• Title/Summary/Keyword: Canine hip dysplasia (CHD)

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Genome-wide association study to identify canine hip dysplasia loci in dogs

  • Kang, Ji Min;Seo, Dongwon;Lee, Soo Hyun;Lee, Doo Ho;Kim, Yeong Kuk;Choi, Bong Hwan;Lee, Seung Hwan
    • Journal of Animal Science and Technology
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    • v.62 no.3
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    • pp.306-312
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    • 2020
  • Korean army dogs are raised for special purposes and have contributed much to society. However, several diseases occur in dogs. Canine hip dysplasia (CHD) is a musculoskeletal disorder that occurs frequently in Korean army dogs and interferes with their activities. If we could control CHD, this would have a positive effect on their performance. This study performed a genome-wide association study (GWAS) in 69 Korean army dogs to find significant loci for CHD using 170K single nucleotide polymorphisms (SNPs). CHD was classified according to the Norberg angle criterion. The control group comprised 62 dogs classified as relatively normal, and 7 dogs with severe CHD formed the case group. From the GWAS analysis, we concluded that SNPs present on chromosome 4 might have a significant impact on the overall expression of canine hip dysplasia.

Evaluation for canine hip dysplasia in Golden and Labrador retrievers using PennHIP method in Korea

  • Choi, Jihye;Kim, Hyunwook;Kim, Hyejin;Jang, Jaeyoung;Kim, Mieun;Yoon, Junghee
    • Korean Journal of Veterinary Research
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    • v.48 no.3
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    • pp.375-379
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    • 2008
  • Hips of the Golden and Labrador retrievers in Korea were evaluated with the University of Pennsylvania Hip Improvement Program (PennHIP) and the severity of joint laxity and degenerative joint disease (DJD) were compared to the PennHIP database. The distraction index (DI) of domestic Golden and Labrador retrievers was significantly higher than the DI of the PennHIP database. In the two breeds, the prevalence of DJD increased according to the DI. However, the severity of DJD did not show a positive correlation with the DI. Overweight dogs and dogs kept indoors showed more severe DJD and more prevalence of clinical signs. This report is thought to be the first case presentation of a large population of Golden and Labrador retrievers in Korea and the findings are representing the overall level of canine hip dysplasia (CHD) of domestic Retrievers, as the PennHIP method was not available in Korea until 2001. We can respect that the stock of retrievers can have a tighter hip joint through control of CHD using an accurate diagnostic method keyed to a phenotype especially concern for joint laxity using PennHIP method and an organized screening program. The clinical manifestation of dysplastic dog can be reduced through control of bodyweight and the environment with regular monitoring the hips with concern for joint laxity using PennHIP method.

Radiographic Evaluation of Coxofemoral Joints in the Jindo (Canis familiaris) (진도개의 고관절이형성에 대한 방사선학적 연구)

  • 오석일;김상기
    • Journal of Veterinary Clinics
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    • v.20 no.4
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    • pp.467-473
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    • 2003
  • The pelvic radiographs of 47 clinically normal Jindoes (26 dogs and 21 bitches) were investigated to evaluate the coxofemoral joints, prospectively. The hip joints were graded according to the Orthopedic Foundation for Animals criteria of excellent, good, fair, borderline, mild canine hip dysplasia (CHD), moderate CHD, severe CHD. Of the 47 Jindoes evaluated, 8 (17%) were graded as dysplastic, 3 (6.4%) were mildly dysplastic, 3 (6.4%) were moderately dysplastic, and 2 (4.3%) were severly dysplastic. Of the 39 Jindoes graded as normal, 16 (34%) were classified as having excellent hip joint phenotype, 15 (31.9%) were classified as having fair, and 8 (17%) were classified as good. Each hip joint was scored based on the British Veterinary Association/The Kennel Club hip scoring system. The normal hip joint (excellent, fair, good) received score less than 5, while dysplastic hip joint (mild, moderate, severe CHD) received score form 5 to 29. Norberg angle (r=0.76) and femoral angle of inclination (r=0.6) were in inverse proportion to grade of the hip joint (P<0.01). The width of medial joint space was in proportion to grade of hip joint (r=0.7, P<0.01).

Radiographic Diagnosis of Degenerative Joint Disease in Canine Hip Joint (개의 고관절 변성관절질환의 방사선학적 진단)

  • 엄기동;장동우;서민호;정주현;장진화;원성준;정우조;최호정;이기창
    • Journal of Veterinary Clinics
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    • v.18 no.3
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    • pp.243-248
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    • 2001
  • Radiographic findings of degenerative joint disease (DJD) in the coxofemoral joints were studied in 108 dogs referred to Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Seoul National University. Radiographic findings were identified with a extended ventrodorsal projection. Clinical signs such as pain in the affected joint, exercise intolerance, lameness, crepitation on flexion and extension of the joint and decreased range of motion, were shown in 40% and radiographic changes of bilateral coxofemoral joints were identified in 69% of a group of dogs. There are no sex predilections. Thirty-seven dogs were diagnosed as canine hip dysplasia (CHD; 10 cases), avascular necrosis of the femoral head (Legg-Calves-Perthes disease [LCPD]; 12 cases), fracture of the acetabulum (1 case), luxation(10 cases) and subluxation (15 cases), however, luxation and subluxation were identified in 11 dogs affected with CHD and LCPD. Causes of DJD in others (71case) were not identified. Radio-graphic findings identified included osteophyte formation at the attachment of the joint capsule (70%), sclerosis of the subchondral bone of the cranial acetabular edge (47%), remodeling of the femoral head (34%), thickening of the femoral neck(31%), perichondral osteophyte formation (31%), joint laxity (30%) and so on. All of the dogs diagnosed as CHD were large breed such as Retriever, Germain Shepherd, and Weimaraner and their age was under 1 year. This condition occurred bilaterally in 70% of affected animals. Dogs diagnosed as LCPD were young (under 1 year), small breed dogs. The incidence of LCPD is greater in Yorkshire Terrier, Miniature Pinscher and Poodle. This condition occurred unilaterally in 67% of affected animals. Clinical signs of dogs with unknown cause were shown in 15% and this condition occurred bilaterally in 75% of affected animals. Radiographic findings varied with patient's age and breed, however, the most common finding was osteophyte formation at the attachment of the joint capsule.

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