• Bulletin of the Korean Chemical Society
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• v.25 no.1
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• pp.69-72
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• 2004

The N-alkylation of 4-aminopyrimidine with a tetrahydro-3-aza-cyclopropa[c]inden-5-one, which is a model reaction of the pharmacophore of duocarmycins, was studied with a quantum chemical method. We consider two factors for the acceleration of the N-alkylation; distortion and protonation of the model pharmacophores. The distortion of the spirocyclopropyl moiety in the model spirocyclopropylcyclohexadienone could induce an intrinsic energy of 3-4 kcal/mol, but the protonation on the carbonyl oxygen of the model cyclohexadienone lowers the transition energy of the N-alkylation of 4-aminopyrimidine dramatically (~46 kcal/mol) and is considered to play a major role in the enzyme reaction. The distorted and protonated spirocyclohexadienone is exothermally relieved to a phenol with the heat of reaction of -37 kcal/mol. The protonation process is proposed to be the mode of action of duocarmycins in the DNA alkylation.

• Bulletin of the Korean Chemical Society
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• v.22 no.6
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• pp.570-574
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• 2001

Magnesium isotope separation was investigated by chemical ion exchange with the 1-aza-12-crown-4 bonded Merrifield peptide resin using an elution chromatographic technique. The capacity of the novel azacrown ion exchanger was 1.0 meq/g dry resin. The heavier isotopes of magnesium were enriched in the resin phase, while the lighter isotopes were enriched in the solution phase. The single stage separation factor was determined according to the method of Glueckauf from the elution curve and isotopic assys. The separation factors of $^{24}Mg^{2+}$-$^{25}Mg^{2+}$, $^{24}Mg^{2+}$-$^{26}Mg^{2+}$, and $^{25}Mg^{2+}$-$^{26}Mg^{2+}$ were 1.008, 1.019, and 1.006, respectively.

• Journal of Microbiology and Biotechnology
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• v.30 no.7
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• pp.1108-1108
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• 2020

• Journal of Environmental Health Sciences
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• v.46 no.5
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• pp.539-547
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• 2020

Objectives: This study was performed to emphasize improvement of the perception of dental hygienists' environmental working conditions by analyzing various factors. Methods: Two hundred ninety-eight female dental hygienists working at 35 medical institutions in Daegu City and Gyeongsangbuk-do Province participated. A self-recording type survey was done in October 2016. Results: Factors influencing the perception of infection control was length of career. Dental hygienists with more experience have a higher level of perception. Factors influencing the perception of working posture was the number of patients per day and career level. Dental hygienists seeing 50 or fewer patients per day and senior staff showed higher levels of this perception. Factors influencing the perception of noise in the working area were length of career and lunchtime break. The perception level was high in the group with longer careers and dental hygienists who rest at lunch time. Factors influencing chemical exposure during work were the number of patients per day and the type of institute. Dental hygienists working in dental clinics or dealing with more patients had lower levels of perception. Conclusions: The sociodemographic and working characteristics of dental hygienists influence the perception of dental hygienists' environmental working conditions.

• Fire Science and Engineering
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• v.34 no.1
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• pp.89-102
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• 2020

Chemical terrorism using toxic and flammable gases, which could be fatal to the health of the human body, poses a serious threat to the security of most advanced countries, as well as those that are suffering from local disputes, due to the asymmetric information that exists between terrorist actors and victims. The countermeasures against chemical terrorism can be roughly divided into three stages: prevention, response, and probation. The critical factors for each professional response agency, and the personnel that determine the degree and range of chemical terrorism damage, are performing missions successfully in the process of the prevention and the response stage against chemical terrorism. To do this, conducting objective and systematical assessments on facilities that could potentially be the subject of chemical terrorism is more important than anything. In this study, we compared the existing domestic and foreign vulnerable classification systems for chemical terrorism, reviewed the current direction of improvement in domestic classification systems, and suggested more scientific and systematic methodologies through the vulnerability assessment on an actual public facility sample.

• Applied Chemistry for Engineering
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• v.20 no.2
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• pp.177-185
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• 2009

The failure analysis of scales deposited on automotive thermostat housing has been carried out. Observations using energy dispersive spectroscopy and electron probe micro analyzer indicate that the main components of scales are some of additives of coolant used. For a detailed investigation of organic matters pyrolysis-GC/MS is employed. The result shows that the main organic component is benzoic acid and furthermore, a small amount of acetophenone, benzene and phenyl group is detected. Based on the results of failure analysis performed, the scales on automotive thermostat housing appear due to the deposition of coolant components, followed by crevice corrosion, into gap between housing and rubber horse. New accelerated test methodology, which could mimic the scale formation and the crevice corrosion on thermostat housing, is developed considering the above results. In order to reproduce the real operating conditions, the accelerating factors, i.e. temperature and humidity, are changed and programmed. The reproducibility of the accelerated test proposed is confirmed after analyzing the scales obtained from the accelerated test.

• Applied Chemistry for Engineering
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• v.22 no.5
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• pp.453-460
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• 2011

Recently, there is growing interests in the application of supercritical fluids for food and medical fields since supercritical fluids ($CO_2$ and $N_2O$) have known to be safe and effective as a non-thermal sterilization technique. Although supercritical fluids have been investigated for various kinds of products, they have not yet been used in common currency due to their lack of knowledge related to the antimicrobial activity or detailed mechanisms. In this review paper, we summarized the characteristics, antimicrobial activity and mechanisms, important factors, and applicability of supercritical fluids to help the investigation and commercialization of supercritical fluids sterilization technique.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.33 no.3
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• pp.346-354
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• 2023

Objectives: Chemical accidents cause extensive human and environmental damage. Therefore, it is important to prepare measures to prevent their recurrence and minimize future damage through accident investigation. To this end, it is necessary to identify the accident occurrence process and analyze the extent of damage. In this study, the development process and damage range of actual chemical leakage accidents were analyzed using CFD. Methods: For application to actual chemical leakage accidents using FLACS codes specialized for chemical dispersion simulation among CFD codes, release rate calculation and 3D geometry were created, and scenarios for simulation were derived. Results: The development process of the accident and the dispersion behavior of materials were analyzed considering the influencing factors at the time of the accident. In addition, to confirm the validity of the results, we compared the results of the actual damage impact investigation and the simulation analysis results. As a result, both showed similar damage impact ranges. Conclusions: The FLACS code allows the detailed analysis of the simulated dispersion process and concentration of substances similar to real ones. Therefore, it is judged that the analysis method using CFD simulation can be usefully applied as a chemical accident investigation technique.

• Journal of the Korean Graphic Arts Communication Society
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• v.12 no.1
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• pp.47-65
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• 1994

Synthetic photoresist have partially displaced the natural materials, but bichromated casein have remained in use until recently at etching industry such as chemical milling. The object of this paper is that the mutual relations among factors and suitable latitude in pattern formation or etching process when is to be applied the casein ammonium bichromate photoresist.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.413-416
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• 2003

Hair fragility is a major concern to most people of African decent due to frequent chemical treatments, thermal appliance use and environmental exposure. It is extremely important to both cosmetic scientists and African-American consumers to understand the internal and external hair damage caused by these factors.(omitted)