• Genomics & Informatics
• /
• 제10권2호
• /
• pp.117-122
• /
• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• 대한간호학회지
• /
• 제42권6호
• /
• pp.771-782
• /
• 2012

Purpose: This study was conducted to develop and implement a case-based small group learning program on the care of children with infectious disease, and to examine its effects on knowledge, attitude and preventive practice behaviors of daycare center teachers compared to a control group. Methods: Based on the need assessment, the case-based learning program for the management of infectious children was developed. For this quasi-experimental study, 69 teachers were recruited from 14 child daycare centers in a city located in J province. Thirty four teachers were assigned to experimental group and participated in the case-based small group learning once a week for 5 weeks. Data were analyzed using the SPSS 18.0 program to perform ${\chi}^2$-test and t-tests. Analysis of covariance was used to treat the covariate of the number of assigned children between experimental and control groups. Results: The experimental group showed significantly higher posttest scores in knowledge, attitude and preventive practice behaviors than those of control group (p<.001). Conclusion: These findings indicate that case-based small group learning is an effective educational strategy for daycare center teachers to learn infection management through the emphasis of self-reflection and discussion.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1999년도 하계학술대회 논문집 B
• /
• pp.1013-1016
• /
• 1999

In this paper, a real-time communication method using a PICNET-NP(Plant Instrumentation and Control Network for Nuclear Power plant) is proposed with an analysis of the control network requirements of DCS (Distributed Control System) in nuclear power plants. The method satisfies deadline in case of worst data traffics by considering aperiodic and periodic real-time data and others. In addition, the method was used to analyze the data characteristics of the DCS in existing nuclear power plant. The result shows that use of this method meets the response time requirement(100ms)

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
• /
• pp.677-680
• /
• 2003

In this paper, the analysis of practical end-to-end delay in worst case is performed for distributed control system considering the implementation of the system. The control system delay is composed of the delay caused by multi-task scheduling of operating system, the delay caused by network communication, and the delay caused by the asynchronous between them. Through simulation tests based on CAN(Controller Area Network), the proposed end-to-end delay in worst case is validated. Additionally, online clock synchronization algorithm is proposed here for the control system. Through another simulation test, the online algorithm is proved to have better performance than offline one in the view of network bandwidth utilization.

• Journal of Information Technology Applications and Management
• /
• 제26권6호
• /
• pp.103-117
• /
• 2019

Demand for high power motors is rapidly increasing as the 4th industry and convergence technology has recently emerged. In order to produce high-strength permanent magnets, the magnets used for magnetization have been increased from DC 300V in the 1970s to DC 2.5kV in the 2010s, Up to DC 10kV in the 2030s, It is expected that higher voltage will be used to magnetize. However, in the case of a magnetizer using an existing electric signal control device, it is necessary to use a control device with a high-voltage insulation function in case a high voltage used for magnetization is leaked to the control device. If a short circuit accident occurs, the controller must be shut down and serious problems such as excessive repair costs arise. In this study, a control system adopting optical communication method instead of electric signal control method is proposed to prevent leakage currents in high-voltage magnetizer. We design a transmitter(Tx) and a receiver(Rx) device for the optical communication control device and implemented a prototype connecting the optical cable. In order to demonstrate the utility of high-voltage magnetizer using the optical communication control device, we analyzed the initial cost and the yearly cost for the years to analyze the net present value. As a result, In the case of the low-voltage magnetizer, the electric signal control method cost less, As the operating voltage of the magnetizer becomes higher. It is confirmed that it takes less cost when the optical communication control device is used.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
• /
• pp.56-59
• /
• 1996

Worst-case state estimation will be proposed in this paper. By using the worst-case disturbance and worst-case state estimation, we can obtain right/left constrained coprime factors. If constrained coprime factors are used in designing a controller, the infinity-norm of closed-loop transfer matrix can be smaller than any constant .gamma.(> .gamma.$_{opt}$) without matrix dilation optimization. The derivation of left/right constrained coprime factors is achieved by doubly coprime factorization for the plant constrained by the infinity norm. And the parameterization of stabilizing controllers gives us easily understanding for H$_{\infty}$ control theory.ry.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
• /
• pp.259-262
• /
• 1995

In this paper, a model of an asymptotically reliable serial production line with quailty control devices is introduced and analyzed. By an asymptotic technique and Taylor series expansion, its average production rate is approximated in a closed form. The results are applied to a case study of a surface mount system.

• 대한전기학회논문지:전력기술부문A
• /
• 제48권5호
• /
• pp.650-657
• /
• 1999

In this paper, a real-time communication method using a PICNET-NP(Plant Instrumentation and Control Network for Nuclear Power plant) is proposed with an analysis of the control network requirements of DCS(Distributed Control System) in unclear power plants. The method satisfies deadline in case of worst data traffics by considering aperiodic and periodic real-time data and others.

• 응용통계연구
• /
• 제25권4호
• /
• pp.563-573
• /
• 2012

Various methods of analysis have been proposed to understand the gene-disease relation and gene-gene interaction effect for a disease through comparison of genotype in case-control study. In this study, we proposed the method to detect a genetic association and gene-gene interaction through the use of a network graph and centrality measures that are used in social network analysis. The applicability of the proposed method was studied through an analysis of real genetic data.

• 품질경영학회지
• /
• 제29권4호
• /
• pp.38-53
• /
• 2001

In resolving industrial quality control problems, a vector of multiple quality characteristic variables is involved rather than a single variable. However, it is not guaranteed that a multivariate control chart based on statistical methods can monitor abnormal signal in case that small changes of relationship between each variables causes abnormal production process. Hence a quality control system for real-time monitoring of the multi-dimensional quality characteristic vector under a multivariate normal process is needed to enhance tile production system quality performance. A pattern analysis approach based on self-organizing map (SOM), an unsupervised learning technique of neural network, is applied to the design of such a quality control system. In this study we present a new material quality control system based on pattern analysis approach and illustrate the effectiveness of proposed system using actual electronic company material data.