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The In Vivo and In Vitro Effects of Terminalia bellirica (Gaertn.) Roxb. Fruit Extract on Testosterone-Induced Hair Loss

  • Min Jeong Woo;Ha Yeong Kang;So Jeong Paik;Hee Jung Choi;Salah Uddin;Sangwoo Lee;Soo-Yong Kim;Sangho Choi;Sung Keun Jung
    • Journal of Microbiology and Biotechnology
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    • v.33 no.11
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    • pp.1467-1474
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    • 2023
  • Due to the continuous increase in patients with androgenetic alopecia (AGA) and psychological disorders such as depression and anxiety, the demand for hair loss treatment and effective hair growth materials has increased. Terminalia bellirica (Gaertn.) Roxb. (TBE) reportedly exerts anti-inflammatory, hepatoprotective, and antidiabetic effects, among others, but its effects on testosterone (TS)-inhibited hair growth remains unclear. In this study, we evaluated the effects of TBE on TS-induced hair growth regression in human follicle dermal papilla cells (HFDPCs) and C57BL/6 mice. Oral administration of TBE increased TS-induced hair growth retardation. Interestingly, effects were greater when compared with finasteride, a commercial hair loss treatment product. Histological analyses revealed that oral TBE administration increased hair follicles in the dorsal skin of C57BL/6 mice. Additionally, western blotting and immunofluorescence showed that oral TBE administration recovered the TS-induced inhibition of cyclin D1, proliferating cell nuclear antigen (PCNA), and Ki67 expression in vivo. Using in vitro proliferation assays, TBE promoted HFDPC growth, which was suppressed by TS treatment. Thus, TBE may be a promising nutraceutical for hair health as it promoted hair growth in AGA-like in vitro and in vivo models.

Comparison of Novel Telemonitoring System Using the Single-lead Electrocardiogram Patch With Conventional Telemetry System

  • Soonil Kwon;Eue-Keun Choi;So-Ryoung Lee;Seil Oh;Hee-Seok Song;Young-Shin Lee;Sang-Jin Han;Hong Euy Lim
    • Korean Circulation Journal
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    • v.54 no.3
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    • pp.140-153
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    • 2024
  • Background and Objectives: Although a single-lead electrocardiogram (ECG) patch may provide advantages for detecting arrhythmias in outpatient settings owing to user convenience, its comparative effectiveness for real-time telemonitoring in inpatient settings remains unclear. We aimed to compare a novel telemonitoring system using a single-lead ECG patch with a conventional telemonitoring system in an inpatient setting. Methods: This was a single-center, prospective cohort study. Patients admitted to the cardiology unit for arrhythmia treatment who required a wireless ECG telemonitoring system were enrolled. A single-lead ECG patch and conventional telemetry were applied simultaneously in hospitalized patients for over 24 hours for real-time telemonitoring. The basic ECG parameters, arrhythmia episodes, and signal loss or noise were compared between the 2 systems. Results: Eighty participants (mean age 62±10 years, 76.3% male) were enrolled. The three most common indications for ECG telemonitoring were atrial fibrillation (66.3%), sick sinus syndrome (12.5%), and atrioventricular block (10.0%). The intra-class correlation coefficients for detecting the number of total beats, atrial and ventricular premature complexes, maximal, average, and minimal heart rates, and pauses were all over 0.9 with p values for reliability <0.001. Compared to a conventional system, a novel system demonstrated significantly lower signal noise (median 0.3% [0.1-1.6%] vs. 2.4% [1.4-3.7%], p<0.001) and fewer episodes of signal loss (median 22 [2-53] vs. 64 [22-112] episodes, p=0.002). Conclusions: The novel telemonitoring system using a single-lead ECG patch offers performance comparable to that of a conventional system while significantly reducing signal loss and noise.

Measurements of mid-frequency transmission loss in shallow waters off the East Sea: Comparison with Rayleigh reflection model and high-frequency bottom loss model (동해 천해환경에서 측정된 중주파수 전달손실 측정: Rayleigh 및 HFBL 모델과의 비교)

  • Lee, Dae Hyeok;Oh, Raegeun;Choi, Jee Woong;Kim, Seongil;Kwon, Hyuckjong
    • The Journal of the Acoustical Society of Korea
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    • v.40 no.4
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    • pp.297-303
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    • 2021
  • When sound waves propagate over long distances in shallow water, measured transmission loss is greater than predicted one using underwater acoustic model with the Rayleigh reflection model due to inhomogeneity of the bottom. Accordingly, the US Navy predicts sound wave propagation by applying the empirical formula-based High Frequency Bottom Loss (HFBL) model. In this study, the measurement and analysis of transmission loss was conducted using mid-frequency (2.3 kHz, 3 kHz) in the shallow water of the East Sea in summer. BELLHOP eigenray tracing output shows that only sound waves with lower grazing angle than the critical angle propagate long distances for several kilometers or more, and the difference between the predicted transmission loss based on the Rayleigh reflection model and the measured transmission loss tend to increase along the propagation range. By comparing the Rayleigh reflection model and the HFBL model at the high grazing angle region, the bottom province, the input value of the HFBL model, is estimated and BELLHOP transmission loss with HFBL model is compared to measured transmission loss. As a result, it agrees well with the measurements of transmission loss.

Comparison of Seed Viability Among 42 Species Stored in a Genebank

  • Lee, Ho-Sun;Jeon, Young-Ah;Lee, Young-Yi;Lee, Sok-Young;Kim, Yeon-Gyu
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.58 no.4
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    • pp.432-438
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    • 2013
  • This study was conducted to compare seed viability among 42 species after ten years of storage in the midterm storage complex ($4^{\circ}C$, 30-40% RH) at the National Agrobiodiversity Center (NAC) Korean genebank maintained by the Rural Development Administration (RDA), Republic of Korea and to suggest the relative seed longevity and suitable monitoring intervals. The germination data from initial tests and after ten years of storage were compared to measure changes in viability during storage. The decline in seed viability varied greatly among seeds from -11.5% for Triticum sp. to 80% for melon. Coriander, crowndaisy, safflower, cosmos, Chinesebellflower, waxgourd, melon, castorbean, Welch-onion, hollyhock, wild barley, and tallfescue showed significant decreases in viability of 34.2%, 73.4%, 36.5%, 30.0%, 40.2%, 71.3%, 80.0%, 65.9%, 45.5%, 51.4%, 53.0%, and 33.5%, respectively. Gardenpea, soybean, perilla, onion, wild rice, Italian-ryegrass, and pepper showed a 15-30% decline in viability, while the viability of morningglory, adzukibean, maize, and Capsicum sp. decreased by 15% to 5%. Chicory, radish, Chinese-cabbage, bottlegourd, watermelon, cucumber, pumpkin, Cucurbita sp., groundnut, kidneybean, clubwheat, sesame, wheat, Triticum sp., rice, barley, orchardgrass, buckwheat, and wild tomato showed changes in viability of <5%. The changes in storage viability also varied within families. The wild types of rice and barley showed rapid viability loss and presented different aspects from cultivars. Since seed viability of species, classified as index 1 or 2, showed germination losses >15% after ten years of storage, a viability test should be conducted with five year intervals, while species with germination loss of <15% (in index 3 or 4) can be retested at ten year intervals.

Analysis of BNNT(Boron Nitride Nano Tube) synthesis by using Ar/N2/H2 60KW RF ICP plasma in the difference of working pressure and H2 flow rate

  • Cho, I Hyun;Yoo, Hee Il;Kim, Ho Seok;Moon, Se Youn;Cho, Hyun Jin;Kim, Myung Jong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.179-179
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    • 2016
  • A radio-frequency (RF) Inductively Coupled Plasma (ICP) torch system was used for boron-nitride nano-tube (BNNT) synthesis. Because of electrodeless plasma generation, no electrode pollution and effective heating transfer during nano-material synthesis can be realized. For stable plasma generation, argon and nitrogen gases were injected with 60 kW grid power in the difference pressure from 200 Torr to 630 Torr. Varying hydrogen gas flow rate from 0 to 20 slpm, the electrical and optical plasma properties were investigated. Through the spectroscopic analysis of atomic argon line, hydrogen line and nitrogen molecular band, we investigated the plasma electron excitation temperature, gas temperature and electron density. Based on the plasma characterization, we performed the synthesis of BNNT by inserting 0.5~1 um hexagonal-boron nitride (h-BN) powder into the plasma. We analysis the structure characterization of BNNT by SEM (Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy), also grasp the ingredient of BNNT by EELS (Electron Energy Loss Spectroscopy) and Raman spectroscopy. We treated bundles of BNNT with the atmospheric pressure plasma, so that we grow the surface morphology in the water attachment of BNNT. We reduce the advancing contact angle to purity bundles of BNNT.

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Effects of Edible Seaweed on Physicochemical and Sensory Characteristics of Reduced-salt Frankfurters

  • Choi, Yun-Sang;Kum, Jun-Seok;Jeon, Ki-Hong;Park, Jong-Dae;Choi, Hyun-Wook;Hwang, Ko-Eun;Jeong, Tae-Jun;Kim, Young-Boong;Kim, Cheon-Jei
    • Food Science of Animal Resources
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    • v.35 no.6
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    • pp.748-756
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    • 2015
  • The effects of sea tangle, sea mustard, hijiki, and glasswort were investigated based on the proximate composition, salinity, cooking loss, emulsion stability, pH, color, texture profile analysis, apparent viscosity, and sensory characteristics of reduced-salt (NaCl) meat batter and frankfurters. The moisture content, salinity, lightness of the meat batter and frankfurter, hardness, gumminess, and chewiness of the reduced-salt frankfurters with sea weeds were lower than the control without seaweed (p<0.05). The protein content, springiness, and cohesiveness of the reduced-salt frankfurters were not significantly different among the treatments (p>0.05). The moisture content, salinity, cooking loss, lightness, redness, hardness, gumminess, and chewiness of treatments with sea tangle and with sea mustard were lower than the control (p<0.05). Among the sensory traits, color was highest in the control (p<0.05). The flavor was also highest in the control. The treatments with sea tangle and with sea mustard samples had high tenderness, juiciness, and overall acceptability scores similar to the control (p<0.05). The results of this study show that the combination of low-salt and seaweed in the formulation successfully improved reduced-salt frankfurters, improving sensory characteristics to levels similar to the regular salt control (1.5%).

Operative Treatment of Tongue Type Intra-articular Calcaneal Fractures: Comparison of the Open Reduction and Essex-Lopresti Technique (관절면을 침범한 설상형 종골골절의 수술적 치료: 관혈적 및 Essex-Lopresti 술식에 따른 비교)

  • Shin, Dong-Eun;Yoon, Hyung-Ku;Han, Soo-Hong;Choi, Woo-Jin;Ahn, Chang-Soo;Ok, Hyun-Soo
    • Journal of Korean Foot and Ankle Society
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    • v.14 no.2
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    • pp.151-156
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    • 2010
  • Purpose: To analyze the clinical and radiological results of operative treatment in patients with tongue type intra-articular calcaneal fracture, and to compare the open reduction and Essex-Lopresti technique. Materials and Methods: We examined a consecutive series of 42 patients who received surgical treatment for tongue type calcaneal fracture (24 cases of the open reduction and 18 cases of the Essex-Lopresti technique) and the postoperative data was compared with a minimum 1 year follow-up. The clinical outcome was analyzed using the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot scale and Salama's criteria. The preoperative, postoperative, and last follow-up changes in the Bohler angle was radiologically analyzed. Results: There were no significant differences between the two groups in terms of the clinical and radiological results at the last follow-up. However, for the Sander's type 3 and 4 fractures, the open reduction group showed more improvement of AOFAS score and less reduction loss in the Bohler angle. Conclusion: Although the clinical results were good irrespective of surgical technique, the open reduction and internal fixation can improve clinical outcome and reduce the reduction loss as compared with the Essex-Lopresti technique in the comminuted tongue type calcaneal fracture.

Dielectric Properties of $Ta_2O_5-SiO_2$ Thin Films Deposited at Room Temperature by Continuous Composition Spread (상온에서 연속 조성 확산법에 의해 증착된 $Ta_2O_5-SiO_2$ 유전특성)

  • Kim, Yun-Hoe;Jung, Keun;Yoon, Seok-Jin;Song, Jong-Han;Park, Kyung-Bong;Choi, Ji-Won
    • Journal of the Microelectronics and Packaging Society
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    • v.17 no.2
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    • pp.35-40
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    • 2010
  • The variations of dielectric properties of $Ta_2O_5-SiO_2$ continuous composition spread thin films prepared by off-axis radio-frequency magnetron sputtering were investigated. The dielectric maps of dielectric constant and loss were plotted via 1500 micron-step measuring. The specific points showing superior dielectric properties of high dielectric constant (k~19.5) and loss (tan${\delta}$<0.05) at 1 MHz were found in area of the distance of 16 mm and 22 mm apart from $SiO_2$ side in $75{\times}25mm^2$ sized Pt/Ti/$SiO_2$/Si(100) substrates.

Design and Fabrication of the 94 GHz Branch-line Bandpass Filter using CPW structure (CPW 구조를 이용한 94 GHz Branch-line 대역통과 여파기의 설계 및 제작)

  • Kwon, Hyuk-Ja;Bang, Suk-Ho;Lee, Sang-Jin;Yoon, Jin Seob;Rhee, Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.44 no.5
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    • pp.36-41
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    • 2007
  • We report the 94 GHz CPW branch-line bandpass filter for planar integrated millimeter-wave circuits. The branch-line coupler operates as a transversal filtering section by connecting the coupling ports to the open load stubs and taking the isolation port as the output node. For design of the 94 GHz branch-line bandpass filter, we built the CPW library and optimized the characteristic impedances and the lengths of the branch-line coupler and the open load stubs. The fabricated 94 GHz bandpass filter exhibits an insertion loss of 2.5 dB with an 11.7 % 3 dB relative bandwidth and the return loss is -18.5 dB at a center frequency of 94 GHz.

Determination of Indicators for Dry Aged Beef Quality

  • Lee, Heeyoung;Jang, Mi;Park, Sunhyun;Jeong, Jiyoun;Shim, You-Shin;Kim, Jong-Chan
    • Food Science of Animal Resources
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    • v.39 no.6
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    • pp.934-942
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    • 2019
  • Previous studies on dry aged beef, which substantially increases the value of low-grade raw beef and non-preferred cuts, are currently limited to the observation of aged beef changes in laboratory settings or under particular aging conditions, whereas the factors influencing aging have so far been underexplored. Herein, we attempt to establish a technique for distinguishing between fresh and aged beef by observing changes in quality during beef aging. Specifically, we analyzed the effect of time on the quality of aged beef sourced from three Korean manufacturers and identified quality indicators that can be used to distinguish between fresh and aged beef, regardless of supplier. Storage/trimming/aging/cooking losses, moisture/fat/protein/collagen contents, and water holding capacity were tested as potential indicators, among other parameters. As a result, the quality of dry aged beef was shown to be supplier-dependent, which made the identification of factors for the above origin-independent discrimination difficult. Nevertheless, as storage loss, water holding capacity, and cooking loss significantly changed with dry aging time in all cases, these parameters were concluded to be potentially suited for discrimination purposes. The insights gained in this work may help promoting further research in this field and contribute to the development of a standard for consistent aged beef production.