• 제목/요약/키워드: Cell space

검색결과 1,247건 처리시간 0.022초

Endothelial cell autophagy in the context of disease development

  • Basheer Abdullah Marzoog
    • Anatomy and Cell Biology
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    • 제56권1호
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    • pp.16-24
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    • 2023

  • Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

  • https://doi.org/10.5115/acb.22.098 인용 PDF

마이크로중력환경에서 사용 가능한 관성저울의 성능평가 (Performance Evaluation of Inertial Balance for Measuring Mass in Microgravity)

  • 장현진;이주희;최재혁;박설현
    • 대한기계학회논문집A
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    • 제38권12호
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    • pp.1395-1401
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    • 2014

  • 중력이 거의 작용하지 않는 마이크로중력환경에서 소동물의 질량이 측정 가능한 고성능 관성저울을 개발하기 위해, 약 100g의 측정시료를 이용하여 관성저울의 핵심 디자인 파라미터인 로드셀의 응답특성을 평가하였다. 정확한 성능평가를 위해서 1.5초의 마이크로중력환경을 제공할 수 있는 15m 자유 낙하탑을 활용하였으며, 살아 있는 동물의 질량을 측정해야 하는 점을 고려하여 측정시료의 감속 크기 변화에 따른 로드셀의 응답특성를 파악하였다. 동일한 가속도로 가 감속되는 표준시료와 측정시료의 관성력 비의 분석결과 로드셀이 장착된 가속판이 평균 이동속도 0.5 m/s 이상으로 운동하는 경우에 한하여 설계 기준에 부합하는 것을 알 수 있었다.

  • https://doi.org/10.3795/KSME-A.2014.38.12.1395 인용 PDF KSCI

Conceptual Design and Demonstration of Space Scale for Measuring Mass in Microgravity Environment

  • Kim, Youn-Kyu;Lee, Joo-Hee;Choi, Gi-Hyuk;Choi, Ik-Hyeon
    • Journal of Astronomy and Space Sciences
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    • 제32권4호
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    • pp.419-425
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    • 2015

  • In this study, a new idea for developing a space scale for measuring mass in a microgravity environment was proposed by using the inertial force properties of an object to measure its mass. The space scale detected the momentum change of the specimen and reference masses by using a load-cell sensor as the force transducer based on Newton's laws of motion. In addition, the space scale calculated the specimen mass by comparing the inertial forces of the specimen and reference masses in the same acceleration field. By using this concept, a space scale with a capacity of 3 kg based on the law of momentum conservation was implemented and demonstrated under microgravity conditions onboard International Space Station (ISS) with an accuracy of ${\pm}1g$. By the performance analysis on the space scale, it was verified that an instrument with a compact size could be implemented and be quickly measured with a reasonable accuracy under microgravity conditions.

  • https://doi.org/10.5140/JASS.2015.32.4.419 인용 PDF KSCI KPUBS HTML

탐색적 방법에 의한 건축공간 배치계획 최적화에 대한 고찰 (A Study on the Optimized Architectural Space Planning by Searching Algorithm Method)

  • 임명구;김수영
    • 한국디지털건축인테리어학회논문집
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    • 제1권1호
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    • pp.51-58
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    • 2001

  • The purpose of this study is to improve productivity of architectural space planning(A.S.P,) by computer system and to optimize ASP. A searching algorithm is the best way to slave optimized A.S.P. Because architectural design is too many various site situations and client's demands to specify the general solving methods. This method seek the best design case in all possibility and to be modeled as this; $\rightarrow$[$\rightarrow$$\rightarrow$