• Toxicological Research
• /
• v.35 no.3
• /
• pp.241-248
• /
• 2019

Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin of health and disease, putative trans-generational effect of exposure to pesticides are insufficiently studied. We therefore aimed to evaluate the biochemical effect of gestational exposure to four pesticides on female Wistar rats and their offspring at adult age. We studied 30 female nulliparous Wistar rats divided into 5 equal groups. Group 1 served as the control group and received distilled water while group 2, 3, 4 and 5 received orally pesticide 1 (imidacloprid), pesticide 2 (chlorpyrifos), pesticide 3 (imidacloprid + lambda cyhalothrin) and pesticide 4 (oxamyl) respectively once daily throughout gestation at a dose equivalent to 1/10 lethal dose 50. The mothers were followed up until one month post gestation. The offspring were followed up from birth until adult age (12 weeks). In all animals at each time point we evaluated malondialdehyde (MDA), oxidative stress and liver function enzymes. There was similar variation of total body weight in all the groups during and after gestation. However, Female Wistar rats of the exposed groups had significant alterations in liver SOD (-30.8% to +64.1%), catalase (-38.8% to -85.7%) and GSH (-29.2% to -86.5%) and; kidney catalase (> 100%), GSH (> 100%). Moreover, MDA, alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly higher in pesticide exposed rats compared to the control group. Similar alterations in antioxidant enzymes, MDA and liver function enzymes were observed in offspring of treated rats evidenced at weaning and persisting until adult age. Exposure to pesticides causes oxidative stress and lipid peroxidation in exposed female Wistar rats and their offspring. The persistence in offspring at adult age suggests transgenerational adverse effects.

• BMB Reports
• /
• v.38 no.1
• /
• pp.65-70
• /
• 2005

Choristoneura fumiferana granulovirus (ChfuGV) infection results two types of enveloped virions: Occlusion-derived virus (ODV) and budded virus (BV). Structural proteins ODVP-6E/ODV-E56 and p74 are two major conserved ODV-associated proteins that may be involved in the initiation of viral infection cycle in susceptible host insect larvae. This study presents the characterization of ChfuGV odvp-6e/odv-e56 and p74 transcription and translation as well as immunolocalization of these proteins in the occluded ChfuGV virion. Our results revealed that the transcription of odvp-6e/odv-e56 and p74 genes, both, start at 24 hours post infection (h p.i.). Using monospecific polyclonal antibodies made against ODVP-6E/ODV-E56 and p74 we demonstrated that these proteins are both expressed late in infection (24 h p.i.). Immunogold labeling using antisera against ODVP-6E/ODV-E56 and p74 proteins demonstrated that ODVP-6E/ODV-E56 and p74 proteins are both associated with the ODV envelop of ChfuGV.

• Proceedings of the KSPS conference
• /
• 1996.10a
• /
• pp.245-245
• /
• 1996

When language A borrows words, it borrows them according to its own phonetic rules. In other words, language B, where borrowed words coming from, has to comply with the phonetic requirements of language A. It may be added that language A only borrows the elements, the types of syllables and accentuation that already exist in its own phonetic struture and rejects all the rest that are not compatible. It operates exactly like a sieve. That is why borrowed words offer an excellent observation post to notice how react in phonetic contexts. The Japanese language has borrowed and is borrowing extensively from other languages and cultures, mainly from the English ones in the fields of sports, medicine, industry, commerce, and natural sciences. Relatively very few new words are created using the ancient Chinese or native backgrounds. This presentation will look for the rules of borrowing and try to show that this way of borrowing represents an organized system of its own. Three levels would be particularly studied : - the phonemic level - the syllable level and - the accentual level. This last point would be specially targeted with the question of syllable tension-relaxation. Such a study of languages in phonetics contacts could shed some new light on the phonetic charaCteristics of Japanese language and will confirm or weaken some conclusion already demonstated otherwise. We will be aming specially at the endings of the borrowed words where, it seems, Japanese language manifests itself very strongly.

• BMB Reports
• /
• v.38 no.4
• /
• pp.457-467
• /
• 2005

Open reading frame (ORF) 3 on the Choristoneura fumiferana granulovirus (ChfuGV), located in the 11 kb fragment of the BamHI genomic bank encodes a predicted 32-kDa putative kinase protein. Bioinformatics analysis on the predicted amino acid sequence of ChfuGV PK-1 revealed the existence of 11 catalytic subdomains. Sequence analysis within the 5'-untranslated region (5'-UTR) of ChfuGV pk-1 indicates the presence of both putative early and late promoter motifs, indicating that pk-1 may be expressed throughout the infection cycle. Promoter sequence analysis reveals that pk-1 is deprived of a TATA box and appears instead to be regulated by other cis-acting transcriptional regulatory elements. Temporal transcription analysis by RT-PCR confirms the appearance of transcripts detected from 2 h p.i. until 72 h p.i. Northern blot hybridization characterizes pk-1 transcription as a 1.2 kb transcript. Homology comparisons reveal that ChfuGV PK-1 protein is most closely related to Phthorimaea operculalla granulovirus (PoGV) with 80% amino acid identity.

• Fashion & Textile Research Journal
• /
• v.4 no.4
• /
• pp.347-357
• /
• 2002

In 1536, two Piedmontese merchants set up workshops in Lyons, and Henri IV encourged further development later in the 16th century. The development of Lyons as a centre of the silk weaving industry was helped by the perfection of drawloom weaving technique there in 1605 by Claude Dangon. In the 17th century, the French silk industry could finally compete with the dominance of the Italian silk trade. The French silk industry was promoted in the mid-17th century under Louis XIV's minister Colbert. In 1667, he published an ordinance creating La Grande Fabrique, a corporation for craftsmen within the silk industry, and Lyons became the undisputed French silk capital. Under Louis X IV, France was becoming the dominant force in Europe in matters of fashion and style. The major innovation of weaving was the Jacquard head attachment, which provided a mechanical means of raising warp threads by a series of punched cards. The are nouveau style did not have much impact on French silk design at the end of the century. Silk manufacturers began to collaborate with haute-couture designers such as the House of Worth. This collaboration with the burgeoning Paris haute-couture industry continued into the 20th century and safeguarded the future production of silk textiles in France.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.19 no.7
• /
• pp.485-490
• /
• 2007

The LNG BOG re-liquefaction system for LNG carriers was designed based on the Claude refrigeration cycle and the thermodynamic analysis was carried out in order to find the design point of the three heat exchangers constituting the system. The thermodynamic analysis revealed that the system state could be defined by the three cold endpoint temperatures of the three-pass heat exchanger. Hence the iso-lines of the specific liquefaction work, taken as the performance indicator, were presented in terms of those three temperatures and discussed. The system was found most economical when those three temperatures approached a single temperature of $-140^{\circ}C$ and thus this system state could be taken as the design point for the heat exchangers.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.39 no.5
• /
• pp.313-319
• /
• 2021

The national geodetic reference frame of Korea was adopted in 2003, which is referenced to ITRF (International Terrestrial Reference Frame) 2000 at the epoch of January 1, 2002. For precise positioning based on the satellites, it should be thoroughly maintained to the newest global reference frame. Other than plate tectonic motion, there are significant events or changes such as earthquakes, antenna replacement, PSD (Post-Seismic Deformation), seasonal variation etc. We processed three years of GNSS (Global Navigation Satellite System) data(60 NGII CORS stations, 51 IGS core stations) to produce daily solutions minimally constrained to ITRF. From the time series of daily solutions, the sites with unexpected discontinuity were identified to set up an event(mostly antenna replacement). The combined solution with minimum constraints was estimated along with the velocity, the offsets, and the periodic signals. The residuals show that the surrounding environment also affects the time series to a certain degree, thus it should be improved eventually. The transformation parameters to ITRF2014 were calculated with stability and consistency, which means the national geodetic reference frame is properly aligned to the global reference frame.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.21 no.4
• /
• pp.571-576
• /
• 2023

The initial development plans for the six reactor designs, soon after the release of Generation IV International Forum (GIF) TRM in 2002, were characterized by high ambition [1]. Specifically, the sodium-cooled fast reactor (SFR) and very-high temperature reactor (VHTR) gained significant attention and were expected to reach the validation stage by the 2020s, with commercial viability projected for the 2030s. However, these projections have been unrealized because of various factors. The development of reactor designs by the GIF was supposed to be influenced by events such as the 2008 global financial crisis, 2011 Fukushima accident [2, 3], discovery of extensive shale oil reserves in the United States, and overly ambitious technological targets. Consequently, the momentum for VHTR development reduced significantly. In this context, the aims of this study were to compare and analyze the development progress of the six Gen IV reactor designs over the past 20 years, based on the GIF roadmaps published in 2002 and 2014. The primary focus was to examine the prospects for the reactor designs in relation to spent nuclear fuel burning in conjunction with small modular reactor (SMR), including molten salt reactor (MSR), which is expected to have spent nuclear fuel management potential.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.21 no.4
• /
• pp.489-502
• /
• 2023

This article presents the crucial role played by the French underground research laboratory (URL) in initiating the deep geological repository project Cigéo. In January 2023, Andra finalized the license application for the initial construction of Cigéo. Depending on Government's decision, the construction of Cigéo may be authorized around 2027. Cigéo is the result of a National program, launched in 1991, aiming to safely manage high-level and intermediate level long-lived radioactive wastes. This National program is based on four principles: 1) excellent science and technical knowledge, 2) safety and security as primary goals for waste management, 3) high requirements for environment protection, 4) transparent and open-public exchanges preceding the democratic decisions and orientations by the Parliament. The research and development (R&D) activities carried out in the URL supported the design and the safety demonstration of the Cigéo project. Moreover, running the URL has provided an opportunity to gain practical experience with regard to the security of underground operations, assessment of environmental impacts, and involvement of the public in the preparation of decisions. The practices implemented have helped gradually build confidence in the Cigéo project.

• Imaging Science in Dentistry
• /
• v.43 no.2
• /
• pp.85-90
• /
• 2013

Purpose: This study was performed to determine the buccal alveolar bone thickness following rapid maxillary expansion (RME) using cone-beam computed tomography (CBCT). Materials and Methods: Twenty-four individuals (15 females, 9 males; 13.9 years) that underwent RME therapy were included. Each patient had CBCT images available before (T1), after (T2), and 2 to 3 years after (T3) maxillary expansion therapy. Coronal multiplanar reconstruction images were used to measure the linear transverse dimensions, inclinations of teeth, and thickness of the buccal alveolar bone. One-way ANOVA analysis was used to compare the changes between the three times of imaging. Pairwise comparisons were made with the Bonferroni method. The level of significance was established at p<0.05. Results: The mean changes between the points in time yielded significant differences for both molar and premolar transverse measurements between T1 and T2 (p<0.05) and between T1 and T3 (p<0.05). When evaluating the effect of maxillary expansion on the amount of buccal alveolar bone, a decrease between T1 and T2 and an increase between T2 and T3 were found in the buccal bone thickness of both the maxillary first premolars and maxillary first molars. However, these changes were not significant. Similar changes were observed for the angular measurements. Conclusion: RME resulted in non-significant reduction of buccal bone between T1 and T2. These changes were reversible in the long-term with no evident deleterious effects on the alveolar buccal bone.