• 대한동의생리학회:학술대회논문집
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• 대한동의생리학회 2005년도 하계학술대회
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• pp.12-12
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• 2005

• Applied Biological Chemistry
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• 제46권2호
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• pp.107-112
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• 2003

천마를 채취한 그대로 이용하는 데에는 생체보존에 따른 불편, 독성 그리고 자극성 등의 부작용으로 간단한 전처리 과정이 필요하다. 본 연구에서는 천마를 이용한 가공제품의 개발을 위한 전처리 과정 중 증자 조건별로 천마의 항산화적 특성을 반응 표면 분석법으로 모니터링하여 최적 증자 조건을 설정하였다. 총페놀성 화합물의 함량은 증자온도 $94.43^{\circ}C$, 증자시간 42.38min에서 최적이었고 전자 공여능은 증자온도 $101.67^{\circ}C$, 증자시간 41.09min에서 최적조건이었다. 항산화능 및 아질산염 소거능은 $100^{\circ}C$, 40min의 동일조건에서 최적으로 나타났다. 위 항산화적 특성의 증자조건을 종합하여 superimposed contour map으로 최적조건을 예측한 결과, 증자온도 96{\sim}107{\circ}C$, 증자시간 $28{\sim}46min$으로 나타났다. 예측된 임의의 증자조건 $100^{\circ}C$, 40min으로 실제 항산화 관련값을 측정한 결과 예측값의 $95.9%{\sim}115.6%$으로 유효성이 높게 나타났다.

• 한국식품저장유통학회지
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• 제13권6호
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• pp.740-748
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• 2006

천마를 채취한 그대로 이용하는 데에는 생체 보존에 따른 불편, 독성 그리고 자극성 등의 부작용으로 간단한 전처리 과정이 필요하다. 따라서 본 연구에서는 천마를 이용한 가공제품의 개발을 위한 전처리 과정 중 건조 조건별로 천마의 이화학적 특성을 반응표면 분석법으로 모니터링하여 최적 건조조건을 설정하였다. 천마 건조물의 수분활성도는 건조온도 $79.56^{\circ}C$, 건조시간 7.17 hr에서 가장 높은 간을 나타내었고, 총 페놀성 화합물 함량은 $79.64^{\circ}C$, 8.74hr에서, 전자공여능은 $79.79^{\circ}C$, 8.57 hr에서 최대값을 나타내었으며, 아질산염 소거능(pH 1.2)은 건조온도 $79.99^{\circ}C$, 건조시간 8.07hr에서 각각 최고의 이화학적 특성을 나타내는 것으로 예측되었다. 천마 건조물의 이화학적 특성을 고려한 최적 건조조건 범위는 건조온도 $75{\sim}80^{\circ}C$와 건조시간 $8{\sim}9 hr$으로 각각 나타났다.

• Natural Product Sciences
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• 제11권3호
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• pp.123-126
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• 2005

Gastrodia elata Blume (Chunma) belongs to Orchidaceae, which is a perennial parasitic herbaceous plant and grows in the woods of the central provinces of China, Korea and Japan. Recently, the constituents of the tubers of this plant have been investigated by researchers who have revealed the presence of phenolic compounds including gastrodin as a major constituent, together with 4-hydroxybenzaldehyde, 4-hydroxybenzyl alcohol, parishin, 4,4-dihydroxybenzyl sulfoxide, vanillin, vanillyl alcohol, beta-sitosterol, organic acids and polysaccharides, etc. In this study, we used ultrasonicator and two kinds of enzymes for enhancement of extraction yield. We also used electronic nose for the aroma pattern analysis of Chunma extracts. The concentrations of glucose and functional constituents (gastrodin, vanillin, 4-hydroxybenzaldehyde and 4-hydroxybenzyl alcohol) were measured by biochemistry analyzer and HPLC, respectively. Therefore, we showed that the yield of extraction was increased and discomfortable odor was reduced.

• 동의신경정신과학회지
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• 제5권1호
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• pp.69-79
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• 1994

In order to prove the effectiveness for anticonvulsion and analgesic of Ukgansan, Ukgansan added Jinphi Banha and Ukgansan added Chunma by experiment, experimental animals(mouse) are injected with strychnine, picrotoxin and caffeine to cause convulsion and ovserved the consumed time from convulsion to death. Comparing data with control group and observation data for frequency of writhing syndrome caused by acetic acid and phenylquinone show the results as follows : 1. Anticonvulsion effect on the convulsion induced by strychnine it was significantly effective in all sample groups. 2. Anticonvulsion effect on the convulsion induced by picrotoxin it was significantly effective in sample A and B. 3. Anticonvulsion effect on the convulsion induced by caffeine it was not recognized in all sample groups. 4. Analgesic effect on the pain induced by acetic acid it was significantly effect in sample A and C. 5. Analgesic effect on the pain induced by phenylquinone it was significantly effective in sample A and C. The results show that Ukgansan can be an effectual cure on anticonvulsion and analgrsic, Ukgansan added Jinphi·Banha on anticonvulsion, and Ukgansan added Chunma on analgesic.

• 동의생리병리학회지
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• 제17권5호
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• pp.1335-1338
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• 2003

We have previously reported that the vasodilatory effect of BanhabackchuIChunma-tang(半夏白朮天麻湯; BCT), a herbal formula, and its mechanism might be associated with at least in part NO pathway. In the present study, we studied the influence of BanhabackchulChenuma-tang (BCT) on the phosphorylation of LC20, in parallel, the distribution of α-protein kinase C(PKCα) by phenylephrine was monitored using laser scan confocal immunofluorescent microscopy in freshly isolated ferret portal vein smooth muscle living single cells. Phenylephrine stimulation induced LC20 phosphorylation and translocation of PKCα. However, BCT dephosphorylated LC20 phosphorylation and inhibited the translocation of PKCα. Our results demonstrate that the mechanism of relaxant effect of BanhabackchulChunma-tang inhibition is associated with inhibition of PKCα activation and LC20 phosphorylation.

• 대한토목학회논문집
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• 제3권3호
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• pp.27-37
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• 1983

본(本) 연구(硏究)는 경기도(京畿道) 설계심의회(設計審議會)에서 천마산(天馬山) 청소년(靑少年) 심신수련장(心身修練場) 현수교(懸垂橋) 설계심의시(設計審議時) 현수교(懸垂橋)의 동적(動的) 거동(擧動)에 대한 설계미비(設計未備)의 원인(原因)이 아직도 체계화(體系化)되지 못한 우리 나라 현수교(懸垂橋)의 설계자료(設計資料)와 지침(指針)의 불비(不備)함에 그 동기(動機)를 얻어, 유한요소법(有限要素法)을 적용(適用)하여 현수교(懸垂橋)의 비틀림진동(振動)에 대한 고유진동수(固有振動數)와 이에 상응(相應)하는 고유진동형(固有振動形)을 구(求)하였다. 실제(實際)로 현수교(懸垂橋)의 일반적(一般的) 거동(擧動)은 수직(垂直) 수평면(水平面) 내(內)에서의 연성(連成)된 운동(運動)으로 표시(表示)되지만 사용목적(使用目的)에 부합(附合)하여 그 진폭(振幅)을 미소(微小)하도록 제한(制限)하면 수직(垂直) 비틀림 진동(振動)은 단독(單獨)으로 비연성화(非連成化)할 수 있으며, 이에 따라 해석하였다. 1973년 6월에 개통된 Streamlined Box-Girder Type인 남해대교(南海大橋)와 Lateral Bracing으로 이루어진 단경간의 천마산(天馬山)의 현수교(懸垂橋)의 설계자료(設計資料)를 이용하여 수치해(數値解)를 얻었으며, 천마산(天馬山) 현수교(懸垂橋)의 경우(境遇) 보조(補助) 보강(補强)케이블의 유무(有無)에 따른 고유진동수(固有振動數)와 진동형(振動形)을 구(求)하여 비교(比較) 검토(檢討)하였다. 보강(補强)케이블의 유무(有無)에 따라 초기의 진동수(振動數) 등에서는 그 영향이 매우 뚜렷하였으나, 진동형(振動形)이 복잡해짐에 따라 보강(補强)케이블의 영향은 미약했거나 또는 오히려 역효과를 가져왔다. 남해대교(南海大橋)에 있어서 유한요소기법(有限要素技法)과 전자계산기에 의해 본(本) 연구(硏究)에서 구한 고유진동수(固有振動數)와 남해대교(南海大橋) 건설지(建設誌)에 있는 Frequency Equation으로 구한 값 또는 풍동실험(風洞實驗)에 의한 결과(結果) 등과 비교(比較) 검토(檢討)하였으며, 비교(比較) 결과(結果) 좋은 일치(一致)를 보여주었다.

• 동의생리병리학회지
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• 제16권1호
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• pp.62-66
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• 2002

Hypertension is not only a well-established cardiovascular risk factor but also increase the risk of atherosclerosis. Most studies conducted to investigate the effectiveness of treatment for cardiovascular disease such as hypertension have focused primarily on conventional drug and physiotherapeutic treatments. BanhabackchulChunma-tang(半夏白朮天麻湯:BCT) is popular herbal medicine used in clinic for the treatment of various symptoms of drulatory disorders and weakness of digestive system, including anorexa and nausea with vertigo, severe headache, vomiting and so on. However, the mechanisms underlying its efficacy are unknown. This study investigated the effects of BCT as an alternative medication on the contraction induced by phenylephrine and KCI in rat thoratic aorta. BCT revealed siginificant relaxation on phenylephrine-induced arterial contraction, but revealed noncompetitive effect on concentration responses of phenylephrine-induced contraction. Treatment of N-L/sup ω/ -argine methyl ester(L-NAME) and methylene blue(MB)(10/sup -5/M) reduced the relaxation of BCT. BCT also increased in vitro NO production. It suggest that the relaxation effect of BBT is related with NO pathway, becausse the effect of L-NAME and MB are due to inhibition of NO synthesis from endothelial cells. These results indicate that BCT would be effective in hypertension treatment and its mechanism of relaxtion on arterial contraction is likely to be related with NO production, blocking of α-receptor and signal transduction after receptor activation.

• 한국식품조리과학회지
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• 제27권5호
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• pp.545-556
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• 2011

The purpose of this study was to investigate the effect of Gastrodia elata Blume concentrate on quality characteristics of Gastrodia elata Blume jelly. The Gastrodia elata Blume jelly samples were divided into five groups by adding different Gastrodia elata Blume concentrates. The five groups were divided into GBJ-0, GBJ-5, GBJ-10, GBJ-15, and GBJ-20 (Gastrodia elata Blume jelly with 0, 5, 10, 15, and 20% Gastrodia elata Blume concentrate). The highest contents of crude protein and crude ash, and the brix in the GBJ-20 sample were 0.34 and 0.59%, and 22.28$^{\circ}$ Brix, respectively. The crude fiber and pH change (4.65-4.76) were not significantly observed in any of the GBJ samples. Turbidity, degree of brownness, and total phenolics increased with an increasing the amount of extract. A significant difference was observed between samples with and without the extracts in terms of hardness, springiness, gumminess, and chewiness, as well as K, Mg, Cu, Mn, and Zn contents. Hardness, gumminess, and chewiness increased in all GBJ samples with an increase the amount of extract added, whereas adhesiveness decreased. The highest tartaric acid content in the GBJ-0 sample and malic acid in the GBJ-20 jelly sample were 15.58 mg/100 g and 137.45 mg/100 g, respectively. The levels of Ca, K, and Mg increased with an increase in the amount of added extract. The highest score for overall acceptance (4.13) was in the GBJ-10 sample with 10% Gastrodia elata Blume concentrate.

• 한국기계가공학회지
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• 제20권2호
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• pp.66-71
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• 2021

A hydraulic quick coupler is a component used to easily connect or disconnect pipes or hoses that transfer high pressure fluid without leakage in various mechanical devices. In this study, to obtain an optimal design of a 3/8" hydraulic quick coupler, the effect of different shapes of the internal piston on the internal flow characteristics of the coupler was analyzed and evaluated through numerical analysis based on computational fluid dynamics. Subsequently, the optimal shape design of the internal piston was obtained by comparing the flow characteristics results such as velocity distribution, temperature distribution, and the pressure drop of the hydraulic quick coupler.