• Title/Summary/Keyword: Chiral palladium catalyst

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Diastereoselective Synthesis of anti-1,2-Aminoalcohol by Palladium(II) Catalyzed Aza-Claisen Rearrangement

  • Yoon, Youn-Jung;Chan, Myung-Hee;Joo, Jae-Eun;Kim, Yong-Hyun;Oh, Chang-Young;Lee, Kee-Young;Lee, Yiu-Suk;Ham, Won-Hun
    • Archives of Pharmacal Research
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    • v.27 no.2
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    • pp.136-142
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    • 2004
  • In this study, a highly diastereoselective synthesis of anti-1 ,2-aminoalcohol was explored starting from L-amino acids as chiral sources. The higher yield and diastereoselectivity was shown when the aza-Claisen rearranqement was performed with allylic trichloroacetimidate 6a in the presence of palldium(II) catalyst.