• Proceedings of the Korean Society for Bioinformatics Conference
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• 2000.11a
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• pp.74-82
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• 2000

Prostate cancer initially responds and regresses in response to androgen depletion therapy, but most human prostate cancers will eventually recur, and re-grow as an androgen independent tumor. Once these tumors become hormone refractory, they usually are incurable leading to death for the patient. Little is known about the molecular details of how prostate cancer cells regress following androgen ablation and which genes are involved in the androgen independent growth following the development of resistance to therapy. Such knowledge would reveal putative drug targets useful in the rational therapeutic design to prevent therapy resistance and control androgen independent growth. The application of genome scale technologies have permitted new insights into the molecular mechanisms associated with these processes. Specifically, we have applied functional genomics using high density cDNA microarray analysis for parallel gene expression analysis of prostate cancer in an experimental xenograft system during androgen withdrawal therapy, and following therapy resistance, The large amount of expression data generated posed a formidable bioinformatics challenge. A novel template based gene clustering algorithm was developed and applied to the data to discover the genes that respond to androgen ablation. The data show restoration of expression of androgen dependent genes in the recurrent tumors and other signaling genes. Together, the discovered genes appear to be involved in prostate cancer cell growth and therapy resistance in this system. We have also developed and applied tissue microarray (TMA) technology for high throughput molecular analysis of hundreds to thousands of clinical specimens simultaneously. TMA analysis was used for rapid clinical translation of candidate genes discovered by cDNA microarray analysis to determine their clinical utility as diagnostic, prognostic, and therapeutic targets. Finally, we have developed a bioinformatic approach to combine pharmacogenomic data on the efficacy and specificity of various drugs to target the discovered prostate cancer growth associated candidate genes in an attempt to improve current therapeutics.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.5
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• pp.1198-1212
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• 2013

Network virtualization enables autonomous and heterogeneous Virtual Networks (VNs) to co-exist on a shared physical substrate. In a Network Virtualization Environment (NVE), the fact that individual VNs are underpinned by diverse naming mechanisms brings about an obvious challenge for transparent communication across multiple VN domains due to the complexity of uniquely identifying users. Existing solutions were mainly proposed compatible to Internet paradigm with little consideration of their applications in a virtualized environment. This calls for a scalable and efficient naming framework to enable consistent communication across a large user population (fixed or mobile) hosted by multiple VNs. This paper highlights the underlying technical requirements and presents a scalable Global Naming Framework (GNF), which (1) enables transparent communication across multiple VNs owned by the same or different SPs; (2) supports communication in the presence of dynamics induced from both VN and end users; and (3) greatly reduces the network operational complexity (space and time). The suggested approach is assessed through extensive simulation experiments for a range of network scenarios. The numerical result clearly verifies its effectiveness and scalability which enables its application in a large-scale NVE without significant deployment and management hurdles.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.4
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• pp.1779-1798
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• 2018

Heterogeneous wireless sensor networks (HEWSN) is a kind of wireless sensor networks (WSN), each sensor may has different attributes, HEWSN has been widely used in many aspects. Due to sensors are deployed in unattended environments and its resource constrained feature, the design of security and efficiency balanced authentication scheme for HEWSN becomes a vital challenge. In this paper, we propose a secure and lightweight user authentication and key agreement scheme based on biometric for HEWSN. Firstly, fuzzy extractor is adopted to handle the user's biometric information. Secondly, we achieve mutual authentication and key agreement among three entities, which are user, gateway and cluster head in the four phases. Finally, formal security analysis shows that the proposed scheme defends against various security pitfalls. Additionally, comparison results with other surviving relevant schemes show that our scheme is more efficient in term of computational cost, communication cost and estimated time. Therefore, the proposed scheme is well suitable for practical application in HEWSN.

• Structural Engineering and Mechanics
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• v.17 no.3_4
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• pp.429-444
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• 2004

The ambient vibration measurement is a kind of output data-only dynamic testing where the traffics and winds are used as agents responsible for natural or environmental excitation. Therefore an experimental modal analysis procedure for ambient vibration testing will need to base itself on output-only data. The modal analysis involving output-only measurements presents a challenge that requires the use of special modal identification technique, which can deal with very small magnitude of ambient vibration contaminated by noise. Two complementary modal analysis methods are implemented. They are rather simple peak picking (PP) method in frequency domain and more advanced stochastic subspace identification (SSI) method in time domain. This paper presents the application of ambient vibration testing and experimental modal analysis on large civil engineering structures. A 15 storey reinforced concrete shear core building and a concrete filled steel tubular arch bridge have been chosen as two case studies. The results have shown that both techniques can identify the frequencies effectively. The stochastic subspace identification technique can detect frequencies that may possibly be missed by the peak picking method and gives a more reasonable mode shapes in most cases.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.434-442
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• 2016

Jansen mechanism is composed of mechanical walking linkages that are designed and optimized by Theo Jansen in 1990. Although he has made optimum values for linkage dimensions for Jansen Mechanism, there are still various applications for this mechanism and also various optimum values for each application. In this paper, Jansen Mechanism optimization has been processed for the Science Box. The Science Box has its own linkage dimensions and related components and makes space for optimization process. For the optimization 3 to 4 linkage were selected which had no similar ratios of linkages between other applied Jansen mechanisms and to reduce experiment numbers. Response Surface Method was used with Minitab 17 for optimization and m.sketch was used for experimentation. Intuitive method had to be used to find optimum values as with RSM optimum value could not be found. EDISON Designer was used to make final CAD model with optimum values and laser cutter was used to get appropriate acryl panels for legs.

• International Journal of Fluid Machinery and Systems
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• v.4 no.2
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• pp.271-288
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• 2011

The mathematical modelling of screw compressor processes and its implementation in their design began about 30 years ago with the publication of several pioneering papers on this topic, mainly at Purdue Compressor Conferences. This led to the gradual introduction of computer aided design, which, in turn, resulted in huge improvements in these machines, especially in oil-flooded air compressors, where the market is very competitive. A review of progress in such methods is presented in this paper together with their application in successful compressor designs. As a result of their introduction, even small details are now considered significant in efforts to improve performance and reduce costs. Despite this, there are still possibilities to introduce new methods and procedures for improved rotor profiles, design optimisation for each specified duty and specialized compressor design, all of which can lead to a better product and new areas of application. A review of methods and procedures which lead to modern screw compressor practice is presented in this paper. This paper is intended to give a cross section through activities being done in mathematical modelling of screw compressor process through last five decades. It is expected to serve as a basis for further contributions in the area and as a challenge to the forthcoming generations of scientists and engineers to concentrate their efforts in finding future and more extended approaches and submit their contributions.

• Journal of The Korean Association of Information Education
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• v.23 no.5
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• pp.441-449
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• 2019

With the introduction of the 2015 revised curriculum, software education became mandatory in elementary school. The practical subject in the content for the software education consists of information ethics, algorithms, programming, and computer science. Especially, elementary school encourages the unplugged activities. Unplugged activities are preferred among the teachers in the education field as a teaching-learning method. However, those teachers pointed out that the lack of suitable unplugged activity materials was the biggest challenge. In addition, it was pointed out that the existing materials were not suitable for achievement standards, and there are many simple playing-oriented educations that are not linked to computing activities. In this study, we developed an unplugged activity-oriented robot that can be used for the elementary students to learn the basic control structure suggested in the achievement criteria SW education and to develop creative problem solving ability through various activities using sensors. The effectiveness was verified through the software class using the developed robot in this study.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2021.11a
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• pp.201-202
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• 2021

Regulations on greenhouse gases emitted from ships in international shipping are being strengthened, and the greenhouse gas reduction target established by the International Maritime Organization is acting as a great challenge for shipping companies in terms of technical and operational aspects. The International Maritime Organization aims to reduce carbon intensity by 30% by 2030, 70% by 2050, and by 50% in terms of gross emissions compared to 2008. To realize this situation, the IMO adopted some short-term and mid-to-long-term measures and adopted technical measures such as the application of EEXI, an energy efficiency index, to existing ships from 2023, and the early application of EEDI phase 3 for some tpe of ships. In addition, reduction measures were introduced to reduce greenhouse gas in the operational aspect.

• BMB Reports
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• v.37 no.3
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• pp.269-274
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• 2004

DNA polymerases without the 3' exonuclease function ($exo^-$ pol) have been widely used in sequencing and SNP genotyping. As a major player that expedited the coming of the postgenomic era, $exo^-$ polymerases worked remarkably well in the Human Genome Sequencing Project. However, it has become a challenge for this class of polymerases to efficiently screen the large number of SNPs that are found in the human genome. For more than three decades it has been recognized that polymerase fidelity varied according to the presence of proofreading activity that is mediated by its internal 3' exonuclease. Polymerases with proofreading function are famous for their high fidelity in DNA replication both in vivo and in vitro, but this well-known class of polymerases has been almost completely neglected in genetic analysis in the postgenomic era. We speculate that $exo^+$ polymerases may exhibit higher nucleotide identification ability when compared to $exo^-$ polymerases for an in vitro genetic analysis. With the application of $exo^+$ polymerases in SNP assays, a novel mechanism for the maintenance of DNA replication, the on/off switch, was discovered. Two new SNP assays have been developed to carry out genome-wide genotyping, taking advantage of the enzymatic properties of $exo^+$ polymerases. Furthermore, the on/off switch mechanism embodies a powerful nucleotide identification ability, which can be used to discriminate the bases that are upstream of the 3' terminus, and thus defines a new concept in de novo sequencing technology. Application of $exo^+$ polymerases to genetic analysis, and especially SNP assays, will greatly accelerate the pace to personalized medicine.

• Journal of Korea Society of Industrial Information Systems
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• v.15 no.2
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• pp.59-67
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• 2010

Rice varietal information exchange is vital for agricultural experiments and trials. With the growing size of rice data gathered around the world, and numerous research and development achievements, the effective collection and convenient ways of data dissemination is an important aspect to be dealt with. The collection of this data is continuously worked out through various international cooperation and network programs. The problem in acquiring this information anytime anywhere is the new challenge faced by rice breeders, scientist and crop information specialists, in order to perform rapid analysis and obtain significant results in rice research, thus alleviating rice production. To address these constraints, we propose an Online Analytical Query System, a web query application to provide breeders and rice scientist around the world a fast web search engine for rice varieties, giving the users the freedom to choose from which trial it has been used, trait observation parameters as well as geographical or weather conditions, and location specifications. The application uses data warehouse techniques and OLAP for summarization of agricultural trials conducted, and statistical analysis in deriving outstanding varieties used in these trials, consolidated in an Model-View-Controller Web framework.