• 대한방사선기술학회지:방사선기술과학
• /
• 제32권1호
• /
• pp.45-52
• /
• 2009

유방 촬영술(Digital mammography)은 유방암의 조기 진단에서 매우 중요한 진단 방법으로서 비촉지성 유방암의 조기 발견율을 높여 유방암에 따른 여성의 사망률을 감소시키고 있다. 그 중에서도 유방 병변의 미세석회화(Microcalcification)는 조기 유방암의 진단에 있어서 중요한 병변으로 보고 되고 있으며, 선별 검사로 임상적 유용성이 확립된 상태이다. 유방 촬영술에서 미세석회화 소견은 영상의학과 전문의가 판독하여 조직 검사에서 양성 및 악성 병변에 대하여 각각 군집의 개수, 군집 당 석회화 수, 미세석회화 크기와 범위, 미세석회화 형태, 동반 종괴의 유무 등을 분석하여 최종적으로 진단을 확정한다. 그러므로 군집화된 미세석회화의 정보는 유방암 예측에 있어 임상적인 실질 정보를 가지고 있으며, 의사에게 진단을 위한 검사의 기본적인 가이드라인을 제시한다. 따라서 본 연구에서는 유방 촬영술의 디지털 영상에 나타난 미세석회화의 정량적인 계산을 위해서 DoG filter, Adaptive thresholding, Expectation Maximization의 3단계를 제안한다. 제안한 알고리듬을 실험을 통하여 군집화 및 각 클러스터 내의 미세석회화의 분포 개수, 길이를 측정하였으며, 임상의 사에게 디지털 유방영상의 분석을 통하여 초기 유방암 진단의 지표를 제시할 것으로 사료된다. 그리고 이는 객관적인 유방암 컴퓨터자동검출(CAD)에 사용될 수 있는 병변의 정보로서 가능성을 보였다.

• 종양간호연구
• /
• 제12권1호
• /
• pp.84-91
• /
• 2012

Purpose: The purpose of this study was to identify relationships between quality of sleep, symptom cluster, depression, environmental disorder, and quality of life among hospitalized cancer patients. Methods: The subjects were 114 patients who underwent chemotherapy for colon cancer, gastric cancer, gynecologic cancer and breast cancer. They were recruited from the cancer center of a university hospital. Data were collected from August 4th to 30th, 2011. The questionnaires included the Korean sleep scale A (quality of sleep), MDASI-K (symptom cluster), the environmental sleep disturbing scale, Zung's depression scale, and the Korean version of EORTC QLQ-C30. The collected data was analyzed by t-test, ANOVA, multiple regression analysis using the SPSS 19.0 program. Results: Functional QOL was negatively associated with symptom QOL (r=-.798, p<.001). Symptom cluster, depression, & spouse (46.3%) were the most powerful predictors for functional QOL (46.3%) and symptom QOL (53.4%). Conclusion: It is evident that oncology nurses need to evaluate two dimensions of quality of life for cancer patients, for example, functional and symptom QOL. We recommend nurses develop specific protocols for relieving physical symptoms and alleviating depression, and furthermore test the effectiveness of them.

• 한국병원경영학회지
• /
• 제28권2호
• /
• pp.9-20
• /
• 2023

Purpose: This study classified the actual functions of geriatric hospitals and examined the differences in their characteristics, in order to provide a basis for discussions on defining the functions of geriatric hospitals and how to pay for care. Methodology: This study used various administrative data such as health insurance data and long-term care insurance data. Cluster analysis was used to categorize geriatric hospitals. To examine the validity of the cluster analysis results, we conducted a discriminant analysis to calculate the accuracy of the classification. To examine cluster characteristics, we examined structure, process, and outcome indicators for each cluster. Findings: The cluster analysis identified five clusters. They were geriatric hospitals with relatively short stays for cancer patients(cluster 1; cancer patient-centered), geriatric hospitals with relatively large numbers of patients using rehabilitation services(cluster 2; rehabilitation patient-centered), geriatric hospitals with a high proportion of relatively severe elderly patients(cluster 3; severe elderly patient-centered), geriatric hospitals with a high proportion of mildly ill elderly patients with various conditions(cluster 4; mildly ill elderly patient-centered), and geriatric hospitals with a significantly higher proportion of dementia patients(cluster 5; dementia patient-centered). The largest number of geriatric hospitals were categorized in clusters 4 and 5, and the structure and process indicators for these clusters were generally lower than for the other clusters. Practical Implications: We have confirmed the existence of geriatric hospitals where the medical function, which is the original purpose of a geriatric hospital, has been weakened. It has been observed that the quality level of these geriatric hospitals is likely to be lower compared to hospitals that prioritize enhanced medical functions. Therefore, it is suggested to consider the conversion of these geriatric hospitals into long-term care facilities, and careful consideration should be given to the review of care-giver payment coverage.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2933-2934
• /
• 2014

Involvement of a multidisciplinary team in cancer care may have added benefits over the existing system of patient management. A paradigm shift in the current patient management would allow more focus on nutritional support, in addition to clinical care. Malnutrition, a common problem in cancer patients, needs special attention from the early days of cancer care to improve quality of life and treatment outcomes. Patient management teams with trained oncology dietitians may provide quality personalized nutritional care to cancer patients.

• 대한예방의학회:학술대회논문집
• /
• 대한예방의학회 2002년도 제54차 추계 학술대회 연제집
• /
• pp.218-219
• /
• 2002

• 한국가시화정보학회지
• /
• 제13권1호
• /
• pp.43-48
• /
• 2015

Collective cell migration is a fundamental phenomenon observed in various biological processes such as development, wound healing, and cancer metastasis. During the collective migration, cells undergo changes in their phenotypes from those of stable to the migratory state via the process called epithelial-mesenchymal transition (EMT). Recent findings in biology and biochemistry have shown that EMT is closely related to the cancer invasion or metastasis, but not much of the correlations in kinematics and physical forces between the neighboring cells are known yet. In this study, we aim to understand the cell migration and stress distribution within the expanding cell cluster. We constructed the in vitro cell cluster on the hydrogel, employed traction force microscopy (TFM) and monolayer stress microscopy (MSM) to visualize the physical forces within the expanding cell monolayer. During the expansion, cells at the cluster edge exhibited enhanced motility and developed focal adhesions that are the essential features of EMT while cells at the core of the cluster maintained the epithelial characteristics. In the aspect of mechanical stress, the cluster edge had the highest traction force of ~90 Pa directed toward the cluster core, which means that cells at the edge actively pull the substrate to make the cluster expansion. The cluster core of the tightly confined cells by neighboring cells had a lower traction force value (~60 Pa) but the highest intercellular normal stress of ~800 Pa because of the accumulation of traction from the edge of the monolayer.

• International journal of advanced smart convergence
• /
• 제4권1호
• /
• pp.93-98
• /
• 2015

Recently, Radon has been gotten attention for problems of Nuclear Generating Station and a variety of nuclear. It is naturally arises that is accumulated in the interior through the soil with radioactive materials. People exposed to indoor a Radon increase the high risks of lung cancer. The data are consisted of regional Country, The Location, Average Radon pCi/L, Geo Mean and Geo S.D etc. The research is experimented using E-M algorithm. The research result appears to make a division of soil distance, regional and cluster. It requires in effort to minimize exposure to people who live in areas with high radon levels. A country must apprise to people about Radon risk and needs to work out measures plan.

• 한국산업보건학회지
• /
• 제22권1호
• /
• pp.26-31
• /
• 2012

Objectives: To review the occurrence of cancer cluster in S Electronics semiconductor factories, process of epidemiological researches and lawsuit for industrial accident compensation. Methods: Occupational Safety and Heatlh Research Institute (OSHRI) epidemiological research report, Seoul National University (SNU) field survey report and Seoul Administrative Court ruling were investigated. Result:: OSHRI denied the association between working environment and outbreak of cancers, but SNU survey team reported that carcinogens do exist in workplace and the workers are exposed to them. Seoul Administrative Court ruled that 2 victims got cancer due to hazardous chemicals in working environment and be compensated but 3 victims were not acknowledged. Conclusions: Procedure of current OSHRI epidemiological research should be reassessed by the purpose of Occupational Accident Compensation Insurance Law.

• Macromolecular Research
• /
• 제13권3호
• /
• pp.167-175
• /
• 2005

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The SOC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.

• Journal of Preventive Medicine and Public Health
• /
• 제41권2호
• /
• pp.84-91
• /
• 2008

The World Health Organization (WHO) reported that cancer killed 7.6 million people in the world in 2005, and that 40% of all cancer deaths can be prevented. According to the WHO Global Action Plan Against Cancer (GAPAC), monitoring of cancer patients is the essential part of cancer control, and should be conducted through cancer registration. Originally, cancer registries were primarily concerned with the description of cancer patterns, trends of cancer occurrence, and etiology of cancer. In the last 20 years, cancer registries provided not only information on the incidence and characteristics of specific cancers, but also supplied the source of cancer control planning and evaluation and the care of individual cancer patients with survival. Cancer Incidence in Five Continents (CI5) presents incidence data from populations all over the world every five year. Volume IX in the series (data for 1998-2002) has recently (November 2007) been published online at International Agency for Research on Cancer (IARC). Nine data from Korea Central Cancer Registry (National data), Seoul, Busan, Daegu, Gwangju, Incheon, Daejeon, Usan, Jejudo regional cancer registries were included in that volume. In this paper, the editorial process, the characteristics of national data, and quality indices in CI5 IX are being described. In addition, cancer control activities related to cancer registration in some selected countries are also presented.