The Korean Journal of Applied Statistics (응용통계연구)

The Korean Statistical Society (한국통계학회)
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Detecting Genetic Association and Gene-Gene Interaction using Network Analysis in Case-Control Study

  • Jin, Seo-Hoon (Department of Informational Statistics, Korea University) ;
  • Lee, Min-Hee (Department of Statistics, Korea University) ;
  • Lee, Hyo-Jung (Department of Statistics, Korea University) ;
  • Park, Mi-Ra (Department of Preventive Medicine, Eulji University)
  • Received : 2012.04.10
  • Accepted : 2012.06.05
  • Published : 2012.08.31
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Abstract

Various methods of analysis have been proposed to understand the gene-disease relation and gene-gene interaction effect for a disease through comparison of genotype in case-control study. In this study, we proposed the method to detect a genetic association and gene-gene interaction through the use of a network graph and centrality measures that are used in social network analysis. The applicability of the proposed method was studied through an analysis of real genetic data.

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References

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