• 제목/요약/키워드: Case-crossover studies

검색결과 22건 처리시간 0.023초

$PM_{10}$ Exposure and Non-accidental Mortality in Asian Populations: A Meta-analysis of Time-series and Case-crossover Studies

  • Park, Hye Yin;Bae, Sanghyuk;Hong, Yun-Chul
    • Journal of Preventive Medicine and Public Health
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    • 제46권1호
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    • pp.10-18
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    • 2013
  • Objectives: We investigated the association between particulate matter less than $10{\mu}m$ in aerodynamic diameter ($PM_{10}$) exposure and non-accidental mortality in Asian populations by meta-analysis, using both time-series and case-crossover analysis. Methods: Among the 819 published studies searched from PubMed and EMBASE using key words related to $PM_{10}$ exposure and non-accidental mortality in Asian countries, 8 time-series and 4 case-crossover studies were selected for meta-analysis after exclusion by selection criteria. We obtained the relative risk (RR) and 95% confidence intervals (CI) of non-accidental mortality per $10{\mu}g/m^3$ increase of daily $PM_{10}$ from each study. We used Q statistics to test the heterogeneity of the results among the different studies and evaluated for publication bias using Begg funnel plot and Egger test. Results: Testing for heterogeneity showed significance (p<0.001); thus, we applied a random-effects model. RR (95% CI) per $10{\mu}g/m^3$ increase of daily $PM_{10}$ for both the time-series and case-crossover studies combined, time-series studies relative risk only, and case-crossover studies only, were 1.0047 (1.0033 to 1.0062), 1.0057 (1.0029 to 1.0086), and 1.0027 (1.0010 to 1.0043), respectively. The non-significant Egger test suggested that this analysis was not likely to have a publication bias. Conclusions: We found a significant positive association between $PM_{10}$ exposure and non-accidental mortality among Asian populations. Continued investigations are encouraged to contribute to the health impact assessment and public health management of air pollution in Asian countries.

환자교차 설계 방법을 적용한 소아천식 입원에 대한 도시 대기오염의 급성영향평가 (Associations between Air Pollution and Asthma-related Hospital Admissions in Children in Seoul, Korea: A Case-crossover Study)

  • 이종태
    • Journal of Preventive Medicine and Public Health
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    • 제36권1호
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    • pp.47-53
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    • 2003
  • Objectives : I used a case-crossover design to investigate the association between air pollution, and hospital admissions for asthmatic children under the age of 15 years in Seoul, Korea Methods : I estimated the changes in the levels of hospitalization risk from theinterquartile (IQR) increase in each pollutant concentrations, using conditional logistic regression analyses, with controls for weather information. Results : Using bidirectional control sampling, the results from a conditional logistic regression model, with controls for weather conditions, showed the estimated relative risk of hospitalization for asthma among children to be 1.04 (95% confidence interval (CI), 1.01-1.08) for particulate matter with an aerodynamic diameter less than or equal to 10m (IQR=40.4ug/m3); 1.05 (95% CI, 1.00- 1.09) for nitrogen dioxide (IQR=14.6ppb): 1.02 (95% CI,0.97-1.06) for sulfur dioxide (IQR=4.4ppb): 1.03 (95% CI, 0.99-1.08) for ozone (IQR=21.7ppb): and 1.03 (95% CI, 0.99-1.08) for carbon monoxide f10R=1.0ppm). Conclusions : This empirical analysis indicates the bidirectional control sampling methods, by design, would successfully control the confounding factors due to the long-term time trends of air pollution. These findings also support the hypothesis that air pollution at levels below the current ambient air quality standards of Korea is harmful to sensitive subjects, such as asthmatic children.

Air pollution and hospital admissions for chronic obstructive pulmonary disease: are their potentially sensitive groups?

  • Tsai, Shang-Shyue;Yang, Ya-Hui;Liou, Saou-Hsing;Wu, Trong-Neng;Yang, Chun-Yuh
    • Advances in environmental research
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    • 제1권1호
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    • pp.57-68
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    • 2012
  • Recent studies showed that air pollution is a risk factor for hospitalization for chronic obstructive pulmonary disease (COPD). However, there is limited evidence to suggest which subpopulations are at higher risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, diabetes, pneumonia, congestive heart failure) on the relationship between hospital admissions for COPD and ambient air pollutants concentrations. Hospital admissions for COPD and ambient air pollution data for Taipei were obtained for the period from 1999-2009. The relative risk of hospital admissions for COPD was estimated using a case-crossover approach. None of the secondary diagnosis we examined showed much evidence of effect modification.

서울지역 대기오염이 천식에 미치는 급성영향: 연구대상의 특성에 따른 비교 (Effects of Air Pollution on Asthma in Seoul: Comparisons across Subject Characteristics)

  • 김선영;김재용;김호
    • Journal of Preventive Medicine and Public Health
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    • 제39권4호
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    • pp.309-316
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    • 2006
  • Objectives: Korean epidemiological studies have used reduced samples according to the subject's characteristics, such as the health services provided, the historical note with asthma, and age, to examine the acute effect of air pollution on asthma using the Korean National Health Insurance records. However, there have been few studies on whether the effects shown in these reduced samples are different from those of all samples. This study compared the effects of air pollution on asthma attacks in three reduced samples with those of entire samples. Methods: The air pollution data for $PM_{10},\;CO,\;SO_2,\;NO_2,\;and\;O_3$, and weather conditions including temperature, relative humidity, and air pressure in Seoul, 2002, were obtained from outdoor monitoring stations in Seoul. The emergency hospital visits with an asthma attack in Seoul, 2002 were extracted from the Korean National Health Insurance records. From these, the reduced samples were created by health service, historical notes with asthma, and age. A case-crossover design was adopted and the acute effects of air pollution on asthma were estimated after adjusting for weather, time trend, and seasonality. The model was applied to each reduced sample and the entire sample. Results: With respect to the health service, the effects on outpatients were similar to those for the total sample but were different for inpatients. These similar effect sizes were also observed in the reduced samples according to the historical note with asthma and age. The relative risks of $PM_{10},\;CO,\;SO_2,\;NO_2,\;and\;O_3$, among the reduced and entire samples were 1.03, 1.04-1.05, 1.02-1.03, 1.04-1.06, and 1.10-1.17, respectively. Conclusions: There was no clear evidence to show a difference between the reduced samples and the entire samples.

오페라 아리아의 크로스오버 편곡기법 연구 - 오페라 사랑의 묘약 중 아리아 Una Furtiva Lagrima를 중심으로 - (Research on Classical Crossover Arrangement Methods of Arias in Operas - Focused on Una Furtiva Lagrima, an Aria of an Opera called L'Elisir d'Amore -)

  • 신델라;신유호
    • 한국엔터테인먼트산업학회논문지
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    • 제14권6호
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    • pp.151-160
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    • 2020
  • 클래식 음악은 '작곡가가 쓴 그대로 연주해야 한다'란 엄격함이 존재했다. 그러나 다양한 개성과 사고를 중시하는 21세기 포스트모더니즘 시대에 들어서면서 전통 클래식 무대를 제외하곤 그 엄격함의 무게가 더 이상 유의미하지 않게 되었다. 클래식의 기품은 간직한 채 엄격한 규칙대신 대중음악의 친숙함을 접목시키며 크로스오버 된 오페라 아리아는 그 동안 어렵게만 느껴졌던 오페라 아리아가 대중들에게 한층 쉽게 다가가며 클래식의 대중화를 이끌어내는 큰 역할을 하게 되었다. 그럼에도 불구하고 클래식 음악을 크로스오버 음악으로 탈바꿈시키는 편곡기법에 관한 연구는 부족한 상황이다. 따라서 본 연구는 객관적 음악분석 방법인 화성, 리듬, 악기 편성 중심으로 기존 선행연구의 연구범위를 확대한 오페라에 대한 크로스오버적 편곡기법을 연구하였다. 분석결과, 원곡과 팝페라 버전은 리듬, 화성에는 유사성을 보이고 있으나 악기 편성에서는 차이점을 보이고 있다. 재즈 버전은 아프로큐반 리듬의 발라드 계열인 볼레로 리듬, 재즈 어쿠스틱 악기 중심의 구성, Tension을 많이 사용한 Voicing을 통해 클래식컬한 느낌을 없애고 재즈의 느낌으로 연출하여 원곡과의 차별을 보이고 있는 것이 특징이었다. 본 연구가 클래식컬 크로스오버 편곡기법 연구 자료로서 유용하게 쓰이길 바란다.

정신과 연구에서 다양한 임상연구방법의 장단점 (Pros and Cons of Various Research Designs in Clinical Psychiatry)

  • 하라연;조현상
    • 생물정신의학
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    • 제19권4호
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    • pp.159-163
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    • 2012
  • An appropriate research design for hypotheses and purposes leads to a good quality of research results. In this review article, we summarized the types of research methods and described the characteristics of clinical trials. Research designs are categorized into observational studies and experimental ones, depending on data collecting methods. In an observational study, there are cross-sectional, cohort and case-control studies. Parallel groups design and crossover trial studies are representative designs in a randomized controlled trial study, a kind of experimental study. Clinical researchers should understand the characteristics of clinical research designs including advantages and disadvantages and choose the suitable design according to their study purposes and the nature of collected data or subjects.

Development of Operation Strategy to improve Efficiency for Twin Automated Transfer Crane in an Automated Container Terminal

  • Park, Byung-Joo;Choi, Hyung-Rim
    • 한국항해항만학회지
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    • 제31권7호
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    • pp.605-611
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    • 2007
  • In order to become a mega hub port, major ports all over the world are making every effort to enhance their productivity through efficiency of internal operation. Accordingly, in order to enhance the competitiveness of a container terminal, an automated container terminal is considered as the best alternative. An automated container terminal is using such automated handling equipment as AGV(Automated Guided Vehicles) and ATC(Automated Transfer Crane). The efficient equipment operation plays a critical role in enhancing the productivity of an automated container terminal. In an automated container terminal, the most important equipments are AGV and ATC. Each block of containers with a vertical layout is generally operating two ATCs. The two ATCs can be crossed or not at each block. In the case of operating crossover ATC, it has an advantage of high flexibility that ATC work is possible at both TP(Transfer Point) of each block. But it has also a disadvantage that the yard has to be operated at a low storage level of containers in the terminal yard. Recently, for automated container terminals, which are being prepared for opening in Korea, they plan to use uncrossed twin ATC in order to make the storage level of their yards high at a low cost. Therefore, studies have to be made in order to increase the efficiency of twin ATC system based on the flexibility that the crossover ATC system has. This research aims to suggest an operation strategy to improve efficiency of twin ATC at each storage block in a yard.

농작업재해의 원인구명 및 코호트 구축방안 (Cohort Study for Investigation of the Causes in Agricultural Injuries and Diseases)

  • 임현술
    • 농촌의학ㆍ지역보건
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    • 제31권2호
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    • pp.119-144
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    • 2006
  • The Korea rural health study, a large prospective cohort study, the objectives of this study are exploration for potential causes of agricultural injuries and diseases among farmers. Current medical research suggests that they may have higher rates of some traumatic injuries, pesticide poisoning, infectious diseases, musculoskeletal diseases, asthma and other respiratory diseases. This study is designed to identify occupational, lifestyle, and environmental factors of workplace that may affect the rate of diseases in farming population. Round 1, initial cohort recruitment, will begin in 2006 and conclude in 2009. Round 2, follow-up will begin in 2010 and conclude in 2014. Approximately 54,000 persons will be selected to study population. Nested case-control studies and case-crossover studies will be conducted for getting to the bottom of agriculture-related diseases. Recruitment and follow-up are conducted in collaboration with multi-centers. As data on the exposures and health outcomes of this study population are collected and analyzed in 2014. This study will be evaluated by public health experts for effort, achievement, adequacy of performance, efficacy, process of study and so on. The author expects that this cohort study may reduce agricultural injuries and diseases and will provide information that agricultural workers can use in making decisions about their health. Also, this study will be significant basis for strengthening the competitiveness of agriculture in Korea.

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Estimation of the National Burden of Disease and Vulnerable Population Associated with Natural Disasters in Korea: Heavy Precipitation and Typhoon

  • Han, Hyun-Jin;Kim, Jong-Hun;Chung, Soo-Eun;Park, Jae-Hyun;Cheong, Hae-Kwan
    • Journal of Korean Medical Science
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    • 제33권49호
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    • pp.314.1-314.15
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    • 2018
  • Background: Despite its growing significance, studies on the burden of disease associated with natural disasters from the perspective of public health were few. This study aimed at estimating the national burden of disease associated with typhoons and torrential rains in Korea. Methods: During the period of 2002-2012, 11 typhoons and five torrential rains were selected. Mortality and morbidities were defined as accentual death, injury and injury-related infection, and mental health. Their incidences were estimated from National Health Insurance Service. Case-crossover design was used to define the disaster-related excess mortality and morbidity. Disability-adjusted life years (DALYs) were directly assessed from excess mortality and morbidity. Results: The burden of disease from typhoons increased with the intensity, with 107.7, 30.6, and 36.6 DALYs per 100,000 per event for strong, moderate, and weak typhoons, respectively. Burden of disease from torrential rains were 56.9, 52.8, and 26.4 DALYs per 100,000 per event for strong, moderate, and weak episodes, respectively. Mental disorders contributed more years lived with disability (YLDs) than did injuries in most cases, but the injury-induced YLDs associated with strong typhoon and torrential rain were higher than those of lower-intensity. The elderly was the most vulnerable to most types of disaster and storm intensities, and males younger than 65 years were more vulnerable to a strong torrential rain event. Conclusion: The intensity of torrential rain or typhoon was the strongest determinant of the burden of disease from natural disasters in Korea. Population vulnerable may vary depending on the nature and strength of the disasters.

Optimal design using genetic algorithm with nonlinear inelastic analysis

  • Kim, Seung-Eock;Ma, Sang-Soo
    • Steel and Composite Structures
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    • 제7권6호
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    • pp.421-440
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    • 2007
  • An optimal design method in cooperated with nonlinear inelastic analysis is presented. The proposed nonlinear inelastic method overcomes the difficulties due to incompatibility between the elastic global analysis and the limit state member design in the conventional LRFD method. The genetic algorithm used is a procedure based on Darwinian notions of survival of the fittest, where selection, crossover, and mutation operators are used to look for high performance ones among sections in the database. They are satisfied with the constraint functions and give the lightest weight to the structure. The objective function taken is the total weight of the steel structure and the constraint functions are load-carrying capacity, serviceability, and ductility requirement. Case studies of a planar portal frame, a space two-story frame, and a three-dimensional steel arch bridge are presented.