• 한국농촌건축학회논문집
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• 제17권4호
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• pp.33-40
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• 2015

This study is aimed at exploring the direction and characteristics of Japanese medical facility improvement in each area, a move to strengthen local medical services. Also, this study is intended to establish implications for Korea, which has similar social conditions as Japan's. Based on the findings, Japanese medical facility improvement has the following characteristics. First, as for medical service supply system, the linkage between facilities was being strengthened. The purpose is to share the functions and roles of limited medical facilities. It allows patients to receive complete medical services in one area. Second, local public health facilities were consolidated to boost their management efficiency and to improvement their original functions. Third, local medical facility roles were divided into different levels. The purpose is to treat patients more efficiently depending on their diseases. In other words, the cooperative medical system was strengthened by dividing the roles of medical facilities. It is aimed at treating each patient more systematically depending on their conditions in line with the treatment stage. The findings suggest the following for Korea. In order to supply and maintain stable medical services regionally in line with social changes, functional issues of medical facilities should be tackled consistently and systematically.

• 한국가정과교육학회지
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• 제6권2호
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• pp.161-174
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• 1994

In this study, among the cognitive learning models for information process, Taba’s inductive thinking model and Joyce&Weil’s concept attainment model, which help to obtain and study the concepts, can be applied to the ranges of consumer-education. Considering this, a new teaching-paln can be made. Applying the plan to the present teaching environments. I will do the research possibilities of applying the concept-learning teaching-plan to the consumer education. In the method of this research, many books, related to home economics & consumer-education, characters of concept-learning, and concept teaching-learning models, were studied. Also, on the basis of theoretical evidence, the teaching-plan, that apply the concept teaching model, were made. In addition, experimental research was done to find out the possibilities that the plan focusing on concept learning was applied or not. As a result of this study, two points are briefly summarized : 1. The teaching plan using Taba’s and Joyce & Weil’s concept-attainment model was made. 2. Concept-learning in consumer-education didn’t have a great a great influence to the changes of consumer-roles and attitudes, but had a great influence to the effects of consumer concept-knowledge(p<0.01) The effects of consumer-knowledge had much relation to consumer-roles and attitudes. The learners whose grade is higher in attainments of consumer-knowledge, also have a high grade in consumer-roles and attitudes.

• Asia pacific journal of information systems
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• 제33권4호
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• pp.1171-1187
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• 2023

This study explores how an organization has successfully implemented ML-supported HR services to resolve high employee turnover problems in the IT sector. The empirical setting of the research is where contradicting institutional logics exist among technical, HR, and business groups regarding the ML model development and use of the model predictions in HR services. Institutional framework is used to identify the roles of organizational actors and the legitimacy structures in the organizational environments that can shape or constrain the ML led organizational changes. In institutional theories, technology adoption and organizational change are not only constrained by organizational context, but also fostered through organizational actors' roles and efforts to increase the legitimacy for the change. This research found that when multiple contradicting institutional logics exist, legitimizing the establishment of an enabling environment for multiple logics to reconcile and for the project to move forward is critical. Industry-wide conditions, previous experiences with the pilot ML project, forming a TFT with clearly defined roles and responsibilities, and relevant KPIs are found to legitimize the HR team and the business division to collaborate with the technical personnel to launch ML-supported HR services.

• 아동학회지
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• 제30권6호
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• pp.195-208
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• 2009

The main body of research literature on peer relations has focused on its effects on children's psychosocial and emotional development from preschool period to adolescence. Topics of the research generally consist of peer acceptance/rejection, friendships, and peer victimization. In the review of domestic and international research conducted since late 1990, research trends and issues are described in this paper. Findings suggest some measures in interventions, prevention, and policies in promoting positive peer relations. Some social skill trainings are needed for children to react appropriately in peer relations and get along with their peers. In addition, there is a need for differentiation of the intervention programs by participants' roles in bullying situations and gender of children. Moreover, a longitudinal research is required to enhance the understanding of developmental changes in peer relations.

• Reproductive and Developmental Biology
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• 제38권1호
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• pp.35-40
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• 2014

Beta-catenin (CTNNB1, catenin (cadherin-associated protein), beta 1) is involved in various biological processes, including embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. CTNNB1, as a multifunctional and oncogenic protein, has important roles in adhesion between Sertoli cells through an N-cadherin-dependent manner and in various cancer types through its over-activation. In addition, CTNNB1 can interact with estrogen/estrogen receptor alpha complex, which regulates the transcription of WNT (wingless-type MMTV integration site family)/CTNNB1 target genes. Recently, we investigated the functional roles and expression pattern of CTNNB1 during the morphological changes of embryonic gonads of chickens and the estrogen-dependent regulation of CTNNB1 in oviduct development and potential functions as a biomarker of CTNNB1 in human epithelial ovarian cancer using the chicken as a biological research model. Therefore, in this review, we provide a new insight of potential role of CTNNB1 in the development of the female reproductive tract during early embryogenesis and ovarian carcinogenesis of laying hen models.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8047-8052
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• 2016

Proteases are important molecules that are involved in many key physiological processes. Protease signaling pathways are strictly controlled, and disorders in protease activity can result in pathological changes such as cardiovascular and inflammatory diseases, cancer and neurological disorders. Many proteases have been associated with increasing tumor metastasis in various human cancers, suggesting important functional roles in the metastatic process because of their ability to degrade the extracellular matrix barrier. Proteases are also capable of cleaving non-extracellular matrix molecules. Inhibitors of proteases to some extent can reduce invasion and metastasis of cancer cells, and slow down cancer progression. In this review, we focus on the role of a few proteases and their inhibitors in tumors as a basis for cancer prognostication and therapy.

• Molecules and Cells
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• 제39권9호
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• pp.645-653
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• 2016

Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate's innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles of reward-related brain regions. Given the accumulated findings, a recent, emerging trend in morphine research is that of examining the dynamics of neuronal interactions in brain reward circuits under the influence of morphine action. In this review, we highlight recent findings on the roles of several reward circuits involved in morphine addiction based on pharmacological, molecular and physiological evidences.

• BMB Reports
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• 제56권2호
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• pp.49-55
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• 2023

Aging is characterized by a gradual decline in biological functions, leading to the increased probability of diseases and deaths in organisms. Previous studies have identified biological factors that modulate aging and lifespan, including non-coding RNAs (ncRNAs). Here, we review the relationship between aging and tRNA-derived small RNAs (tsRNAs), ncRNAs that are generated from the cleavage of tRNAs. We describe age-dependent changes in tsRNA levels and their functions in age-related diseases, such as cancer and neurodegenerative diseases. We also discuss the association of tsRNAs with aging-regulating processes, including mitochondrial respiration and reduced mRNA translation. We cover recent findings regarding the potential roles of tsRNAs in cellular senescence, a major cause of organismal aging. Overall, our review will provide useful information for understanding the roles of tsRNAs in aging and age-associated diseases.

• Molecules and Cells
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• 제40권9호
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• pp.607-612
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• 2017

When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the development of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.

• Architectural research
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• 제22권3호
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• pp.85-95
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• 2020

While there has been a substantial amount of studies on public rental housing of Korea, most have focused on housing policy changes, international comparisons, and current characteristics and future prospects. This article aims to examine the evolving roles of the national and local governments, and the private sector in provision of Korea's public rental housing. The findings suggest that one, although the wave of neoliberalism and financial crisis have prompted the national government to reduce its role and to encourage engagement of other actors by utilizing incentivizing tools, it has continued to assume a central position in formulating and implementing housing supply plans. Two, local governments have played a marginal role throughout the history of public rental housing supply, although they have expanded their participation through redevelopment projects and utilization of existing housings. Three, private sector actors have expanded their role to delivering public benefits of making housing available for a wider range of populace leveraging various incentives that make projects financially more feasible. The study poses a question on how responsibilities and risks can appropriately be allocated among three key actors to achieve housing welfare going forward.