• Toxicological Research
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• v.8 no.2
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• pp.217-233
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• 1992

This study was performed to determine the toxic effects of graded dose levels of SKI 2053R after repeated administration. Three groups of Sprague-Dawley rats(10M and 10F per group) were given a total of 25 i.v. injections of SKI 2053R (1.50,3.75,9.38mg/kg/day). In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group of Sprague-Dawley rats (10M and 10F per group) were given a total of 25 i.v.injections of cisplatin (1.70mg/kg/day). The dosing schedule was divided into five courses of 5 consecutive days with 16-day dose-free intervals between each course. No drug-related toxicity occurred in low dose level group (1.50mg/kg/day) of SKI2053R. From the results of hematological examination, peripheral WBC counts, RBC counts and hemoglobin of high dose level group(9.38mg/kg/day)of SKI 2053R were significantly lower than those of no-treated group. Other toxicities including reduced final body weight, proteinuria and hematuria were observed in high dose level group of SKI 2053R. But, no change was detected in serum biochemical values of SKI 2053R treated groups. All of the rats in cisplatin treated group were died between 3 and 13 weeks, while rats treated with SKI2053R survived to the end except one rat of middle dose level group(3.75mg/kg/day). In histopathological examinations, rats that received cisplatin manifested severe tubular damage in kidney and hemosiderosis in spleen, but no critical pathological lesion was observed in rats of other groups. Considering the results of this study, it was concluded that non-toxic dose of SKI 2053R in this treatment schedule was estimated to be 3.75 mg/kg/day and the maximum tolerated dose was to be higher than 9.38mg/kg/day. The toxic profiles fo SKI 2053R were different from those of cisplatin, and its toxicity was considerably lower than that of cisplatin.

• Preventive Nutrition and Food Science
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• v.1 no.2
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• pp.244-251
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• 1996

Molecular weight and partial amino acid sequence of the cis, 9-cis, 12-octadecadienoate isomerase(linoleate isomerase) of Butyrivibrio fibrisovens A-38 were determined. Linoleate isomerase was isolated from the bac-teria cultured anaerobically and purified by ultracentrifugation in conjunction with Sepharose 6B column chro-matography, Phenyl sepharose 4B column chromatography and fast performance liquid chromatography (EPLC). The isomerase was single polypeptide with 19KD of molecular weight, when determined by SDS-PAGE. Fourteen amino acids sequence of N-terminal of the linoleate isomerase was N-GEIDKYPRIIKQQ determined by Edman method.

• Food Science of Animal Resources
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• v.38 no.4
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• pp.693-702
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• 2018

The purpose of this study was to develop a commercially viable method for synthesis of conjugated linoleic acid (CLA) using the linoleic acid fraction obtained from six pork by-products (liver, lung, heart, stomach, small intestine, and large intestine). The workflow of CLA synthesis from each by-product was as follows: washing${\rightarrow}$crude fat extraction${\rightarrow}$fractionation into saturated and unsaturated fatty acids${\rightarrow}$repeat unsaturated fatty acid fractionation${\rightarrow}$CLA synthesis. Cis-9, trans-11, and trans-10, cis-12 CLA was synthesized from pork by-products. The yield of CLA synthesis of pork by-products ranged from 1.55 to 11.18 g per 100 g of by-products. The amount of synthesized CLA was the highest in the small intestine and large intestine by-products. Fractionation of pork by-products nearly doubled the yield of CLA. We suggest that commercial fractionation methods could increase the yield of CLA at low cost, reduce waste, and improve the efficiency of by-product utilization.

• The Journal of Information Technology
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• v.7 no.4
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• pp.9-20
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• 2004

Result Dos that materialization KNU Virus Wall to solve serious problem Hurtfulness Virus is present network chiefly in this research to do not become and do correct disposal in situation such as internet and Multiple Protocol that is done intelligence anger for ESM, CIS and MIS side as secondary to solve this problem about out log analysis system embody. As a result, could use comprehensively, and can click by Site Design, Packet transmission, and used to interior internet (GroupWare) in information protection aspect because intelligence enemy to face each other ESM's various hacking and virus uses Enterprise Security Management system and CIS, whole web through Smart View and relation of security could do monitoring.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.4
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• pp.512-515
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• 2005

An in vitro study was conducted to determine the effect of C18-polyunsaturated fatty acid on direct incorporation into the rumen bacteria, bio-hydrogenation and production of CLA in vitro. Sixty milligrams of linoleic acid ($C_{18:2}$) or linolenic acid ($C_{18:3}$) were absorbed into the 0.5 g cellulose powder was added to the 150 ml culture solution consisting of 120 ml McDougall's buffer and 30 ml strained rumen fluid. Four uCi of 1-$^{14}C_{18:2}$ or 1-$^{14}C_{18:3}$ (1 uCi/15 mg each fatty acid) were also added to the corresponding fatty acids to estimate the direct incorporation into the bacterial lipids. The culture solution was then incubated anaerobically in a culture jar with stirrer at 39$^{\circ}C$ for 12 h. Ammonia concentration and pH of the culture solution were slightly influenced by the fatty acids. Amount of fatty acid incorporated into the bacteria was 1.20 mg and 0.43 mg/30 ml rumen fluid for $C_{18:2}$ and $C_{18:3}$, respectively during 12 h incubation. Slightly increased CLA (sum of cis-9, trans-11 and cis-10, trans-12 $C_{18:2}$) was obtained from the $C_{18:3}$ addition compared to that from $C_{18:2}$ after 12 h incubation in vitro.

• Journal of the Korean Chemical Society
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• v.7 no.2
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• pp.128-132
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• 1963

A study has been made on the applicability of gas-liquid partition chromatography to the qualitative and quantitative analysis of complex mixture of gaseous hydrocarbons. While phthalate columns are widely used for this $purpose^9$, they separates neither saturated hydrocarbons from the unsaturated nor n-butane from isobutene or butene-1, therefore combined columns such as phthalate and dimethylsulfolane have been used for the perfect separation of gaseous hydrocarbons. It is shown by this study, however, that hydrocarbons having $C_1$ through $C_4$ can be separated with a 2-meters tetraethyleneglycol dimethylether column except ethane from ethylene, and trans-from cis-2-butene especially operated at $15^{\circ}C$$ using helium as the carrier gas. The column effluents were in order of methane, (ethane, ethylene), propane, propylene, isobutane, n-butane, isobutylene, butene-1, (trans-& cis-2-butene, isopentane), (butadiene-1, 3, n-pentane). Two kinds of liquified petroleum gases in market are analysed qualitatively and quantitatively. The results indicate that use of this 2-meters TEGDE column permits the separation and identification of all the commonly encountered aliphatic gaseous hydrocarbons.

• Korean Journal of Clinical Pharmacy
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• v.29 no.4
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• pp.247-253
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• 2019

Background: Glutamate is implicated in the pathophysiology of migraine, a common neurological disorder. Therefore, glutamate receptor antagonists (GluRAs) have been suggested as a novel migraine treatment that are able to overcome the limitations of triptans. Objective: The aim of this study was to perform a meta-analysis to assess the efficacy of GluRAs for patients with migraine. Method: The PubMed, Cochrane Library, CINAHL, and Clinical Trial.gov databases were searched for randomized placebo-controlled trials of the efficacy of GluRAs for patients with migraine conducted up to August 2019. Two independent reviewers screened the literature according to inclusion and exclusion criteria and performed quality assessment and data extraction. Review Manager 5.3 software was used for the meta-analysis. Results: Three studies involving a total of 206 patients were included in the final analysis. Compared with placebo, GluRAs significantly improved the pain-free response at 2 hours (odds ratio [OR]=3.85, 95% confidence intervals [CIs]=1.63-9.09) and the 24-hour sustained pain freedom (OR=7.40; 95% CIs=2.36-23.20). The use of rescue medications with GluRAs was lower compared to that with placebo, but the difference was not significant (OR=0.39, 95% CI=0.10-1.47). Conclusion: Our meta-analysis showed that GluRAs were more effective than placebo for patients with migraine.

• Journal of Photoscience
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• v.6 no.2
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• pp.67-70
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• 1999

trans-1-(9-Anthryl)-2-(n-pyridyl)ethene (t-n-APyE, n=2 or 4) and trans-1-(9-anthryl)-2-pyrazinylethene (T-APzE) exhibits solvent-dependent fluorescence and efficient trans)cis photoisomerization. Photochemical reactivities of t-2-APyE, t-4-APyE, and t-APzE have been investigated in nonpolar and polar solvents. In nonpolar solvent, parallel photocyclization reaction occurs very efficiently in competition with the fluorescence and photoisomerization. But, in polar solvent, photocyclization was not observed. It is probably due to the stabilization of charge separated state in polar solvent, which is an intermediate in photoisomerization reaction.

• Macromolecular Research
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• v.9 no.1
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• pp.45-50
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• 2001

Formation of bound rubber depends on the filler-polymer interactions including physical adsorption, chemisorption, and mechanical interaction. Bound rubbers consist of tightly and loosely bound ones. Styrene-butadiene rubber (SBR) is composed of styrene, 1,2-, cis-1,4-, and trans-1,4-units. Filler-polymer interactions of each components of SBR with fillers, carbon black and silica, were studied by analysis of microstructure of the bound rubber. Filler-polymer interaction of the 1,2-unit with the fillers was found to be stronger than those of the other components and this phenomenon was shown more clearly in the tightly bound rubber.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.230.2-230
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• 1998

No Abstract, See Full Text