• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.12
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• pp.1801-1807
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• 2014

Blue mussels (Mytilus edulis) are widely distributed among the world's oceans in various habitats. The purpose of this study was to investigate the effects of freeze-drying on the antioxidant and antigenotoxic activities of blue mussels collected in the Gyeongnam coast area of Korea. Raw (RM) and freeze-dried blue mussel flesh (FRM) were extracted with ethanol, methanol, and water. Antioxidant activities were evaluated on the basis of DPPH radical scavenging activity, oxygen radical absorbance capacity (ORAC), cellular antioxidant capacity (CAC), and antigenotoxic activity (comet assay). Except for the water extract, RM and FRM showed DPPH radical scavenging activities, which increased upon freeze-drying in MeOH extract. The highest ORAC value was observed in water extract of RM and MeOH extract of FRM. CAC was protected against AAPH-induced oxidative stress in HepG2 cells by both RM and FRM extracts. Freeze-drying lowered ORAC value of water extract, whereas it increased CAC activity, suggesting that antioxidant activities varied according to the generated radicals. All extracts from RM and FRM showed antigenotoxic activities by reducing $H_2O_2$-induced DNA damage in human leukocytes. Freeze-drying had no effect on antigenotoxicity of blue mussels. Taken together, these results indicate that blue mussels possess antioxidant and antigenotoxic properties, and freeze-drying might be a useful processing method for blue mussels to retain their maximum physiological potential as a functional food.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.5
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• pp.403-409
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• 2014

The Bis protein is known to be involved in a variety of cellular processes including apoptosis, migration, autophagy as well as protein quality control. Bis expression is induced in response to a number of types of stress, such as heat shock or a proteasome inhibitor via the activation of heat shock factor (HSF)1. We report herein that Bis expression is increased at the transcriptional level in HK-2 kidney tubular cells and A172 glioma cells by exposure to oxidative stress such as $H_2O_2$ treatment and oxygen-glucose deprivation, respectively. The pretreatment of HK-2 cells with N-acetyl cysteine, suppressed Bis induction. Furthermore, HSF1 silencing attenuated Bis expression that was induced by $H_2O_2$, accompanied by increase in reactive oxygen species (ROS) accumulation. Using a series of deletion constructs of the bis gene promoter, two putative heat shock elements located in the proximal region of the bis gene promoter were found to be essential for the constitutive expression is as well as the inducible expression of Bis. Taken together, our results indicate that oxidative stress induces Bis expression at the transcriptional levels via activation of HSF1, which might confer an expansion of antioxidant capacity against pro-oxidant milieu. However, the possible role of the other cis-element in the induction of Bis remains to be determined.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.10
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• pp.937-945
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• 2014

As various services requiring high data rate are supported by introducing LTE/LTE-adv., mobile traffic increases rapidly. To cope with the continuous growth of traffic demand, small cell technology is considered as one of the most promising one. Small cell can increase system capacity by increasing the number of base stations with reduced cell radius. In this paper, we analyze the effect of cell densification with small cells in terms of SINR and average UE throughput considering cell split and the number of UE per unit area. As the cell becomes smaller, SINR degradation arises from high ICI(Inter Cell Interference) and we evaluate the effect of interference mitigation scheme in small cell environment where the proper interference mitigation technique is applied.

• The KIPS Transactions:PartC
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• v.10C no.5
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• pp.617-624
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• 2003

This paper proposes a modified DCPC (Distributed Constrained Power Control, M-DCPC) algorithm that can improve the performance of a CDMA power control system. The control performance of the proposed method is verified using two performance measures : the SIR response of each mobile and the outage probability in a cell. As regards the SIR response, in simulations, the M-DCPC algorithm has shown a faster convergence and lower overshoot in transient time than the other power control algorithms when the desired SIR value was varying. For the outage probability. M-DCPC converged to a fixed outage rate faster than CSOPC while also maintaining the system capacity to make as high a connection as CSOPC. In particular, when the desired SIR was varying, CSOPC showed an abrupt outage probability increase during the desired SIR Increase, yet M-DCPC was unaffected.

• Journal of Advanced Navigation Technology
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• v.11 no.4
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• pp.415-422
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• 2007

In this paper, we proposed a new dynamic channel allocation algorithm for TD-SCDMA with cross time slots. In order to reduce the interference in cross time slot, the mobile stations (MSs) are divided into two groups: the Near Group consisting of MSs near by the base station(BS) and the Far Group including the MSs far from the BS. The reverse link for MSs in the Near Group and forward link for MSs in the Far Group are allocated to the cross time slot. In cellular systems, a BS has multiple neighbor BSs. Some of neighbor BSs can operate in the same direction link while the others have cross time slot. Thus, it is required to determine which BS has the most significant impact in terms of interference. We divide each cell into 6 areas based on the direction of arrival of smart antenna and the most significant neighbor sector is determined with this division. The proposed allocation method and area division method can avoid the severe interference in cross time slots and increase the system capacity about 2%~9% compared to FCA, and 0.5%~1.3% compared to RCA.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.3
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• pp.347-353
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• 2012

Recently, multi-functionalization (as in smart phones) has been in demand, and the connectors connecting the electrical signals of each board in a cellular phone have become key components. The miniaturization of these connectors is required to achieve a finer pitch design and enhance the electrical signal transfer capacity. However, the miniaturization of connectors reduces the structural safety, and a finer pitch design may cause contact problems under external impact. In this paper, a preliminary design for miniaturized, finer-pitch connectors is suggested for a product with 50 pins and a thickness of 0.2 mm. The assembly process of the FPCB (Flexible Printed Circuit Board) and connector was simulated to ensure the holding force between the two components and avoid overstressing. The design optimization process was performed with the Taguchi method. Fatigue analysis was also conducted to predict the fatigue life of the terminal, and the theoretical and experimental results were compared.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.105-117
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• 2015

In this paper, we consider 19 cells with the two tiers for polar-rectangular coordinates (PRCs) and provide the cell edge performance of cellular networks based on distance from cell center i.e., BS (base station). When FFR is applied(or adopted) to cell edge, it is expected that BS cooperation, or a coordinated multipoint (CoMP) multiple access strategy will further improve the system performance. We proposed a new method to evaluate the sum rate capacity of the MIMO DC of multicell system. We improve the performance of cell edge users for intercell interference cancelation in cooperative downlink multicell systems. Simulation results show that the proposed scheme outperforms the reference schemes, in terms of cell edge SINR (signal-to-interference-noise ratio) with a minimal impact on the network path loss exponent. We show 13 dB improvements in cell-edge SINR by using reuse of three relative to reuse of one. BS cooperation has been proposed to mitigate the cell edge effect.

• Journal of Periodontal and Implant Science
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• v.30 no.3
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• pp.675-687
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• 2000

Multiple periodontal pathogens sequentially colonize the subgingival niche during the conversion from gingivitis to destructive periodontal disease. An animal model of sequential immunization with key periodontal pathogens has been developed to determine whether T and B lymppocyte effector functions are skewed and fail to protect the host from pathogenic challenge. The present study was performed to evaluate immunomodulatory effect of exposure to Fusobacterium nucleatum(F. nucleatum) prior to Porphyromonas gingivalis(P. gingi - valis). Group 1(control) mice were immunized with phosphate-buffered saline, Group 2 were immunized with F. nucleatum prior to P. gingivalis, while Group 3 were immunized P. gingivalis alone. All the T cell clones derived from Group 2 demonstrated type 2 helper T cell clone(Th2 subsets), while those from Group 3 mice demonstrated Th1 subsets. Exposure of mice to F . nucleatum prior to P. gingivalis interfered with opsonophagocytosis function of sera against P. gingivalis. In adoptive T cell transfer experiments, in vivo protective capacity type 2 helper T cell clones(Th2) from Group 2 was significantly lower than type 1 helper T cell clones(Th1) from Group 3 against the lethal dose infection of P. gingivalis. Western blot analysis indicated the different pattern of recognition of P .gingivalis fimbrial proteins between sera from Group 2 and Group 3. In conclusion, these study suggest that colonization of the subgingival niche by F .nucleatum prior to the periodontal pathogen, P. gingivalis, modulates the host immune responses to P. gingivalis at humoral, cellular and molecular levels.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1598-1608
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• 2013

An optimum dietary carbohydrate content is important for maximum fish growth. In this study, we fed Wuchang bream (Megalobrama amblycephala) with either control diet (30.42%) or high carbohydrate diet (52.92%) for 90 d. Fish were fed to apparent satiation three times daily in an aquarium with automatic temperature control and circulated water. Growth performance, plasma biochemical parameters, hepatic morphology and enzyme activities were determined. It was shown that compared to fish fed control diet, fish fed high carbohydrate diet had higher plasma triglyceride and cortisol levels for d 90, and lower alkaline phosphatase level for d 45, lower hepatic superoxide dismutase and total antioxidative capacity for d 90, higher malondialdehyde for d 45 and glycogen content for d 45 and 90 (p<0.05). Histological and transmission electron microscopy studies showed that hepatocytes of fish fed high carbohydrate diet contained large lipid droplets, causing displacement of cellular organelles to periphery of hepatocytes. The relative level of hepatic heat shock protein 70 (HSP70) mRNA of Wuchang bream fed high carbohydrate diet was significantly higher than that of fish fed the control diet for 90 d (p<0.05). These changes led to decreased specific growth rate and increased feed conversion ratio (p<0.05). Upon hypoxia challenge, fish fed high carbohydrate diet had higher cumulative mortality than those fed the control diet (p<0.05). These results suggested that high dietary carbohydrate (52.92%) was detrimental to the growth performance and health of Wuchang bream.

• Journal of Nutrition and Health
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• v.24 no.1
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• pp.40-47
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• 1991

To investigate a possible effect of pectinate(apple and carrot) and alginate (tangle or green laver) on blood pressure and sodium retention, male spontaneous hypertensive rats (SHR) were assigned to 5 different experimental groups and fed diets containing 5% dietary fiber and 1% NaCl for 3 weeks. Dietary fibers were provided from one of the followings : cellulose, freeze dried apple, carrot, tangle(Undardia pinnatifda) or green laver(Monostroma nitidium). Fecal sodium excretion did not change significantly among the groups, however, urinary sodium excretion was increased in groups fed either carrot. tangle or green laver compared to group fed cellulose. Sodium balance was also negative in groups fed either carrot, tangle or green laver. most effectively in green laver group. Blood pressure of groups fed apple. carrot. tangle or green laver were decreased, especially those of group fed tangle, compared to those of group fed cellulose. Dietary fiber containing alginate. such as tangle and green laver, might have cellular binding capacity to sodium so that increased urinary sodium excretion and decreased blood pressure occur.