• Structural Engineering and Mechanics
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• v.62 no.6
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• pp.759-769
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• 2017

The effect of central axial load on natural frequencies of various thin-walled beams, are investigated by some researchers using different methods such as finite element, transfer matrix and dynamic stiffness matrix methods. However, there are situations that the load will be off centre. This type of loading is called eccentric load. The effect of the eccentricity of axial load on the natural frequencies of asymmetric thin-walled beams is a subject that has not been investigated so far. In this paper, the mentioned effect is studied using exact dynamic stiffness matrix method. Flexure and torsion of the aforesaid thin-walled beam is based on the Bernoulli-Euler and Vlasov theories, respectively. Therefore, the intended thin-walled beam has flexural rigidity, saint-venant torsional rigidity and warping rigidity. In this paper, the Hamilton‟s principle is used for deriving governing partial differential equations of motion and force boundary conditions. Throughout the process, the uniform distribution of mass in the member is accounted for exactly and thus necessitates the solution of a transcendental eigenvalue problem. This is accomplished using the Wittrick-Williams algorithm. Finally, in order to verify the accuracy of the presented theory, the numerical solutions are given and compared with the results that are available in the literature and finite element solutions using ABAQUS software.

• Structural Engineering and Mechanics
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• v.38 no.3
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• pp.261-281
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• 2011

A new method of formulation of a class of elements that are immune to mesh distortion effects is proposed here. The simple three-noded bar element with an offset of the internal node from the element center is employed here to demonstrate the method and the principles on which it is founded upon. Using the function space approach, the modified formulation is shown here to be superior to the conventional isoparametric version of the element since it satisfies the completeness requirement as the metric formulation, and yet it is in agreement with the best-fit paradigm in both the metric and the parametric domains. Furthermore, the element error is limited to only those that are permissible by the classical projection theorem of strains and stresses. Unlike its conventional counterpart, the modified element is thus not prone to any errors from mesh distortion. The element formulation is symmetric and thus satisfies the requirement of the conservative nature of problems associated with all self-adjoint differential operators. The present paper indicates that a proper mapping set for distortion immune elements constitutes geometric and displacement interpolations through parametric and metric shape functions respectively, with the metric components in the displacement/strain replaced by the equivalent geometric interpolation in parametric co-ordinates.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.21 no.9
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• pp.818-824
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• 2008

The Separated Pulsed Laser Deposition (SPLD) technique uses two chambers that are separated by a conic metallic wall with a central orifice. The pressures of ablation chamber and deposition chamber were controlled by the differential vacuum system. We deposited zinc oxide (ZnO) thin films by SPLD method to obtain high quality thin films. When the bias voltage of +500 V was applied between a substrate and an orifice, the ZnO thin film was deposited efficiently. The deposited ZnO thin film at ablation chamber gas pressure of Ar 5 mTorr showed the sharpest ultraviolet absorption edge indicatory the band gap of about 3.1 eV. ZnO thin films were deposited using effect of electric and magnetic fields in the SPLD method. E${\times}$B drift happened by an electric fields and a magnetic fields, activated plasma plume, as a result the film surface became very smooth. When the bias voltage of +500 V and magnet of 0,1 T were applied the ZnO thin films surface state showed high quality. Grain size was 41.99 nm and RMS was 0.84 nm.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.185-190
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• 2002

To improve the solubility of poorly water-soluble drug and to develop a sustained release tablets, the need for the technique, the formation of solid dispersion with polymeric materials that can potentially enhance the dissolution rate and extent of drug absorption was considered in this study. The 1:1, 1:4, and 1:5 solid dispersions were prepared by spray drying method using PVP K30, ethanol and methylene chloride. The dissolution test was carried out at in phosphate buffer solution at $37^{\circ}C$ in 100 rpm. Solid dispersed drugs were examined using differential scanning calorimetry and scanning electron microscopy, wherein it was found that felodipine is amorphous in the PVP K30 solid dispersion. Felodifine SR tablets were prepared by direct compressing the powder mixture composed of solid dispersed felodipine, lactose, Eudragit and magnesium stearate using a single punch press. In order to develop a sustained-release preparation containing solid dispersed felodipine, a comparative dissolution study was done using commercially existing product as control. The dissolution rate of intact felodipine, solid dispersed felodipine and its physical mixture, respectively, were compared by the dissolution rates for 30 minutes. The dissolution rates of felodipine for 30 minutes from 1:1, 1:4, 1:5 PVP K30 solid dispersion were 70%, 78% and 90%. However, dissolution rate offelodipine from the physical mixture was 5% of drug for 30 minutes. Our developed product Felodipine SR Tablet showed dissolution of 17%, 50% and 89% for 1, 4, and 7 hours. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. The dissolution rate of felodipine was significantly enhanced, following the formation of solid dispersion. The solid dispersion technique with water-soluble polymer could be used to develop a solid dispersed felodipine SR tablet.

• Steel and Composite Structures
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• v.25 no.2
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• pp.141-155
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• 2017

This paper presents an investigation into the magneto-thermo-mechanical vibration and damping of a viscoelastic functionally graded-carbon nanotubes (FG-CNTs)-reinforced curved microbeam based on Timoshenko beam and strain gradient theories. The structure is surrounded by a viscoelastic medium which is simulated with spring, damper and shear elements. The effective temperature-dependent material properties of the CNTs-reinforced composite beam are obtained using the extended rule of mixture. The structure is assumed to be subjected to a longitudinal magnetic field. The governing equations of motion are derived using Hamilton's principle and solved by employing differential quadrature method (DQM). The effect of various parameter like volume percent and distribution type of CNTs, temperature change, magnetic field, boundary conditions, material length scale parameter, central angle, viscoelastic medium and structural damping on the vibration and damping behaviors of the nanocomposite curved microbeam is examined. The results show that with increasing volume percent of CNTs and considering magnetic field, material length scale parameter and viscoelastic medium, the frequency of the system increases and critically damped situation occurs at higher values of damper constant. In addition, the structure with FGX distribution type of CNTs has the highest stiffness. It is also observed that increasing temperature, structural damping and central angle of curved microbeam decreases the frequency of the system.

• Journal of the Korean housing association
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• v.20 no.5
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• pp.9-21
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• 2009

This study classified visual perception types of access space at 17 five-star hotels in Jejudo and examined their cognitive characteristics and image formation structures in an effort to provide basic information important for designing the elevation and the access spaces of a hotel. The results of this study are as follows. Access space image of experimental hotels showed more negative evaluations at both city hotels and resort hotels, viewing angle (upward angle) was also positively evaluated between $10^{\circ}{\sim}12^{\circ}$ and $18^{\circ}$ and central type in arrangement type and detour access and straight access types in access circulation type were positively evaluated. When viewed from an upward angle of $10^{\circ}$ to $12^{\circ}$, the most important factors were as plasticity, decorativeness, and creativity; from $18^{\circ}$ it was such factors as harmony and peculiarity; and at $45^{\circ}$ it was factors like decorativeness and stability. In considering the various access types, the most important factors in a straight access type were peculiarity and harmony; for one-time curved access type it was by decorativeness, creativity, Peculiarity, and stability; and for detour access types it was decorativeness, stability, and peculiarity. Influential of factors affecting image formation and plasticity and harmony factors and the form had more influences on image formation.

• Steel and Composite Structures
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• v.26 no.6
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• pp.673-691
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• 2018

The main goal of this research is to examine the in-plane and out-of-plane forced vibration of a curved nanocomposite microbeam. The in-plane and out-of-plane displacements of the structure are considered based on the first order shear deformation theory (FSDT). The curved microbeam is reinforced by functionally graded carbon nanotubes (FG-CNTs) and thus the extended rule of mixture is employed to estimate the effective material properties of the structure. Also, the small scale effect is captured using the strain gradient theory. The structure is rested on a nonlinear orthotropic viscoelastic foundation and is subjected to concentrated transverse harmonic external force, thermal and magnetic loads. The derivation of the governing equations is performed using energy method and Hamilton's principle. Differential quadrature (DQ) method along with integral quadrature (IQ) and Newmark methods are employed to solve the problem. The effect of various parameters such as volume fraction and distribution type of CNTs, boundary conditions, elastic foundation, temperature changes, material length scale parameters, magnetic field, central angle and width to thickness ratio are studied on the frequency and force responses of the structure. The results indicate that the highest frequency and lowest vibration amplitude belongs to FGX distribution type while the inverse condition is observed for FGO distribution type. In addition, the hardening-type response of the structure with FGX distribution type is more intense with respect to the other distribution types.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6069-6075
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• 2013

Background: At present, the diagnosis of colorectal cancer (CRC) requires a colorectal biopsy which is an invasive procedure. We undertook this pilot study to develop an alternative method and potential new biomarkers for diagnosis, and validated a set of well-integrated tools called ClinProt to investigate the serum peptidome in CRC patients. Methods: Fasting blood samples from 67 patients diagnosed with CRC by histological diagnosis, 55 patients diagnosed with colorectal adenoma by biopsy, and 65 healthy volunteers were collected. Division was into a model construction group and an external validation group randomly. The present work focused on serum proteomic analysis of model construction group by ClinProt Kit combined with mass spectrometry. This approach allowed construction of a peptide pattern able to differentiate the studied populations. An external validation group was used to verify the diagnostic capability of the peptidome pattern blindly. An immunoassay method was used to determine serum CEA of CRC and controls. Results: The results showed 59 differential peptide peaks in CRC, colorectal adenoma and health volunteers. A genetic algorithm was used to set up the classification models. Four of the identified peaks at m/z 797, 810, 4078 and 5343 were used to construct peptidome patterns, achieving an accuracy of 100% (> CEA, P<0.05). Furthermore, the peptidome patterns could differentiate the validation group with high accuracy close to 100%. Conclusions: Our results showed that proteomic analysis of serum with MALDI-TOF MS is a fast and reproducible approach, which may provide a novel approach to screening for CRC.

• The Korean Journal of Ecology
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• v.18 no.1
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• pp.63-87
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• 1995

The present study was undertaken to classify and describe the Quercus mongolica forest on Mt. Sobaek (36°50'∼ 37°07'N, 128°25'∼ 128°35'E), Korea by a reciprocal averaging methol (RA ordination) and the methodology of the ZM school of phytosociology. Atemporal vegetation tabel was prepared by the RA ordination. As a result it showed that the RA ordination on the first axis is very applicable for selecting the character and differential species of vegetation units of the Quercus mongolica forest. The phytosociological investigations were carried out in 34 stands on the mountain. The field data obtained were classified by the tabel comparison method. For the establishment of new vegetation units, the floristic composition of the Quercus mongolica forest was compared with those of the other vegetation units of the Mt. Sobaek, Considering the candidates of the character and differential species derived from RA ordination. As the result, the forest vegetation was classified into the following vegetation units; Fagetea crenatae Miyawaki et al. 1968 Acero-Quercetalia mongolicas Song 1988 em. Takeda et al.1994 Lindero-Quercetalia mongolicae Kim 1990 1. Lindero-Quercetum mongolicae assoc. nov. 1-1. quercetosum serratae subassoc. nov 1-2. typicum subassoc. nov. Rhododendro-Qurcion mongolicas Song 1988 em. Takeda et al. 1994. It is inferred that the Lindero-Quercion mongolicae and the Rhododendro-Quercion mongolicae corresponded to the cool-temperate forests of central and northern areas, respectively, in Korean Peninsula. Syntaxonomical synonyms were also rearranged based on the result of the present study. On the other hand, the RA ordination of stands and species on the first and second axes revealed some environmental gradients such as altitute, human impact and species richness between the vegetation units. However, the RA ordinations is considered to be less indicative for the gradients of the lower vegetation units than association. With the present study. some phytosociological problems in Korea were discussed here in detail from the floristic viewpoint.

• Journal of the wind engineering institute of Korea
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• v.22 no.4
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• pp.155-161
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• 2018

In modern society, damage caused by strong winds such as typhoons is expected to increase due to urbanization and global warming. In order to test the reinforcement performance of the newly developed window protection device, two-point force test and uniformly distributed load test were carried out on non-reinforced plate glass. It reinforcement performance of the window protection device was evaluated based on the flexural performance improvement. The analytical performance of the window protection device was evaluated by analysis using differential equations of elastic loading method and deflection curve and Midas-Gen. First, the analytical window protection device was evaluated by formulae derived using differential equations of elastic loading and deflection curve. The validity of the derived formulae investigated by comparing the maximum deflection of the central part of the plate with the experimental value and the theoretical value at maximum load. Then the results were compared with those by finite element FE method using Midas-Gen. Under the experimental conditions, with the window protection device, stress reduction effect up to 40% and deflection reduction up to 71.4% under the same load were obtained. It was also found that it is advantageous to perform the FE analysis using the plate element when the performance is evaluated because the error of FE analysis result using plate elements is far less than that using beam elements.