• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVI)
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• pp.570-573
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• 2005

분무법을 이용한 alginate microsphere를 제조한 결과 구형을 형성하는 것을 관찰하였고, 이러한 alginate microsphere에서 alginate 농도가 증가할수록 크기는 작아지고, chitosan/alginate microsphere에서 chitosan의 농도가 증가할수록 그 크기가 증가하는 것을 확인하였다. OVA의 방출정도는 alginate microsphere에서 alginate 농도가 증가할수록 잘 이루어지지 않았고, HCl buffer에서보다 PBS buffer에서 방출이 잘되는 것을 확인하였다. Chitosan/alginate microspheres에서는 chitosan의 농도가 증가할수록 방출이 잘되지 않았고, 이는 alginate microsphere에서와 마찬가지로 PBS buffer에서 방출이 잘 이루어지는 것을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제9권1호
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• pp.50-55
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• 1999

To develop a new form of controlled release dosage for administering for indomethacin (IND), two formulations of IND-loaded nanoparticles were designed based on polysaccharide (guar) derivatives. Nanoparticles prepared by the dialysis method were characterized with respect to morphology, size distribution, drug content, and in vitro drug release. Morphological studies by scanning electron microscopy (SEM) indicated that guar acetate (GA) nanoparticles were spherical in shape and had a smooth surface. The particle size distributions of formulation I (40mg of GA) and formulation II (80mg of GA) were shown to be $250.78\pm185.13nm$ and $718\pm145.90nm$ in distilled water ($20$^{\circ}C$), respectively. The drug loading efficiencies of nanoparticles were approximately 26% and 31% for formulations I and II, respectively. The differential scanning calorimetry (DSC) results indicated that the IND was perfectly distributed within GA nanoparticles. We also found, from the X-ray diffractometry analysis, that a decrease in the degree of crystallinity of the drug occurred in the nanoparticles. No changes between the original IND and the released IND from GA nanoparticles were detected by FT-IR. Using guar acetate, it is possible to design nanoparticles which allow the controlled release of IND over an extended period of time.

• The Journal of Korean Physical Therapy
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• 제13권1호
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• pp.237-243
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• 2001

Skeletal muscle cells are activated by ${\alpha}$-motorneurons which release acetylcholine at the neuromuscular junction. This results in a local depolarization of surface membrane which triggers an action potential. The action potential propagates along the surface membrane and also into the T-tubule system. In the triads T-tubules are in close connection with the terminal cisternae of the sarcoplasmic reticulum(SR). The action potential activaies T-tubule voltage sensors(DHP receptors). which activates SR Ca$^{2+}$ release channels(ryanodinc receptors). Ca$^{2+}$ have a key role in skeletal muscle in that an increase of free myoplasmic Ca$^{2+}$ concentration. The process of coupling chemical and electrical signals at the cell surface to the intracellular release of Ca$^{2+}$and ultimate contraction of muscle fibers is termed excitation-contraction coupling(ECC). Coupling of cel1 surface signals to intracellular Ca$^{2+}$ release proceeds by several mechanisms in skeletal muscle cells. This review focus on sarcopiasmic reticulum(SR) Ca$^{2+}$ releasing mechanisms from sarcoplasmic reticulum in the skeletal muscle. The mechanisms include DCCR, CICR, and HCR.

• Macromolecular Research
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• 제10권5호
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• pp.246-252
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• 2002

In order to the development of the delivery device of long-acting local anesthetics for postoperative analgesia and control of chronic pain of cancer patient, fentnyl-loaded poly (L-lactide-co-glycolido) (PLGA, molecular weight, 5,000 g/mole; 50 : 50 mole ratio by lactide to glycolide) microspheres (FMS) were studied. FMS were prepared by an emulsion solvent-evaporation method. The influence of several preparation parameters such as initial drug loading, PLGA concentration, emulsifier concentration, oil phase volume, and fabrication temperature has been investigated on the fentanyl release profiles. Generally, the drug showed the biphasic release patterns, with an initial diffusion followed by a lag period before the onset of the degradation phase, but there was no lag time in our system. Fentanyl was slowly released from FMS over 10 days in vitro with a quasi-zero order property. The release rate increased with increasing drug loading as well as decreasing polymer concentration with relatively small initial burst effect. From the results, FMS may be a good formulation to deliver the anesthetic for the treatment of chronic pain.

• Environmental Engineering Research
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• 제17권1호
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• pp.17-25
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• 2012

Concern about green water problem has surfaced as a serious issue in Korea. In order to solve this problem, it is necessary to research inhibition of green water and corrosion control of copper pipe in water service. This paper discovered that moderate corrosion inhibitors can solve the green water problem and copper corrosion in water service by adding the optimal concentration of corrosion inhibitors based on regulation. Firstly, in the case of phosphate based corrosion inhibitors, as dosage of the corrosion inhibitor increases from 1 mg/L to 5 mg/L, the relative effect of corrosion inhibitor declines rapidly. Secondly, except for 1 mg/L dosage of silicate based inhibitor, relative effects of the inhibitor displays a positive number depending on inhibitor concentration. The most significant result is that the amount of copper release shows a downward trend, whereas the phosphate based inhibitor accelerates copper ion release as the inhibitor dosage increases. Thirdly, as the dosage of mixed inhibitors increases to 10 mg/L, the copper release change shows a similar trend of phosphate based inhibitor. Lastly, according to the Langelier saturation index (LI), silicate based inhibitors have the most non corrosive value. Larson ratio (LR) indicates that phosphate based inhibitors are the least corrosive. Korea water index (KWI) represents that silicate based inhibitors are most effective in controlling copper pipe corrosion.

• International Journal of Automotive Technology
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• 제8권1호
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• pp.1-7
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• 2007

The effect of the di-tertiary butyl peroxide (DTBP) additive on the heat release rate and emissions of a homogeneous charge compression ignition (HCCI) engine fueled with high Research Octane Number (RON) fuels were investigated. The experiments were performed using 0%, 1%, 2%, 3%, and 4% (by volume) DTBP-RON90 blends. The RON90 Fuel was obtained by blending 90% iso-octane with 10% n-heptane. The experimental results show that the operation range was remarkably expanded to lower temperature and lower engine load with the DTBP additive in RON90 fuel. The first ignition phase of HCCI combustion was observed at 850 K and ended at 950 K while the hot ignition occurred at 1125 K for all fuels at different engine working conditions. The chemical reaction scale time decreases with the DTBP addition. As a result, the ignition timing advances, the combustion duration shortens, and heat release rates were increased at overall engine loads. Meanwhile, the unburned hydrocarbon (UHC) and CO emissions decrease sharply with the DTBP addition while the NOx emissions maintain at a lower level.

• Archives of Pharmacal Research
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• 제21권4호
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• pp.418-422
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• 1998

Aim of this work is to prepare poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by dialysis method without surfactant and to investigate drug loading capacity and drug release. The size of PLGA nanoparticles was 269.9 $\pm$118.7 nm in intensity average and the morphology of PLGA nanoparticies was spherical shape from the observation of SEM and TEM. In the effect of drug loading contents on the particle size distribution, PLGA nanoparticles were monomodal pattern with narrow size distribution in the empty and lower drug loading nanoparticles whereas bi- or trimodal pattern was showed in the higher drug loading ones. Release of clonazepam from PLGA nanoparticles with higher drug loading contents was slower than that with lower loading contents.

• 한국가스학회지
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• 제17권4호
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• pp.26-32
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• 2013

산업현장에서 중대산업사고를 예방하기 위해서는 원천적으로 위험물질의 사용을 금지하고 안전이 확보된 대체물질을 사용하는 것이 최상의 안전을 확보하는 방법이다. 그러나 대체물질의 비효율적인 경제성과 생산기술의 부재로 인해 위험물질을 취급할 수밖에 없는 상황이라면 사고가 발생하지 않도록 예방을 철저하게 하는 것이 차선의 안전대책이라 하겠다. 이에 본 연구는 최근 연속적인 누출사고로 인해 위험성이 대두 되었음에도 산업현장에서 사용 및 취급될 수밖에 없는 HF에 대해 누출사고가 발생함과 동시에 향후에도 누출사고 가능성이 높은 HF 충진공정의 위험성 평가시 사고결과 영향분석과 비상조치계획 수립에 효율적으로 활용 할 수 있는 사고 시나리오를 발굴 및 선정하였다.

• 한국가스학회지
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• 제21권3호
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• pp.9-16
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• 2017

위험물을 취급하는 사업장에서 인근에 미치는 영향을 평가할 때 독성물질의 누출은 가장 관심있는 분야중의 하나이다. 대표적인 시설로서 염산 생산시설을 선정하여 공정정보로부터 사고 시나리오를 선정하고 독성물질 누출시 사업장외로 영향을 미치는 사고 시나리오를 선정하여 환경부의 지침에 따라서 평가하였다. ALOHA를 활용하여서 최악의 사고 시나리오를 비롯한 사고 시나리오를 평가하였으며 이들의 사고시 피해완화대책도 살펴보았다. 평가결과 염산생산시설은 현재의 안전조치가 충분하여서 추가의 개선대책이 필요하지 않은 것으로 판명되었다.

• 한국물환경학회지
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• 제33권4호
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• pp.387-393
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• 2017

A chemical batch tests were conducted to evaluate if microwave heating enhances phosphorous release from waste activated sludge (WAS) at pH 2.5, 5, 7, 9 and 11. Polyphosphate-accumulating organisms have a unique physiological feature, which releases intracellular polyphosphate granules when they are exposed under high temperature environments. Microwave irradiation was found to encourage large amount of phosphorus release from WAS, depending on pH and temperature conditions. Most of phosphorus was released below $59^{\circ}C$ within 30 min. A marked increase in phosphorus release was observed under alkaline or acidic conditions. However, based on control tests for phosphorus release under different pH conditions without microwave heating, the largest amount of phosphorus released by microwave irradiation was found at pH 7, followed by 5, 9, 11. On the other hand, crystallization was conducted to obtain magnesium ammonium phosphate (MAP) from phosphate released by microwave heating at pH 7. X-ray diffraction analysis confirmed that the recovered crystalline materials were MAP. MAP is an environmentally friendly fertilizer, which slowly releases ammonia and phosphorus in response to the demand of plant root. Thus, the recovered MAP as a phosphate fertilizer is fully expected to play a important role in the reduction of agricultural non-point pollution.