• 대한치과의사협회지
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• 제53권10호
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• pp.712-725
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• 2015

The clinical dentistry system and research tendency of dentistry in North Korea has a difference with South Korea. In North Korea, preventive dentistry has been developed, and government of North Korea clame a free medical service to all the people. And there are tendency that Korean medicine(Oriental medicine) is applied to clinical dentistry in North Korea. Research tendency of dentistry in North Korea have a difference from South Korea. Articles of dentistry in North Korea have some freatures. Terminology of dentistry is writtened in original Korean developed uniquely in North Korea. Recent articles of dentistry in North Korea have a reference from english articles, and it is different that reference articles in the past were from Chinese or Russian articles. In order to get ready for the United Korea, we need to know the feature of dentistry in North Korea, and increase an academic exchange between South and North Korea.

• Mycobiology
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• 제48권3호
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• pp.228-232
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• 2020

Cordyceps is a genus of ascomycete fungi and is well known as one of the important medical fungi in Chinese, Korea, and other Asian countries, because of its various beneficial effects on human health. The pharmacological activities of Cordyceps extract are mainly focused on anti-cancer, anti-metastatic, and immune modulating effects. In the present study, we investigated whether the antiplatelet effect of ethanol extract of cultured Cordyceps militaris (CMEE) with FeCl₃-induced arterial thrombosis model. We observed that CMEE exhibited a significant inhibitory effect against ADP and collagen-induced platelet aggregation. However, there were no significant differences in prothrombin time (PT) and activated partial thromboplastin time (aPTT). These results suggest that antithrombotic activity of CMEE is related to antiplatelet effect rather than anticoagulation effect, and CMEE may be a positive effect on improving blood circulation against vessel injury and occlusion.

• 대한상한금궤의학회지
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• 제7권1호
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• pp.1-14
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• 2015

Objectives : The purpose of this study is to show the importance of Shanghanlun(傷寒論) paleography. Shanghanlun(傷寒論) must be thoroughly reinterpreted through graphonomy evidence. Methods : The object of this study is Gangpyeong-Shanghanlun(康平傷寒論), which is known as the oldest edition of Shanghanlun(傷寒論). This study compares the paleographic meaning of Shanghanlun(傷寒論), Mai(脈), Shanghanlun provisions 96 and 103 to existing interpretations. Results : Mai(脈) doesn't mean 'Radial pulse(Chon.Gwan.Cheok)' in Shanghanlun(傷寒論), so the meaning of Mai(脈) should be redefined. Mai(脈) means 'Continuous movement of human body' based on Chinese paleography. Also it's being verified as reasonable hypothesis in recent clinical researches. In addition, Shanghanlun(傷寒論) paleography makes it possible to grasp the true intention of Zhang Zhongjing(張仲景). Conclusions : Shanghanlun(傷寒論) paleography has a limit that it cannot be perfectly applied to clinical diagnosis. Also, it may not represent the whole meaning of Shanghanlun (傷寒論). Therefore, the value of Shanghanlun(傷寒論) reinterpretation should be recognized through this study, and we should continuously find out future values from Shanghanlun(傷寒論).

• Mycobiology
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• 제30권4호
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• pp.208-212
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• 2002

For comparison of mycelial colonization of Phellinus linteus on logs, several techniques of inoculation were tested; sterilized short log inoculation, drilling inoculation and log-end sandwich inoculation. The mycelial colonization of P. linteus on logs was good in the treatment of sterilized short log inoculation, but poor in the traditional methods such as drilling inoculation and log-end sandwich inoculation. The initial mycelial growth and the full mycelial colonization of P. linteus in logs were the best in case of 20 cm logs under the condition of 42% moisture content. Also, the initial mycelial growth of P. linteus was accelerated over 12 hours of sterilization. Burying method of logs after $5{\sim}6$ months of incubation was the best for formation of basidiocarps of P. linteus. The formation of fruiting body of P. linteus was quite good in the cultivation house at $31{\sim}35^{\circ}C$ and over 96% of relative humidity.

• 대한의생명과학회지
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• 제15권4호
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• pp.273-279
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• 2009

Cordycepin (3'-deoxyadenosine) is an adenosine analogue isolated from Cordyceps militaris, and it has been used as an anti-cancer and anti-inflammation ingredient in traditional Chinese medicine. We investigated the effects of cordycepin on human platelet aggregation induced by thapsigargin, and determined the cytosolic free $Ca^{2+}$ levels ($[Ca^{2+}]_i$), an aggregation-stimulating factor. Cordycepin significantly inhibited thapsigargin-induced platelet aggregation. Its inhibitory effect was continually sustained at the maximal aggregation concentration of thapsigargin. The thapsigargin-induced $[Ca^{2+}]_i$ were clearly reduced by cordycepin in the presence of exogenous $CaCl_2$ or extracellular $Ca^{2+}$-chelator (EDTA). These results suggest that cordycepin inhibited thapsigargin-induced $Ca^{2+}$-influx from extracellular domain and thapsigargin-induced $Ca^{2+}$-mobilization from intracellular $Ca^{2+}$ storage. Accordingly, our data demonstrated that cordycepin may have a beneficial effect on platelet aggregation-mediated thrombotic diseases by inhibiting a $[Ca^{2+}]_i$-elevation.

• 셀메드
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• 제10권3호
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• pp.20.1-20.6
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• 2020

The Karafs is a dried herb of whole plant of Apium graveolens L. from Apiaceae (carrot family). The seeds (fruits) of Apium graveolens are known as Tukhm-e- Karafs in Unani Medicine. Karafs is known as Celeri in French, Apio in Spanish, Selderiji in Dutch, Syelderey in Russian and Chin in Chinese. It is cultivated in different parts of the world for its seeds as spice and green leaves and root as salad crop. Its seeds are also used for medicinal purposes in complementary and alternative medicines. In Unani it is used as a single drug or as an ingredient in compound formulations used for management in various ailments. The seeds have various pharmacological actions like hepatoprotective, diuretic and lithotriptic etc. It is commonly found in Western Asia, Europe, North Africa and various parts of India like Punjab, Uttar Pradesh and Himachal Pradesh etc. In Unani its actions are described as Mudirr-i-Bawl (Diuretic), Mufattit-i-Hasāh (Lithotriptic), Dafi'-i-Tashannuj (Antispasmodic) and Kāsir-i-Riyāh (Carminative). It is used for the treatment of Hasah al-Kulya (Nephrolithiasis), Nafkh al-Mi'da (Flatulence), Istisqā' (Oedema) and Ihtibās al-Bawl (Retention of urine) etc.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1349-1354
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• 2013

Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, $^1H$ NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5-fluoropyrimidine (5) with $IC_{50}$ values of 0.10, 1.66 and $0.59{\mu}M$, respectively. Compounds 6d and 6e were effective against MCF-7 with $IC_{50}$ $9.73{\mu}M$ and HL-60 with $IC_{50}$ $8.83{\mu}M$, respectively.

• 약학회지
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• 제50권4호
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• pp.234-243
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• 2006

Three important books in the oriental medicine are Huangjenaekyung (medical book), Sanghanron (pharmacological book) and Shinnongbonchokyung (herbal book). Chang, joong-kyung who is the writer of Sanghanron would be recommended as a saint physician and his book, Sanghanron is granted for a best book in this field by Chinese people. Also, Japanese physicians would estimate Sanghanron as the most magnificent book ever written by a human being. Sanghanron contains a lot of confirmations (證) of diseases, their progressing courses and exact therapeutic ways. Therefore modern physicians and pharmacists who are interested in the oriental medicine might study and practice more scientific approach of therapy for patients. The aim of this bibliographical study on Sanghanron is to explain systematically theories of this book and harmonize them with the modern medicinal study: In this study we have acquired three main results, the first is that we could get the coincidence between western & oriental way on the five therapeutic principles-sweating, vomiting, harmonizing, excreting and bleeding : the second, notice the exclusion of the Five Element Theory(the fundamental one in oriental medicine) and the third, found out the possibility of the immunological and neuroscientific explanation for pharmacological application to the oriental medicine.

• Current Optics and Photonics
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• 제6권2호
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• pp.151-160
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• 2022

Fundus images can reflect ocular diseases and systemic diseases such as glaucoma, diabetes mellitus, and hypertension. Thus, research on fundus-detection equipment is of great importance. The fundus camera has been widely used as a kind of noninvasive detection equipment. Most existing devices can only obtain two-dimensional (2D) retinal-image information, yet the fundus of the human eye also has spectral characteristics. The fundus has many pigments, and their different distributions in the eye lead to dissimilar tissue penetration for light waves, which can reflect the corresponding fundus structure. To obtain more abundant information and improve the detection level of equipment, a snapshot nonmydriatic fundus imaging spectral system, including fundus-imaging spectrometer and illumination system, is studied in this paper. The system uses a microlens array to realize snapshot technology; information can be obtained from only a single exposure. The system does not need to dilate the pupil. Hence, the operation is simple, which reduces its influence on the detected object. The system works in the visible and near-infrared bands (550-800 nm), with a volume less than 400 mm × 120 mm × 75 mm and a spectral resolution better than 6 nm.

• 대한한의학방제학회지
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• 제31권2호
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• pp.125-132
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• 2023

Objective : The objective of this study is to report a case of atopic dermatitis (AD) treated with Hoeyeok-tang. Methods : We retrospectively reviewed the course of herbal medicine treatment in a 20-year-old male patient with a topic dermatitis. Changes in main symptoms were confirmed based on the gross findings and assessed using SCORing Atopic Dermatitis(SCORAD) Index. Accompanying symptoms and side effects that can be referred to for diagnosis were analyzed By referring to the clinical records. Results : According to the Shanghanlun provision, the patient's AD was diagnosed with Terminal-yin Gwakran 389^th provision. The patient was treated with Hoeyeok-tang for 90 days. The severity of pruritus decreased, and SCORAD Index was decreased from 44.6 to 8.4. VAS for eye fatigue and nausea was decreased from 10 to 5, also. No particular side effects occurred to the patient while taking the Hoeyeok-tang. Conclusions : The result suggests the clinical applicability of 389^th provision of Shanghanlun.