• Title/Summary/Keyword: Cell Matrix

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Targeting Cell-Cell and Cell-Matrix Interactions and Its Therapeutic Applications

  • Kim, In-San
    • Proceedings of the PSK Conference
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    • 2003.10a
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    • pp.100-101
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    • 2003
  • Cell-cell and cell-matrix interaction is clearly required for metazoans not only to hold their cells together but also to conduct more sophisticated biological processes. Each cell has adhesion molecules on its cell membrane to link extracellular matrix and adjacent cells to the intracellular cytoskeleton, and also to transduce signals. In complex metazoans, information is transmitted from one cell to another by mechanisms such as direct intercellular communication, soluble signal molecules among distant cells, and local cellular environments formed by highly specialized extracellular matrix. (omitted)

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The effect of the matrix thickness on the long term performance of MCFC (매트릭스 두께가 MCFC 장기 성능에 미치는 영향)

  • Kim, Yun-Young;Han, Jong-Hee;Yoon, Sung-Pil;Nam, Suk-Woo;Lim, Tae-Hoon
    • Transactions of the Korean hydrogen and new energy society
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    • v.16 no.2
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    • pp.170-179
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    • 2005
  • Electrolyte loss is considered as one of the major obstacles limiting the life time of molten carbonate fuel cells (MCFCs). Unit cells with an effective area of 100 $cm^2$ were prepared and were operated to determine the optimum matrix thickness which contains the maximum amount of electrolyte without serious preformance loss caused by high resistance. Matrices with different thickness, 1.45, 1.8, and 2.3 mm, were used in unit cells and those cells were operared about 5000, 10000, and 4000 hrs. The unit cell used 1.8 mm thick matrix showed 0.85 V (at 150 mA/$cm^2$) as the intial performance and this cell voltage is not lower than the cell voltage obtained in the cell with 1 mm thick matrix. This cell was operated for 10000 hrs. The cell used 1.45 mm thick matrices showed 16.6 % in the electrolyte loss after 5000 hr operation. In the case of the cell with 2.3 mm thick matrix, the initial cell voltage was below 0.80 V (at 150 mA/$cm^2$). For thermal cycle test, the gas crossover amount of unit cell used 1.8 mm thick matrix was much less than that of the cell with 1.0 mm thick matrix.

AN HISTOPATHOLOGICAL STUDY ABOUT THE CHANGE OF SUBMANDIBULAR GLANDULAR CELL IN WHITE RAT FOLLOWING $HgCl_{2}$ INJECTION (승홍 투여가 백서 악하선 세포의 조직병리학적 변화에 미치는 영향에 관한 연구)

  • Kim, In-Su;Kim, Kyung-Wook
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.28 no.6
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    • pp.413-420
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    • 2002
  • Mercury is one of the most frequently used heavy metal in dental clinic. Mercury poisoning rises up when someone is exposed to mercury chronically. In 1818, Amalgam was used for dental restorative procedure, and after then study about mercury toxicity has begun. Clinical signs of mercury toxicity in oral & maxillofacial area were increases of salivation, metallic taste, swelling and pain of tongue, redness and ulceration of oral mucosa, and increased mobility and loss of teeth. After we injected mercury($HgCl_{2}$) into intraperitoneum of rat, studied about histopathological changes of submandibular gland cell. Experimental group was divided into two groups by amount of mercury. (Group 1 was 0.5mg/Kg of mercury injection, group 2 was 1.0mg/Kg of mercury injection.) 1. After 3days of intraperitoneal injection, black granules were observed at macrophage cell in both group. In group 2, author found hyperchromatism of nucleus, and vacuolization of cellular matrix and nucleus of acinar cell. 2. After 1week of intraperitoneal injection, author found severe vacuolization of nucleus and cellular matrix, and irregular granules around nuclear membrane at mucous cell and serous cell in both group. Vacuolization of nucleus and cellular matrix was seen at duct cell in group 2. 3. After 2weeks of intraperitoneal injection, author could found severe vacuolization of cellular matrix, and sometimes nucleus was positioned in central area of cellular matrix at mucous and serous cell in both group. Vacuolization of nucleus and cellular matrix was found at vascular endothelial cell in group 2. 4. After 4weeks of intraperitoneal injection, destruction and distortion of gland cells were distinct. Vacuolization and destruction of nucleus and cellular matrix was found at duct cell in group 2. After intraperitoneal injection of mercury, we found equanimity of mercury and destruction of cellular matrix at serous cell, mucous cell, and duct cell of submandibular gland. So, we thought that metallic taste of mercury poisoning patient would be due to excretion of saliva containing mercury.

A Novel Current Steering Cell Matrix DAC Architecture with Reduced Decoder Area (디코더 면적을 줄이는 새로운 전류구동 셀 매트릭스 DAC 구조)

  • Jeong, Sang-Hun;Shin, Hong-Gyu;Cho, Seong-Ik
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.58 no.3
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    • pp.627-631
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    • 2009
  • This paper presents a novel current steering cell matrix DAC(digital-to-analog converter) architecture to reduce decoder area. The current cell matrix of a existing architecture is selected by columns and lows thermometer code decoder of input bits. But The current cell matrix of a proposal architecture is divided 2n by the thermometer code decoder of upper input bits and are selected by the thermometer code decoder of middle and lower input bits. Because of this configuration, decoder numbers have increased. But the gate number that composed of decoder has decreased. In case of the designed 8 bit current steering cell matrix DAC, the gate number of decoder has decreased by about 55% in comparison with a existing architecture.

Cell Opening of High Resilience Polyurethane Foam I. Concentration Effect of Polyether Type Cell Opener (고탄성 폴리우레탄 발포체의 기포개방 I. 폴리에테르형 기포개방제의 농도 영향)

  • 송기천;이상목;이동호
    • Polymer(Korea)
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    • v.25 no.5
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    • pp.679-690
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    • 2001
  • High resilience PU foams were prepared with polyether type cell opener. The influences of cell opener concentration on the kinetics, rheology, structural stability morphology and open cell content of the obtained foam were investigated and the role of cell opener during cell opening was determined. And mechanical properties as a function of cell opener concentration were studied. It was observed that urea formation reaction was delayed due to high hydrophilicity of cell opener The decrease of viscosity and the increase of tan $\delta$ were confirmed with increasing cell opener concentration so that the resulted foam had low structural stability and high open cell content. The deterioration of matrix and uniform dispersion of hydrogen-bonded urea in matrix with cell opener concentration was revealed by SEM analysis. As a result, elastic properties of the foam matrix were decreased due to high hydrophilicity of cell opener during the preparation of high resilience polyurethane foam and foam with high open cell content resulted. Hardness, tensile strength, tear strength, elongation of foam were decreased with increasing cell opener concentration.

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Effects of Epigallocatechin Gallate on Adhesion, Invasion and Matrix Metalloproteinase Activity in MDA-MB-231 Human Breast Cancer Cells (Epigallocatechin Gallate(EGCG)가 MDA-MB-231 인체 유방암 세포의 부착성, 침윤성과 Matrix Metalloproteinase 활성에 미치는 영향)

  • Bang Myung Hee;Kim Ji Hye;Kim Woo Kyoung
    • Journal of Nutrition and Health
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    • v.38 no.2
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    • pp.104-111
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    • 2005
  • Tumor invasion is composed of four steps: cell adhesion to the extracellular matrix, degradation of the extracellular matrix components, tumor cell motility followed by cell detachment. Matrix metalloproteinases (MMPs) are important proteinases that associated with degradation of matrix component. Epigallocatechin gallate (EGCG) is a major polyphenotic constituent of green tea. In the study, we examined the anti-invasive and MMP activity suppression effects of EGCG in MDA-MB-231 human breast cancer cells. MDA-MB-23l human breast cancer cells were cultured with various concentrations 0 - 100 μM of EGCG. EGCG significantly inhibited the cell adhesion to the fibronectin. Cell motility through gelatin filter and invasion to Matrigel were inhibited dose-dependently by EGCG treatment. EGCG also inhibited the activities of MMP-2, -9 and the amount of MMP-9 (α = 0.05). Therefore, EGCG may contribute to the potential beneficial food component to prevent the invasion and metastasis in breast cancer. (Korean J Nutrition 38(2): 104~111, 2005)

Characterization of SiC-SiC Whisker Matrix Retaining Electrolyte in Phosphoric Acid Fuel Cell (인산형 연료전지용 SiC-SiC Whisker 전해질 매트릭스의 특성)

  • 윤기현;이현임;이근행;김창수
    • Journal of the Korean Ceramic Society
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    • v.29 no.8
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    • pp.587-592
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    • 1992
  • Sheets of SiC-SiC whisker maxed matrix were prepared from the mixed slurry of SiC whisker and SiC matrix by the rolling method. With the increase of SiC whisker, the pore size, the porosity and the phosphoric acid absorbency of the matrix were increased, while the bubble pressure was decreased. The activation energy for the transfer of H+ ion was decreased with the increase of mixing ratio of SiC whisker to the SiC matrix from the measurement of hydrogen ion conductivity. The activation energy was evaluated as 0.25 eV when the mixing ratio of SiC whisker to the SiC matrix was 1 : 2 and the activation energy was 0.16 eV for the 2 : 1 matrix. It means that SiC whisker matrix contributes to attain a better microstructure for the diffusion of hydrogen ion. From the measurement of single cell performance of matrix with various mixing ratio, it is concluded that if SiC-SiC whisker maxed matrix has a sufficient bubble pressure to prevent the crossover of H2 gas, the current density of a fuel cell is increased with the increase of acid absorbency of the matrix. Current density was improved from 140 mA/$\textrm{cm}^2$ for 0.25 mm thickness of matrix to 170 mA/$\textrm{cm}^2$ for the 0.20 mm one at 700 mV.

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Effects of Bambusae Caulis in Taeniam Extract on the UVB-induced Cell Death, Oxidative Stress and Matrix Metalloproteinase 1 Expression in Keratinocytes (각질세포에서 자외선B가 유도한 세포 사멸, 산화적 스트레스 및 matrix metalloproteinase 1 발현에 대한 죽여추출물의 영향)

  • Seok, Jin Kyung;Kwak, Jun Yup;Seo, Hyeong Ho;Suh, Hwa Jin;Boo, Yong Chool
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.1
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    • pp.9-20
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    • 2015
  • Ultraviolet radiation (UV) is a major cause of skin photoaging, and effective UV protecting agents are needed for the skin health and beauty. This study was undertaken to examine the effects of Bambusae caulis in Taeniam extract (BCTE) on UVB-induced cell death, oxidative stress and matrix metalloproteinase 1 (MMP1) expression in cell-based assays. HaCaT human keratinocytes were exposed to UVB in the presence of BCTE at different concentrations and resulting changes in cell viability and biochemical events were determined. The results showed that BCTE enhanced the viabilities of UVB-exposed cells, and attenuated apoptotic events such as cleavage of procaspase 3 to its active form, and the increase of Bax to Bcl-2 ratios. BCTE also attenuated the reactive oxygen generation and lipid peroxidation in cells exposed to UVB. Additionally, it attenuated the expression of matrix metalloproteinase 1 and the phosphorylation of c-Jun N-terminal kinase stimulated by UVB. Conclusively, the present study demonstrated that BCTE pro tected skin cells from the UVB-induced cell death, oxidative stress and MMP1 expression, suggesting its potential use as a cosmetic ingredient mitigating some features of the skin photoaging.

Graphene-matrix nanotopography as a biomimetic scaffold for engineering structure and function of stem cells

  • Park, Seon-Ho;Kim, Jang-Ho
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2017.05a
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    • pp.82-82
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    • 2017
  • It is a great challenge to design and develop biologically inspired hierarchical platforms composed of nano and sub-nanopatterned topography for cell and tissue engineering. In this work, we have developed the novel platforms as a synthetic extracellular matrix using graphene and nanopatterned substrates for promoting functions of cells. Monolayer graphene was coated on the nanopatterned matrix with various nanoscale parallel ridges and grooves as scaffolds with hierarchical structures. Strictly, it was found that graphene-matrix nanotopography platforms could promote the functions of cells including stem cells, osteoblast cells, and endothelial cells through the synergically controlled cell-substrate and cell-cell interactions. Our results proposed that the graphene-based nanopatterned scaffolds would allow us to set up an efficient strategy for designing advanced biomimetic engineering systems toward stem cell-based tissue regeneration.

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