in the future. Methods: All RCT-derived papers for chronic fatigue-related symptoms were collected via PubMed Database. We surveyed elementary information of RCTs such as clinical question, study design, and its quality and results. Results: A total of fifty-three RCTs met these review criteria. Most of the RCTs were performed in Western countries, particularly the UK and USA. The major portion of RCTs focused on chronic fatigue syndrome using immune modulators, psychotherapeutic and anti-depressants. Five RCTs using complementary and alternative medicine, including herbal remedies, showed positive results. Conclusions: Fatigue-related symptoms are a main target of Oriental medicine. This study provides helpful information for planning clinical study of chronic fatigue-related symptoms using traditional Korean medicine.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권1호
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• pp.1-6
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• 2021

Next-generation sequencing (NGS) technologies have changed the process of genetic diagnosis from a gene-by-gene approach to syndrome-based diagnostic gene panel sequencing (DPS), diagnostic exome sequencing (DES), and diagnostic genome sequencing (DGS). A priori information on the causative genes that might underlie a genetic condition is a prerequisite for genetic diagnosis before conducting clinical NGS tests. Theoretically, DPS, DES, and DGS do not require any information on specific candidate genes. Therefore, clinical NGS tests sometimes detect disease-related pathogenic variants in genes underlying different conditions from the initial diagnosis. These clinical NGS tests are expensive, but they can be a cost-effective approach for the rapid diagnosis of rare disorders with genetic heterogeneity, such as the glycogen storage disease, familial intrahepatic cholestasis, lysosomal storage disease, and primary immunodeficiency. In addition, DES or DGS may find novel genes that that were previously not linked to human diseases.