• Biomolecules & Therapeutics
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• v.30 no.2
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• pp.151-161
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• 2022

This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we used diverse experimental methods such as cell viability assay, colony formation assay, tumor spheroid formation assay, cell cycle analysis, TUNEL assay, Western blot analysis, xenograft mouse model and histological analysis. Treatment with GA inhibited cell proliferation in dose-dependent manner as measured by cell viability assay at 48 h. GA and cisplatin (CDDP) also inhibited colony formation and tumor spheroid formation. In addition, GA and CDDP induced apoptosis, as determined by the distribution of early and late apoptotic cells and DNA fragmentation. Western blot analysis revealed that inhibition of the PI3K/Akt pathway induced upregulation of p53 (tumor suppressor protein), which in turn regulated cell cycle related proteins such as p21, p27, Cyclin D1 and E1, and intrinsic apoptotic proteins such as Bax, Bcl-2 and cleaved caspase-3. The anti-cancer effect of GA was further confirmed in an in vivo mouse model. Intraperitoneal injection with GA for 4 weeks in an A549-derived tumor xenograft model reduced the size of tumor mass. Injection of them downregulated the expression of proliferating cell nuclear antigen and p-Akt, but upregulated the expression of cleaved caspase-3 in tumor tissues. Taken together, these results indicated that GA hindered lung cancer progression by inducing cell cycle arrest and apoptosis, suggesting that GA would be a potential therapeutic agent against non-small cell lung cancer.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.12
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• pp.3187-3195
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• 1993

Combustion of liquid-fuelled combustion in a high-temperature vitiated-air stream was studied. The mathematical formulation comprise the application of Eulerian conservation equation to the gas phase and Lagrangian equation of droplet motion. The latter is coupled with a droplet-tracking technique (PSI-CELL Model) which regard the droplet phase as a source of mass, momentum, and energy to the gaseous phase. Reaction rate is determined by taking into account the Arrhenius reaction rate based on a single-step reaction mechanism. The calculated profiles show somewhat uncertainess at the upstream, but bases data for designing the combustor followed by 2-phase flow were obtained.

• Proceedings of the KAIS Fall Conference
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• 2004.11a
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• pp.272-273
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• 2004

Filter media are one of themost important choices when bilfiltration is applied. Filter media provide adsorbing microbes with available sites for residence and the residential cells grow to degrade or decompose target waste gases. Up to date, filter media were only qualitatively analyzed. As a quantitative approach to filter material for biofiltration, a simple model based on reaction kinetics and mass action law (Ottengraf's Model in 1983) was presented. Cork, zeolite, and granulated activated carbon were tested in terms of effective surface area, cell covered fraction of adsorbing sites, surface roughness, and pore size distribution. The cell covered fraction, surface roughness and hydrophilicity was found to be closely related to the efficiency of gas degradation in biofiltration. The cork was the best candidate for cell residence and growth in this work.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.24 no.10
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• pp.784-789
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• 2011

A linear spring model, where the interactions among atoms are assumed to be isotropic and elastic, is employed for the study of non-polar optical phonon scattering in the valence band of alloy semiconductors. The force equations of n atoms are used in the spring model for the consideration of the random distribution of constituent atoms in an alloy semiconductor. When the number of atoms in a unit cell is assumed to be two based on the experimental result, the optical deformation potent is valid for compound semiconductors as well as alloy semiconductors.

• Journal of the Korean Operations Research and Management Science Society
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• v.22 no.2
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• pp.99-123
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• 1997

Performance analysis of NTT/BT protocol is investigated, which is a GFC (Generic Flow Control) ptotocol in ATM (Asynchronous Transfer Mode ) network and is based on cyclic reset mechanism. THe mean cell delay time is proposed as a performance measure of NTT/BT protocol. The mean cell delay time is defined as the duration from the instant the cell arrives at the transmission buffer until the cell is fully transmitted. The process of cell transmission can be described as a single server queueing modle with two dependent services. By utilizing this model, mean cell delay time is obtained and sensitivity of the factors such as window size and reset period is also analysed.

• Journal of applied mathematics & informatics
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• v.8 no.1
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• pp.81-95
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• 2001

This paper models and evaluates the AAL multiplexer to analyze AAL protocol in ATM networks. We consider an AAL multiplexer in which a single periodically determinsitic CBR traffic stream and several variable size bursty background traffic streams are multiplexed and one ATM cell stream goes out. We model the AAL multiplexer as a B/sup X/ + D/D/1/K queue and analyze this queueing system. We represent various performance measures such as loss probability and waiting time in the basis of cell and packet.

• Journal of Korea Water Resources Association
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• v.47 no.9
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• pp.767-776
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• 2014

Changes in climate have largely increased concentrated heavy rainfall, which in turn is causing enormous damages to humans and properties. Floods are one of the most deadly and damaging natural disasters known to mankind. The flood forecasting and warning system concentrates on reducing injuries, deaths, and property damage caused by floods. Therefore, the exact relationship and the spatial variability analysis of hydrometeorological elements and characteristic factors is critical elements to reduce the uncertainty in rainfall-runoff model. In this study, grid resolution depending on the topographic factor in rainfall-runoff models presents how to respond. semi-distribution of rainfall-runoff model using the model GRM simulated and calibrated rainfall-runoff in the Gamcheon and Naeseongcheon watershed. To run the GRM model, input grid data used rainfall (two event), DEM, landuse and soil. This study selected cell size of 500 m(basic), 1 km, 2 km, 5 km, 10 km and 12 km. According to the resolution of each grid, in order to compare simulation results, the runoff hydrograph has been made and the runoff has also been simulated. As a result, runoff volume and peak discharge which simulated cell size of DEM 500 m~12 km were continuously reduced. that results showed decrease tendency. However, input grid data except for DEM have not contributed increase or decrease runoff tendency. These results showed that the more increased cell size of DEM make the more decreased slope value because of the increased horizontal distance.

• Journal of Magnetics
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• v.6 no.4
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• pp.132-141
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• 2001

The switching characteristics and the magnetization-flop behavior in magnetic tunnel junctions exchange biased by synthetic antiferromagnets (SyAFs) are investigated by using a computer simulations based on a single-domain multilayer model. The bias field acting on the free layer is found to be sensitive to the thickness of neighboring layers, and the thickness dependence of the bias field is greater at smaller cell dimensions due to larger magnetostatic interactions. The resistance to magnetization flop increases with decreasing cell size due to increased shape anisotropy. When the cell dimensions are small and the synthetic antiferromagnet is weakly, or not pinned, the magnetization directions of the two layers sandwiching the insulating layer are aligned antiparallel due to a strong magnetostatic interaction, resulting in an abnormal magneto resistance (MR) change from the high-MR state to zero, irrespective of the direction of the free-layer switching. The threshold field for magnetization-flop is found to increase linearly with increasing antiferromagnetic exchange coupling in the synthetic antiferromagnet. Irrespective of the magnetic parameters and cell sizes, magnetization flop does not exist near zero applied field, indicating that magnetization flop is driven by the Zeeman energy.

• Preventive Nutrition and Food Science
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• v.16 no.2
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• pp.174-178
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• 2011

The cell permeability and cytotoxic effects of different-sized zinc oxide (ZnO) particles were investigated using a human colorectal adenocarcinoma cell line called Caco-2. Morphological observation by scanning electron microscopy revealed that three zinc oxides with different mean particle sizes (ZnO-1, 20 nm; ZnO-2, 90~200 nm; ZnO-3, $1\sim5\;{\mu}m$) tended to aggregate, particularly in the case of ZnO-1. When cytotoxicities of all three sizes of zinc oxide particles were measured at concentration ranges of $1\sim1000\;{\mu}g$/mL, significant decreases in cell viability were observed at concentrations of $50\;{\mu}g$/mL and higher. Among the three zinc oxides, ZnO-1 showed the lowest viability at $50\;{\mu}g$/mL in Caco-2 cells, followed by ZnO-2 and ZnO-3. The permeate concentration of ZnO-1 from the apical to the basolateral side in the Caco-2 model system after four hours was about three-fold higher than that of either ZnO-2 or ZnO-3. These results demonstrated that ZnO-1, with a 20 nm mean particle size, had poorer viability and better permeability in Caco-2 cells than ZnO-2 and ZnO-3.

• Journal of Ginseng Research
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• v.10 no.2
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• pp.167-179
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• 1986

Obesity is common disease resultly accumulated excess fat. In the model for obesity induced by high fat diet contains 30% fat, administration of ginseng extract inhibited increment of body weight, epididymal fat pads and enlargement of fat cell size. This was as the result of inhibition of lipogenesis in the liver and fat accumulation in the adipose tissues.