• 한국가시화정보학회지
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• 제20권1호
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• pp.52-63
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• 2022

Direct numerical simulation of blood flow in a stenosed, patient-specific carotid artery was conducted to explore the transient behavior of blood flow with special emphasis on the wall-shear stress distribution over the transition region. We assumed the blood as an incompressible Newtonian fluid, and the vessel was treated as a solid wall. The pulsatile boundary condition was applied at the inlet of the carotid. The Reynolds number is 884 based on the inlet diameter, and the maximum flow rate and the corresponding Womersley number is approximately 5.9. We found the transitional behavior during the acceleration and deceleration phases. In order to quantitatively examine the wall-shear stress distribution over the transition region, the probability density function of the wall-shear stress was computed. It showed that the negative wall-shear stress events frequently occur near peak systole. In addition, the oscillatory shear stress index was used to further analyze the relationship with the negative wall-shear stress appearing in the systolic phase.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.289-290
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• 2022

동맥경화증은 경동맥 혈관 벽이 두꺼워지는 질병으로 진단을 위해 혈관 벽의 두께를 모니터링하는 것이 중요하다. 본 연구에서는 경동맥 MRI 영상에서 324개의 라디오믹스 특징을 추출하고 머신러닝 기법을 이용하여 동맥경화증을 진단하는 모델을 제안한다. 라디오믹스 특징을 통해 로지스틱 회귀, 서포트 벡터 머신, 랜덤 포레스트, XGBoost의 총 4가지 분류 모델을 학습하였다. 5-fold 교차 검증에서 가장 높은 성능의 모델인 XGBoost는 정확도 0.9023, 민감도 0.9517, 특이도 0.8035, AUC 0.8776의 결과값을 보여준다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제15권2호
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• pp.100-104
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• 1993

저자들은 두개저 골절을 동반하지 않은 단순 안면골 골절환자에서 본과에서 안면골 정복 수술후 발현한 외상성 경동맥해변동루 환자를 신경외과에 의뢰하여 분리풍선술식으로 처치한 후 현저한 임상적 증상의 개선을 가져왔고 12개월간 관찰시 다른 합병증도 유발되지 않았다. 외상성 경동맥해면동루는 두경부 손상시 매우 드물게 발생되는 심각한 합병증으로 임상증상의 복잡성 때문에 혼동하기 쉬으므로 Neurosurgeon과 협조하여 조기에 정확한 진단과 적절한 치료가 이루어지는 것이 바람직하다.

• 대한두경부종양학회지
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• 제9권1호
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• pp.63-67
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• 1993

저자들은 극소진행형 비인강암(제 4기, $N_4N_{2c}$) 환자에서 종양으로 인한 경동맥동 과민증후군과 관련되어 실신이 발생하였으며 방사선치료후 호전된 환자 1예를 경험하였다.

• Journal of Preventive Medicine and Public Health
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• 제41권2호
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• pp.107-114
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• 2008

Objectives : The aim of this study is to investigate the association between obesity indices(body mass index, weight, waist-hip ratio and waist circumference) in adolescents and the carotid intima-media thickness (C-IMT) in early adulthood. We also wanted to identify the best predictor for C-IMT among these obesity indices. Methods : This study used community-based prospective cohort study, known as the Kangwha Study, and the data we used were from subjects who were 16-years old in 1996 (defined as "adolescence") and 25 years-old in 2005 (defined as "early adulthood"). The 256 subjects (113 men and 143 women) who were used for analysis participated in both follow-ups, and they underwent B-mode ultrasonography of the carotid arteries at the early adulthood follow-up. Obesity indices were defined as the body mass index, weight, waist-hip ratio and waist circumference. The C-IMT was defined as the mean of the maximal IMT of each common carotid artery. The C-IMT and obesity indices associations were evaluated via multivariable regression, logistic regression and the receiver-operator characteristic curve analyses. Results : In men, all the obesity indices in adolescence were showed to have statistically significant positive association with C-IMT in early adulthood. However, no such relationship was showed in women. On multiple regression and logistic regression analysis, the waist-hip ratio showed the biggest relationship with the C-IMT among the 4 obesity indices. However, there were no statistical significant differences and no best predictor was found. For the women, the obesity incidences and C-IMT showed no relationships. Conclusions : This study suggested that obesity in adolescence was related to an increase C-IMT in healthy young Korean men.

• 비파괴검사학회지
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• 제31권5호
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• pp.479-486
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• 2011

의료영상을 기반으로 한 경동맥 분기부 혈류유동장 전산유체역학 해석의 수행에 있어 입구부 경계 조건 도출을 위한 환자 특정 시간 변동 상세 유속 분포를 얻는 것은 일반적으로 쉽지 않다. 그러므로 대부분의 경우 계측된 혈류량을 바탕으로 이상적인 축대칭 완전발달 유속 분포를 적용하게 된다. 그러나 MRI로 직접 계측한 총경동맥 혈류 유속분포를 적용한 기존의 연구에서 입구부 유속분포 경계 조건이 경동맥 분기부 혈류 유동장 해석 결과에 중요한 영향을 미친다는 것을 보였으며, 특히 계측된 혈류 유속분포가 전형적인 Dean type 유동과 다른 독특한 형태를 가진다는 것을 보고하였다. 본 연구에서는 이러한 독특한 형태의 유속 분포가 경동맥 입구부 형상의 이차곡률에 의해 생성됨을 보이고, 직접 경동맥 분기부 유동장 CFD 해석의 경계 조건으로 적용하여 이의 영향을 조사하였다. 이를 통하여 충분한 길이의 실제 경동맥 입구부 형상을 적용 할 경우, 입구부 경계 조건의 영향이 의료영상으로 부터 혈관 형상을 도출하는 과정에서 불가피하게 유기되는 영상 처리 오차에 의한 영향에 비해 상대적으로 크지 않음을 알 수 있었다.

• Journal of Korean Neurosurgical Society
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• 제55권6호
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• pp.313-320
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• 2014

Objective : The purpose of this study is to demonstrate the technical feasibility and clinical efficacy of emergent carotid angioplasty and stenting (CAS) for acute stroke due to athero-thrombotic occlusion of the cervical internal carotid artery (ICA). Methods : Review of medical records identified 17 patients who underwent emergent CAS for treatment of athero-thrombotic occlusion of the cervical ICA with acute stroke between 2009 and 2013. Eleven patients (64.7%) presented with concomitant intracranial artery occlusion, which was treated primarily by mechanical thrombectomy after CAS. Results : Successful revascularization of the cervical ICA with emergent CAS was achieved in all patients. After CAS, intracranial recanalization with Thrombolysis in Cerebral Infarction ${\geq}2b$ flow was achieved in four of the 11 patients (36.4%). The overall recanalization rate (cervical ICA and intracranial artery) was 10 of 17 patients (58.8%). Symptomatic intracranial hemorrhage occurred in two patients (11.8%), resulting in death. Ten patients (58.8%) showed improvement (decrease in NIHSS score of ${\geq}4$ points) at seven days after recanalization. Nine patients (52.9%) showed a favorable outcome ($mRS{\leq}2$) at the last follow-up. A favorable outcome ($mRS{\leq}2$) was obtained in four of the six patients with isolated cervical ICA occlusion (4/6, 66.7%) and five of 11 patients with intracranial tandem occlusion (5/11, 45.5%). Conclusion : Emergent CAS for acute stroke due to athero-thrombotic occusion of the cervical ICA showed a good technical feasibility and favorable clinical outcome.

• Journal of Korean Neurosurgical Society
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• 제41권5호
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• pp.343-346
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• 2007

Hypoplasia of the internal carotid artery is a rare congenital anomaly. Agenesis, aplasia, and hypoplasia of the internal carotid artery [ICA] are frequently associated with cerebral aneurysms in the circle of Willis. Authors report two cases with congenital hypoplasia of the ICA accompanying with the aneurysms. Transfemoral cerebral angiography [TFCA] in one patient identified nonvisualization of the left ICA. Bilateral anterior cerebral artery [ACA] and middle cerebral artery [MCA] were supplied from the right ICA accompanying with two aneurysms at anterior communicating artery [AcoA] and A1 portion of the left ACA. TFCA in another patient demonstrated hypoplastic left ICA and left ACA filled from the right ICA accompanying with AcoA aneurysm. Left MCA was filled from basilar artery via posterior communicating artery [PcoA]. Skull base computed tomography [CT] in two patients showed hypoplastic carotid canal. Authors performed direct aneurysmal neck clipping. Follow up CT angiography [CTA] at one year after surgery did not show regrowth or new development of the aneurysm. In patients with hypoplastic ICA, neurosurgeons should be aware of the possibility of development of the aneurysms, presumably because of hemodynamic process. Direct aneurysmal neck clipping is a good treatment modality. After operation, regular CTA, magnetic resonance angiography [MRA] or TFCA is needed to find progressive lesion and to prevent cerebrovascular attack [CVA].

• 한국융합학회논문지
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• 제6권6호
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• pp.195-200
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• 2015

본 연구는 2014년 경기 남부의 종합건강검진센터에서 30-55세의 건강한 성인 47명을 대상으로 경동맥 초음파검사와 혈액검사 그리고 체격측정을 실시하여 성별과 연령 간에 동일한 집단으로 분석되었고, 대상자의 엉덩이둘레는 연령에 따라 40대가 50대보다 높은 결과로 나타났다(p<0.05). 경동맥 초음파 검사결과에서는 30대와 50대에서 차이를 보였다(p<0.05). CIMT와 BMI, CIMT와 엉덩이둘레에서 양의 상관관계를 보였다(p<0.05). 또한 혈압에서 CIMT와 수축기혈압은 양의 상관관계를 보였다(p<0.05). 결론적으로 이번 연구에서는 경동맥 내중막 두께로 대사증후군 인자와의 상관성을 입증하였으며, 향후 질병의 진단을 위해서는 초음파를 활용한 대사증후군 인자들의 융합적 연구가 보다 질적인 질병진단을 위해서는 지속적으로 연구되어야 할 것으로 사료된다.

• 대한한의학회지
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• 제39권1호
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• pp.86-94
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• 2018

Objectives: This study is aimed to examine the effect of Geopungchunghyul-dan on circumferential strain of carotid artery in outpatients of Kyung Hee University hospital of Korean Medicine. Methods: Retrospective chart review is used from June 2016 to August 2017 for outpatients of Kyung Hee University hospital of Korean Medicine. 14 patients taking Geopungchunghyul-dan over 1 month were speculated. Data of circumferential strain and intima-media thickness was taken from carotid ultrasonography and processed by Wilcoxon signed-rank test. Results: Geopungchunghyul-dan lowered circumferential strain of both carotid arteries after 1 month of administration (p<0.05). Intima-media thickness of both carotid arteries did not changed significantly. Conclusions: Geopungchunghyul-dan may ameliorate arterial stiffness.