• Title/Summary/Keyword: Chemical potential distribution

Search Result 214, Processing Time 0.028 seconds

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death

  • Park, So-Jung;Shin, Ji-Hyun;Kang, Hee;Hwang, Jung-Jin;Cho, Dong-Hyung
    • BMB Reports
    • /
    • v.44 no.8
    • /
    • pp.517-522
    • /
    • 2011
  • Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.

A Study on the Characteristics of Natural Organic Matter and Disinfection By-Product Formation in the Juam Reservoir

  • Shin, Dae-Yewn;Moon, Ok-Ran;Yoon, Mi-Ran;Kim, Nam-Joung;Kang, Gang-Unn;Seo, Gwang-Yeob
    • Proceedings of the Korean Environmental Health Society Conference
    • /
    • 2005.06a
    • /
    • pp.259-262
    • /
    • 2005
  • This study aims to identify the relationship between characteristics of aqueous organic matter and chlorination by-products formation potential according to temporal effect of Juam reservoir in Sun-Choen. The molecular weight distribution and chemical composition of precursors and their relationship with disinfection by-products(DBPs) were investigated. Most of the organic matters was responsible for the major DBP precursors in the raw water are small compounds with a molecular weight less than IKDa, Aromatic contents determined by SUVA correlated well with DBPs, THMs, and HAAs formation. Especially, THMFP/DOC showed better correlation with SUVA than HAAFP/DOC and DBPFP/DOC with SUVA in Juam reservoir. Therefore, effective removal of small molecules or hydrophobic organic matter prior to disinfection process will significantly reduce the DBP concentration in the finished water.

  • PDF

유류오염토양 복원을 위한 지중 오존산화기술의 현장규모 적용

  • 정해룡;손규동;최희철;김수곤;양지원
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
    • /
    • 2003.09a
    • /
    • pp.172-175
    • /
    • 2003
  • Field scale application of in-situ ozonation were carried out for remediation of variably saturated soils contaminated with diesel fuel with 3 dimensional test cell (3m$\times$2m$\times$2m). After 20 days of ozone injection, more than 90% of removal rate was observed through the 3-D test cell. This result might be caused by uniform distribution, relatively low oxidant demand, and low water content of soils, as well as high oxidation potential of ozone. However, less than 50 % of injected ozone was monitored through the 3-D test cell even after 20 days of injection.

  • PDF

A Study on the Atmospheric Dry Deposition Flux and Soil Contamination in a Completed Landfill - A case study on Nanji landfill - (사후관리단계에 있는 매립지의 건식침적량 및 토양오염에 관한 연구 -난지도 매립지 사례를 중심으로-)

  • Yi, Seung Muk;Cho, Kyung Suk;Lee, Eun Young;Kim, Yoon Jung;Park, Jae Woo;Park, Seok Soon
    • Journal of Environmental Impact Assessment
    • /
    • v.8 no.2
    • /
    • pp.31-44
    • /
    • 1999
  • Atmospheric dry deposition flux and ambient particle mass size distribution were measured to evaluate the impact of atmospheric deposition around the Nanjido landfill sites. Wind direction affects greatly on the variation of mass flux and mass size distribution and made two times higher when the wind was blown from the road side. The effect of Nanjido landfill on the mass size distribution was significant comparing to simultaneously measured mass size distribution at the other sampling site. The results showed that the particle diameter bigger than $10{\mu}m$ explained the majority of atmospheric dry deposition flux. A survey was also carried out to investigate the contamination of soils in a completed Nanjido landfill. The chemical properties of the soil analyzed in the present study include pH, oxidation-reduction potential (ORP), anion and cation concentration, total organic carbon(TOC), and some-metal elements concentrations were analyzed. Microbial activity in the soils was also evaluated by measuring dehydrogenase activities. TOC in the soil contaminated with leachate was $467.0{\mu}g/g-dry$ soil, and the TOC in the soil, where Nanjido landfill gases were emitted from, was $675{\mu}g/g-dry$ soil. The highest microbial activity of $968.0{\sim}2147{\mu}g-TPF/g-dry$ soil day was found in the soil spouting Nanjido landfill gases. Compared with those in the uncontaminated soil, the concentrations of Cr, Cu and Ph in the contaminated soil were higher.

  • PDF

Materials Chemical Point of View for Durability Issues in Solid Oxide Fuel Cells

  • Yokokawa, Harumi;Horita, Teruhisa;Yamaji, Katsuhiko;Kishimoto, Haruo;Brito, M.E.
    • Journal of the Korean Ceramic Society
    • /
    • v.47 no.1
    • /
    • pp.26-38
    • /
    • 2010
  • Degradation in Solid Oxide Fuel Cell performance can be ascribed to the following fundamental processes from the materials chemical point of view; that is, diffusion in solids and reaction with gaseous impurities. For SOFC materials, diffusion in solids is usually slow in operation temperatures $800\sim1000^{\circ}C$. Even at $800^{\circ}C$, however, a few processes are rapid enough to lead to some degradations; namely, Sr diffusion in doped ceria, cation diffusion in cathode materials, diffusion related with metal corrosion, and sintering of nickel anodes. For gaseous impurities, chromium containing vapors are important to know how the chemical stability of cathode materials is related with degradation of performance. For LSM as the most stable cathode among the perovskite-type cathodes, electrochemical reduction reaction of $CrO_3$(g) at the electrochemically active sites is crucial, whereas the rest of the cathodes have the $SrCrO_4$ formation at the point where cathodes meet with the gases, leading to rather complicated processes to the degradations, depending on the amount and distribution of reacted Cr component. These features can be easily generalized to other impurities in air or to the reaction of nickel anodes with gaseous impurities in anode atmosphere.

Effect of Earthworms on Collembola Abundance in Temperate Forest Soil Ecosystem (온대 숲 토양 생태계에서 지렁이가 톡토기류 개체수에 미치는 영향)

  • Lee, Ju-Hyung;Park, Ji-Hyun;Yoo, Ji-Yeon;Han, Su-Hyun;Nam, Bo-Eun;Kim, Jae-Geun
    • Journal of the Korean Society of Environmental Restoration Technology
    • /
    • v.13 no.6
    • /
    • pp.97-106
    • /
    • 2010
  • Earthworm, a prominent ecosystem engineer within many terrestrial ecosystems, can exert profound influences on various abiotic/biotic environments through bioturbation processes such as burrowing, casting and mixing of litter and soil. In this study, we investigated how the presence or absence of earthworm (Oligochaeta) can alter the soil physico-chemical conditions and ultimately the distribution and abundance of Collembola which constitutes a large proportion of the soil fauna. During September 2010, soil organisms along with soil samples were collected from randomly installed 20 plots in Mt. Gwan-ak. We examined the differences in the abundance of Collembola among plot samples in respect to the presence/absence of earthworm and soil physico-chemical conditions (i.e., pH, $PO_4^{3-}$, $NO_3^{2-}$, organic matter (OM), electrical conductance and water content). Analysis of soil physico-chemical environment revealed a significantly higher organic matter content and electrical conductance in plots with earthworm compared to plots without earthworm. Abundance of Collembola were not only higher in plots with earthworm than in plots without earthworm, but were also positively correlated with availability of OM present in the environment. The results suggest that positive impacts of earthworm on the abundance of Collembola in this study may have been due to their ability to effectively modify soil physico-chemical conditions favored by Collembola. Such conspicuous influence of earthworm's activity on below-ground community suggests their potential significance in forest restoration or revegetation process.

Distribution of potential risky species on phytoplankton at ports in Korea (항만 환경에서 식물플랑크톤 잠재적 위해종의 분포)

  • Kwon, Oh Youn;Kang, Jung-Hoon
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.14 no.1
    • /
    • pp.506-510
    • /
    • 2013
  • This study aimed to understand relationship between potential risky species and environmental factors at ports in Korea. During the study periods, 25 potential risky species (red tide and toxic species) representing 20 red-tide species, 5 toxic species were observed in the all ports. Skeletonema costatum (red-tide species) was predominated in all study area. This species showed positive correlation with pH, while negative correlation with dissolved oxygen (p<0.05) at Busan port. Also, this species showed positive correlation with total suspended solids and pH (p<0.05) at Ulsan port. However, Sk. costatum showed positive correlation with nitrate at Incheon port (p<0.01). Pseudo-nitzschia spp. producing amnesic shellfish poison (domoic acid) showed positive correlation with nitrate and silicate in all study areas (p<0.05). Alexandrium spp. (paralytic shellfish poison) and Dinophysis acuminata (diarrhetic shellfish poison) were affected by chemical oxygen demand (p<0.01). Our results indicated that red-tide species were affected by physical factors, while chemical factors affected toxic species.

Distribution of Polycyclic Aromatic Hydrocarbons (PAHs) in Surface Sediments inside Songsanpo and Seogwipo Harbors of Jeju Island, Korea

  • Moon Sang-Hee;Lee Young-Don;Lee Min-Gyu;Kam Sang-Kyu
    • Journal of Environmental Science International
    • /
    • v.14 no.2
    • /
    • pp.105-119
    • /
    • 2005
  • The surface sediments inside Songsanpo and Seogwipo Harbors, major harbors of Jeju Island, were collected three times (June, September and December, 2001) and analyzed for 16 polycyclic aromatic hydrocarbons (PAHs) recommended by US-EPA as priority pollutants to assess their distribution levels and their biological effects on the marine organisms, and to suggest their possible origins. The concentrations of total PAHs inside Songsanpo and Seogwipo Harbors ranged from 41 to 288 ng/g on a dry weight basis with a mean value of 121 ng/g and from 14 to 268 ng/g with a mean value of 119 ng/g, respectively, and the levels were low as compared with those in other areas of the world. The sedimentary PAHs may be correlated with organic carbon and mud content to some extent. Based on comparisons of individual and total concentrations with effects-based sediment quality guidelines, the potential for the biological effects on the marine organisms were expected to be very low. From the examinations of the four PAH origin indices, such as LMW /HMW (low molecular weight 2-3 ring PAHs over high molecular weight 4-6 ring PAHs), phenanthrene/anthracene ratio, fluoranthene/pyrene ratio, chrysene/benzo[a]anthracene ratio, it can be concluded that the sediment PAH contaminations were ascribed to both of pyrolytic and petrogenic origins.

Performance and Emissions Characteristics of Agricultural Generator and Air Heater using DME Fuel (DME를 이용한 농업용 온풍기와 발전기의 성능 및 배출가스 특성 연구)

  • KIM, SHIN;MIN, KYOUNIL;PARK, CHEUNKYU;LEE, HYUNCHAN;NA, BYUNGKI
    • Journal of Hydrogen and New Energy
    • /
    • v.27 no.4
    • /
    • pp.431-440
    • /
    • 2016
  • Electric or hydrogen energy source is expected to solve a various issues including energy security and exhaust pollution. However, it is required a lot of time and a variety of development to apply for commercialization. Therefore, it is needed to translation fuels between the future and the present. DME (Dimethyl Ether) can play a reduce exhaust emission from medium- to heavy-duty engines that are mostly used in commercial sector. It have applied to the DME fuel as a various alternative fuel including power generation in many countries. Especially, it is necessary to secure the energy of energy-poor areas that are widely distributed around the world. And Korea also has the energy-poor areas due to geographical characteristics. These areas has been covered by their own energy through some small diesel generators, diesel boiler etc. If DME fuels are supplied in new demand such as rural sector with energy poor area, DME fuel will be available in the wider sector. In this study, it investigated performance and emission characteristics of agricultural generator and air heater using DME fuel. So the existing equipment of generator and air heater was modified to apply DME fuel. And combustion characteristics and properties of exhaust gas according to the contents of the DME fuel were evaluated. DME fuel showed a potential application in agricultural generator and air heater.

Induced Polarization Surveys of Contaminants and Introduction to Case Studies (오염원에 대한 유도분극탐사 반응 및 사례 소개)

  • Kim, Bitnarae;Caesary, Desy;Yu, Huieun;Cho, AHyun;Song, Seo Young;Cho, Sung Oh;Joung, Inseok;Nam, Myung Jin
    • Journal of Soil and Groundwater Environment
    • /
    • v.25 no.2_spc
    • /
    • pp.86-100
    • /
    • 2020
  • Analyzing and monitoring environmental contaminants based on geophysical exploration techniques have become important and it is now widely applied to delineate spatial distribution geophysical characteristics in wide area. Among the techniques, induced polarization (IP) method, which measures polarization effects on electrical potential distribution, has drawn much attention as an effective tool for environmental monitoring since IP is sensitive to changes in biochemical reactions. However, various reactions stemming from the presence of multiple contaminants have greatly enhanced heterogeneity of polluted sites to result in highly variable electrical characteristics of the site. Those contaminants influence chemical and physical state of soil and groundwater to alter electrical double layer, which in turn influences polarization of the media. Since biochemical reactions between microbes and contaminants result in various IP effects, IP laboratory experiments were conducted to investigate IP responses of the contaminated soil samples under various conditions. Field IP surveys can delineate the spatial distribution of contamination, while providing additional information about electrical properties of a target medium, together with DC resistivity. Reviewing IP effects of contaminants as well as IP surveys can serve as a good starting point for the application of IP survey in site assessment for environmental remediation.