• Journal of Genetic Medicine
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• v.17 no.1
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• pp.27-33
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• 2020

Purpose: Duchenne muscular dystrophy (DMD) is the most common lethal muscular dystrophy and is caused by the genetic variants of DMD gene. Because DMD is X-linked recessive and shows familial aggregates, prenatal diagnosis is an important role in the management of DMD family. We present our experience of prenatal molecular diagnosis and carrier detection based on multiplex polymerase chain reaction (PCR), multiplex ligation-dependent probe amplification (MLPA), and linkage analysis. Materials and Methods: During study period, 34 cases of prenatal diagnosis and 21 cases of carrier detection were performed at the Seoul National University Hospital. Multiplex PCR and MLPA was used to detect the exon deletions or duplications. When the DMD pathogenic variant in the affected males is unknown and no DMD pathogenic variant is detected in atrisk females, linkage analysis was used. Results: The prenatal molecular diagnosis was offered to 34 fetuses. Twenty-five fetuses were male and 6 fetuses (24.0%) were affected. Remaining cases had no pathogenic mutation. We had 24 (80.0%) cases of known proband results; exon deletion mutation in 19 (79.2%) cases and duplication in 5 (20.8%) cases. Linkage analysis was performed in 4 cases in which 2 cases (50.0%) were found to be affected. In the carrier testing, among 21 cases including 15 cases of mother and 6 cases of female relative, 9 (42.9%) cases showed positive results and 12 (57.1%) cases showed negative results. Conclusion: Prenatal molecular diagnosis and carrier detection of DMD are effective and feasible. They are useful in genetic counseling for DMD families.

• Proceedings of the IEEK Conference
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• 2000.11b
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• pp.309-312
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• 2000

In this paper, The Influence of chromatic fiber dispersion on the transmission distance of MMW(millimeter-wave) link is analyzed and discussed. It is shown that dispersion significantly limits the transmission distance in intensity modulated direct detection and heterodyne links operating in the above 20㎓ frequency region by inducing a carrier to noise penalty on the transmitted signal. We analyze and discuss the influence of dispersion induced CNR(Carrier to Noise Ratio) penalty for direct detection and heterodyne method from simulation.

• Journal of Korean Academy of Nursing
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• v.33 no.6
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• pp.686-692
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• 2003

Purpose: To assess the effect of handwashing improving program and MRSA carrier detection program on MRSA(methicillin resistant Staphylococcus aureus) infection rate in a intensive care unit. Method: The intervention was Nosocomial Infection(NI) control program consisted of hand washing improving program and identification and treatment of MRSA carrier. Data on the NI and MRSA infections were collected by an infection control nurse based on the definition of CDC. MRSA infection rates were calculated by the number of MRSA infection per 100 admissions or 1,000 patients-days. The difference of MRSA infection rates between pre and post intervention was tested by Chi-square at =.05. Result: MRSA infection rates 3.0% or 3.2 per 1,000 patient-days at the pre, 4.6% or 3.7 per 1,000 patient-days at the post, and the differences were not statistically significant (p=.411, p=.769 respectively). Conclusion: The handwashing improving program and MRSA carrier detection program was not effective in reducing the Nosocomial Infection(NI) or MRSA infection rates. It is recommended further studies with a longer intervention and follow-up period.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.4A
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• pp.440-449
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• 2008

In this paper, we propose a 16-QAM carrier recovery loop which is suitable for the implementation of Inmarsat M4 system receiver. Because the frequency offset of ${\pm}924\;Hz$ on signal bandwidth 33.6 kHz is recommended in Inmarsat M4 system specification, carrier recovery loop having stable operation in the channel environment with large relative frequency offset is required. the carrier recovery loop which adopts only PLL can't be stable in relatively large frequency offset environment. Therefore, we propose a carrier recovery loop which has stable operation in large relative frequency offset environment for Inmarsat M4 system. The proposed carrier recovery loop employed differential filter-based noncoherent UW detector which is robust to frequency offset, CP-AFC for initial frequency offset acquisition using UW signal, and 16-QAM DD-PLL for phase tracking using data signal to overcome large relative frequency offset and achieve stable carrier recovery performance. Simulation results show that the proposed carrier recovery loop has stable operation and satisfactory performance in large relative frequency offset environment for Inmarsat M4 system.

• Journal of Electrical Engineering and Technology
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• v.7 no.3
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• pp.429-435
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• 2012

In this study, a real-time architecture for the detection of clock jumps in the GPS clock behavior is proposed. GPS satellite atomic clocks have characteristics of a second order polynomial in the long term showing sudden jumps occasionally. As satellite clock anomalies influence on GPS measurements which could deliver wrong position information to users as a result, it is required to develop a real time technique for the detection of the clock anomalies especially on the real-time GPS applications such as aviation. The proposed strategy is based on Teager Energy operator, which can be immediately detect any changes in the satellite clock bias estimated from GPS carrier phase measurements. The verification results under numerous cases in the presence of clock jumps are demonstrated.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.40 no.12
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• pp.1048-1054
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• 2012

This paper presents a Carrier phase fault detection (FD) method for GPS RTK (Global Positioning System Real Time Kinematic) in dynamic environment. There are various error sources in dynamic environment and these errors decrease the reliability of FD results. Due to the reason, Carrier phase measurements are separated into satellite induced signal, user induced signal and other remaining errors. Especially the user-induced signal is computed by user dynamic which is estimated by time-differenced Carrier phase (TDCP) and Doppler shift. TDCP makes it possible to avoid integer ambiguity resolution. Computer simulation is conducted to verify the suggested method. By applying impulse, step and ramp faults, the FD performance is analyzed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.3A
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• pp.232-239
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• 2006

In this paper, we analyze the preamble model for Wireless PAN(WPAN) in proposed Ultra WideBand(UWB) Multi-Band OFDM(MB-OFDM) system of IEEE 802.15.3a standard. Besides, we propose effective Carrier Frequency Offset and Symbol Timing Offset Estimation algorithm which offers enhanced performance, and analyze its performance using Detection Probability, False Alarm Probability, Missing Probability, Mean Acquisition Time and MSE(Mean Square Error) through simulation in AWGN and UWB channel environments.

• Journal of Communications and Networks
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• v.15 no.6
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• pp.569-575
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• 2013

In this paper, we present a photonic approach for generating highly stable coherent sub-terahertz (THz) signals for wireless communications. As proof-of-concept we transmit data at 100 GHz carrier frequency using on-off keying modulation and heterodyne detection. The sub-THz carrier signals are generated by photo-mixing two optical carrier signals at different frequencies, extracted from an optical frequency comb. We introduce a novel system to stabilize the phase of the optical carrier signals. Error-free transmission is successfully achieved up to a bit rate of 8.5 Gbit/s at 100 GHz.

• Journal of Positioning, Navigation, and Timing
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• v.4 no.4
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• pp.195-203
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• 2015

In this study, the carrier acceleration-ramp-step test was applied to GPS carrier phase measurements, and the results were compared and analyzed. In the carrier acceleration-ramp-step test, the acceleration, ramp, and measurements are estimated using 10 consecutive carrier phase measurements for satellites observed at the same time based on the least square method. As for the characteristic of this test, if failure occurs in the measurement, the value jumps significantly compared to the previous result; but it judges that failure has occurred in all the satellites although failure has occurred in one satellite. Therefore, in this study, a method that eliminates a satellite with failure was suggested, and thresholds of the carrier acceleration, ramp, and step were suggested. The evaluation of the failure detection performance of carrier phase measurement using the suggested thresholds showed that failure could be detected when the carrier phase measurement changed abruptly by more than about 0.1 cycles.

• Journal of Advanced Navigation Technology
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• v.17 no.6
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• pp.593-599
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• 2013

In this paper, the GPS cycle-slip detection for carrier-phase based positioning of land vehicle is presented. For the carrier phase based positioning, cycle-slip detection is necessary to get the reliability of positioning result. There exists many cycle-slip detection algorithms, but we detect the cycle-slip by using the monitoring value which is defined as residual between the carrier phase measurement and estimated value from low-cost inertial sensor. To achieve goal of paper, low-cost cycle-slip detection system, permissible specification region of inertial sensor is derived. By using the result of permissible region, appropriate inertial sensor of cycle-slip detection can be decided, proper cost and proper specification. To verify the result of this paper, we conduct the rate table test. As a result, required cycle-slip detection performance is satisfied conservatively.