• Molecules and Cells
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• v.42 no.9
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• pp.617-627
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• 2019

Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, and the integration of glial cells into a neural network. This suggests that brain organoids could serve as a representative model system to study the human brain. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.

• Korean Journal of Biological Psychiatry
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• v.20 no.4
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• pp.136-143
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• 2013

Objectives We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia. Method We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia. Results The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as 'a misconnection syndrome of neural circuit or neural network'. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process. Conclusion Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2002.05a
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• pp.231-234
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• 2002

셀룰라 신경회로망의 연상 메모리를 이용하여 시각적인 입력 데이터의 연산을 통하여 영상 패턴의 분류와 인식을 수행한다. 셀룰라 신경회로망은 일반적인 신경회로망과 같이 비선형 데이터의 실시간 처리가 가능하고, 세 포자동자와 같이 격자구조의 셀로 이루어져 인접한 셀과 직접 정보를 주고받는다. 응용 분야로는 최적화, 선형/비선형화, 연상 메모리, 패턴인식, 컴퓨터 비젼 등에 적용할 수 있다. 영상의 이미지 픽셀을 셀룰라 신경회로망의 셀에 대응하여 전체 이미지 영상을 모든 셀룰라 신경회로망의 셀에서 동시에 병렬로 처리할 수 있어 2-D 이미지 처리에 적합하다 본 논문은 셀룰라 신경회로망에 의한 연상 메모리 구조를 설계하고, 학습된 하중값 메모리에서 가장 적당한 하중값을 선택하여 학습된 영상과 정확히 일치하는 출력을 얻는 방법을 제시한다. 학습을 통한 연상 메모리 구현에는 각각의 뉴런에서 일정하지 않은 다른 템플릿을 사용한다. 각각의 템플릿은 뉴런들 간의 연결 하중값을 나타내고 학습011 따라 갱신된다. 학습방법으로는 템플릿 하중값 학습에 뉴런들 간의 연결 하중값을 조정하는 가장 단순한 규칙인 Hebb의 학습방법이 사용되었고 분류값 학습에 LMS 알고리즘이 사용되었다

• The Transactions of the Korea Information Processing Society
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• v.6 no.2
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• pp.439-448
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• 1999

In this paper, two optimization algorithms based on artificial neural networks and genetic algorithms are proposed for cellular radio channel assignment problems. The channel assignment process is characterized as minimization of the energy function which represents constraints of the channel assignment problems. All three constraints such as the co-channel constraint, the adjacent channel constraint and the co-site channel constraint are considered. In the neural networks approach, certain techniques such as the forced assignment and the changing cell order are developed, and in the genetic algorithms approach, data structure and proper genetic operators are developed to find optimal solutions, As simulation results, the convergence rates of the two approaches are presented and compared.

• Molecules and Cells
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• v.46 no.1
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• pp.65-67
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• 2023

SMILES (simplified molecular-input line-entry system) information of small molecules parsed by one-hot array is passed to a convolutional neural network called black box. Outputs data representing a gene signature is then matched to the genetic signature of a disease to predict the appropriate small molecule. Efficacy of the predicted small molecules is examined by in vivo animal models. GSEA, gene set enrichment analysis.

• Journal of KIISE:Software and Applications
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• v.27 no.5
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• pp.463-472
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• 2000

In this paper, we consider the problem of realizing associative memories via cellular neural network(CNN). After introducing qualitative properties of the CNN model, we formulate the synthesis of CNN that can store given binary vectors with optimal performance as a constrained optimization problem. Next, we observe that this problem's constraints can be transformed into simple inequalities involving linear matrix inequalities(LMIs). Finally, we reformulate the synthesis problem as a generalized eigenvalue problem(GEVP), which can be efficiently solved by recently developed interior point methods. Proposed method can be applied to both space varying template CNNs and space-invariant template CNNs. The validity of the proposed approach is illustrated by design examples.

• The Journal of Korean Physical Therapy
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• v.13 no.3
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• pp.791-797
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• 2001

After brain injury, patients show a wide range in the degree of recovery. By a variety of mechanisms, the human brain is constantly undergoing plastic changes. Spontaneous recovery from brain injury in the chronic stage omes about because of plasticity. The brain regions are altered. resulting in functionally modified cortical network. This review cnsidered the neural plasticity from cellular and molecular mechanisms of synapse formation to behavioural recovery from brain injury in elderly humans. The stimuli required to elicit plasticity are thought to be activity-dependent elements. especially exercise and learning. Knowledge about the physiology of brain plasticity has led to the development of methods for rehabilitation.

• Journal of the Semiconductor & Display Technology
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• v.2 no.1
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• pp.7-9
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• 2003

In order to predict the moldability of an injection molded part, a simulation of filling is needed. Short shot is one of the most frequent troubles encountered during injection molding process. The adjustment of process conditions is the most economic way to troubleshoot the problematic short shot in cost and time since the mold doesn't need to be modified at all. But it is difficult to adjust the process conditions appropriately in no times since it requires an empirical knowledge of injection molding. In this paper, the intelligent CAE system synergistically combines fuzzy-neural network(FNN) for heuristic knowledge with CAE programs for analytical knowledge. To evaluate the intelligent algorithms, a cellular phone flip has been chosen as a finite element model and filling analyses have been performed with a commercial CAE software. As the results, the intelligent CAE system drastically reduces the troubleshooting time of short shot in comparison with the expert's conventional way which is similar to the golden section search algorithm.

• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2002.11a
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• pp.127-129
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• 2002

In order to predict the moldability of an injection molded part, a simulation of filling is needed. Short shot is one of the most frequent troubles encountered during injection molding process. The adjustment of process conditions is the most economic way to troubleshoot the problematic short shot in cost and time since the mold doesn't need to be modified at all. But it is difficult to adjust the process conditions appropriately in no times since it requires an empirical knowledge of injection molding. In this paper, the intelligent CAE system synergistically combines fuzzy-neural network(FNN) for heuristic knowledge with CAE programs for analytical knowledge. To evaluate the intelligent algorithms, a cellular phone flip has been chosen as a finite element model and filling analyses have been performed with a commercial CAE software. As the results, the intelligent CAE system drastically reduces the troubleshooting time of short shot in comparison with the expert's conventional way which is similar to the golden section search algorithm.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.3
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• pp.83-89
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• 2016

The group formation problem of the machine and part is a critical issue in the planning stage of cellular manufacturing systems. The machine-part grouping with alternative process plans means to form machine-part groupings in which a part may be processed not only by a specific process but by many alternative processes. For this problem, this study presents an algorithm based on self organizing neural networks, so called SOM (Self Organizing feature Map). The SOM, a special type of neural networks is an intelligent tool for grouping machines and parts in group formation problem of the machine and part. SOM can learn from complex, multi-dimensional data and transform them into visually decipherable clusters. In the proposed algorithm, output layer in SOM network had been set as one-dimensional structure and the number of output node has been set sufficiently large in order to spread out the input vectors in the order of similarity. In the first stage of the proposed algorithm, SOM has been applied twice to form an initial machine-process group. In the second stage, grouping efficacy is considered to transform the initial machine-process group into a final machine-process group and a final machine-part group. The proposed algorithm was tested on well-known machine-part grouping problems with alternative process plans. The results of this computational study demonstrate the superiority of the proposed algorithm. The proposed algorithm can be easily applied to the group formation problem compared to other meta-heuristic based algorithms. In addition, it can be used to solve large-scale group formation problems.