• 한국환경생태학회지
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• 제19권4호
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• pp.385-392
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• 2005

본 연구는 대형 산불이 발생한 강원도 고성군 산불피해지 역에 서식하는 맹금류의 현황을 통해 산불피해지 역이 맹금류의 서식에 미치는 영향을 알아보고자 실시하였다. 고성군 산불피해지역에서 관찰된 맹금류는 총2목 3과 8종 최대 개체수 합계 28개체가 확인되었다. 최우점종은 새홀리기였으며, 말똥가리, 황조롱이, 붉은배새매의 순으로 조사되었다. 2002년 5월에 가장 많은 종과 개체수가 관찰되었으며, 부분적 미피해지역과 미피해지역에서 5종으로 가장 많은 맹금류가 관찰되었다. 이 한 맹금류들의 종과 개체수를 증가시키기 위해서 산불피해지 역에 맹금류들이 둥지를 만들 수 있는 조건을 조성해준다면, 산불피해지 역에 서식하는 맹금류의 종과 개체수는 더욱 늘어날 것으로 판단된다.

• 해양환경안전학회지
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• 제19권2호
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• pp.155-163
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• 2013

최근 일부 연구자들은 9세기 장보고 휘하의 신라인들이 항해에 나침반과 첨저선을 이용하여 동북아 해역을 자유롭게 항해하였다고 주장하고 있다. 그러나 항해에 나침반이 이용된 것은 중국이 11세기이고, 유럽이 12세기이다. 게다가 우리 선조들은 평저선을 사용하였다는 것이 학계의 중론이다. 이 논문은 중국 주산군도에서 흑산도를 잇는 동중국해 사단항로(서해남부 사단항로)의 이용 시점에 관하여 해양기상학적 관점에서 재검토해 보려는 시도이다. 이를 위해 고대 동중국해 사단항로에 관한 이제까지의 연구성과를 정리한 뒤, 동중국해의 해황(海況)을 바람과 해류, 안개를 중심으로 살펴보고, 뗏목으로 동중국해를 항해함으로써 장보고 선단이 동중국해 사단항로를 이용하였음을 입증하였다는 주장을 비판적으로 재구성해 보았다. 분석 결과 6 7월 해황은 동중국해 사단항로의 범주 항해가 가능함을 보여주고 있지만, 그것도 기상 조건이 아주 유리했을 경우에 한하여 한정적으로 가능했음을 확인하였다. 뗏목 탐사의 경우 제시된 항로도와 실제 선위간 이동경로와는 다소 상이하였고, 속력 또한 1.7 2노트 내외로 빠르게, 그것도 직선에 가깝게 이동한 것으로 분석되어 아주 이례적이었음을 확인하였다. 결론적으로 명확한 사료와 확실한 근거가 없는 한 동중국해 사단항로는 1068년 이후 주항로로 이용되었다는 설이 견지되어야함을 재확인하였다.

• 대한수의학회지
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• 제43권2호
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• pp.181-188
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• 2003

Cordyceps has a reputation for its broad biological activities and as a tonic which replenishs vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the development of new type Cordyceps, the effects of the fruiting bodies of cultivated fungus of Paecilomyces japonica grown on silkworm larvae on radiationinduced damages were investigated. We performed this study to determine the effect of Dongchongxiacao (Paecilomyces japonica) on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells and hair follicles of mice irradiated with high and low dose of gamma-radiation. Treatment with Dongchongxiacao showed no significant modifying effects on the jejunal crypt survival and endogenous spleen colony formation. The frequency of radiationinduced apoptosis was reduced by pretreatment of Dongchongxiacao (i.p.: 50 mg/kg of body weight, at 12 and 36 hours before irradiation, p<0.01). The spontaneous levels of apoptotic cells are $0.082{\pm}0.041$ in intestinal crypts and $0.231{\pm}0.084$ per hair follicle section of skin. Pretreatment of Dongchongxiacao was associated with decreases of 26.86% in intestinal crypt and 66.36% in hair follicle decrease in the number of cells with nuclei positively stained for apoptosis compared with the irradiation control group. We demonstrated for the first time that Dongchongxiacao administration could reduce the extent of apoptosis produced by radiation in the hair follicle. The results presented herein that Dongchongxiacao given before irradiation is capable of reducing the severity of cell loss as a result of apoptosis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4443-4448
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• 2014

Background: A number of studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism with susceptibility to hepatocellular carcinoma (HCC). However, the results were inconsistent and inconclusive. The aim of this study was to comprehensively explore the association of XRCC1 Arg399Gln variant with HCC risk. Materials and Methods: Systematic searches of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database were performed. Pooled odds ratio (OR) with 95% confidence intervals (CI) was calculated to estimate the strength of association. Results: Overall, we observed an increased HCC risk among subjects carrying XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/Gln+Arg/Gln genotypes (OR=1.20, 95%CI: 1.05-1.38, OR=1.16, 95%CI: 1.05-1.28, and OR=1.14, 95%CI: 1.04-1.24, respectively) based on 20 studies including 3374 cases and 4633 controls. In subgroup analysis, we observed an increased risk of XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/Gln+Arg/Gln polymorphisms for HCC in hospital-based study (OR=1.25, 95%CI: 1.03-1.51, OR=1.21, 95%CI: 1.07-1.36 and OR=1.18, 95%CI: 1.06-1.31, respectively) and in Asian population (OR=1.19, 95%CI: 1.03-1.38, OR=1.17, 95%CI: 1.04-1.30 and OR=1.14, 95%CI: 1.04-1.25, respectively). Limiting the analysis to the studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased HCC risk among Gln/Gln, Arg/Gln and Gln/ Gln+Arg/Gln genotype carriers (OR=1.17, 95%CI: 1.05-1.29, OR=1.12, 95%CI: 1.00-1.25 and OR=1.11, 95%CI: 1.02-1.21, respectively). Conclusions: This updated meta-analysis results suggest that XRCC1 Arg399Gln variants may contribute to HCC risk. Well-designed studies with larger sample size were required to further verify our findings.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4697-4703
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• 2014

Background: Interleukin-16 (IL-16) is a multifunctional cytokine which plays a key role in inflammatory and autoimmune diseases as well as in cancer. Genetic polymorphisms of IL-16 have been implicated in susceptibility to cancer. However, associations remain inconclusive. The present meta-analysis was therefore carried out to establish a more conclusive association of IL-16 polymorphisms with cancer risk. Materials and Methods: Relevant studies were searched through the PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated in October 2013. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to assess the association between IL-16 polymorphisms and cancer risk. Results: Eight eligible studies (rs4778889 T/C: 8, rs11556218 T/G: 7, rs4072111 C/T: 6) that met our selection criteria were included. The meta-analysis indicated that rs11556218 T/G was associated with a significant increased risk of cancer (G vs. T, OR=1.321, 95% CI=1.142-1.528, P<0.001; TG vs. TT, OR=1.665, 95% CI=1.448-1.915, P<0.001; GG+TG vs. TT, OR=1.622, 95% CI=1.416-1.858, P<0.001),as well as nasopharyngeal carcinoma and colorectal cancer. Furthermore, in the subgroup of Chinese, significant associations were found between rs11556218 polymorphism and cancer risk. There was no statistically significant association between the other two variants (rs4778889, rs4072111) and risk of cancer. Conclusions: This meta-analysis suggests that the IL-16 rs11556218 polymorphism is associated with increased cancer risk. Large well-designed studies involving various cancer types and different populations are now needed.

• 분석과학
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• 제14권4호
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• pp.311-316
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• 2001

본 연구는 한약재 중 우리 나라의 여러 지역에서 재배되고 있는 황기를 선택하여 유도결합 플라스마 분광분석법(inductively coupled plasma-atomic emission spectroscopy ; ICP-AES)을 이용한 미량성분을 분석하여 principal component analysis(PCA)와 pattern recognition의 원리를 이용한 chemometrics Analysis로 한약재에 함유된 미량 금속 성분 함량에 의한 원산지 판별의 가능성을 조사하였다. 황기와 토양시료는 각각 $HNO_3$와 $H_2O_2$ 그리고 $HNO_3$와 HCl를 첨가하여 microwave oven을 사용하여 전처리 하였다. ICP-AES를 사용하여 황기와 황기를 재배한 토양 속에 들어 있는 미량 금속 성분으로는 Mg, Al, K, Ca, Ti, Mn, Fe, Cu, Zn, and Ba 등이 있으며 그 중 Al과 Fe 그리고 Zn과 Ti의 함량으로는 PCA와 pattern recognition을 이용하여 각 재백지의 황기와 토양간의 연계성을 살펴보았다. 그 결과 국내산 황기와 중국산 황기를 PCA 방법으로 원산지 판별이 가능하였으며 구례, 예천, 제천, 그리고 정선의 국내산 황기의 원산지 판별이 가능하였다.

• 산경연구논집
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• 제10권2호
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• pp.65-75
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• 2019

Purpose - Along with Chinese exchange rate's reform advancement, the issue of exchange rate of RMB has increasingly become the heated focus in the world. In July 2005, China carried out the reform of the exchange rate system, and this behavior has aroused the attention of the world. However, the dispute on whether the theory of purchasing power parity holds or not in China still exists. As such, this paper will attempt to explore whether the purchasing power parity is significant in China. Research design, data, and methodology - The monthly data from July 2005 to December 2017 will be employed to analyze the nominal exchange rate of RMB against the US dollar and the nominal exchange rate of RMB against the euro. Based on these datum, an empirical analysis will be conducted under the unit root test and the cointegration test to exploit the significance of purchasing power parity in China. Results - The findings of this paper reveal that an increase in China's consumer price index will lead to an increase in the RMB exchange rate, which will lead to the depreciation of RMB. Concomitantly, an increase in the consumer price index in the US and Europe will result in a decrease in the RMB exchange rate, which will lead to an appreciation of RMB. In general, in terms of the US, if US consumer price index increases by 1%, China's nominal exchange rate against US dollar will decrease by 0.905%; if China's consumer price index increases by 1%, China's nominal exchange rate against US dollar will increase by 0.648%. In terms of Europe, if Europe consumer price index increases by 1%, China's nominal exchange rate against euro will decrease by 0.277%; If China's consumer price index increases by 1%, China's nominal exchange rate against euro will increase by 0.235%. Conclusions - Generally speaking, the empirical evidences this paper provided show that the purchasing power parity theory has a certain explanatory ability for the decision of RMB exchange rate. As such, the purchasing power parity cannot hold completely, and China's government should continue to deepen the reform of the exchange rate system to improve China's exchange rate market.

• Journal of Periodontal and Implant Science
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• 제28권4호
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• pp.545-559
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• 1998

Magnoliae cortex has been used as a drug for treatment of fractures in Chinese medicine and safflower(Carthamus tinctorius $Linn{\acute{e}}$) has been traditionally used for treatment of blood stasis. The purpose of present study was to examine the biologic effects of magnoliae cortex extract and safflower extract mixture(MSM) on human periodontal ligament cells and fetal rat calvarial osteoblasts and on healing of rat calvarial defects. The ethanolic extracts of magnoliae cortex(MCE), safflower seed(SSE), Zea May L(ZML) were prepared as positive control group. MSM mixed to the ratios of 1 : 1, 1 : 2, 1 : 5 and 1 : 10 were used as test group. The effects of each agents on the growth and survival, ALPase activity, cell proliferation and tissue regenerative effect of each extracts was evaluated by histomorphometric measuring of newly formed bone on the 8 mm defect in rat calvaria after oral administration of 2 ratio groups(1 : 5 and 1 : 10) at 3 different doses (0.1, 0.25 and 0.5g/kg per day). MSM stimulated the growth and survival rate of osteoblasts and PDL cells more than any other agents. The growth and survival rate were increased as the proportion of safflower seed extract was increased. MCE, SSE, ZML stimulated the ALPase activity of osteoblast and PDL cell in comparison to the negative control group. But all groups of MSM regardless of ratio of safflower seed extract stimulated the ALPase activity than any other agent. The ALPase activity was also increased as the proportion of safflower seed extract was increased. Although MCE, SSE, ZML stimulated the proliferation of osteoblasts. 1 : 5 and 1 : 10 ratio MSM showed significant increase in stimulation of proliferation of osteoblasts. No agent significantly increased proliferation of PDL cells. Significant new bone formation were seen where 1 : 5 ratio, 0.5g/kg group and 1 : 10 ratio, 0.25, 0.5g/kg groups were used. These results show that magnoliae cortex extract and safflower seed extract mixture can potentially increase bone regeneration ability.

• 한국환경농학회지
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• 제20권4호
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• pp.232-237
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• 2001

이상의 결과에서, 방사오리의 벼 접촉자극에 의해 줄기를 포함한 지상부 및 지하부의 건물중량은 유의적으로 증가하고, 벼초장, 간장 및 하위절간의 신장생장은 현저하게 억제되는 것이 인정되었다. 또한 오리 접촉자극에 의해 줄기의 좌절저항력은 크게 증가하는 반면, 휨 모멘트는 감소함을 보여 벼 도복억제 또는 도복경감의 효과가 시사되었다. 수량형질에 있어서 오리의 접촉자극에 의해 1이삭당 평균영화수, 등숙율 및 천립중은 대차 없었으나 유효분얼경수 및 포기당 이삭수의 현저한 증가가 인정되어 최종적으로 벼 수량의 증가를 볼 수 있었다. 금후, 본 연구에서 얻어진 결과를 바탕으로 방사오리의 접촉자극과 벼 생장과의 메커니즘을 보다 과학적으로 해명할 필요가 있고, 이를 위해서는 오리행동을 모방한 인위적인 접촉자극에 의한 영향 및 식물의 생장 반응에 영향하는 것으로 알려진 메치오닌, 에칠렌, 지베렐린 등의 식물생장호르몬과 접촉자극과의 관련성에 대한 추가적인 검증과정이 필요할 것으로 사료된다.

• 분석과학
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• 제25권6호
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• pp.364-369
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• 2012

Isotianil은 쌀 도열병을 방제하기 위한 새로이 개발된 식물활성 살균제로 다른 식물활성제에 비해 소량으로도 장시간의 효과를 나타내는 특징을 가지고 있다. 신규 농약 Isotianil에 대한 기준은 국내의 경우 2010년 쌀에 대하여 0.1 mg/kg으로 최초 설정되었으며, 이에 따른 식품 중 안전관리를 위해 Isotianil을 분석하기위한 검사법을 개발하였다. 검체 일정량에 acetonitrile을 가하고 균질화하여 대상농약을 추출하였으며, 액-액분배하고 florisil 카트리지를 이용한 고체상 추출 후 GC-NPD 및 GC-MSD로 분석하였다. 분석결과 농산물에 의한 간섭물질은 없었으며, 대표 농산물 현미 등 6 종에 대한 Isotianil의 분석 시험법의 정량한계와 직선성은 각각 0.05 mg/kg과 0.999($r^2$)이었다. 회수율은 대표 농산물에서 70.0~103.9%이었으며, 분석오차는 10% 미만으로 CODEX 잔류분석 기준에 적합하였다.