• 대한중풍순환신경학회지
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• 제8권1호
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• pp.58-62
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• 2007

Objective : Stroke patients tend to take antibiotics due to infection resulting from complication. One of many side effects from using antibiotics is diarrhea, which infact causes anaerobic organism dysfunction resulting Pseudo-Membranous Colitis (P.M.C). To treat P.M.C, antibiotics and antibacterial agents are usually used. But they may cause other side effects, therefore extreme caution must be taken. Methods : We treated an antibiotic induced P.M.C patient who diagnosed by sigmoid scopy with only Yijoong-tang (Lizhong-tang) without antibiotics and observed patients stool aspects. Results and Conclusion : Patiensts symptom was improved after 7days, and we can see the improvement by follow-up sigmoid scopy. This case may give us a possibility of that oriental medical treatments as complementary and alternative medicine to standard antibiotic treatment.

• 대한한의학회지
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• 제21권2호
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• pp.60-67
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• 2000

Objectives : Radix Angelicae Gigantis(RAG) and Resina Ferulae(RF) have been used in oriental medicine or folk medicine to increase stamina. The aim of this study was the characterization of the mechanism of action of RAG and RF on smooth muscle and macrophages in rats to find new substances for the treatment of erectile dysfunction, cardiovascular diseases and immune dysfunction. Methods : We investigated the effects of the water extracts of RAG and RF on phenylephrine or KCl-contracted rat endothelium-denuded aorta, the production of NO in vascular smooth muscle cell (VSMC) and the production of NO and induction of iNOS in the $IFN-{\gamma}-primed$ RAW 264.7 cells. Results : The water extracts of the RAG and RF showed significant concentration-dependent relaxation effects on phenylephrine or KCl-contracted rat endothelium-denuded aorta. It also reduced the tension of the rat endothelium denuded aorta which was contracted in $Ca^{2+}-free$ media. On the other hand, it increased production of NO in VSMC which was stimulated with $IL-{\beta}$ or $IL-{\beta}$ plus $IFN-{\gamma}$. The water extracts of RAG and RF increased production of NO and induction of iNOS in the $IFN-{\gamma}-primed$ RAW 264.7 cells. Conclusions : According to the above results, the water extracts of RAG and RF relaxed the smooth muscle effectively and increased the production of NO in VSMC and macrophages. So, these herbs can be applied to erectile dysfunction, hypertension, angina pectoris, artherosclerosis and a defense defect for virus or microbe.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.208-215
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• 1998

Ginseng has been used in maintaining physical vitality all over the East Asian countries and recently its metabolism and actions on neurologic, cardiovascular and endocrinologic systems are being elucidated. Korean red ginseng (KRG) has been used in various aliments, and to prove its efficacy icy erectile dysfunction an international study on Asians other than Korean was performed. Patients with borderline organic and psychogenic erectile dysfunction were included. KRG were given daily, and placebos were given as controls. Treatment lasted a total of 3 months. Surveys including libido, erectile potency, the sexual satisfactions were given. Serum testosterone and erectile function study were taken. Among the 23 patients with KRG, 18 patients were followed. Four had diabetes, 2 hypertension, 3 hyperchole, iterolemia, 1 low testosterone,4 psychogenic, and 4 idiopathic. In 10 patients with placebo, 7 were followed for more than three months. The clinical efficacy of KRG was 66.7% on objective Questionnaire and 72.2% on subjective analysis. When KRG were given, all parameters surveyed have shown improvements compared to the controls. Serum testosterone Bevels were normalized in 2 patients with KRG, whose serum testosterone levels were reduced from prestudy. When the erectile functions after audiovisual stimuli evaluated using Rigiscan in 6 patients with KRG,4 showed rigidity move than 70oyc. One patient reported constipation, and 2 gastric up-sets in the KRG group. In conclusion, KRG has beneficiary action on male erectile capabilities with minimal side effects. Thus KRG has been proven effective in Koreans, and a result on other Asians is pending. The exact action mechanism and the active ingredients in KRC need to be itudied.

• Journal of Cardiovascular Imaging
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• 제26권4호
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• pp.201-213
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• 2018

BACKGROUND: Children with significant adenotonsillar hypertrophy (ATH) may show right ventricular (RV) dysfunction. We aimed to evaluate RV dysfunction in such children before adenotonsillectomy by evaluating peak longitudinal right atrial (RA) strain (PLRAS) in systole. PLRAS, electrocardiogram (ECG) and conventional echocardiographic parameters were compared to distinguish children with significant ATH with sleep-related breathing disorder (ATH-SRBD) from controls. METHODS: Fifty-six children (23 controls and 33 children with ATH-SRBD without symptoms of heart failure) were retrospectively studied. Preoperative echocardiograms and ECGs of children with ATH-SRBD who underwent adenotonsillectomy were compared to those of controls. Available postoperative ECGs and echocardiograms were also analyzed. RESULTS: Preoperatively, prolonged maximum P-wave duration (Pmax) and P-wave dispersion (PWD), decreased PLRAS, and increased tricuspid annulus E/E' were found in children with ATH-SRBD compared to those of controls. From the receiver operating characteristic curves, PLRAS was not inferior compared to tricuspid annulus E/E', Pmax, and PWD in differentiating children with ATH-SRBD from controls; however, the discriminative abilities of all four parameters were poor. In children who underwent adenotonsillectomy, echocardiograms $1.2{\pm}0.4$ years after adenotonsillectomy showed no difference in postoperative PLRAS and tricuspid annulus E/E' when compared with those of the preoperative period. CONCLUSIONS: Impaired RA deformation was reflected as decreased PLRAS in children with ATH-SRBD before adenotonsillectomy. Decreased PLRAS in these children may indicate subtle RV dysfunction and increased proarrhythmic risk. However, usefulness of PLRAS as an individual parameter in differentiating preoperative children with ATH-SRBD from controls was limited, similar to those of tricuspid annulus E/E', Pmax, and PWD.

• Journal of Chest Surgery
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• 제37권9호
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• pp.755-761
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• 2004

말기 허혈성 심근질환에서 좌심실내 원형패취 성형술(Dor 술식)이 심근 기능의 개선에 미치는 영향을 알아보고자 서울대학교병원 흉부외과에서 시행한 Dor 술식의 결과를 분석해 보았다. 대상 및 방법： 1998년 4월부터 2002년 12월 사이에 좌심박출계수 35% 이하의 허혈성 심근질환으로 관상동맥우회술과 함께 Dor 술식을 시행한 45례의 환자를 대상으로 수술 전, 수술 직후 및 술 후 1년째에 심초음파, 심근 SPECT, 심도자 및 조영술을 시행하여 좌심실 박출계수 및 용적 등의 변화를 비교 분석하였다. 결과: 심폐바이패스 및 대동맥 차단시간은 각각 평균 141$\pm$64, 69$\pm$24분이었다. 7례에서 수술전에 대동맥내풍선펌프를 사용하였으며 수술 중 및 수술 후 저심박출 증후군을 보인 9례와 3례에서 대동맥내 풍선펌프를 삽입하였다. 수술 사망은 1례(2.2%)가 있었으며, 합병증으로는 저심박출 증후군(12례), 심방세동(5례), 급성신부전(4례), 출혈에 의한 재수술(4례) 등이 있었다. 술 후 1개월째 환자의 NYHA 기능지수는 평균 2.8에서 1.1로 유의하게 향상되었다(p < 0.01). 수술 직후 시행한 좌심실조영술상 박출계수는 수술 전과 비교해서 32 $\pm$ 9%에서 52$\pm$11%로, asynergy 분획은 57 $\pm$ 12%에서 22 $\pm$ 9%로, 좌심실확장기말, 수축기말 용적 계수들도 각각 125$\pm$39 mL/$m^2$, 85 $\pm$30 mL/$m^2$에서 66$\pm$23 mL/$m^2$, 32$\pm$16 mL/$m^2$으로 통계적으로 유의한 개선을 보였다(p<0.01). 술 후 1년째에 시행한 심초음파검사, 심근 SPECT, 심도자 및 조영술상 수술 직후와 비교해서 좌심박출계수, 좌심실 확장기말용적, 좌심실 수축기말용적은 큰 차이는 없었으나, 좌심실 용적들은 조금씩 늘어나는 양상을 보였다. 결론: 허혈성심근질환에서 좌심실내 패취 성형술은 현저하게 좌심박출계수의 향상과 좌심실용적의 감소를 가져오며 술 후 1년까지도 지속되었으나, 좌심실용적은 다소 증가하는 양상을 보여 술 후에도 좌심실의 재확장을 막기 위한 적극적인 약물치료가 필요함을 시사하였다.

• Journal of Chest Surgery
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• 제26권5호
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• pp.422-426
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• 1993

We report three cases of children who underwent definitive conversion to the Fontan circulation using a new surgical technique, Extracardiac Epicardial Lateral Tunnel. This new procedure allows the operation to be performed as a totally extracardiac operation [especially in ventricular dysfunction] and allows it to be performed in a very small atrium and in cases with unsuitable pulmonary venous drainage.Our data suggest that this procedure may achieve satisfactory hemodynamics of the total cavopulmonary connection.

• Journal of Chest Surgery
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• 제23권5호
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• pp.1040-1046
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• 1990

Despite the improved diagnostic and treatment modalities recently introduced for a variety of esophageal disorders, a perforation or leak from the esophagus remains a sources of morbidity and mortality regardless of the cause of leak. After the perforation of esophagus, the contamination of mediastinum and pleural cavity with food, bacteria and corrosive gastric juice leads to sepsis and cardiopulmonary dysfunction. The early diagnosis and early treatment are very important, and the delayed treatment leads to high risk of morbidity and mortality. We experienced one case of esophageal perforation, after forced vomiting in 48 years old male patient. We used omentum on the treatment of ruptured esophagus, and it was successfully managed.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1261-1263
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• 1992

Primary cardiac fibroma of the left ventricular myocardium is a rare tumor of the heart which is usually located within the anterior wall and /or septum of the left ventricle and is the second most common cardiac tumor in infant and children. Although the tumor is benign histologically, it may cause severe cardiac dysfunction and sudden death. A 30-day-old neonate with a huge intramural fibroma involving the posterolateral wall of the left ventricle underwent it`s partial resection under extracorporeal circulation on April 1992.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.155-155
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• 2002

Several epidemiological studies have suggested that exposure to arsenic is strongly correlated with the development of cardiovascular diseases such as hypertension. To determine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on vasorelaxation using isolated rat aortic rings in an organ bath system.(omitted)

• Journal of Chest Surgery
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• 제24권2호
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• pp.197-201
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• 1991

Twenty-three patients with traumatic diaphragmatic injuries treated at the Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Medical Center from Aug. 1978 to Nov. 1990 were reviewed. There were 19 male and 4 female patients. The age distribution was ranged from 1.5 to 72 years, with a mean age of 34.3 years. Sixteen patients had blunt trauma[traffic accident 14, fall down 2], and 7 had penetrating injuries[stab wound 6, broken glass 1]. Sixteen [70 percent]of the injuries occurred on the left side and 7[30 percent] on the right side. Fifteen patients were operated on during the acute phase, 5 patients during the latent phase, 2 patients during the obstructive phase. The surgical approach in 20 patients was through a thoracotomy; in 2 patients, a thoracoabdominal incision was necessary, and in 1 patient, a laparotomy was performed. Herniated organs in thorax included stomach[10], colon[5], small bowel[5], spleen[4], liver[2]. Postoperative complications included wound infection, empyema, pneumonia, hepatitis and respiratory failure. There were 3 postoperative deaths, 2 with cerebral dysfunction and 1 with sepsis.