• The KIPS Transactions:PartA
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• v.15A no.6
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• pp.325-334
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• 2008

Flash memory is widely used as a storage medium for mobile devices such as cell phones, MP3 players, PDA's due to its tiny size, low power consumption and shock resistant characteristics. Additionally, some computer manufacturers try to replace hard-disk drives used in Laptops or personal computers with flash memory. More recently, there are some literatures on developing a flash memory-aware $B^+$-tree index for an efficient key-based search in the flash memory storage system. They focus on minimizing the number of "overwrites" resulting from inserting or deleting a sequence of key values to/from the $B^+$-tree. However, in addition to this factor, the size of a physical page allocated to a node can affect the maintenance cost of the $B^+$-tree. In this paper, with diverse experiments, we compare and analyze the costs of construction and search of the $B^+$-tree and the space requirement on flash memory as the node size increases. We also provide sorting-based or non-sorting-based algorithms to be used when inserting a key value into the node and suggest an header structure of the index node for searching a given key inside it efficiently.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2277-2284
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• 2016

Ribosome-inactivating protein (RIP) from Mirabilis jalapa L. leaves has cytotoxic effects on breast cancer cell lines but is less toxic towards normal cells. However, it can easily be degraded after administration so it needs to be formulated into nanoparticles to increase its resistance to enzymatic degradation. The objectives of this study were to develop a protein extract of M. jalapa L. leaves (RIP-MJ) incorporated into nanoparticles conjugated with Anti-EpCAM antibodies, and to determine its cytotoxicity and selectivity in the T47D breast cancer cell line. RIP-MJ was extracted from red-flowered M. jalapa L. leaves. Nanoparticles were formulated based on polyelectrolyte complexation using low viscosity chitosan and alginate, then chemically conjugated with anti-EpCAM antibody using EDAC based on carbodiimide reaction. RIP-MJ nanoparticles were characterised for the particle size, polydispersity index, zeta potential, particle morphology, and entrapment efficiency. The cytotoxicity of RIP-MJ nanoparticles against T47D and Vero cells was then determined with MTT assay. The optimal formula of RIP-MJ nanoparticles was obtained at the concentration of RIP-MJ, low viscosity chitosan and alginate respectively 0.05%, 1%, and 0.4% (m/v). RIP-MJ nanoparticles are hexagonal with high entrapment efficiency of 98.6%, average size of 130.7 nm, polydispersity index of 0.380 and zeta potential +26.33 mV. The $IC_{50}$ values of both anti-EpCAM-conjugated and non-conjugated RIP-MJ nanoparticles for T47D cells (13.3 and $14.9{\mu}g/mL$) were lower than for Vero cells (27.8 and $33.6{\mu}g/mL$). The $IC_{50}$ values of conjugated and non-conjugated RIP-MJ for both cells were much lower than $IC_{50}$ values of non-formulated RIP-MJ (>$500{\mu}g/mL$).

• Journal of Chest Surgery
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• v.38 no.12 s.257
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• pp.835-843
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• 2005

Background: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to be the prognostic factors. However, their clinical significances in esophageal squamous cell carcinoma are controversial and p53 accumulation may not correlate with genetic mutation. The current study investigates their prognostic significance in squamous cell carcinoma of the esophagus. Material and Method: The Subjects studied were 124 esophageal squamous cell carcinoma patients who underwent esophagectomy. The mutation of p53, over expression of Cyclin D1, Ki67 labelling index, mitotic index were examined by using an immunohistochemical staining. We compared the results and investigated the correlation with the mutation of p53, overexpression of Cyclin D1, Ki67 labelling index, mitotic index and tumor size, and duration of survival. Result: There was no correlation between the results in immunohistochemical staining according to age, sex, tumor size, Iymph node status, and clinical stage of the disease. Mutant p53 protein was found in 69 cases (55.6$\%$). Median survival time was 21 months in cases with negative for mutant p53 protein and 22 months in positive cases. There was no significant difference in survival (p=0.46). Median survival time was 22 months in cases with negative for Cyclin D1 and 16 months in positive cases (p=0.18). Median and mean survival time was 22 months and 36 months when Ki67 labeling index was 40 or less (102 cases). Median and mean survival was 16 months and 23 months, when Ki67 labeling index was more than 40 (22 cases). There was significant difference in survival rate (p=0.011). Conciusion: Positivity of p53 and cyclin D1 was not useful in predicting the prognosis in our study. There was no significant correlation among mutant p53 protein accumulation, Cyclin D1 over expression, and Ki67 labeling index. However, in several studies, PCR single strand conformational polymorphism analysis of p53 showed a correlation to the prognosis. We thought that there was a significant discordance between p53 gene mutation and mutant p53 protein accumulation. When Ki67 labeling index was more than 40, prognosis was poorer, Ki67 seems to be a prognostic factor in our study. Therefore, we confirmed the possibility of using molecular markers as prognostic factors.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6419-6425
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• 2013

Background: Neoadjuvant chemotherapy (NACT) is a treatment modality whereby chemotherapy is used as the initial treatment of HNSCC in patients presenting with advanced cancer that cannot be treated by other means. It leads to shrinkage of tumours to an operable size without significant compromise to essential oro-facial organs of the patients. The molecular mechanisms behind shrinkage due to NACT is not well elucidated. Materials and Methods: Eleven pairs of primary HNSCCs and adjacent normal epithelium, before and after chemotherapy were screened for cell proliferation and apoptosis. This was followed by immunohistochemical analysis of some cell cycle (LIMD1, RBSP3, CDC25A, CCND1, cMYC, RB, pRB), DNA repair (MLH1, p53) and apoptosis (BAX, BCL2) associated proteins in the same set of samples. Results: Significant decrease in proliferation index and increase in apoptotic index was observed in post-therapy tumors compared to pre-therapy. Increase in the RB/pRB ratio, along with higher expression of RBSP3 and LIMD1 and lower expression of cMYC were observed in post-therapy tumours, while CCND1 and CDC25A remained unchanged. While MLH1 remained unchanged, p53 showed higher expression in post-therapy tumors, indicating inhibition of cell proliferation and induction of apoptosis. Increase in the BAX/BCL2 ratio was observed in post-therapy tumours, indicating up-regulation of apoptosis in response to therapy. Conclusions: Thus, modulation of the G1/S cell cycle regulatory proteins and apoptosis associated proteins might play an important role in tumour shrinkage due to NACT.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.7
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• pp.73-80
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• 2009

This paper describes a path planning algorithm, which is the minimal turning path based on the shape and size of the cell to clean up the whole area with two cleaning robots. Our method divides the whole cleaning area with each cell by cellular decomposition, and then provides some path plans among of the robots to reduce the rate of energy consumption and cleaning time of it. In addition we suggest how to plan between the robots especially when they are cleaning in the same cell. Finally simulation results demonstrate the effectiveness of the algorithm in an unknown area with multiple robots. And then we compare the performance index of two algorithms such as total of turn, total of time.

• The Journal of Korean Medicine
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• v.21 no.2
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• pp.25-36
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• 2000

Objectives : This study demonstrates the effects of Daejo-hwan on learning and memory impairment induced by L-NAME (75 mg/kg) treatment and on cerebral ischemic damage induced by middle cerebral artery (MCA) occlusion in rats. Methods : Daejo-hwan emulsion (73.3 mg/100 g/l ml) was administered to rats along a timed study schedule. The Moms water maze was used for learning and memory test of the rats. The MCA was occluded by using the intraluminal thread method. The brain slices were stained by 2 % triphenyl tetrazolium chloride (TTC) and 1 % cresyl violet solution. Infarct size, neuron cell number and size in penumbra was measured by using computer image analysis system. Results : 1. The escape latency of the Daejo-hwan treated group decreased significantly with respect to the control group. 2.The memory score of the Daejo-hwan treated group showed increase tendency, And the swimming distance was not different between the normal, the control, and the Daejo-hwan treated group. 3. The infarct size of the Daejo-hwan treated group decreased significantly with respect to the control group. 4. The total infarct volume of the Daejo-hwan treated group showed decrease tendency. And the brain edema index of the Daejo-hwan treated group decreased significantly with respect to the control group. 5. The neuron cell number and cell size in penumbra of the Daejo-hwan treated group increased significantly with respect to the control group. Conclusions : According to the above results, it is supposed that Daejo-hwan is clinically applicable to the vascular dementia.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.2
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• pp.13-20
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• 2009

Recently there is growing interest in LBS requiring real-time services and the spatial main memory DBMS for efficient Telematics services. In order to optimize existing disk-based spatial indexes of the spatial main memory DBMS in the main memory, spatial index structures have been proposed, which minimize failures in cache access by reducing the entry size. However, because the reduction of entry size requires compression based on the MBR of the parent node or the removal of redundant MBR, the cost of MBR reconstruction increases in index update and the efficiency of search is lowered in index search. Thus, to reduce the cost of MBR reconstruction, this paper proposed the RSMB (relative-sized MBR)compression technique, which applies the base point of compression differently in case of broad distribution and narrow distribution. In case of broad distribution, compression is made based on the left-bottom point of the extended MBR of the parent node, and in case of narrow distribution, the whole MBR is divided into cells of the same size and compression is made based on the left-bottom point of each cell. In addition, MBR was compressed using a relative coordinate and size to reduce the cost of search in index search. Lastly, we evaluated the performance of the proposed RSMBR compression technique using real data, and proved its superiority.

• Polymer(Korea)
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• v.29 no.5
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• pp.457-462
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• 2005

Polyurethane foams (PUFs) were prepared from polymeric 4,4'-diphenylmethane diisocyanate (PMDI), mixed polyol with OH value of 480, silicone surfactant, three catalysts, and hydrofluorocarbon(HFC) as blowing agent. Balance (PC-8), gelling (33LV), and trimerization (TMR-2) catalysts were used. The effect of the catalysts on the physical properties of PUF with increase of isocyanate (NCO) index and aging time was investigated. The cell size of the PUF with PC-8 and 33LV slightly increased with an increase in NCO index from 100 to 170 but compressive strength did not change significantly. In case of trimerization catalyst, the compressive strength of PUF increased from 8.75 to 1$10.5 kg_f/cm^2$ and the cell size decreased with an increase in NCO index. The compressive strength of the PUF with 33LV increased from 9.21 to $10.15 kg_f/cm^2$ with an increase in aging time. However, there was no detectable change in the compressive strength of PUF with TMR-2. A possible interpretation of the results includes an additional cross-link reaction of non-reacted MDI and FTIR spectrum illustrated the change of NCO peak.

• YAKHAK HOEJI
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• v.50 no.2
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• pp.84-92
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• 2006

The present study investigated an effect of arsenic trioxide on the urethane-induced lung carcinogenesis in mice. To understand its carcinogenesis, we examined proliferating cell nuclear antigen (PCNA), apoptotic index as well as cell cycle-related proteins (cyclin D1, p21, and p27). Urethane was injected intraperitoneally in ICR mice, and then they were sacrificed at 5, 15, or 25 weeks following treatment of arsenic trioxide. Arsenic trioxide was given with tap water at a concentration of 1 mg/l (low-dose) and 5mg/1 (high-dose) for 25 weeks. During the carcinogenesis, sequential histological changes from hyperplasia to adenomas, and ultimately to overt carcinomas were noted. The development of hyperplasias, adenomas, and carcinomas in the lung were slightly increased by the treatment of low-dose arsenic trioxide. However, there is no correlation between dose and tumor multiplicity. The administration of low-dose arsenic trioxide, significantly increased the tumor size. The proliferative index observed on 5 weeks after significantly increased. Cyclin D1 and p21 protein, cell cycle related proteins, were more significantly increased in hyperplasia and adenoma in low dose arsenic treated group than urethane alone group. The p27 protein expression did not show any significantly changes with arsenic treated or untreated group. Low dose exposure to arsenic trioxide resulted in increased expression of cyclin D1 and p21 protein. The present results indicate that low-dose treatment of arsenic trioxide, but not high dose of it, partly modulate the cellular proliferation, cyclin D1, and p21 protein expression, and that this effect may contribute to accelerated development of lung adenocarcinomas in urethane-induced mice.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.1
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• pp.26-32
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• 2010

This paper proposes a new effective installed reserve rate in order to evaluate reliability of power system considering renewable generators, which include uncertainty of resource supply. It is called EIRR(effective installed reserve rate) in this paper. It is developed with considering capacity credit based on ELCC by using LOLE reliability criterion. While the conventional installed reserve rate index yields over-evaluation reliability of renewable generators, the proposed EIRR describes actual effective installed reserve rate. However, it is not the probabilistic reliability index as like as LOLE or EENS but another deterministic effective reliability index. The proposed EIRR is able to evaluate the realistic contribution to the reliability level for power system considering wind turbine generators and solar cell generators with high uncertainty in resource supply. The case study in model system as like as Jeju power system size presents a possibility that the proposed EIRR can be used practically as a new deterministic reliability index for generation expansion planning or operational planning in future.