• BMB Reports
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• v.36 no.1
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• pp.138-143
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• 2003

Of many viral causes of human cancer, few are of greater global importance than the hepatitis B virus (HBV). Over 250 million people worldwide are persistently infected with HBV. A significant minority of these develop severe pathologic consequences, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Earlier epidemiological evidence suggested a link between chronic HBV infection and HCC. Further, the existence of related animal viruses that induce acute and chronic infections of the liver, and eventually HCC, confirms the concept that HBV belongs to one of the few human oncogenic viruses. Although it is clear that chronic HBV infections are major risk factors, relatively little is understood about how the viral factors contribute to hepatocarcinogenesis. This review will introduce molecular aspects of the viral infection, and highlight recent findings on the viral contribution to hepatocarcinogenesis.

• Korean Journal of Clinical Laboratory Science
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• v.44 no.3
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• pp.142-146
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• 2012

Hepatitis B surface antigen (HBsAg) seroclearance is a rare event in chronic hepatitis B virus (HBV) infection which acquires the disease early in life. A case study have examined with asymptomatic chronic hepatitis B carrier who exhibits HBsAg seroclearance in anti-HBe positive. We comprehensively studied the biochemical, virological and clinical aspects of a patient with HBsAg seroclearance. Liver biochemistry, serological markers, serum HBV DNA levels, and development of clinical complications were monitored. Mutation of hepatitis B virus is suspected serum HBsAg detected by the HBsAg assay systems of VITROS (OrthoClinical Diagnostics, USA), AxSYM (Abbott Laboratories, USA), Elecsys (Roche Diagnostics, Germany) and ADVIA Centaur (Bayer Diagnostics, USA). These four immunoassays showed negative results. Also, the patient had undetectable serum HBV DNA. Therefore, no mutation within the "a" determinant of HBsAg, which might escape detection from HBsAg immunoassay were found. Natural seroclearance was confirmed.

• Journal of Home Health Care Nursing
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• v.22 no.1
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• pp.69-77
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• 2015

Purposes: The purpose of the study was to evaluate knowledge of hepatitis C and compliance with therapeutic guidelines and their correlation. Methods: Participants included a total of 197 subjects with chronic hepatitis C from 4 general hospitals. Subjects were asked 25 items of knowledge on hepatitis C and 17 items of compliance with therapeutic guidelines. The collected data was analyzed for frequency, percentage, average, standard deviation, t-test, ANOVA and Pearson's correlation coefficient. with the help of SPSS 21.0 program. Results: The subject's knowledge on chronic hepatitis C expressed as percentage was 67.1%. Compliance of the research participants gained $3.96({\pm}0.76)$ points in general on a 5-point scale. Learned compliance was higher when the patients were 45 years old and over. female and with spouse. There was a statistically significantly positive correlation between knowledge and compliances. Conclusions: Development of educational programs requires consideration of patient characteristics, particularly education on the male patients under 45 years of age.

• Journal of KIISE:Computer Systems and Theory
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• v.34 no.7
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• pp.276-281
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• 2007

In this paper, we use Support Vector Machine to predict the susceptibility of chronic hepatitis from single nucleotide polymorphism data. Our data set consists of SNP data for 328 patients based on 28 SNPs and patients classes(chronic hepatitis, healthy). We use leave-one-out cross validation method for estimation of the accuracy. The experimental results show that SVM with SNP is capable of classifying the SNP data successfully for chronic hepatitis susceptibility with accuracy value of 67.1%. The accuracy of all SNPs with health related feature(sex, age) is improved more than 7%(accuracy 74.9%). This result shows that the accuracy of predicting susceptibility can be improved with health related features. With more SNPs and other health related features, SVM prediction of SNP data is a potential tool for chronic hepatitis susceptibility.

• The Journal of Korean Academic Society of Nursing Education
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• v.20 no.1
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• pp.108-117
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• 2014

Purpose: The purpose of this study was to develop and validate health care providers' counseling manual in mobile application for lifelong health care among patients with chronic hepatitis B. Methods: The mobile application was developed using a prototyping approach and system developing life cycle method, evaluated by users for their satisfaction with the counseling manual and experts for the quality of the manual. To evaluate application of the counseling manual, knowledge and counselor self-efficacy of the subjects were measured and compared before and after application of the counseling manual. Results: There were statistically significant increases in knowledge and counselor self-efficacy in the user group. A mobile application with high accessibility and applicability including information and counseling factors can promote counseling competence of the nurse as health care provider caring chronic hepatitis B patients. Conclusion: The results of this study indicate that the counseling manual in mobile application is effective in increasing knowledge and counselor self-efficacy among nurses to promote lifelong health care among patients with chronic hepatitis B. Therefore, it can be usefully utilized in the field of nursing for patients with chronic hepatitis B as a nursing intervention.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5025-5030
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• 2015

Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This study aimed to determine whether single nucleotide polymorphisms (SNP) in IFN- ${\gamma}$ and IL-10 genes are associated with susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN ${\gamma}$ (+874T/A) and IL-10 (-1082G/A) genotypes were determined in 75 HCV genotype 4 patients with different disease severities (chronic hepatitis, n=25, liver cirrhosis and hepatocellular carcinoma (HCC) on top of liver cirrhosis, n=50) and 25 healthy participants using allele-specific polymerase chain reaction. No statistical differences in allele or genotype distributions of IFN ${\gamma}$ and IL-10 genes were detected between patients and controls or between patientgroups. No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-${\gamma}$ at position +874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosis or HCC. In conclusion; interferon-${\gamma}$ and interleukin-10 gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C (Genotype-4).

• The Journal of Internal Korean Medicine
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• v.27 no.4
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• pp.1014-1026
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• 2006

Liver cirrhosis is a liverdisease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. Liver cirrhosis is regarded as a serious health problem with high prevalence in the world as well as in Korea. Liver cirrhosis is an irreversible disease. However, in cases of liver cirrhosis induced by chronic hepatitis B, we should treat the chronic hepatitis B, because it frequently progresses to cirrhosis and hepatoma. We observedimprovements of symptoms and laboratory tests with herb medicine Injinchunggan-tang (茵蔯淸肝湯) in five cases ofliver cirrhosis and chronic hepatitis B. The serum aminotransferase was preserved within normal value levels for a long time, 3 years to 7 years. However, further study is necessary to determine the effect of herb medicine on liver cirrhosis and chronic hepatitis B.

• The Journal of Korean Medicine
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• v.30 no.3
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• pp.106-110
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• 2009

Objective : To study the Oriental Medicine-based strategies or therapeutics for chronic HBV infection. Methods : A chronic HBV carrier was treated with only oriental therapies. Then, serum biochemical parameters were serially chased, and change of HBV-DNA level was evaluated. Result : The biochemical indicators (AST, ALT, gamma-GTP, bilirubin) fluctuated during the treatment period. After one episode of drastic elevation of serum aminotransferase, HBV-DNA disappeared from the blood along with normalization of biochemical parameters within two years of beginning treatment. Conclusion : Oriental Medicine-based therapeutics could be an alternative strategy against chronic infection of HBV.

• The Journal of Internal Korean Medicine
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• v.37 no.3
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• pp.529-538
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• 2016

Objectives: The purpose of this case study is to report the efficacy and safety of treatment with Korean medicine of a patient with HBeAg-positive chronic viral hepatitis B.Methods: The patient took Korean medicine (mainly Injinchunggan-tang-gamibang) from July 20th, 2010, to March 14th, 2016, without any antiviral or interferon therapy. Changes to laboratory records, abdomen ultrasonography, and clinical symptoms were reviewed.Results: The laboratory records showed that AST, ALT, and HBV DNA had decreased to normal ranges, and HBeAg showed seroconversion. Clinical symptoms also improved after taking Korean medicine.Conclusion: The results suggest that treatment with Korean medicine and without antiviral or interferon therapy could be effective for HBeAg-positive chronic hepatitis B.

• Korean Journal of Clinical Laboratory Science
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• v.45 no.1
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• pp.9-15
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• 2013

Hepatitis B virus (HBV) infection has recently shown to be associated with diabetes mellitus. The objective of this study was to investigate the relationship between chronic hepatitis B and diabetes mellitus indicators. We evaluated anthropometry, metabolic syndrome risk factors, fasting glucose, HbA1c, and C-peptide among the normal and HBV subjects. The partial correlation and average comparison analysis were used to assess the independent association between chronic hepatitis B and diabetes mellitus indicators. Average comparisons of normal and HBV subjects were significantly different in fasting glucose (p<0.000), HbA1c (p<0.000), C-peptide (p<0.000), alanine transaminase (ALT) (p<0.000) and aspartate transaminase (AST) (p<0.000). We may suggest that HBV infection is related to diabetes mellitus indicators such as fasting glucose, HbA1c and C-peptide.