• Journal of Nutrition and Health
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• 제26권5호
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• pp.585-592
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• 1993

In order to investigate the hypocholesteremic effect of soybean perptides, soybean protein(ISP), casein(CNP), their peptic hydrolyzates fractionated by acid precipitation at different pH's(SHT, SH8, SH6, SH4, CHT, CH5, CH4) and amino acid mixtures of the same composition as the proteins(SAA, CAA) were fed to rats and the concentration of serum cholesterol was measured. Then in vitro digestibility and molecular weight distribution of the peptides by pepticpancreatic hydrolysis was measured by FPLC. The lower the in vitro digestibility of peptides is, the lower the concentration of serum cholesterol becomes(r=0.986) and the higher the ratio of macropeptides is, the lower the concentration of serum cholesterol becomes(r=-0.932) in rats. These results suggest that the in vitro digestibility of peptides has close relationship to the concentration of serum cholesterol in rats and non-digestible meacropeptides or polypeptides especially more than 1 kDa, formed through digestion in gut, may lower the serum cholesterol in rats.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.755-758
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• 2002

The physical phenomena of rectangular open cavity are numerically investigated in this paper Two-dimensional cavity problems with laminar boundary layers in upstream are simulated by using the compressible Wavier-Stokes equations. The high-order and high-resolution numerical schemes are used for the evaluation of spatial derivatives and the time integration. Cross-correlation is used to analyze the characteristics of wave propagation along time and spatial. Sudden phase shifting of 90 degrees is appeared near downstream edge, and this is coincident with the phase lag suggested in original Rossiter's equation. The results give a further understanding of the physical phenomenon of noise generation, and the resonance of flow and acoustic in cavity. Moreover, modified Rossiter's equation, which is more accurate and can be applied in various conditions, is suggested. The distance from the point of vortex generation to the point of vortex collapsing acts as effective distance of cavity resonance, and the phase difference between the point of vortex collapsing and the point of acoustic source acts as phase lag. The mechanism of acoustic generation is fully understood in this paper. The mechanism of acoustic generation is fully understood in this paper.

• 한국동물학회지
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• 제38권2호
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• pp.167-176
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• 1995

Glucose-regulated proteins (grp's), srp94 3nd grp78/BiP, are a group of stress proteins which are highly synthesized in cells exposed to a variety of stressful agents including tunicamycin 3nd Ca2+ ionophore. Grp78/BiP is hon to function as a molecular chaperone which regulates the folding and assembly of secretory or membrane proteins, but the biological function of grp941 remains to be elucidated. In this study, we have examined the intracellular distribution of grV's and the function of srp94. Grp's are resident in the endoplasmic reticulum (ERI 3nd a specific sequence (Lys-Asp-Glu-Leu) at their C-terminus is known to be responsible for their retention within the ER. However, it has been unclear whether upon disturbance of cellular Caa+ homeostasis by the Ca2+ ionophore, grp94 is retained within the ER or secreted into the medium. In this study, we showed that in the presence of C3a+ ionophore, grp94 and gif78/BiP are present in the cells, mainly within the ER. We have also investigated whether grp94 might function as a molecular chaperone. Here we showed that in the immunoglobulin (Ig)-secreting hvbridom3 cells, grp94 transientlY interacts with fully glycosylated Is heavy chain, suggesting that grpg94 may be involved in facilitating the folding and assembly of Ig heavy chains.

• 한국중재학회지:중재연구
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• 제26권3호
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• pp.121-147
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• 2016

Factual issues in most patent litigation are related to very complicated techniques. Thus, the courts has emphasised that the technology in dispute has to be read and understood through the eyes of a person to whom it is directed. Therefore, among the various processes in federal litigation, most litigation in the field of patent infringement relies on at least some expert evidence. This paper focuses on issues regarding patent dispute evidence, and explore whether there are unresolved issues in evidential rules and procedures of patent proceedings. Further, this paper seeks to demonstrate that both the parties and the courts in patent disputes generally benefit from the current evidence system. However, in a number of Australian cases, the scope of expert evidence in patent cases has been strictly limited. Australian Government identified uncertain issues associated with the present patent enforcement system, due to factors such as a low level of knowledge about what patent rights entail, the high degree of uncertainty of outcome in legal proceedings, etc. Arbitration shall be reviewed and suggested as an alternative to tackling the ongoing problems in the trial system.

• 대한교통학회지
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• 제32권5호
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• pp.431-440
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• 2014

ICAO에서 제시한 국가항공프로그램(State Safety Program, SSP)에 따르면, 국가의 항공안전 목표 달성을 위해 안전성과 측정 및 평가에 활용되는 안전성과지표(SPI)의 설정과 관리가 필수적이다. 이에 따라, 세계 여러 국가들은 자국의 실정에 맞는 SPI 수립을 연구개발하고 있다. 그에 반해, 우리나라는 2008년 국가항공안전프로그램이 제정된 이후로 지금까지 동일한 지표를 사용해왔으며, SPI 수립체계에 대한 체계적인 정책 사업 및 관련 연구가 미비한 실정이다. 따라서, 본 연구는 국내 SPI체계 개발의 일환으로 항공선진국인 유럽과 미국의 SPI 개발계획에 대한 동향 조사를 하고자 한다. 이를 위해 EU의 유럽항공안전국 (EASA), 영국의 민간항공국 (CAA), 핀란드의 교통안전국(FTSA) 및 미국의 연방항공청 (FAA) 사례를 분석했다. 도출 결과를 기반으로 국내외 SPI 개발계획 및 수립체계의 차이점을 밝혔다. 본 연구를 통하여 도출된 분석 결과들은 향후 국내 SPI 수립체계의 발전방향 제시하기 위한 기틀을 마련할 수 있을 것이다.

• Bulletin of the Korean Chemical Society
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• 제34권7호
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• pp.2016-2022
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• 2013

Ionically modified ${\beta}$-cyclodextrins, which have excellent water-solubility, have been interested in purification technology as well as drug carrier system. The present study summarizes the synthesis and characterization of cationic and anionic ${\beta}$-cyclodextrin (${\beta}$-CyD) products using by polycondensation. The oligo (${\beta}$-CyD)s are synthesized from ${\beta}$-CyD, epichlorohydrin (EP) and choline chloride (CC; for cationic polymer) or chloroacetic acid (CAA; for anionic polymer) through one step polycondenstaion process. Unlike the previous studies, we successfully purified the ionic ${\beta}$-CyD condensation products from the ${\beta}$-CyD reaction mixtures and accomplished a great level of structural analysis. The detailed structural analysis of these ionic ${\beta}$-CyD compounds is done by $^1H$ NMR, MALDI-TOF as well as GPC analysis and confirms the formation of oligomers with a few units of ${\beta}$-CyD. We found that the sequence of reactant addition also could effect on the molecular weight of the resulting product as well as the molar ratio of the reactants. Finally, we used the cationic and anionic ${\beta}$-CyD oligomers for fabricating multilayer films by layer-layer process.

• 한국유체기계학회 논문집
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• 제3권2호
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• pp.15-23
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• 2000

The present work describes the prediction method for the unsteady flow field and the acoustic pressure field of a ducted axial fan. The prediction method is comprised of time-marching free-wake method, acoustic analogy, and the Kirchhoff-Helmholtz BEM. The predicted sound signal of a rotor is similar to the experiment one. We assume that the rotor rotates with a constant angular velocity and the flow field around the rotor is incompressible and inviscid. Then, a time-marching free-wake method is used to model the fan and to calculate the flow field. The force of each element on the blade is calculated by the unsteady Bernoulli equation. Lowson's method is used to predict the acoustic source. The newly developed Helmholtz-Kirchhoff BEM lot thin body is used to calculate tile sound field of the ducted fan. The ducted fan with 6 blades is analysed and the sound field around the duct is calculated.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.843-846
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• 2004

Cavity tone is generated due to the feedback between flow and acoustic wave. It is recognized that the period is determined by the time required for the flow convection in one direction, the time required for the acoustic propagation in the other direction and the time for phase shift depending on the flows and mode. Most of the phenomena have been investigated by experiments and a simple but fundamental theory. But the cause of the phase shift and the correctness of the theory have not been clearly explained so far. In this paper, the phenomena are calculated numerically to obtain detail information of flow and acoustic wave to explain the mechanism including the phase. High order high resolution scheme of optimized high order compact is used to resolve the small acoustic quantities and large flow quantities at the same time. The data are reduced using cross correlation function in space and time and cross spectral density function which has phase information. Abrupt change in pressure near corner in cavity is observed and is relate to phase variation. The time required for the feedback between the flow and acoustic wave is calculated after the numerical simulation f3r various modes. The periods based on the time calculated using the above method and direct observation from the acoustic waves generated and propagated in the numerical simulation are compared. It is found that no phase shift is required if we examine the time required carefully. Rossiter's formula for the cavity tone used for quick estimation needs to be modified far some modes.

• Plant Resources
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• 제7권3호
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• pp.174-180
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• 2004

Calmodulin, a $Ca^{2+}$-binding protein, has no enzyme activity. It combines with $Ca^{2+}$ and makes variable proteins to an active form. Calmodulin 2 is a ubiquitous protein in plants. To investigate the defense mechanism against various stresses, a clone encoding a calmodulin 2 protein was isolated from a cDNA library prepared from taproot mRNAs of Codonopsis lanceolata. The cDNA, designated CICAM2, is 719 nucleotides long and has an open reading frame of 450 bp with a deduced amino acid sequence of 149 residues. The deduced amino acid sequence of CICAM2 showed a high similarity with calmodulins of P. x hybrida (P27163) 97%, N. tabacum (BAB61908) 97%, S. tuberosum (AAA74405) 96%, Z. mays (CAA74307) 92%, C. richardii (AF510075) 93%, M. truncatula (AAM81203) 91%, and G. max (P62163) 91%. The transcriptional expression of the CICAM2 gene, was gradually increased by the CaCl$_2$ treatment. Whereas its expression And it was gradually decreased in the cold stress treatment.ent.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2013년도 추계학술대회 논문집
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• pp.775-780
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• 2013

In recent years, a notebook like an ultrabook gets thinner. Its thickness causes problems in cooling fan performance, system installation condition, and so on. In this study, we installed a small turbofan in notebook system with very narrow gap in order to generate similar condition to a real product. Experiments were performed to measure the fan's performance and the flow and noise characteristics, its results were compared with computational ones. Prediction of P-Q curve using CFD showed under about 5% error in high flow rate and its trend was agreed with experimental one over the flow field. Experimental data to measure the noise at a distance of 100 mm from a rotation axis direction of an impeller corresponded well with computational ones of broadband and BPF noise. The noise experiments to measure at a distance of 100 mm from a rotation axis direction of an impeller corresponded well with computational ones of broadband and BPF noise. Especially, tip part of impeller blade and part of exit and bottom near in an analysis by a commercial program(FlowNoise).