• Biomolecules & Therapeutics
• /
• v.29 no.2
• /
• pp.184-194
• /
• 2021

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been made to find drugs or small molecules such as HDAC inhibitors that can revert acetylation levels to normal in cancer cells. We observed dose-dependent reduction in the endogenous and exogenous protein expression levels of KAT8 (also known as human MOF), a member of the MYST family of HATs, and its corresponding histone acetylation at H4K5, H4K8, and H4K16 in chemotherapy drug gemcitabine (GEM)-exposed T24 bladder cancer (BLCA) cells. Interestingly, the reduction in MOF and histone H4 acetylation was inversely proportional to GEM-induced γH2AX, an indicator of chemotherapy drug effectiveness. Furthermore, pGL4-MOF-Luc reporter activities were significantly inhibited by GEM, thereby suggesting that GEM utilizes an MOF-mediated anti-BLCA mechanism of action. In the CCK-8, wound healing assays and Transwell® experiments, the additive effects on cell proliferation and migration were observed in the presence of exogenous MOF and GEM. In addition, the promoted cell sensitivity to GEM by exogenous MOF in BLCA cells was confirmed using an Annexin V-FITC/PI assay. Taken together, our results provide the theoretical basis for elucidating the anti-BLCA mechanism of GEM.

• (The)Study of the Eastern Classic
• /
• no.66
• /
• pp.277-301
• /
• 2017

The modern political scientist Liang, qi-chao (1873-1929), who insisted on the richness of China, was a major axis of Korean intellectuals in the nineteenth century. His patriotism for Chinese reconstruction oppressed by Western powers has greatly influenced Korea 's will to build a modern nation. There was military power and physical education at the center of Liang, qi-chao thought. He emphasized military strength through military strength with a strong stamina, so he mentioned the necessity of military and physical education. Based on the idea of this kind of Liang, qi-chao, the korean intellectuals believed that the Korean people should be born healthy through physical education. The initial introduction of physical education in Korea was integrated with the Military Sports. For the first time, Being introduced Western Sports in 1895, The fact that the army athletic gymnastics was first introduced into school education in 1896 proves this oneness. Moreover, Ethnic scholars continued to focus on fostering strong nationality through physical education based on the spirit of Liang, qi-chao, and was emphasizing the gymnastics of the military sportsman at the central idea.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.24 no.4
• /
• pp.392-402
• /
• 2021

Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk proteinfree complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.

• Atmosphere
• /
• v.31 no.1
• /
• pp.17-28
• /
• 2021

We investigated the impact of domain size on the simulated summer precipitation over the Korean Peninsula using the Weather Research and Forecasting (WRF) model. Two different domains are integrated up to 72-hours from 29 June 2017 to 28 July 2017 when the Changma front is active. The domain sizes are adopted from previous RDAPS (Regional Data Assimilation and Prediction System) and current LDAPS (Local Data Assimilation and Prediction System) operated by the Korea Meteorological Administration, while other model configurations are fixed identically. We found that the larger domain size showed better prediction skills, especially in precipitation forecast performance. This performance improvement is particularly noticeable over the central region of the Korean Peninsula. Comparisons of physical aspects of each variable revealed that the inflow of moisture flux from the East China Sea was well reproduced in the experiment with a large model domain due to a more realistic North Pacific high compared to the small domain experiment. These results suggest that the North Pacific anticyclone could be an important factor for the precipitation forecast during the summer-time over the Korean Peninsula.

• Journal of Information Technology Services
• /
• v.20 no.1
• /
• pp.29-40
• /
• 2021

North Korea's science and technology policies are being pursued under strong leadership and control by the central government. In particular, a large part of the research and development of science and technology related to the Fourth Industrial Revolution in North Korea is controlled and absorbed by the defense organizations under the national defense-oriented policy framework, among which North Korea is making national efforts to develop advanced technologies in artificial intelligence and actively utilize them in the military affairs. The future weapon system based on AI will have superior performance and destructive power that is different from modern weapons systems, which is likely to change the paradigm of the future battlefield, so a thorough analysis and prediction of the level of AI militarization technology, the direction of development, and AI-based weapons system in North Korea is needed. In addition, research and development of South Korea's corresponding weapon systems and military science and technology are strongly required as soon as possible. Therefore, in this paper, we will analyze the level of AI technology, the direction of AI militarization, and the AI-based weapons system in North Korea, and discuss the AI military technology and corresponding weapon systems that South Korea military must research and develop to counter the North Korea's. The next study will discuss the analysis of AI militarization technologies not only in North Korea but also in neighboring countries in Northeast Asia such as China and Russia, as well as AI weapon systems by battlefield function, detailed core technologies, and research and development measures.

• The Journal of the Korea Contents Association
• /
• v.21 no.5
• /
• pp.105-117
• /
• 2021

This study examined the factors that influence the emotional expression in comments on the hot news about the 'Restaurant Collapse in Linfen City, Shanxi Province' published in Sina Weibo.. As a result of the study, first, there were differences in emotional expression according to gender. Women expressed stronger anger, disappointment, sadness, and condemnation than men. Second, the intensity of emotional expression of users in the eastern region was significantly higher than that of users in the central and western region. Third, the greater the number of Weibo, the total number of blogs where users participated in comments and posted emotional expressions, the stronger the emotional expression was. Fourth, unauthenticated users showed stronger emotional expressions of disappointment and sadness than authenticated users. The results of this study present implications for the factors influencing emotional expression on hot news. This study is meaningful in that it can be compared with social networks such as Twitter and Facebook in the West by looking at the factors that influence emotional expression in the process of online public opinion formation in China, and also meaningful in that a big data analysis method was used in online news analysis.

• Journal of Creative Information Culture
• /
• v.7 no.2
• /
• pp.111-118
• /
• 2021

In order to establish the correct direction for the use of digital textbooks in the future, it is necessary to derive implications for improving the domestic digital textbook utilization policy by analyzing the actual conditions of other countries that are already using digital textbooks. Therefore, in this paper, we compared the policies of using digital textbooks in the United States, Canada, Malaysia, and China, and reviewed ways to improve Korea's digital textbook policies. First, each country's digital textbook promotion subject and strategy, scope of use, issuance system, and usage method were compared, and then the implications of each country's digital textbook policy were analyzed. And based on these implications, a plan to improve Korea's digital textbook policy was suggested. It is expected that this will be used as meaningful basic data in preparing policies for the development of digital textbooks in the future.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.11
• /
• pp.295-304
• /
• 2022

The purpose of this study is to investigate the influencing factors and mechanism of the characteristics of the live broadcast e-commerce platform and the characteristics of the host on the impulse purchase intention of live broadcast viewers. Based on the ELM model, this study complements existing research content. This study adopts the form of questionnaire survey and conducts empirical analysis using SPSS, AMOS, Mplus and other analysis software for online live broadcast users. The results show that the characteristics of live broadcast platforms have a positive impact on consumers' flow experience and satisfaction; the personal characteristics of anchors have a positive impact on consumers' flow experience and satisfaction; consumers' flow experience and satisfaction have a positive impact on impulse Purchase intention has a positive impact, and flow experience and satisfaction have a mediating effect on the characteristics of the live broadcast platform and the personal characteristics of the host.

• Journal of Oriental Neuropsychiatry
• /
• v.33 no.3
• /
• pp.301-316
• /
• 2022

Objectives: To compare Korean medicine (KM) and traditional Chinese medicine (TCM) psychotherapy for anxiety. Methods: Databases including MEDLINE (via PubMed), EMBASE (via Elsevier), Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, and Oriental Medicine Advanced Searching Integrated System were comprehensively searched. Prospective clinical studies on KM or TCM psychotherapy for patients with anxiety disorder or individuals with elevated anxiety levels published up to August 3, 2022 were reviewed. Psychotherapy was divided into counselling, art therapy, and meditation according to its characteristics. Results: A total of 12 clinical studies were reviewed, including nine randomized controlled trials. The most common disorder investigated was post-traumatic stress disorder. Ten studies used TCM psychotherapy and two used KM psychotherapy. As for differences between TCM psychotherapy and KM psychotherapy, TCM psychotherapy utilized pattern identification in the procedure more actively than KM psychotherapy. In addition, some TCM studies have attempted to directly converge Western psychotherapy (i.e., hypnosis) and Eastern psychotherapy (i.e., Taoin qigong therapy). In the case of KM psychotherapy, there was an attempt to incorporate psychotherapy with Sasang constitutional medicine. Reported effects of TCM psychotherapy and KM psychotherapy on anxiety were positive. Conclusions: Research status of KM psychotherapy and TCM psychotherapy for anxiety was investigated, revealing some of their characteristics, commonalities, and differences. Findings of this review have the potential to provide a clue to the development of conventional KM psychotherapy and new medical technology for KM psychotherapy.

• Journal of architectural history
• /
• v.31 no.4
• /
• pp.71-86
• /
• 2022

This study examines the process of the introduction of stupa, which has originated in India, to the Xinjiang Uyghur region and the features of the stupas in the Xinjiang Uyghur region in detail. This study examines the layout of the buildings in temple compounds and the types, structural elements, and construction methods of the stupas in the Xinjiang Uyghur region in particular by looking into the content of the Da Tang Xi Yu Ji and remaining stupas, which provide examples of stupas at the time. This study finds that due to the characteristics of dry deserts, stupas in Xinjiang Uyghur region, where assimilation between Eastern and Western cultures is seen, were mostly made by pressing clay into a mold and had no interior spaces. Also, construction materials and techniques had been developed and improved in a way that enabled stupas to combat the challenging desert conditions. However, the stupas in this region differed significantly from the wooden tower-like stupas discovered in central China(zhongyuan 中原). The shape of the dome of most stupas in Xinjiang Uyghur region was chosen under the influence of the Gandharan style. Some of the stupas in the region have taken the general forms of the wooden stupas and the others have taken many forms, from cylindrical drums to towers. Also, there have been forests of stupas and stupas similar in form to chaityas and stupas of Vajrayana. Such different forms were transformed and modified through regional history and it was related to the peoples and cultures that produced and used stupas. Stupas evolved into distinct forms in Xinjiang Uyghur region in this way.