• Applied Biological Chemistry
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• v.32 no.4
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• pp.338-343
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• 1989

The volatile oil of the root of Codonopsis lanceolata Traut. (Benth. et Hook.) was isolated by steam distillation and extraction method and fractionated by silica gel column chromatography. The total volatile oil and each fractions were analyzed by GG, GC-MS and retention indices matching. A total of 50 components were identified in the volatile oil including 16 terpene and terpene alcohols, 13 hydrocarbons, 5 alcohols, 6 aldehyde and ketones, 6 acids, 2 esters and 2 miscellaneous components. The major components were n-hexanal (7.3% of total volatile oil), trans-2-hexenal (24.9%), n-hexanol (19.8%), cis-3-hexen-1-ol (5.6%) and trans-2-hexen-1-ol (29.4%).

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.5
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• pp.648-652
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• 2012

This study was conducted to determine the effects of dietary addition of tea saponins (TS) and soybean oil (SO) on fatty acid profile and gene expression of stearoyl-CoA desaturase (SCD) in longissimus dorsi (LD) muscle of growing lambs. Thirty-two Huzhou lambs were assigned to four dietary treatments in a $2{\times}2$ factorial arrangement with main effects of TS (0 or 3 g/d) and SO (0 or 30 g/kg of diet DM). The diet without additives was considered as NTNS (no TS or SO). After a feeding trial for 60 d, four lambs of each treatment were slaughtered to collect the samples of LD muscle. Percentage of trans-11 vaccenic acid was enhanced (p<0.05) in muscle of lambs fed TS and SO. The proportion of total conjugated linoleic acid (CLA) was increased (p<0.05) by SO, but decreased (p<0.05) by TS in LD muscle. The percentage of total saturated fatty acids in muscle was decreased (p<0.05) by addition of TS and SO, while addition of SO increased (p<0.05) the percentage of total polyunsaturated fatty acids. The ratio of cis-9, trans-11 CLA to tran-11 vaccenic acid was decreased (p<0.05) by TS, but increased (p<0.05) by SO. The same effects were observed in SCD mRNA expression. From these results it is indicated that including TS and SO in the diet of growing lambs affect the fatty acid profiles of LD muscle and that the proportion of cis-9, trans-11 CLA in the muscle influenced by TS and SO may be related to the SCD gene expression.

• The KIPS Transactions:PartB
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• v.9B no.4
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• pp.471-480
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• 2002

In this paper, we implemented a real-time system improving the performance of the paper currency discrimination by integrating a weighted region of interest matching algorithm with a weighted shape feature matching algorithm of the blocked image. The system classifies the paper currency by comparing a query image with compared images based on the database that contain images of paper currency. Especially, the system has good efficiency at the contaminated, rotated, and translated paper currency. The system hardware consists of three parts as follows : the paper currency image acquired by CIS(contact image sensor) is applied to the pre-processing part with A/D converter and PLD. Finally the pre-processed image data are classified by the main image processing part with a high-speed DSP based on the proposed algorithm.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.7
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• pp.149-156
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• 2013

This paper presents a hardware edge detector of image signal at pixel level of CMOS image sensor (CIS). The circuit detects edges of an image based on a bump circuit combining with the pixels. The APS converts light into electrical signals and the bump circuit compares the brightness between the target pixel and its neighbor pixels. Each column on CIS 64 by 64 pixels array shares a comparator. The comparator decides a peak level of the target pixel comparing with a reference voltage. The proposed edge detector is implemented using 0.18um CMOS technology. The circuit shows higher fill factor 34% and power dissipation by 0.9uW per pixel at 1.8V supply.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.3
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• pp.302-307
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• 1992

The methanol extract of perilla leaves contained compounds to reduce the mutagenicity of aflatoxin B$_1$(AFB$_1$) in Salmonella typhimurium TA98 and 100. They were separated by solvent extractions and identified by GC and GC-MS as 2-ethoxy acetate, 1, 2, 3, 4-tetramethyl-cis-cyclobutene, two isomers of methyl 11, 14, 17-eicosatrienoate, 12-acetyl-9-octadecanoic acid, and phytol. The antimutagenicities of phytol and methyl 11, 14, 17-eicosatrienoate were dependent on the mutagens tested. Phytol reduced the mutagenicity of Trp-p-2 but not of AFB$_1$and methyl 11, 14, 17-eicosatrienoate reduced the activities both of the mutagens.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.7
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• pp.459-466
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• 2014

In this paper, we suggest an efficient image processing method for fast paper currency counting with pattern recognition. The patterns are consisted of feature data in each note object extracted from full reflection image of notes and a general contact image sensor(CIS) is used to aggregate the feature images. The proposed pattern recognition algorithm can endure image variation when the paper currency is scanned because it is not sensitive to changes of image resulting in successful note recognition. We tested 100 notes per denomination and currency of several countries including Korea, U.S., China, EU, Britain and Turkey. To ensure the reliability of the result, we tested a total of 10 times per each direction of notes. We can conclude that this algorithm will be applicable to commercial product because of its successful recognition rates. The 100% recognition rates are obtained in almost cases with exceptional case of 99.9% in Euro and 99.8% in Turkish Lira.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.89-89
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• 2003

Exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a variety of biological and toxicology effects, most of which are mediated by aryl hydrocarbon receptor (AhR). The ligand-bound AhR as a heterodimer with AhR nuclear translocator (ARNT) binds to its specific DNA recognition site, the dioxin-responsive element (DRE), and it results in increased transcription of CYP1A1 gene. Retinoic acid (RA) regulates the transcription of various genes for several essential functions through binding to two classes of nuclear receptors, the retinoic acid receptor (RAR) and retinoid X receptor (RXR). Constitutive androstane receptor (CAR) also regulates the transcription of gene. In this study, we have examined how RAR, RXR and CAR regulated CYP1A1 in rainbow trout hepatoma cell (RTH 149) using luciferase reporter gene assay system. We did transient transfection with CYP1A1 luciferase reporter gene and treated with TCDD, all-trans RA, 9-cis RA and phenobarbital. Treatment of all-trans RA, 9-cis RA or phenobarbital decreased the TCDD induced transcription of CYP1Al. When we did transient cotransfection with CYP1A1 luciferase reporter gene and RXR, as increase of RXR concentration, the TCDD induced transcription of CYP1A1 was decreased. Transfection with CAR also decreased the TCDD induced transcription of CYP1A1 in RTH 149 cells.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.9 no.2
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• pp.115-127
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• 1998

Laryngopharyngeal reflux(LPR) is one firm of the gastroesophageal reflux diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, foreign body sensation in throat, chronic throat clearing, chronic cough, etc. Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus should be suspected as LPR-related diseases. In this multi-center trial, we tried to evaluate the effect of cisapride(10mg tid) on LPR-related symptoms as the part I study(CIS-KOR-051) in 19 centers, and as the part II study(CIS-KOR-052) comparative evaluation of effect between cisapride(10mg tid) and ranitidine(150mg bid) on LPR-related symptoms in 4 centers. In part I study, efficacy of cisapride on LPR-related symptoms after 4 weeks was 53.5% and that of after 8weeks was 77.9% in per protocol(PPA) analysis group. In part II study, efficacy of the cisapride was much better than that of ranitidine not only from 8 weeks trial(p<0.001) but also from 4 weeks trial(p<0.021) in PPA group. In the multiple logistic regression analysis among the parameters which affect the efficacy of the treatment, cisapride prescribed group showed 10 times greater than that of ranitidine prescribed group(p<0.0001, Odds ratio : 10) in PPA group. LPR was proved by 24Hr double probe pHmetry in 13 patients out of 19 patients tested(68.4%). Thus these results indicated that inducing the improvement of motility functions could affect the amelioration of the LPR-related symptoms much better than reducing acid secretion from the stomach. And maybe it suggests that LPR-related symptoms mainly developed by the reduced motility functions of the esophagus and/or delayed gastric emptying.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3759-3765
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• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• Journal of the Korean Chemical Society
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• v.36 no.5
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• pp.661-668
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• 1992

The polymeric compound [{Mo(NO)_2Cl_2}n] was prepared by reductive nitrosylation of NaNO_2 and acidified FeSO_4 with MoCl_5. The reactions of [{Mo(NO)_2Cl_2}n] with unidentate and bidentate ligands afforded neutral monomeric $[Mo(NO)_2Cl_2L_2(or L-L)] in high yield (80∼90%). 3,5-Lutidine, {\gamma}-Cyanopyridine, 1,2-Phenylenediamine, 1,10-Phenanthroline, sym-Diphenylethylenediamine, 9,10-Phenanthrenequinone, 1,3-Bis(diphenylphosphino)propane and 8-Hydroxyquinoline were used as coordinating ligands. The preparation and characterization of these dinitrosylmolybdenum complexes by elemental analysis, 1H NMR, infrared, and UV-Visible spectroscopy are reported. The infrared spectra indicate that in all of the compounds prepared, the NO groups occupy cis-positions in the octahedral group of ligands.